利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

82 条记录 (耗时 0.033 秒)

    Pattern transfer in device fabrication
    21.
    发明授权
    Pattern transfer in device fabrication 有权
    器件制造中的图案转移

    公开(公告)号：US07090967B2

    公开(公告)日：2006-08-15

    申请号：US10248232

    申请日：2002-12-30

    申请人： Zhijian Lu ,  Chieh-Yu Lin

    发明人： Zhijian Lu ,  Chieh-Yu Lin

    IPC分类号： G03F7/26

    CPC分类号： G03F7/40 ,  H01L21/0273 ,  H01L21/31144 ,  H01L21/32139

    摘要： A method of transferring a pattern onto a substrate, in the fabrication of ICs, is disclosed. The substrate is coated with a photoresist layer, wherein the photoresist layer is selectively exposed and developed, producing sidewalls that exhibit roughness. The roughness is smoothened out by coating the photoresist layer with a coating layer.

    摘要翻译： 公开了一种在IC的制造中将图案转印到基板上的方法。 衬底涂覆有光致抗蚀剂层，其中光致抗蚀剂层被选择性地暴露和显影，产生表现出粗糙度的侧壁。 通过用涂层涂覆光致抗蚀剂层，使粗糙度平滑化。

    Method of reducing post-development defects in and around openings formed in photoresist by use of non-patterned exposure
    22.
    发明授权
    Method of reducing post-development defects in and around openings formed in photoresist by use of non-patterned exposure 有权
    通过使用非图案曝光来减少在光致抗蚀剂中形成的开口周围和周围的显影后缺陷的方法

    公开(公告)号：US06420101B1

    公开(公告)日：2002-07-16

    申请号：US09598376

    申请日：2000-06-21

    申请人： Zhijian Lu ,  Alan Thomas ,  Alois Gutmann ,  Kuang Jung Chen ,  Margaret C. Lawson

    发明人： Zhijian Lu ,  Alan Thomas ,  Alois Gutmann ,  Kuang Jung Chen ,  Margaret C. Lawson

    IPC分类号： G03F720

    CPC分类号： H01L21/0274 ,  G03F7/2022 ,  G03F7/2037 ,  G03F7/2039 ,  Y10S430/168

    摘要： In the exposure and development of available deep ultraviolet (DUV) sensitive photoresist it has been observed that following the standard prior art methods of exposure and development results in a high density of undesirable pieces of components of the photoresist material, Blob Defects, remaining on the semiconductor substrate (body). A method of exposing and developing the photoresist material which results in a reduced incidence of these Blob Defects consists of introducing a low level uniform flood exposure of light in addition to the commonly used exposure to patterned light, followed by standard development. The flood exposure is in the range of 5 to 50% of the dose-to-clear for a non-patterned exposure.

    摘要翻译： 在可用的深紫外（DUV）敏感光刻胶的曝光和显影中，已经观察到遵循现有技术的标准曝光和显影方法导致光致抗蚀剂材料的不希望的部件的高密度，残留在 半导体衬底（主体）。 曝光和显影光致抗蚀剂材料的方法导致这些斑点缺陷的发生率降低，除了通常使用的图案光曝光之外，还引入低等级的均匀泛光曝光，随后进行标准开发。 对于非图案化曝光，洪水暴露在5至50％的剂量清除范围内。

    Piperidines promote release of growth hormone
    23.
    发明授权
    Piperidines promote release of growth hormone 失效
    皮质激素促进生长激素的释放

    公开(公告)号：US5965565A

    公开(公告)日：1999-10-12

    申请号：US988816

    申请日：1997-12-11

    申请人： Meng H. Chen ,  Zhijian Lu ,  Ravi Nargund ,  Arthur A. Patchett ,  James R. Tata ,  Lihu Yang ,  Mu Tsu Wu

    发明人： Meng H. Chen ,  Zhijian Lu ,  Ravi Nargund ,  Arthur A. Patchett ,  James R. Tata ,  Lihu Yang ,  Mu Tsu Wu

    IPC分类号： C07D401/06 ,  C07D413/14 ,  C07D471/10 ,  C07D495/10 ,  C07D209/04 ,  A61K31/445 ,  C07D211/00

    CPC分类号： C07D401/06 ,  C07D413/14 ,  C07D471/10 ,  C07D495/10

    摘要： The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R.sup.1, R.sup.1a, R.sup.2a, R.sup.3a, R.sup.3b, R.sup.4, R.sup.4a, R.sup.4b, R.sup.4c, R.sup.5, D, X, Y, n, x and y are as defined herein. These compounds promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such compounds as the active ingredient thereof are also disclosed.

    摘要翻译： 本发明涉及一般结构式的某些哌啶，吡咯烷和六氢-1H-吖庚因：其中B选自：和R1，R1a，R2a，R3a，R3b，R4，R4a，R4b，R4c，R5， D，X，Y，n，x和y如本文所定义。 这些化合物促进人和动物中生长激素的释放。 这种性质可以用于促进食用动物的生长，使食用肉制品的生产更有效，并且在人类中，用于治疗以生长激素分泌不足为特征的生理或医学病症，例如生长激素缺乏的身材矮小 儿童，并且治疗通过生长激素的合成代谢作用改善的医疗状况。 还公开了含有这些化合物作为其活性成分的生长激素释放组合物。

    INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR
    27.
    发明申请
    INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR 审中-公开
    白细胞介素-17F抗体及其他IL-17F信号拮抗剂及其用途

    公开(公告)号：US20110033451A1

    公开(公告)日：2011-02-10

    申请号：US12827199

    申请日：2010-06-30

    申请人： Beatriz M. Carreno ,  Mary Collins ,  Jill F. Wright ,  Neil M. Wolfman ,  Maya Arai ,  Kenneth Jacobs ,  Zhijian Lu ,  Yongjing Guo ,  Yongchang Qiu

    发明人： Beatriz M. Carreno ,  Mary Collins ,  Jill F. Wright ,  Neil M. Wolfman ,  Maya Arai ,  Kenneth Jacobs ,  Zhijian Lu ,  Yongjing Guo ,  Yongchang Qiu

    IPC分类号： A61K39/395 ,  A61K33/24 ,  A61K38/02 ,  A61K31/7088 ,  A61P11/06 ,  A61P29/00 ,  A61P19/02 ,  A61P17/06

    CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/55527 ,  C07K14/54 ,  C07K14/7155 ,  C07K16/2866 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1138 ,  G01N33/6869

    摘要： The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling.

    摘要翻译： 本发明提供与IL-17F信号通路相关的分离和纯化的多核苷酸和多肽。 本发明还提供了对IL-17F同源二聚体和IL-17A / IL-17F异二聚体的抗体，以及从天然来源分离和纯化IL-17家族成员（包括IL-17A / IL-17F异源二聚体）的方法。 本发明还涉及用于诊断，预后，监测与IL-17F信号传导相关的疾病的进展和/或预防的新方法，即IL-17F相关疾病，包括但不限于炎性 诸如自身免疫性疾病（例如关节炎（包括类风湿性关节炎），牛皮癣，系统性红斑狼疮和多发性硬化症），呼吸系统疾病（例如COPD，囊性纤维化，哮喘，过敏），移植排斥（包括实体器官移植排斥 ）和炎症性肠病或疾病（IBD，例如溃疡性结肠炎，克罗恩病）。 本发明还涉及新的治疗和治疗靶标，以及筛选和评估用于干预（治疗）的试验化合物和预防与IL-17F信号传导相关的紊乱的方法。

    Optical diffusers, photomasks and their methods of fabrication
    28.
    发明授权
    Optical diffusers, photomasks and their methods of fabrication 有权

    公开(公告)号：US07838204B2

    公开(公告)日：2010-11-23

    申请号：US12623529

    申请日：2009-11-23

    申请人： Zhijian Lu

    发明人： Zhijian Lu

    IPC分类号： G03F1/00

    CPC分类号： G03F7/0007 ,  G02B1/12 ,  G02B5/0215 ,  G02B5/0221 ,  G02B5/0231 ,  G02B5/0268 ,  G02B5/0278 ,  G02B6/0051 ,  G02F1/133606 ,  G03F1/00

    摘要： A large mask with random apertures may be formed by forming a smaller mask (also called a cell mask) with a random pattern of transmissive apertures which is then repeatedly replicated to create the large mask. The random pattern may be created by perturbing the aperture locations by a small amount or the apertures may be randomly placed within the cell mask provided certain criteria are met. Alternatively, a large mask with a random pattern of transmissive apertures may be formed without using a cell mask. This large mask may be used to fabricate diffusers and other devices that do not suffer from the interference, diffraction and other optical effects common in devices having structures that are non-randomly patterned.

    SYSTEMS AND METHODS FOR PROTEIN PRODUCTION
    29.
    发明申请
    SYSTEMS AND METHODS FOR PROTEIN PRODUCTION 有权
    蛋白质生产的系统和方法

    公开(公告)号：US20090221035A1

    公开(公告)日：2009-09-03

    申请号：US12419018

    申请日：2009-04-06

    申请人： Yijie Gao ,  Nicole M. Piche ,  Mei Geng ,  Stephen H. Herrmann ,  Xiaotian Zhong ,  Ronald Kriz ,  Zhijian Lu

    发明人： Yijie Gao ,  Nicole M. Piche ,  Mei Geng ,  Stephen H. Herrmann ,  Xiaotian Zhong ,  Ronald Kriz ,  Zhijian Lu

    IPC分类号： C12P21/00 ,  C12N5/04 ,  C12N5/06 ,  A01K67/027 ,  C12N15/00

    CPC分类号： C07K14/4705 ,  A01K2217/075 ,  C07K14/51 ,  C12P21/02

    摘要： The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-engineered cells comprising one or more recombinant expression cassettes which encode (1) a protein of interest and (2) a polypeptide that is functional in the unfolded protein response (UPR) pathway of the cells. Co-expression of the polypeptide significantly increases the yield of the protein of interest in the genetically-engineered cells. In one example, the genetically-engineered cells are animal cells, and the co-expressed polypeptide is a component or modulator of an XB1- or ATF6-mediated UPR pathway.

    摘要翻译： 本发明涉及生产目标蛋白质的系统和方法。 本发明使用具有改变的蛋白质折叠或加工能力的遗传工程化的动物或植物细胞。 一方面，本发明的特征在于遗传工程改造的细胞，其包含一个或多个编码（1）目的蛋白质的重组表达盒，和（2）在细胞的未折叠的蛋白质应答（UPR）途径中有功能的多肽。 多肽的共表达显着提高了遗传工程细胞中目标蛋白的产量。 在一个实例中，遗传工程改造的细胞是动物细胞，共表达的多肽是XB1或ATF6介导的UPR途径的组分或调节剂。