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21.发明授权公开(公告)号：US08426422B2
公开(公告)日：2013-04-23
申请号：US12689106
申请日：2010-01-18
申请人： Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
发明人： Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号： A61K31/496 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14 , C07D295/155
CPC分类号： C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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22.发明申请BCL-XL Inhibitory Compounds and Antibody Drug Conjugates Including the Same 审中-公开BCL-XL抑制剂及其抗体药物结合物公开(公告)号：US20160158377A1
公开(公告)日：2016-06-09
申请号：US14963510
申请日：2015-12-09
申请人： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
发明人： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC分类号： A61K47/48 , C07K16/18 , C07D513/04 , C07D417/14 , C07D487/04
CPC分类号： C07K16/18 , A61K47/6803 , C07D417/14 , C07D487/04 , C07D513/04 , C07K2317/73
摘要： Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
摘要翻译： 本文公开了包含小分子Bcl-xL抑制剂的小分子Bcl-xL抑制剂和抗体药物偶联物（ADC）。 本公开的Bcl-xL抑制剂和ADC尤其可用于抑制抗凋亡Bcl-xL蛋白作为治疗涉及失调性凋亡途径的疾病的治疗方法。
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23.发明授权公开(公告)号：US09006247B2
公开(公告)日：2015-04-14
申请号：US13115376
申请日：2011-05-25
IPC分类号： A61K31/497 , C07D401/00 , C07F9/02 , A61K31/44 , A61K31/18 , C07D471/04
CPC分类号： C07D471/04 , A61K31/18 , A61K31/44 , A61K31/496 , A61P35/00 , C07F9/65616 , Y02A50/385 , Y02A50/401 , Y02A50/411 , Y02A50/463
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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24.发明申请公开(公告)号：US20120028925A1
公开(公告)日：2012-02-02
申请号：US13115376
申请日：2011-05-25
IPC分类号： A61K31/675 , A61P35/00 , A61P35/02 , C07F9/6561
CPC分类号： C07D471/04 , A61K31/18 , A61K31/44 , A61K31/496 , A61P35/00 , C07F9/65616 , Y02A50/385 , Y02A50/401 , Y02A50/411 , Y02A50/463
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20090030196A1
公开(公告)日：2009-01-29
申请号：US12133985
申请日：2008-06-05
申请人： Le Wang , Lisa A. Hasvold , Zhi-Fu Tao , Laura Hexamer , Thomas D. Penning
发明人： Le Wang , Lisa A. Hasvold , Zhi-Fu Tao , Laura Hexamer , Thomas D. Penning
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
摘要翻译： 披露了Pim激酶的抑制剂，制备方法以及使用它们治疗患者的方法。
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![Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics](/abs-image/US/2012/04/03/US08148384B2/abs.jpg.150x150.jpg)
26.发明授权Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics 有权取代的噻吩并[3,2-d]嘧啶PIM激酶抑制剂作为癌症化学治疗剂公开(公告)号：US08148384B2
公开(公告)日：2012-04-03
申请号：US11951546
申请日：2007-12-06
申请人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
发明人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00 , C07D495/14
CPC分类号： C07D495/04
摘要： Compounds of formula I wherein A1, A2, and A3 are as defined herein are inhibitors of PIM kinase. The compounds of formula I are useful for the treatment of diseases such as cancer.
摘要翻译： 其中A1，A2和A3如本文所定义的式I化合物是PIM激酶的抑制剂。 式I化合物可用于治疗诸如癌症的疾病。
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公开(公告)号：US20080161559A1
公开(公告)日：2008-07-03
申请号：US11951546
申请日：2007-12-06
申请人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
发明人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
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28.发明授权公开(公告)号：US08557983B2
公开(公告)日：2013-10-15
申请号：US12793413
申请日：2010-06-03
申请人： George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
发明人： George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
IPC分类号： C07D403/14 , C07D413/14
CPC分类号： C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US07956185B2
公开(公告)日：2011-06-07
申请号：US11753279
申请日：2007-05-24
申请人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
发明人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
IPC分类号： C07D239/02
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
摘要翻译： 其中X1，C1和D1在本文中定义的式（I）化合物是polo样激酶的抑制剂。 式（I）化合物可用于治疗细胞增殖疾病，例如癌症。
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公开(公告)号：US20080015192A1
公开(公告)日：2008-01-17
申请号：US11753279
申请日：2007-05-24
申请人： Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
发明人： Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
IPC分类号： A61K31/50 , A61K31/34 , A61K31/40 , A61K31/505 , A61P35/00 , C07D233/61 , C07D239/24 , C07D307/04 , C07D413/02 , C07D277/08 , C07D239/20 , C07D207/30 , A61K31/5377 , A61K31/4164 , A61K31/425
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译： 公开了抑制Plk1的化合物，含有该化合物的组合物和使用该化合物治疗疾病的方法。
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