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公开(公告)号：US20100217537A1
公开(公告)日：2010-08-26
申请号：US12718362
申请日：2010-03-05
CPC分类号： G01J3/28
摘要： System and method for assessing the occurrence of an unknown substance in a sample that comprises multiple entities. A reference library is provided comprising a plurality of reference data sets representative of at least one known substance. A first feature of the entities is assessed wherein the first feature is characteristic of the unknown substance. A region of interest is selected wherein the region of interest comprises at least one entity exhibiting the first feature. A spatially accurate wavelength resolved Raman image is obtained wherein each pixel in the image is the Raman spectrum of the sample at the corresponding location. The spatially accurate wavelength resolved image is assessed to thereby identify the unknown substance.
摘要翻译： 用于评估包含多个实体的样品中未知物质的发生的系统和方法。 提供了包括代表至少一种已知物质的多个参考数据集的参考文库。 评估实体的第一特征，其中第一特征是未知物质的特征。 选择感兴趣区域，其中感兴趣区域包括展示第一特征的至少一个实体。 获得空间精确的波长分辨拉曼图像，其中图像中的每个像素是相应位置处样品的拉曼光谱。 评估空间上准确的波长分辨图像，从而识别未知物质。
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公开(公告)号：US07595878B2
公开(公告)日：2009-09-29
申请号：US11091126
申请日：2005-03-28
CPC分类号： G06K9/00127
摘要： The invention relates to methods of assessing one or more geometric properties of a particle of a substance using an infrared spectroscopic property of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials.
摘要翻译： 本发明涉及使用该物质的红外光谱特性评估物质颗粒的一种或多种几何性质的方法。 该方法例如用于评估含有物质颗粒和其它材料的混合物的粒度和尺寸分布是有用的。
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公开(公告)号：US20070133984A1
公开(公告)日：2007-06-14
申请号：US11585535
申请日：2006-10-24
申请人： John Maier , Patrick Treado , Matthew Nelson , Lindy McClelland , Shona Stewart
发明人： John Maier , Patrick Treado , Matthew Nelson , Lindy McClelland , Shona Stewart
CPC分类号： G01N21/65 , G01J3/28 , G01J3/2823 , G01J3/44 , G01N21/274 , G01N2021/656
摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.
摘要翻译： 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。
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24.发明申请公开(公告)号：US20070081156A1
公开(公告)日：2007-04-12
申请号：US11544648
申请日：2006-10-10
申请人： Patrick Treado , Thomas Voigt , Wesley Hutchison
发明人： Patrick Treado , Thomas Voigt , Wesley Hutchison
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0227 , G01J3/0256 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0286 , G01J3/0289 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/2803 , G01J3/2823 , G01J3/44 , G01J3/4406 , G01J3/447 , G01N2021/656 , G01N2201/0846
摘要： The disclosure relates to a portable and/or handheld bioagent detector and methodology described herein that is based in part on advanced Raman Chemical Imaging (“RCI”) technology. According to one embodiment of the present disclosure, the detection system may include a fiber array spectral translator (“FAST”) and may also include a probe which may include a complementary metal oxide semiconductor (CMOS) camera. The probe alleviates the need to place the main instrument close to an unconfined release of a potentially hazardous material and facilitates analysis of a sample that is situated in a hard-to-reach location while minimizing contamination of the detector and operator.
摘要翻译： 本公开涉及部分基于先进的拉曼化学成像（“RCI”）技术的本文描述的便携式和/或手持式生物代谢检测器和方法。 根据本公开的一个实施例，检测系统可以包括光纤阵列光谱转换器（“FAST”），并且还可以包括可以包括互补金属氧化物半导体（CMOS）照相机的探针。 探头减轻了将主仪器置于非限制性释放潜在危险物质的需要，并有助于分析位于难以到达的位置的样品，同时最大限度地减少检测器和操作者的污染。
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25.发明申请Ultrasonic spray deposition of analytes for improved molecular chemical imaging detection 审中-公开分析物的超声波喷雾沉积用于改进分子化学成像检测公开(公告)号：US20070070342A1
公开(公告)日：2007-03-29
申请号：US11527391
申请日：2006-09-27
申请人： Patrick Treado
发明人： Patrick Treado
摘要： A device and method is described that uses an ultrasonic nozzle for high efficiency deposition of an analyte. Certain embodiments include a plurality of spray applications over the same spatial location to thereby increase the analyte concentration so as to localize and improve the overall molecular chemical imaging sensitivity and specificity. A spectral analysis of the analyte may be conducted and compared with the spectra of biothreat agents.
摘要翻译： 描述了使用超声波喷嘴来分析物高效沉积的装置和方法。 某些实施方案包括在相同空间位置上的多个喷雾应用，从而增加分析物浓度，以便定位和改善整个分子化学成像的敏感性和特异性。 可以进行分析物的光谱分析，并与生物降解剂的光谱进行比较。
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公开(公告)号：US20060268266A1
公开(公告)日：2006-11-30
申请号：US11366660
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
CPC分类号： G01N21/65 , G01N21/6456 , G01N2021/6421 , G01N2201/0221
摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.
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公开(公告)号：US20060157652A1
公开(公告)日：2006-07-20
申请号：US11366887
申请日：2006-03-02
申请人： Patrick Treado , Matthew Nelson , Scott Keitzer
发明人： Patrick Treado , Matthew Nelson , Scott Keitzer
IPC分类号： G01N21/35
CPC分类号： G01N21/359 , G01J3/2823 , G02B21/0016 , G02B21/06
摘要： A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.
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公开(公告)号：US20050030657A1
公开(公告)日：2005-02-10
申请号：US10893332
申请日：2004-07-19
申请人： John Maier , Patrick Treado , Chenhui Wang
发明人： John Maier , Patrick Treado , Chenhui Wang
IPC分类号： G01B9/02 , G01J20060101 , G01J3/02 , G01J3/10 , G01J3/28 , G01J3/30 , G01J3/44 , G01N21/64 , G01N21/65 , G02F1/1333 , G02F1/1335 , G02F1/1347
CPC分类号： G01N21/65 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/10 , G01J3/44 , G01J3/4406 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6471 , G01N2201/0221 , G01N2201/0627 , G02F1/133371 , G02F1/1347
摘要： The disclosure generally relates to a method and apparatus for multi-wavelength imaging spectrometer. More specifically, in one embodiment, the disclosure relates to an optical filter for passing photons therethrough. The filter includes a first filter stage and a second filter stage. The first filter stage may include a first retarder element and a first liquid crystal cell. The first element may include an input face and an output face. One of the first element faces is not oriented substantially normal to the trajectory of photons passing through the filter.
摘要翻译： 本公开一般涉及用于多波长成像光谱仪的方法和装置。 更具体地，在一个实施例中，本发明涉及一种用于使光子通过其的滤光器。 该滤波器包括第一滤波器级和第二滤波级。 第一滤波器级可以包括第一延迟元件和第一液晶单元。 第一元件可以包括输入面和输出面。 第一元件面之一不是基本上垂直于通过过滤器的光子的轨迹。
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29.发明申请Portable system for detecting explosive materials using near infrared hyperspectral imaging and method for using thereof 审中-公开用于使用近红外光谱成像检测爆炸性材料的便携式系统及其使用方法公开(公告)号：US20130341509A1
公开(公告)日：2013-12-26
申请号：US13134978
申请日：2011-06-22
CPC分类号： G01J3/0208 , G01J3/0224 , G01J3/0248 , G01J3/0264 , G01J3/027 , G01J3/0272 , G01J3/0283 , G01J3/0289 , G01J3/0291 , G01J3/1256 , G01J3/26 , G01J3/2823 , G01J3/42 , G01N21/359 , G01N33/227 , G01N2201/0221 , G01N2201/067 , G01N2201/129
摘要： The present disclosure provides for a portable device for detecting the presence of explosive materials, including bulk explosive materials and out-gassed by products of explosive materials. The portable device may comprise a tunable filter and a NIR detector, configured so as to generate a NIR hyperspectral image representative of a target. The portable device may also comprise a RGB detector configured to generate a video image of a region of interest. The disclosure also provides for a method of detecting explosive materials using NIR hyperspectral imaging which may comprise collecting interacted photons, passing the interacted photons through a tunable filter, and detecting the interacted photons to generate a NIR hyperspectral image representative of a target. The method may also comprise surveying a region of interest using a RGB detector to identify a target for further inspection using NIR hyperspectral imaging.
摘要翻译： 本公开提供了一种便携式装置，用于检测爆炸物质的存在，包括爆炸物质的爆炸物质和由爆炸物质的产物冒出的气体。 便携式设备可以包括可调谐滤波器和NIR检测器，其被配置为产生代表目标的NIR高光谱图像。 便携式设备还可以包括被配置为生成感兴趣区域的视频图像的RGB检测器。 本公开还提供了使用NIR高光谱成像检测爆炸性材料的方法，其可以包括收集相互作用的光子，使相互作用的光子通过可调谐滤光器，并且检测相互作用的光子以产生代表目标的NIR高光谱图像。 该方法还可以包括使用RGB检测器来测量感兴趣的区域，以使用NIR高光谱成像识别用于进一步检查的目标。
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公开(公告)号：US08436987B2
公开(公告)日：2013-05-07
申请号：US13209670
申请日：2011-08-15
IPC分类号： G01N21/00
摘要： A system and method for locating and identifying unknown samples. A targeting mode may be utilized to scan regions of interest for potential unknown materials. This targeting mode may interrogate regions of interest using SWIR and/or fluorescence spectroscopic and imaging techniques. Unknown samples detected in regions of interest may be further interrogated using a combination of Raman and LIBS techniques to identify the unknown samples. Structured illumination may be used to interrogate an unknown sample. Data sets generated during interrogation may be compared to a reference database comprising a plurality of reference data sets, each associated with a known material. The system and method may be used to identify a variety of materials including: biological, chemical, explosive, hazardous, concealment, and non-hazardous materials.
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