公开(公告)号：US20100099617A1

公开(公告)日：2010-04-22

申请号：US12585371

申请日：2009-09-14

Applicant: Henry Yue ,  Monique G. Yao ,  Ameena R. Gandhi ,  Mariah R. Baughn ,  Anita Swarnakar ,  Narinder K. Chawla ,  Madhusudan M. Sanjanwala ,  Michael B. Thornton ,  Vicki S. Elliott ,  Yan Lu ,  Kimberly J. Gietzen ,  Neil Burford ,  Li Ding ,  April J. A. Hafalia ,  Y. Tom Tang ,  Olga Bandman ,  Bridget A. Warren ,  Cynthia D. Honchell ,  Dyung Aina M. Lu ,  Kavitha Thangavelu ,  Sally Lee ,  Yuming Xu ,  Junming Yang ,  Preeti G. Lal ,  Bao Tran ,  Craig H. Ison ,  Brendan M. Duggan ,  Stephanie K. Sapperstein

Inventor： Henry Yue ,  Monique G. Yao ,  Ameena R. Gandhi ,  Mariah R. Baughn ,  Anita Swarnakar ,  Narinder K. Chawla ,  Madhusudan M. Sanjanwala ,  Michael B. Thornton ,  Vicki S. Elliott ,  Yan Lu ,  Kimberly J. Gietzen ,  Neil Burford ,  Li Ding ,  April J. A. Hafalia ,  Y. Tom Tang ,  Olga Bandman ,  Bridget A. Warren ,  Cynthia D. Honchell ,  Dyung Aina M. Lu ,  Kavitha Thangavelu ,  Sally Lee ,  Yuming Xu ,  Junming Yang ,  Preeti G. Lal ,  Bao Tran ,  Craig H. Ison ,  Brendan M. Duggan ,  Stephanie K. Sapperstein

IPC: A61K38/16 ,  C07K14/00 ,  A61K38/22 ,  C07K14/575 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00 ,  A61P25/00 ,  A61P9/00 ,  C12P21/02

CPC classification number: C12N15/1055 ,  A61K39/3955 ,  A61K47/64 ,  A61K47/643 ,  A61K2039/505 ,  C07K14/47 ,  C07K14/4711 ,  C07K14/4713 ,  C07K16/18 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/75 ,  C07K2317/76 ,  G01N33/5023

Abstract: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.

Abstract translation: 本发明提供鉴定和编码SECP的人分泌蛋白（SECP）和多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与SECP异常表达相关的疾病的方法。

公开(公告)号：US07536892B2

公开(公告)日：2009-05-26

申请号：US11446997

申请日：2006-06-05

Applicant: Hiroyuki Amino ,  Shigeo Matsubara ,  Yan Lu

Inventor： Hiroyuki Amino ,  Shigeo Matsubara ,  Yan Lu

IPC: B21D11/02 ,  B21D7/00

CPC classification number: B21D22/16 ,  B21D22/185

Abstract: In order to provide a method and apparatus for forming a sheet metal, in which a three-dimensional product such as a prototype for commercialized press-forming can be formed in short time without limitations as to the shape and with high accuracy, preventing body wrinkles or reduction of the sheet thickness, a process of: performing drawing-forming to a predetermine height by pushing the forming punch having a desired shape in the sheet thickness direction with the edges of the blank workpiece being clamped; performing shape-forming with the shaping tool in the opposite side to the forming punch by increasing a clamping pressure to lock movement of a material with the forming punch being pushed; performing drawing-forming again by decreasing the clamping pressure and raising the forming punch by a desired height; and performing shape-forming with the shaping tool by increasing the clamping pressure to lock movement of a material, is repeated at least once.

Abstract translation: 为了提供用于形成金属板的方法和装置，其中可以在短时间内形成诸如用于商业压制成型的原型的三维产品，而不限于形状和高精度，防止体皱纹 或减少片材厚度的方法;以下步骤：通过在坯料工件的边缘被夹持的同时将具有期望形状的成形冲头沿片材厚度方向推压到预定高度; 通过增加夹紧压力来与成型冲头的相对侧的成形工具进行成形，以锁定成形冲头被推动的材料的运动; 通过减小夹紧压力并将成形冲头提高希望的高度来再次进行拉伸成形; 并且通过增加夹持压力以锁定材料的运动，通过成形工具进行成形，至少重复一次。

公开(公告)号：US20050245925A1

公开(公告)日：2005-11-03

申请号：US10999230

申请日：2004-11-30

Applicant: Kobi Iki ,  William Ambrisco ,  Douglas Lorang ,  Alan Gannon ,  Richard Ranalli ,  Mathew Mitchell ,  Marie Meyer ,  Mark Markel ,  Yan Lu ,  Ryland Edwards

Inventor： Kobi Iki ,  William Ambrisco ,  Douglas Lorang ,  Alan Gannon ,  Richard Ranalli ,  Mathew Mitchell ,  Marie Meyer ,  Mark Markel ,  Yan Lu ,  Ryland Edwards

IPC: A61B18/14

CPC classification number: A61B18/1402

Abstract: An electrosurgical instrument includes a shaft, a flexible portion, and a head coupled to the shaft through the flexible portion and pivotably coupled to the flexible portion. The head includes a non-conductive surface and an electrically conductive surface. The flexible portion is configured to bias the non-conductive surface and the electrically conductive surface towards a tissue surface, such as cartilage. The non-conductive surface may include a material having a thermal conductivity less than or equal to about 30 W/m*K and/or a volume resistivity greater than or equal to about 1×1014 ohm*cm. The non-conductive surface may include a ceramic such as Macor® ceramic, ZTA ceramic, and/or 99.5% alumina ceramic.

Abstract translation: 电外科器械包括轴，柔性部分和通过柔性部分联接到轴的头部，并可枢转地联接到柔性部分。 头部包括非导电表面和导电表面。 柔性部分构造成将非导电表面和导电表面朝向诸如软骨的组织表面偏置。 非导电表面可以包括热导率小于或等于约30W / m×K的材料和/或体积电阻率大于或等于约1×10 14欧姆·厘米3的材料。 非导电表面可以包括陶瓷，例如陶瓷，ZTA陶瓷和/或99.5％的氧化铝陶瓷。

公开(公告)号：US20050186568A1

公开(公告)日：2005-08-25

申请号：US10491467

申请日：2002-10-17

Applicant: Olga Bandman ,  Mariah Baughn ,  Shanya Becha ,  Mark Borowsky ,  Brendan Duggan ,  Brooke Emerling ,  Ian Forsythe ,  Ameena Ganhi ,  Jennifer Griffin ,  Rajagopal Gururajan ,  April Hafalia ,  Farrah Khan ,  Preeti Lal ,  Ernestine Lee ,  Soo Lee ,  Erika Lindquist ,  Dyung Aina Lu ,  Yan Lu ,  Joseph Marquis ,  Danniel Nguyen ,  Chandra Arvizu ,  Jayalaxmi Ramkumar ,  Shirley Recipon ,  Thomas Richardson ,  Anita Swarnakar ,  Y.Tom Tang ,  Michael Thornton ,  Uyen Tran ,  Narinder Chawla ,  Bridget Warren ,  Junming Yang ,  Monique Yao ,  Henry Yue ,  Yeganeh Zebarjadian

Inventor： Olga Bandman ,  Mariah Baughn ,  Shanya Becha ,  Mark Borowsky ,  Brendan Duggan ,  Brooke Emerling ,  Ian Forsythe ,  Ameena Ganhi ,  Jennifer Griffin ,  Rajagopal Gururajan ,  April Hafalia ,  Farrah Khan ,  Preeti Lal ,  Ernestine Lee ,  Soo Lee ,  Erika Lindquist ,  Dyung Aina Lu ,  Yan Lu ,  Joseph Marquis ,  Danniel Nguyen ,  Chandra Arvizu ,  Jayalaxmi Ramkumar ,  Shirley Recipon ,  Thomas Richardson ,  Anita Swarnakar ,  Y.Tom Tang ,  Michael Thornton ,  Uyen Tran ,  Narinder Chawla ,  Bridget Warren ,  Junming Yang ,  Monique Yao ,  Henry Yue ,  Yeganeh Zebarjadian

IPC: G01N33/50 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K49/00 ,  A61P3/06 ,  A61P9/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07H21/04 ,  C07K16/46 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N9/16 ,  C12N15/02 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/42 ,  C12Q1/48 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N37/00

CPC classification number: C12N9/1205 ,  A01K2217/05

Abstract: Various embodiments of the invention provide human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.

Abstract translation: 本发明的各种实施方案提供鉴定和编码KPP的人类激酶和磷酸酶（KPP）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与KPP异常表达相关的紊乱的方法。

公开(公告)号：US20050164275A1

公开(公告)日：2005-07-28

申请号：US11048744

申请日：2005-02-03

Applicant: Michael Thornton ,  Li Ding ,  Chandra Arvizu ,  Monique Yao ,  Catherine Tribouley ,  Preeti Lal ,  April Hafalia ,  Mariah Baughn ,  Jayalaxmi Ramkumar ,  Yan Lu ,  Narinder Chawla

Inventor： Michael Thornton ,  Li Ding ,  Chandra Arvizu ,  Monique Yao ,  Catherine Tribouley ,  Preeti Lal ,  April Hafalia ,  Mariah Baughn ,  Jayalaxmi Ramkumar ,  Yan Lu ,  Narinder Chawla

IPC: A01K67/00 ,  C07H21/04 ,  C12N9/16 ,  C12Q1/68

CPC classification number: C12N9/16 ,  A01K2217/05

Abstract: The invention provides human phosphodiesterases (HPDE) and polynucleotides which identify and encode HPDE. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of HPDE.

公开(公告)号：US20050101529A1

公开(公告)日：2005-05-12

申请号：US10433757

申请日：2001-12-05

Applicant: Henry Yue ,  Yalda Azimzai ,  Deborah Kallick ,  Mariah Baughn ,  Jennifer Griffin ,  Anita Swarnakar ,  Preeti Lal ,  Narinder Chawla ,  April Hafalia ,  Ameena Gandhi ,  Janice Au-Young ,  Vicki Elliott ,  Jayalaxmi Ramkumar ,  Kavitha Thangavelu ,  Yan Lu ,  Bridget Warren ,  Dyung Lu ,  Ernestine Lee ,  Catherine Tribouley ,  Chandra Arvizu ,  Angelo Delegeane ,  Monique Yao ,  Farrah Khan ,  Madhusudan Sanjanwala

Inventor： Henry Yue ,  Yalda Azimzai ,  Deborah Kallick ,  Mariah Baughn ,  Jennifer Griffin ,  Anita Swarnakar ,  Preeti Lal ,  Narinder Chawla ,  April Hafalia ,  Ameena Gandhi ,  Janice Au-Young ,  Vicki Elliott ,  Jayalaxmi Ramkumar ,  Kavitha Thangavelu ,  Yan Lu ,  Bridget Warren ,  Dyung Lu ,  Ernestine Lee ,  Catherine Tribouley ,  Chandra Arvizu ,  Angelo Delegeane ,  Monique Yao ,  Farrah Khan ,  Madhusudan Sanjanwala

IPC: G01N33/50 ,  A61K38/00 ,  A61K45/00 ,  A61P1/00 ,  A61P1/04 ,  A61P1/08 ,  A61P1/14 ,  A61P1/16 ,  A61P1/18 ,  A61P3/06 ,  A61P7/02 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/06 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P19/02 ,  A61P19/10 ,  A61P21/04 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P29/00 ,  A61P31/18 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P37/08 ,  C07K1/14 ,  C07K14/47 ,  C07K16/40 ,  C07K16/46 ,  C12M1/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/50 ,  C12N9/64 ,  C12N9/76 ,  C12N15/09 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

CPC classification number: C12N9/12 ,  C07K14/47 ,  C12N9/16 ,  C12N9/64

Abstract: The invention provides human protein modification and maintenance molecules (PMMM) and polynucleotides which identify and encode PMMM. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of PMMM.

公开(公告)号：US06402195B1

公开(公告)日：2002-06-11

申请号：US09549571

申请日：2000-04-14

Applicant: Lutz Eisenmann ,  Yan Lu

Inventor： Lutz Eisenmann ,  Yan Lu

IPC: B60R2132

CPC classification number: B60N2/002 ,  B60N2/809 ,  B60N2002/0268

Abstract: In a device for adjusting a vehicle's head support with reference to the position of a passenger's head, with a sensor disposed in the head support for detecting the position of the head, the sensor contains two condenser plates which are arranged one above the other and are part of a condenser, in which the head of the passenger acts as a dielectric. In the method for the adjustment of the vehicle's head support, the height is varied, starting from a rest position with the head support retracted, to such an extent that the increase of the sensor signal of the one condenser plate takes place simultaneously with the decrease of the sensor signal of the other condenser plate.

Abstract translation: 在用于根据乘客头部的位置来调节车辆头部支撑的装置中，传感器设置在头部支撑件中，用于检测头部的位置，传感器包括两个彼此并排布置的电容器板 冷凝器的一部分，其中乘客的头部作为电介质。 在调整车辆头部支撑的方法中，高度随着头部支撑件缩回从静止位置开始变化，使得一个电容器板的传感器信号的增加与减少的同时发生 的另一个冷凝器板的传感器信号。

公开(公告)号：USD856978S1

公开(公告)日：2019-08-20

申请号：US29643095

申请日：2018-04-04

Applicant: Yan Lu

Designer： Yan Lu

公开(公告)号：USD836637S1

公开(公告)日：2018-12-25

申请号：US29599089

申请日：2017-03-30

Applicant: Yan Lu

Designer： Yan Lu

公开(公告)号：US10155728B2

公开(公告)日：2018-12-18

申请号：US15858183

申请日：2017-12-29

Applicant: Yan Lu ,  James T Dalton ,  Wei Li ,  Duane D Miller

Inventor： Yan Lu ,  James T Dalton ,  Wei Li ,  Duane D Miller

IPC: C07D401/02 ,  C07D401/10 ,  C07D401/14 ,  A61K31/437 ,  A61K31/4353 ,  C07D235/18 ,  A61K31/4184 ,  C07D403/04 ,  C07D417/12 ,  C07D471/04 ,  C07D277/24 ,  A61K31/426 ,  A61K45/06

Abstract: The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating various forms of cancer.