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公开(公告)号：US08647619B2
公开(公告)日：2014-02-11
申请号：US12573413
申请日：2009-10-05
IPC分类号： A61K38/43
CPC分类号： C12Y111/01007 , A23K20/189 , A23K50/10 , A23K50/40 , A23L33/19 , A23V2002/00 , A61K38/44 , A23V2250/5425 , A23V2200/306
摘要： It is intended to provide an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts, and foods, drinks, drugs or feeds for promoting osteogenesis. Namely, an osteogenesis promoter capable of promoting osteogenesis by promoting the differentiation of osteoblasts which comprises, as the active ingredient, lactoperoxidase and/or a digestion product obtained by digesting lactoperoxidase with a protease such as trypsin; and foods, drinks, drugs or feeds for promoting osteogenesis containing lactoperoxidase and/or its digestion product.
摘要翻译： 旨在通过促进成骨细胞和用于促进成骨的食物，饮料，药物或饲料的分化来提供能够促进成骨的骨形成促进剂。 即，通过促进成骨细胞的分化来促进成骨的成骨促进剂，其包含作为活性成分的乳过氧化物酶和/或通过用蛋白酶如胰蛋白酶消化乳过氧化物酶获得的消化产物; 以及用于促进含有过氧化物酶和/或其消化产物的成骨的食物，饮料，药物或饲料。
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公开(公告)号：US08420599B2
公开(公告)日：2013-04-16
申请号：US12740709
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
CPC分类号： A61K35/20 , A21D2/263 , A23C19/082 , A23C19/0917 , A23J1/20 , A23L2/66 , A23L33/19 , A23V2002/00 , A23V2300/30 , A23V2200/306 , A23V2250/5424
摘要： Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.
摘要翻译： 公开了一种骨增强剂，其包含具有以下性质（1）至（4）的乳蛋白质级分：（1）乳蛋白质级分来自牛奶; （2）乳蛋白质级分是含有分子量为6,000至150,000道尔顿的蛋白质组分的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为12〜14重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.5〜0.7; 和（4）乳蛋白质级分具有促进成骨细胞钙化的活性。
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公开(公告)号：US20100099848A1
公开(公告)日：2010-04-22
申请号：US12529660
申请日：2008-02-29
申请人： Aiko Ono , Atsushi Serizawa , Yoshikazu Morita , Hiroshi Kawakami
发明人： Aiko Ono , Atsushi Serizawa , Yoshikazu Morita , Hiroshi Kawakami
IPC分类号： C07K14/00
CPC分类号： A61K38/018 , A23K20/147 , A23L33/19 , A23V2002/00 , A23V2200/306 , A23V2200/324 , A23V2250/5424
摘要： The production of RANKL may be inhibited by orally ingesting a milk-derived basic protein. Thus, a RANKL production inhibitor containing a milk-derived basic protein fraction as an active ingredient; a therapeutic agent for a metabolic bone disease and a therapeutic agent for an immune disease each containing the RANKL production inhibitor; and a food/beverage and a feed each containing a specified amount of the RANKL production inhibitor and being characterized by inhibiting the production of RANKL have a remarkable effect of inhibiting the production of RANKL, can be ingested on a daily basis, and exhibit high safety even when being ingested over a long period.
摘要翻译： 通过口服摄取乳源性碱性蛋白质可以抑制RANKL的产生。 因此，含有乳衍生的碱性蛋白质级分作为活性成分的RANKL产生抑制剂; 每种含有RANKL产生抑制剂的代谢骨疾病治疗剂和免疫疾病治疗剂; 并且每种含有特定量的RANKL产生抑制剂的食品/饮料和饲料，其特征在于抑制RANKL的产生具有显着的抑制RANKL产生的作用，可以每天摄取并显示高安全性 即使长时间摄入也是如此。
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公开(公告)号：US20100087372A1
公开(公告)日：2010-04-08
申请号：US12531227
申请日：2008-03-11
CPC分类号： A61K38/018 , A23L2/52 , A23L2/66 , A23L33/19
摘要： Provided are: an agent for promoting growth hormone-secretion, containing a milk-derived basic protein fraction as an active ingredient, with the promotion of growth hormone-secretion being mediated by the promotion of secretion of ghrelin having an effect for promoting growth hormone-secretion; and a method of promoting the secretion of ghrelin by using a milk-derived basic protein fraction. The agent for promoting growth hormone-secretion may be ingested on a daily basis and is highly safe even with its ingestion for a long period.
摘要翻译： 提供：促进生长激素分泌的药剂，其含有来自乳的碱性蛋白质级分作为活性成分，促进生长激素分泌是通过促进生长激素分泌促进生长激素释放的生长素释放肽介导的， 分泌; 以及通过使用乳源性碱性蛋白质级分促进生长素释放肽的分泌的方法。 促进生长激素分泌的药物可以每天摄入，即使长时间摄取，也是高度安全的。
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公开(公告)号：US07070877B2
公开(公告)日：2006-07-04
申请号：US10405895
申请日：2003-04-02
申请人： Yoshikazu Morita , Shinichi Kamoshida , Takeshi Shimizu , Tsutomu Miyano , Keiji Izumi , Yuichi Yagami , Tsuyoshi Takahashi , Yoshiaki Kajikawa , Kouta Kodama
发明人： Yoshikazu Morita , Shinichi Kamoshida , Takeshi Shimizu , Tsutomu Miyano , Keiji Izumi , Yuichi Yagami , Tsuyoshi Takahashi , Yoshiaki Kajikawa , Kouta Kodama
IPC分类号： H01M2/00
CPC分类号： H01M8/021 , C23G1/081 , C25F3/06 , Y10T428/12993
摘要： A stainless steel separator, which is good of corrosion-resistance and low of contact-resistance, is proposed for a fuel cell. Its surface faced to a fuel electrode is pickled, which the other surface faced to an oxidizing electrode is roughened by electrolytic etching or the like. The roughening treatment may be performed before or after pickling and passivation. The roughened surface of the stainless steel separator without pickling or passivation may be faced to the oxidizing electrode.
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26.发明授权公开(公告)号：US06929806B2
公开(公告)日：2005-08-16
申请号：US10789193
申请日：2004-02-27
CPC分类号： A21D2/268 , A21D2/263 , A23J1/20 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , A61K38/1709 , A23V2250/5424 , A23V2250/5488 , A23V2250/61 , A23V2250/156 , A23V2250/032
摘要： A milk-derived basic protein fraction and a basic peptide fraction are provided for use as an effective component for agents for improving lipid metabolism and reducing high blood pressure which can be administered orally, are effective with a relatively small dosage, have good taste and are stable during storage.
摘要翻译： 提供乳衍生的碱性蛋白质级分和碱性肽级分作为口服改善脂质代谢和降低高血压的药剂的有效成分，其用量相当小，具有良好的味道，并且是有效的 储存时稳定。
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公开(公告)号：US09522178B2
公开(公告)日：2016-12-20
申请号：US14418257
申请日：2012-07-31
申请人： Aiko Ohmachi , Hiroaki Matsuyama , Yoshikazu Morita , Yuko Ishida , Takayuki Nara , Ken Kato , Atsushi Serizawa , Hiroshi Ueno , Hiroshi Urazono
发明人： Aiko Ohmachi , Hiroaki Matsuyama , Yoshikazu Morita , Yuko Ishida , Takayuki Nara , Ken Kato , Atsushi Serizawa , Hiroshi Ueno , Hiroshi Urazono
IPC分类号： A23C9/152 , A61K38/46 , A23C9/12 , A23C9/13 , A23C9/146 , A23C9/16 , A61K9/00 , A61K38/44 , A61K38/18 , A61K38/01 , A61K9/16
CPC分类号： A61K38/465 , A23C9/1213 , A23C9/1216 , A23C9/1322 , A23C9/1465 , A23C9/1526 , A23C9/16 , A23V2002/00 , A23V2200/00 , A61K9/0095 , A61K9/1664 , A61K38/012 , A61K38/1891 , A61K38/443 , C12Y111/01007 , C12Y301/27 , A23V2200/30 , A23V2200/306 , A23V2250/55 , A61K2300/00
摘要： The invention relates to a powdered milk product includes angiogenin and/or angiogenin hydrolysate in an amount of 1.4 to 24 mg/15 g, and lactoperoxidase and/or lactoperoxidase hydrolysate in the mass ratio to the angiogenin and/or angiogenin hydrolysate of 0.35 to 10.
摘要翻译： 本发明涉及一种粉末状乳制品，其含量为1.4〜24mg / 15g的血管生成素和/或血管生成素水解物，以及与血管生成素和/或血管生成素水解物的质量比为0.35〜10的乳过氧化物酶和/或乳过氧化物酶水解物 。
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公开(公告)号：US20130310318A1
公开(公告)日：2013-11-21
申请号：US13982012
申请日：2012-02-07
申请人： Hiroshi Ueno , Yoshikazu Morita , Aiko Ono , Ken Katoh , Noriko Ueda
发明人： Hiroshi Ueno , Yoshikazu Morita , Aiko Ono , Ken Katoh , Noriko Ueda
CPC分类号： A61K8/64 , A23L2/02 , A23L2/52 , A23L2/66 , A23L33/17 , A23L33/175 , A23L33/18 , A23L33/19 , A23V2002/00 , A61K8/676 , A61K38/018 , A61K38/1841 , A61K2800/592 , A61K2800/74 , A61Q19/00 , A61Q19/007 , A61Q19/08 , A23V2200/318 , A23V2250/54
摘要： A problem of the present invention is to provide a skin collagen production-promoting agent without safety problems. Another problem of the present invention is to provide a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product containing such a substance. TGF-β and/or a TGF-β degradation product, which is acquired by degrading TGF-β with a protease such as pepsin, pancreatin, etc., are used as a skin collagen production-promoting agent or the active ingredient of a skin collagen production-promoting food or drink product and a skin collagen production-promoting cosmetic product. The aforementioned TGF-β and/or TGF-β degradation product have an effect of increasing the collagen content of the skin.
摘要翻译： 本发明的问题是提供一种没有安全问题的皮肤胶原蛋白生产促进剂。 本发明的另一个问题是提供一种皮肤胶原蛋白生产促进食品或饮料产品和含有这种物质的皮肤胶原蛋白生产促进化妆品。 使用通过蛋白酶如胃蛋白酶，胰酶等降解TGF-β获得的TGF-β和/或TGF-β降解产物用作皮肤胶原蛋白生产促进剂或皮肤活性成分 胶原蛋白生产促进食品或饮料产品和皮肤胶原蛋白生产促进化妆品。 上述TGF-β和/或TGF-β降解产物具有增加皮肤胶原含量的作用。
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29.发明授权公开(公告)号：US08580740B2
公开(公告)日：2013-11-12
申请号：US12740711
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
CPC分类号： A23K50/40 , A21D2/263 , A23C19/082 , A23J1/20 , A23J3/343 , A23K20/147 , A23L2/395 , A23L2/66 , A23L33/19 , A23V2002/00 , A61K35/20 , C07K14/4703 , A23V2250/5424 , A23V2200/306
摘要： A milk protein fraction having following properties (1) to (4) is excellent in bone resorption inhibitory effect, and is useful for preventing or treating bone diseases: (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein having a molecular weight of 12,000 to 16,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 18 to 20 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.7 to 0.9; and (4) the milk protein fraction has a bone resorption inhibitory effect.
摘要翻译： 具有以下特性（1）〜（4）的乳蛋白质级分骨吸收抑制效果优异，可用于预防或治疗骨病：（1）乳蛋白质分数来自牛奶; （2）乳蛋白质级分是含有分子量为12,000至16,000道尔顿的蛋白质的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为18〜20重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.7〜0.9; 和（4）乳蛋白质分数具有骨吸收抑制作用。
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公开(公告)号：US20100298228A1
公开(公告)日：2010-11-25
申请号：US12740709
申请日：2008-10-28
申请人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
发明人： Atsushi Serizawa , Yoshikazu Morita , Daisuke Uetsuji , Aiko Ono , Hiroaki Matsuyama , Satoshi Higurashi
CPC分类号： A61K35/20 , A21D2/263 , A23C19/082 , A23C19/0917 , A23J1/20 , A23L2/66 , A23L33/19 , A23V2002/00 , A23V2300/30 , A23V2200/306 , A23V2250/5424
摘要： Disclosed is a bone-reinforcing agent which comprises a milk protein fraction having the following properties (1) to (4): (1) the milk protein fraction is derived from milk; (2) the milk protein fraction is a fraction containing a protein component having a molecular weight of 6,000 to 150,000 Daltons; (3) the milk protein fraction has a basic amino acid content of 12 to 14 wt % in the constitutional amino acid composition, and the ratio of the amount of a basic amino acid(s) to the amount of an acidic amino acid(s) is 0.5 to 0.7; and (4) the milk protein fraction has an activity of accelerating the calcification in an osteoblast.
摘要翻译： 公开了一种骨增强剂，其包含具有以下性质（1）至（4）的乳蛋白质级分：（1）乳蛋白质级分来自牛奶; （2）乳蛋白质级分是含有分子量为6,000至150,000道尔顿的蛋白质组分的级分; （3）在构成氨基酸组成中，乳蛋白质级分的碱性氨基酸含量为12〜14重量％，碱性氨基酸的量与酸性氨基酸的量（s ）为0.5〜0.7; 和（4）乳蛋白质级分具有促进成骨细胞钙化的活性。
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