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    INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR
    24.
    发明申请
    INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR 审中-公开
    白细胞介素-17F抗体及其他IL-17F信号拮抗剂及其用途

    公开(公告)号：US20110033451A1

    公开(公告)日：2011-02-10

    申请号：US12827199

    申请日：2010-06-30

    申请人： Beatriz M. Carreno ,  Mary Collins ,  Jill F. Wright ,  Neil M. Wolfman ,  Maya Arai ,  Kenneth Jacobs ,  Zhijian Lu ,  Yongjing Guo ,  Yongchang Qiu

    发明人： Beatriz M. Carreno ,  Mary Collins ,  Jill F. Wright ,  Neil M. Wolfman ,  Maya Arai ,  Kenneth Jacobs ,  Zhijian Lu ,  Yongjing Guo ,  Yongchang Qiu

    IPC分类号： A61K39/395 ,  A61K33/24 ,  A61K38/02 ,  A61K31/7088 ,  A61P11/06 ,  A61P29/00 ,  A61P19/02 ,  A61P17/06

    CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/55527 ,  C07K14/54 ,  C07K14/7155 ,  C07K16/2866 ,  C07K2317/76 ,  C07K2319/30 ,  C12N15/1138 ,  G01N33/6869

    摘要： The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease). The present invention is further directed to novel therapeutics and therapeutic targets, and to methods of screening and assessing test compounds for the intervention (treatment) and prevention of disorders related to IL-17F signaling.

    摘要翻译： 本发明提供与IL-17F信号通路相关的分离和纯化的多核苷酸和多肽。 本发明还提供了对IL-17F同源二聚体和IL-17A / IL-17F异二聚体的抗体，以及从天然来源分离和纯化IL-17家族成员（包括IL-17A / IL-17F异源二聚体）的方法。 本发明还涉及用于诊断，预后，监测与IL-17F信号传导相关的疾病的进展和/或预防的新方法，即IL-17F相关疾病，包括但不限于炎性 诸如自身免疫性疾病（例如关节炎（包括类风湿性关节炎），牛皮癣，系统性红斑狼疮和多发性硬化症），呼吸系统疾病（例如COPD，囊性纤维化，哮喘，过敏），移植排斥（包括实体器官移植排斥 ）和炎症性肠病或疾病（IBD，例如溃疡性结肠炎，克罗恩病）。 本发明还涉及新的治疗和治疗靶标，以及筛选和评估用于干预（治疗）的试验化合物和预防与IL-17F信号传导相关的紊乱的方法。

    Optical diffusers, photomasks and their methods of fabrication
    25.
    发明授权
    Optical diffusers, photomasks and their methods of fabrication 有权

    公开(公告)号：US07838204B2

    公开(公告)日：2010-11-23

    申请号：US12623529

    申请日：2009-11-23

    申请人： Zhijian Lu

    发明人： Zhijian Lu

    IPC分类号： G03F1/00

    CPC分类号： G03F7/0007 ,  G02B1/12 ,  G02B5/0215 ,  G02B5/0221 ,  G02B5/0231 ,  G02B5/0268 ,  G02B5/0278 ,  G02B6/0051 ,  G02F1/133606 ,  G03F1/00

    摘要： A large mask with random apertures may be formed by forming a smaller mask (also called a cell mask) with a random pattern of transmissive apertures which is then repeatedly replicated to create the large mask. The random pattern may be created by perturbing the aperture locations by a small amount or the apertures may be randomly placed within the cell mask provided certain criteria are met. Alternatively, a large mask with a random pattern of transmissive apertures may be formed without using a cell mask. This large mask may be used to fabricate diffusers and other devices that do not suffer from the interference, diffraction and other optical effects common in devices having structures that are non-randomly patterned.

    SYSTEMS AND METHODS FOR PROTEIN PRODUCTION
    26.
    发明申请
    SYSTEMS AND METHODS FOR PROTEIN PRODUCTION 有权
    蛋白质生产的系统和方法

    公开(公告)号：US20090221035A1

    公开(公告)日：2009-09-03

    申请号：US12419018

    申请日：2009-04-06

    申请人： Yijie Gao ,  Nicole M. Piche ,  Mei Geng ,  Stephen H. Herrmann ,  Xiaotian Zhong ,  Ronald Kriz ,  Zhijian Lu

    发明人： Yijie Gao ,  Nicole M. Piche ,  Mei Geng ,  Stephen H. Herrmann ,  Xiaotian Zhong ,  Ronald Kriz ,  Zhijian Lu

    IPC分类号： C12P21/00 ,  C12N5/04 ,  C12N5/06 ,  A01K67/027 ,  C12N15/00

    CPC分类号： C07K14/4705 ,  A01K2217/075 ,  C07K14/51 ,  C12P21/02

    摘要： The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-engineered cells comprising one or more recombinant expression cassettes which encode (1) a protein of interest and (2) a polypeptide that is functional in the unfolded protein response (UPR) pathway of the cells. Co-expression of the polypeptide significantly increases the yield of the protein of interest in the genetically-engineered cells. In one example, the genetically-engineered cells are animal cells, and the co-expressed polypeptide is a component or modulator of an XB1- or ATF6-mediated UPR pathway.

    摘要翻译： 本发明涉及生产目标蛋白质的系统和方法。 本发明使用具有改变的蛋白质折叠或加工能力的遗传工程化的动物或植物细胞。 一方面，本发明的特征在于遗传工程改造的细胞，其包含一个或多个编码（1）目的蛋白质的重组表达盒，和（2）在细胞的未折叠的蛋白质应答（UPR）途径中有功能的多肽。 多肽的共表达显着提高了遗传工程细胞中目标蛋白的产量。 在一个实例中，遗传工程改造的细胞是动物细胞，共表达的多肽是XB1或ATF6介导的UPR途径的组分或调节剂。

    Method of implementing account charging and account charging system
    28.
    发明授权
    Method of implementing account charging and account charging system 有权
    实行帐户收费和账户收费系统的方法

    公开(公告)号：US07526075B2

    公开(公告)日：2009-04-28

    申请号：US10566952

    申请日：2004-07-30

    申请人： Xiaozheng Guo ,  Zhijian Lu ,  Xin Zhang ,  Qingchen Chu ,  Youkun Chen

    发明人： Xiaozheng Guo ,  Zhijian Lu ,  Xin Zhang ,  Qingchen Chu ,  Youkun Chen

    IPC分类号： H04M15/00

    CPC分类号： G06Q40/04 ,  H04L12/14 ,  H04L12/66

    摘要： A method for realizing charging includes setting up mapping relation between service attribute and charging rule acquiring service attribute of the to-be-charged service when it is demanded to charge the to-be-charged service acquiring charging rule of the to-be-charged service according to service attribute of the to-be-charged service, and charging the to-be-charged service according to the acquired charging rule. Also disclosed is a charging system having an acquiring charging rule module and charging processing module. When it is demanded to develop new services or modify charging rules of original services, it can be fulfilled by modifying the service information provided for charging processing module accordingly, thus charging requirements of various services can be satisfied. Charging processing module of charging system is independent of services, so that cost of charging system is reduced, and stability, reliability and versatility of charging system are improved.

    摘要翻译： 一种用于实现计费的方法包括：当要求对要收费的服务获取收费规则进行收费时，建立服务属性与收费服务的收费规则获取服务属性之间的映射关系 根据收费服务的服务属性进行服务，并根据获取的收费规则对待收费的服务收费。 还公开了一种具有获取计费规则模块和计费处理模块的计费系统。 当要求开发新服务或修改原始服务的计费规则时，可以通过相应地修改提供给计费处理模块的服务信息来实现，从而满足各种服务的收费要求。 充电系统的充电处理模块独立于服务，从而降低了充电系统的成本，提高了充电系统的稳定性，可靠性和通用性。

    Systems and methods for protein production
    29.
    发明授权
    Systems and methods for protein production 有权
    蛋白质生产的系统和方法

    公开(公告)号：US07514237B2

    公开(公告)日：2009-04-07

    申请号：US11217137

    申请日：2005-09-01

    申请人： Yijie Gao ,  Nicole M. Piche ,  Mei Geng ,  Stephen H. Herrmann ,  Xiaotian Zhong ,  Ronald Kriz ,  Zhijian Lu

    发明人： Yijie Gao ,  Nicole M. Piche ,  Mei Geng ,  Stephen H. Herrmann ,  Xiaotian Zhong ,  Ronald Kriz ,  Zhijian Lu

    IPC分类号： C12P21/06 ,  C12N1/20

    CPC分类号： C07K14/4705 ,  A01K2217/075 ,  C07K14/51 ,  C12P21/02

    摘要： The invention relates to systems and methods for producing proteins of interest. The invention employs genetically-engineered animal or plant cells that have modified protein folding or processing capacities. In one aspect, the invention features genetically-engineered cells comprising one or more recombinant expression cassettes which encode (1) a protein of interest and (2) a polypeptide that is functional in the unfolded protein response (UPR) pathway of the cells. Co-expression of the polypeptide significantly increases the yield of the protein of interest in the genetically-engineered cells. In one example, the genetically-engineered cells are animal cells, and the co-expressed polypeptide is a component or modulator of an XBP1- or ATF6-mediated UPR pathway.

    摘要翻译： 本发明涉及生产目标蛋白质的系统和方法。 本发明使用具有改变的蛋白质折叠或加工能力的遗传工程化的动物或植物细胞。 一方面，本发明的特征在于遗传工程改造的细胞，其包含编码（1）目的蛋白质的一种或多种重组表达盒，和（2）在细胞的未折叠蛋白质应答（UPR）途径中有功能的多肽。 多肽的共表达显着提高了遗传工程细胞中目标蛋白的产量。 在一个实例中，遗传工程改造的细胞是动物细胞，共表达的多肽是XBP1或ATF6介导的UPR途径的组分或调节剂。

    Minimizing resist poisoning in the manufacture of semiconductor devices
    30.
    发明授权
    Minimizing resist poisoning in the manufacture of semiconductor devices 有权
    最大限度地减少半导体器件制造中的抗蚀剂中毒

    公开(公告)号：US07425502B2

    公开(公告)日：2008-09-16

    申请号：US11828217

    申请日：2007-07-25

    申请人： Zhijian Lu ,  Thomas M. Wolf ,  Scott W. Jessen

    发明人： Zhijian Lu ,  Thomas M. Wolf ,  Scott W. Jessen

    IPC分类号： H01L21/04

    CPC分类号： H01L21/76808 ,  H01L21/31144

    摘要： The present invention provides a method for manufacturing an interconnect and a method for manufacturing an integrated circuit including the interconnect. The method of manufacturing an interconnect, among other steps, includes forming a via (160) in a substrate (130) and then forming a base getter material (210) in the via (160). The method further includes forming a photoresist layer (410) over the base getter material (210), the photoresist layer (410) having an opening (420) therein positioned over the via (160), and etching a trench (510) into the substrate (130) using the opening (420) in the photoresist layer (410).

    摘要翻译： 本发明提供了一种用于制造互连的方法和用于制造包括该互连的集成电路的方法。 制造互连的方法以及其它步骤包括在衬底（130）中形成通孔（160），然后在通路（160）中形成基底吸气材料（210）。 该方法还包括在基底吸气材料（210）上形成光致抗蚀剂层（410），光致抗蚀剂层（410）在其上具有位于通孔（160）上方的开口（420），并且将沟槽（510）蚀刻到 使用光致抗蚀剂层（410）中的开口（420）的衬底（130）。