公开(公告)号：US09663589B2

公开(公告)日：2017-05-30

申请号：US14767841

申请日：2014-02-13

申请人： The Board of Trustees of the University of Alabama

发明人： Robin D. Rogers ,  Patrick S. Barber ,  Chris S. Griggs ,  Gabriela Gurau ,  Xingmei Lu ,  Suojiang Zhang

IPC分类号： C08B37/08 ,  C08B15/08 ,  C08B37/00 ,  C08J3/14 ,  C08L5/08 ,  C08L97/02 ,  C08J5/08

CPC分类号： C08B37/003 ,  C08B15/08 ,  C08B37/0003 ,  C08J3/14 ,  C08J5/08 ,  C08J2300/16 ,  C08L5/08 ,  C08L97/02 ,  Y02P20/544

摘要： Disclosed herein are processes for providing a biopolymer from a biomass or source of chitin using ionic liquids. The processes involve contacting a biomass or source of chitin with an ionic liquid to produce a biopolymer comprising solution and precipitating the biopolymer from the solution with supercritical CO2, gaseous CO2, or combinations thereof.

公开(公告)号：US09637561B2

公开(公告)日：2017-05-02

申请号：US13984209

申请日：2012-02-08

申请人： Paul Gatenholm

发明人： Paul Gatenholm

IPC分类号： C08B37/00 ,  C08B37/14 ,  C08L5/14 ,  C08H8/00 ,  C12P19/04 ,  D21C5/00 ,  B65D81/18 ,  D21H27/10 ,  D21H21/16

CPC分类号： C08B37/006 ,  B65D81/18 ,  C08B37/0003 ,  C08B37/0057 ,  C08H8/00 ,  C08L5/14 ,  C12P19/04 ,  C12P2201/00 ,  D21C5/005 ,  D21H21/16 ,  D21H27/10 ,  Y10T428/31986

摘要： Food, consumer, and industrial product packaging materials are provided by embodiments of the present invention. Films and laminates based on a combination of negatively charged polysaccharides are provided as such packaging materials. The films can be prepared by mildly treating soft wood with steam followed by alkali extraction and enzymatic treatment. Negatively charged non-cellulosic polysaccharides are isolated with weight average molecular weight Mw higher than 10,000 g/mol and molecular structure comprising a xylan main chain substituted with more than 15 molar % of glucuronic acid and more than 5 molar % arabinose. The negatively charged non-cellulosic polysaccharides can be casted from water solution on a suitable carrier and surface acetylated or coated with acetylated polysaccharide to obtain oxygen and water barrier packaging laminate. Inventive packaging materials can have strength at break above 55 MPa, elongation to break above 2.5%, cohesive and adhesive properties and good oxygen and moisture barrier properties.

公开(公告)号：US20170036169A1

公开(公告)日：2017-02-09

申请号：US15303058

申请日：2015-04-30

申请人： SABIC GLOBAL TECHNOLOGIES B.V.

发明人： Albin Peter Berzinis ,  Rachel Elizabeth Halbfinger ,  Matias Bikel ,  Pooja Bajaj

IPC分类号： B01D61/14 ,  B01D69/08 ,  B01D71/76 ,  B01D69/06 ,  B01D71/52 ,  B01D71/68 ,  B01D67/00 ,  B01D69/02

CPC分类号： B01D61/145 ,  A61M1/1623 ,  A61M1/1698 ,  B01D61/18 ,  B01D61/243 ,  B01D61/28 ,  B01D61/364 ,  B01D61/366 ,  B01D63/02 ,  B01D63/10 ,  B01D67/0009 ,  B01D67/0016 ,  B01D67/0095 ,  B01D69/02 ,  B01D69/06 ,  B01D69/08 ,  B01D69/085 ,  B01D69/088 ,  B01D69/12 ,  B01D71/52 ,  B01D71/68 ,  B01D71/76 ,  B01D2325/022 ,  B01D2325/20 ,  B01D2325/24 ,  B01D2325/34 ,  B01D2325/36 ,  C07K1/34 ,  C08B37/0003 ,  Y02W10/37

摘要： A porous membrane made from a poly(phenylene ether) copolymer has at least one of: a molecular weight cut off of less than 40 kilodaltons or a surface pore size of 0.001 to 0.1 micrometers. The porous membrane is made by dissolving the poly(phenylene ether) copolymer in a water-miscible polar aprotic solvent to form a porous membrane-forming composition; and phase-inverting the porous asymmetric membrane forming-composition in a first non-solvent composition to form the porous membrane. The porous membrane can be in the form of a sheet or a hollow fiber, and can be fabricated into separation modules.

摘要翻译： 由聚（苯醚）共聚物制成的多孔膜具有以下至少之一：分子量切断小于40千道尔顿或表面孔径为0.001至0.1微米。 多孔膜通过将聚（苯醚）共聚物溶解在与水混合的极性非质子溶剂中以形成多孔成膜组合物而制成; 并将第一非溶剂组合物中的多孔不对称膜形成组合物反相以形成多孔膜。 多孔膜可以是片状或中空纤维的形式，并且可以制成分离模块。

公开(公告)号：US09540454B2

公开(公告)日：2017-01-10

申请号：US14565671

申请日：2014-12-10

申请人： University of Miyazaki ,  Fuso Pharmaceutical Industries, Ltd.

发明人： Michio Muguruma ,  Hiroshi Murata

IPC分类号： A61K31/726 ,  A61K31/70 ,  C08B37/00 ,  A61K31/727 ,  G01N30/14

CPC分类号： C08B37/0075 ,  A61K31/727 ,  C08B37/0003 ,  C08B37/0078 ,  G01N30/14 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333

摘要： The present invention provides a high purity heparin useful to be a pharmaceutical product, cosmetics, research reagent, or the like, and a method for producing the same, more specifically, a heparin which does not substantially contain a nitrous acid degradation-resistant impurity and a method for producing a heparin, comprising mixing an aqueous solution of 5 to 30% by weight of the heparin with ethanol having an amount (volume) 0.2 to 1 times the amount (volume) of the aqueous heparin solution to obtain a colloidal precipitate of heparin.

摘要翻译： 本发明提供了可用作药物，化妆品，研究试剂等的高纯度肝素及其制造方法，更具体而言，是基本上不含有亚硝酸降解性杂质的肝素， 一种肝素的制造方法，其特征在于，将5〜30重量％的肝素水溶液与乙醇配合（体积）为肝素水溶液的量（体积）的0.2〜1倍，得到胶体沉淀物 肝素。

公开(公告)号：US09539281B2

公开(公告)日：2017-01-10

申请号：US14131812

申请日：2012-07-12

申请人： Dennis L. Kasper ,  Deniz Erturk-Hasdemir ,  Barbara Reinap

发明人： Dennis L. Kasper ,  Deniz Erturk-Hasdemir ,  Barbara Reinap

IPC分类号： C08B37/00 ,  A61K31/739 ,  C08L5/00 ,  A61K35/74

CPC分类号： A61K31/739 ,  A61K35/74 ,  C08B37/0003 ,  C08B37/006 ,  C08L5/00

摘要： The invention provides compositions comprising lipid-conjugated forms of capsular polysaccharide A (PSA) from B. fragilis (referred to herein as PSA-LT), methods of isolating such forms and of making such compositions and methods for their use.

摘要翻译： 本发明提供了包含来自脆弱脆弱病毒（本文称为PSA-LT）的荚膜多糖A（PSA）的脂质缀合形式的组合物，分离这些形式的方法以及制备其使用的组合物和方法。

公开(公告)号：US20160361348A1

公开(公告)日：2016-12-15

申请号：US14856397

申请日：2015-09-16

申请人： Chang Gung Biotechnology Corp.

发明人： Yun-Fei Ko ,  Jan Martel ,  Jian-Ching Liau ,  I-Te Chang ,  Chien-Sheng Lee ,  Wei-Chang Wang ,  Chen-Yaw Chiu ,  Chih-Jung Chang ,  Chuan-Sheng Lin ,  Tsung-Ru Wu ,  Chia-Chen Lu ,  David Marcelo Ojcius ,  Hsin-Chih Lai ,  Ding-E Young

IPC分类号： A61K31/736 ,  C08B37/00 ,  A61K36/062

CPC分类号： A61K31/736 ,  A61K36/062 ,  A61K45/06 ,  A61K2236/53 ,  C08B37/0003 ,  C08B37/0087

摘要： The present invention provides a method to prepare polysaccharides from Hirsutella sinensis. The prepared polysaccharides reduce body weight and fat accumulation in laboratory animals, and can therefore be used to prevent and treat obesity.

摘要翻译： 本发明提供了一种制备中华百草枯多糖的方法。 制备的多糖减少实验动物的体重和脂肪积累，因此可用于预防和治疗肥胖。

公开(公告)号：US20160347867A1

公开(公告)日：2016-12-01

申请号：US14854901

申请日：2015-09-15

申请人： Chang Gung Biotechnology Corp.

发明人： Yun-Fei Ko ,  Jan Martel ,  Jian-Ching Liau ,  I-Te Chang ,  Wei-Ting Jian ,  Mei-Feng Lin ,  Chia-Jen Yang ,  Chen-Yaw Chiu ,  Chih-Jung Chang ,  Chuan-Sheng Lin ,  Tsung-Ru Wu ,  Chia-Chen Lu ,  David Marcelo Ojcius ,  Hsin-Chih Lai ,  Ding-E Young

IPC分类号： C08B37/00

CPC分类号： C08B37/006 ,  A61K31/715 ,  A61K36/074 ,  A61K2236/00 ,  C08B37/0003

摘要： The present invention provides a method to prepare polysaccharides from Ganoderma lucidum. The prepared polysaccharides reduce body weight and fat accumulation in laboratory animals, and can therefore be used to prevent and treat obesity.

摘要翻译： 本发明提供了一种从灵芝制备多糖的方法。 制备的多糖减少实验动物的体重和脂肪积累，因此可用于预防和治疗肥胖。

公开(公告)号：US20160297895A1

公开(公告)日：2016-10-13

申请号：US15150302

申请日：2016-05-09

申请人： GlaxoSmithKline Biologicals SA

发明人： Allan James SAUL ,  Francesca MICOLI

IPC分类号： C08B37/00

CPC分类号： C08B37/0006 ,  A61K39/02 ,  A61K39/0275 ,  A61K39/095 ,  A61K39/385 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  C07K14/34 ,  C07K16/1285 ,  C07K16/44 ,  C07K2317/734 ,  C08B37/0003 ,  C08B37/006 ,  C08B37/0063 ,  C08B37/0081 ,  Y02A50/482

摘要： The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination is carried out at a pH between 4 and 5. The invention also provides a process for preparing a conjugate of a polysaccharide and a carrier molecule, comprising the steps of: (a) coupling the polysaccharide to a linker, to form a polysaccharide-linker compound in which the free terminus of the linker is an ester group; and (b) reacting the ester group with a primary amine group in the carrier molecule, to form a polysaccharide-linker-carrier molecule conjugate in which the linker is coupled to the carrier molecule via an amide linkage. The invention also provides a process for reducing contamination of a polysaccharide-linker compound with unreacted linker, comprising a step of precipitating unreacted linker under aqueous conditions at a pH of less than 5. The invention also provides polysaccharide-linker-carrier molecule conjugates and intermediate compounds obtained or obtainable by these processes.

摘要翻译： 本发明提供了在多糖的还原末端还原胺化羰基的方法，其中还原胺化在pH4至5之间进行。本发明还提供了制备多糖和 载体分子，其包括以下步骤：（a）将多糖偶联至接头，以形成其中接头的游离末端为酯基的多糖 - 接头化合物; 和（b）在载体分子中使酯基与伯胺基反应，以形成多糖 - 连接体 - 载体分子缀合物，其中连接体经由酰胺键与载体分子偶联。 本发明还提供了一种减少多糖 - 接头化合物与未反应接头的污染的方法，包括在pH小于5的水性条件下沉淀未反应的接头的步骤。本发明还提供多糖 - 接头 - 载体分子缀合物和中间体 通过这些方法获得或可获得的化合物。

公开(公告)号：US09453249B2

公开(公告)日：2016-09-27

申请号：US13950289

申请日：2013-07-25

申请人： API Intellectual Property Holdings, LLC

发明人： Theodora Retsina ,  Vesa Pylkkanen

IPC分类号： C12P19/02 ,  C08B37/00 ,  C08H8/00 ,  C12P19/14 ,  C13K1/02 ,  C13K13/00 ,  F23G5/04

CPC分类号： C12P19/02 ,  C08B37/0003 ,  C08B37/0057 ,  C08H8/00 ,  C12P19/14 ,  C13K1/02 ,  C13K13/00 ,  F23G5/04

摘要： A method for the production of alcohol and other bioproducts hemicelluloses extracted from biomass prior to thermal conversion of the biomass to energy. The process can be integrated with the host plant process to minimize the energy loss from extracting hemicelluloses. Also disclosed is a Stepwise enzymatic break down of cellulose fibers from a pulping operation which is performed with the redeployment of equipment and vessels contained within typical existing pulp and paper manufacturing mills. The preferred feedstock is highly delignified pulp from acid or alkaline pulping process or from bleaching stage.

公开(公告)号：US09447199B2

公开(公告)日：2016-09-20

申请号：US14355535

申请日：2012-11-01

申请人： Shenyang Kesi High-Technology Co, Ltd.

发明人： Jinsong Zhang ,  Mingtian Li ,  Zhiyu Liu ,  Lei Xu

IPC分类号： C08B37/00 ,  C08L5/04

CPC分类号： C08B37/0084 ,  C08B37/0003 ,  C08L5/04

摘要： This invention relates to an extraction process of brown algae polysaccharides in a field of pharmaceutical chemistry. This invention particularly discloses a process of extracting brown algae polysaccharides based on a microwave chemistry method and brown algae polysaccharides obtained by said process. The process of the invention comprises: 1) putting pulverized brown algae powder into a microwave reaction chamber, adding acid solution to conduct reaction; optionally concentrating the mixer, and then washing with organic solvent to remove excess acid; conducting grading alcohol precipitation after water extract to obtain mannuronic acid rich fragment (M rich) algin, fucoidan and/or laminaran respectively; and adding an alkali solution to the brown algae residue to conduct alkaline digestion, filtering the residue off, adjusting pH of the filtrate to neutral, conducting alcohol precipitation to obtain guluronic acid rich fragment (G rich) algin precipitates. The present invention has significant advantages like fast processing rate, high yield of polysaccharides, strong controllable polysaccharide degradation, using less organic acid and efficient recovery, small water consumption, low power consumption, etc., the active polysaccharides has high yield and content, better water-soluble, and good biological activities.

摘要翻译： 本发明涉及药物化学领域中褐藻多糖的提取方法。 本发明特别公开了一种基于微波化学方法提取褐藻多糖的方法和通过所述方法获得的褐藻多糖。 本发明的方法包括：1）将粉碎的褐藻粉放入微波反应室中，加酸溶液进行反应; 任选地浓缩混合器，然后用有机溶剂洗涤以除去过量的酸; 在水提取物后进行分级酒精沉淀，分别得到富含甘露糖醛酸的片段（富M），藻酸盐和/或层流蛋白; 并向棕色藻类残渣中加入碱溶液进行碱性消化，过滤残余物，调节滤液pH至中性，进行酒精沉淀，得到富含富罗勒浓的片段（富G）藻酸盐沉淀物。 本发明具有加工速度快，多糖收率高，多糖降解可靠，有机酸少，有效回收，耗水量少，功耗低等优点，活性多糖具有较高的产量和含量，较好的 水溶性好，生物活性好。