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61 条记录 (耗时 0.04 秒)

    PAV regions for encapsidation and E1 transcriptional control
    27.
    发明申请
    PAV regions for encapsidation and E1 transcriptional control 有权
    PAV区域用于壳化和E1转录控制

    公开(公告)号：US20040214162A1

    公开(公告)日：2004-10-28

    申请号：US10622869

    申请日：2003-07-18

    发明人： Suresh K. Tikoo

    IPC分类号： C12Q001/70 ,  C07H021/04

    CPC分类号： C12N15/86 ,  A61K48/00 ,  A61K2039/5256 ,  C12N2710/10343 ,  C12N2830/30 ,  C12N2830/32

    摘要： The present invention provides porcine adenovirus sequence essential for encapsidation and provides adenovirus vectors comprising such sequences. The present invention provides host cells and composition comprising adenovirus vectors comprising porcine adenovirus sequence essential for encapsidation as well as methods for making and using such adenovirus vectors. The present invention discloses porcine adenovirus sequence for E1 transcriptional control and provides porcine adenovirus vectors comprising a modification(s) in the E1 transcriptional control region.

    摘要翻译： 本发明提供了对于壳化所必需的猪腺病毒序列，并提供了包含这种序列的腺病毒载体。 本发明提供宿主细胞和包含腺病毒载体的组合物，其包含对于壳化所必需的猪腺病毒序列以及制备和使用这种腺病毒载体的方法。 本发明公开了用于E1转录控制的猪腺病毒序列，并提供了包含E1转录控制区中的修饰的猪腺病毒载体。

    Tissue-vectors specific replication and gene expression
    28.
    发明授权
    Tissue-vectors specific replication and gene expression 失效
    用于组织特异性复制和基因表达的载体

    公开(公告)号：US06638762B1

    公开(公告)日：2003-10-28

    申请号：US08974391

    申请日：1997-11-19

    申请人： Yung-Nien Chang ,  Paul L. Hallenbeck ,  Carl M. Hay ,  David A. Stewart

    发明人： Yung-Nien Chang ,  Paul L. Hallenbeck ,  Carl M. Hay ,  David A. Stewart

    IPC分类号： C12N1500

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/30 ,  C12N2830/32 ,  C12N2830/85 ,  C12N2840/20 ,  C12N2840/44

    摘要： The invention generally relates to cell-specific expression vectors. It particularly relates to targeted gene therapy using recombinant expression vectors and particularly adenovirus vectors. The invention specifically relates to replication-conditional expression vectors and methods for using them. Such vectors are able to selectively replicate in a target cell or tissue to provide a therapeutic benefit in a tissue from the presence of the vector per se or from one or more heterologous gene products expressed from the vector and distributed throughout the tissue. In such vectors, a gene essential for replication is placed under the control of a heterologous tissue-specific transcriptional regulatory sequence. Thus, replication is conditioned on the presence of a factor(s) that induces transcription or the absence of a factor(s) that inhibits transcription of the gene by means of the transcriptional regulatory sequence with this vector; therefore, a target tissue can be selectively treated.

    摘要翻译： 本发明一般涉及细胞特异性表达载体。 它特别涉及使用重组表达载体，特别是腺病毒载体的靶向基因治疗。 本发明具体涉及复制条件表达载体及其使用方法。 这样的载体能够在靶细胞或组织中选择性复制，以从载体本身的存在或从载体表达的一种或多种异源基因产物提供组织中的治疗益处并且分布在整个组织中。 在这样的载体中，将复制必需的基因置于异源组织特异性转录调控序列的控制之下。 因此，复制受到诱导转录或不存在通过与该载体的转录调控序列抑制基因转录的因子的因素的制约; 因此，可以选择性地处理靶组织。

    Retroviral vector for the transfer and expression of genes for therapeutic purposes in eukaryotic cells
    30.
    发明申请
    Retroviral vector for the transfer and expression of genes for therapeutic purposes in eukaryotic cells 失效
    用于在真核细胞中用于治疗目的的基因的转移和表达的逆转录病毒载体

    公开(公告)号：US20020106790A1

    公开(公告)日：2002-08-08

    申请号：US09970597

    申请日：2001-10-04

    发明人： Odile Cohen-Haguenauer

    IPC分类号： C12N015/867 ,  C12N007/01

    CPC分类号： C12N15/86 ,  C12N2740/13043 ,  C12N2830/32 ,  C12N2830/85 ,  C12N2840/203 ,  C12N2840/206 ,  C12N2840/44

    摘要： The invention relates to a recombinantvector for the cloning and/or expression and/or transfer of an exogenous nucleotide sequence characterized in that it consists of any sequence contained in the ClaI-PvuII fragment comprising nucleotides 7702 to 1527 of the sequence given in FIG. 1 and comprising the LTR sequence included between nucleotides 7842 and 144, the PBS site starting at nucleotides 145, the packaging sequence included in the sequences of 250 nucleotides following the end of the LTR sequence, the said sequence being capable of controlling the cloning and/or expression and/or transfer at the exogenous sequence whatever its transcriptional orientation with respect to the transcriptional orientation of the virus. It relates to the use of this vector for the transfer and/or cloning and/or expression of genes, in particular in the context of gene therapy.

    摘要翻译： 本发明涉及用于克隆和/或表达和/或转移外源核苷酸序列的重组载体，其特征在于其由包含在图1中给出的序列的核苷酸7702至1527的ClaI-PvuII片段中包含的任何序列组成。 1，并且包含核苷酸7842和144之间的LTR序列，从核苷酸145开始的PBS位点，包含在LTR序列结束后的250个核苷酸的序列中的包装序列，所述序列能够控制克隆和/ 或表达和/或在外源序列上转移，无论其关于病毒的转录取向的转录取向如何。 它涉及使用该载体用于转移和/或克隆和/或表达基因，特别是在基因治疗的背景下。