公开(公告)号：US09400174B2

公开(公告)日：2016-07-26

申请号：US14246912

申请日：2014-04-07

申请人： Palo Alto Research Center Incorporated

发明人： Peter Kiesel ,  Joerg Martini ,  Eugene M. Chow ,  Scott Uhland ,  Noble M. Johnson

IPC分类号： G01B11/14 ,  G01N15/14 ,  A61M5/30 ,  G01N15/10 ,  G01N15/00

CPC分类号： A61M5/3015 ,  A61M5/2053 ,  A61M2205/3306 ,  A61M2210/04 ,  G01B11/14 ,  G01N15/00 ,  G01N15/1434 ,  G01N2015/0003 ,  G01N2015/0046 ,  G01N2015/1075 ,  G01N2015/1087 ,  G01N2015/1093

摘要： Approaches for determining the delivery success of a particle, such as a drug particle, are disclosed. A system for monitoring delivery of particles to biological tissue includes a volume, an optical component, a detector, and an analyzer. The volume comprises a space through which a particle can pass in a desired direction. The optical component is configured to provide a measurement light. The detector is positioned to detect light emanating from the particle in response to the measurement light. The detected light is modulated as the particle moves along a detection axis. The detector is configured to generate a time-varying signal in response to the detected light. The analyzer is configured to receive the time-varying signal and determine a delivery success of the particle into a biological tissue based upon characteristics of the time-varying signal.

摘要翻译： 公开了确定颗粒如药物颗粒的递送成功的方法。 用于监测颗粒递送到生物组织的系统包括体积，光学部件，检测器和分析器。 该体积包括颗粒可以通过其沿所需方向通过的空间。 光学部件被配置成提供测量光。 检测器被定位成响应于测量光来检测从颗粒发出的光。 随着粒子沿着检测轴移动，被检测的光被调制。 检测器被配置为响应于检测到的光而产生时变信号。 分析器被配置为接收时变信号，并且基于时变信号的特性来确定颗粒进入生物组织的递送成功。

公开(公告)号：US09377381B2

公开(公告)日：2016-06-28

申请号：US14111273

申请日：2012-04-05

申请人： Harald Eichner ,  Michael Huck

发明人： Harald Eichner ,  Michael Huck

IPC分类号： G01N1/22 ,  G01N15/00 ,  G01N1/00 ,  G01N1/02

CPC分类号： G01N1/2214 ,  G01N15/00 ,  G01N2001/002 ,  G01N2001/024 ,  G01N2015/0019

摘要： Secure areas, such as at airports or other security-critical facilities, are entered from freely accessible areas, often by means of access locks. This bottleneck, which is present in any case, is used to check for substances of concern, such as drugs or explosive materials. In the case of solids, as is known, particles extracted from the access lock and retained in a screen are vaporized and the vapor is examined. Several of the screens are arranged on rotatable carrying disks and undergo consecutively the steps of vaporization and analysis. The aim of the invention is to make known methods more efficient in order to increase the throughput through such access locks. The aim is achieved by a device for which available heating and extraction elements are assigned to multiple rotational positions of the carrying disks, whereby adjacent rotational positions lie apart from each other by only half the distance of two screens.

摘要翻译： 安全区域，例如在机场或其他安全关键设施，通常通过访问锁从自由访问的区域进入。 无论如何，存在这种瓶颈，用于检查药物或爆炸物质等有关的物质。 在固体的情况下，如已知的，从进入锁中提取并保留在筛网中的颗粒被蒸发并且检查蒸汽。 几个屏幕布置在可旋转的承载盘上，并且连续地经历蒸发和分析的步骤。 本发明的目的是使已知方法更有效，以便通过这种访问锁提高吞吐量。 目的是通过一种可用的加热和提取元件被分配到承载盘的多个旋转位置的装置来实现的，由此相邻的旋转位置彼此分开只有两个屏幕的距离的一半。

公开(公告)号：US09310328B1

公开(公告)日：2016-04-12

申请号：US14742618

申请日：2015-06-17

申请人： KING ABDULAZIZ UNIVERSITY

发明人： Soliman Mahmoud Soliman Abdalla ,  Abdullah Yousif Obaid

IPC分类号： G01R27/08 ,  G01N27/06 ,  G01N27/07

CPC分类号： G01N15/00 ,  G01N33/57426 ,  G01N2015/0073

摘要： The method of detecting leukemia involves placing a suspension of red blood cells in a reservoir having a capillary tube partially immersed in the reservoir. An alternating current is applied to electrodes (one in the reservoir, the other in the capillary tube) at different frequencies. The electrical resistance is measured at the interface between the electrode and the suspension in the capillary tube. At the same time, CCD (charge coupled device) cameras take images, both top views and side views. The electrical resistance will show a peak at a characteristic resonant frequency, which is different for cancerous blood cells than for normal blood cells. The CCD images will show a pattern of maximum repulsion from the electrode at the resonant frequency in the top view, and minimum height of blood cells on the side of the electrode at the resonant frequency in the side view.

摘要翻译： 检测白血病的方法包括将红细胞悬浮液放置在具有部分浸入储器中的毛细管的储存器中。 以不同的频率将交流电施加到电极（一个在储存器中，另一个在毛细管中）。 在电极和毛细管中的悬浮液之间的界面处测量电阻。 同时，CCD（电荷耦合器件）相机拍摄图像，包括顶视图和侧视图。 电阻将在特征谐振频率处显示出峰值，该峰值对于癌细胞比正常血细胞不同。 CCD图像将在顶视图中以共振频率显示电极的最大排斥模式，并且在侧视图中将以共振频率显示电极侧面上的血细胞的最小高度。

公开(公告)号：US20160030981A1

公开(公告)日：2016-02-04

申请号：US14858043

申请日：2015-09-18

申请人： VASILY N. ASTRATOV

发明人： VASILY N. ASTRATOV

IPC分类号： B07C5/342

CPC分类号： G01N15/0205 ,  B01L3/502761 ,  B07C5/3427 ,  G01N15/00 ,  G01N21/53 ,  G02B6/00 ,  G02B27/56

摘要： Microspheres are sorted by resonant light pressure effects. An evanescent optical field is generated when light is confined within the interior of an optical element such as a surface waveguide, a tapered microfiber, or a prism. Microspheres brought within vicinity of the surface are subjected to forces that result from a coupling of the evanescent field to whispering gallery modes (WGM) in the microspheres. Alternatively, a focused laser beam is directed close to the edge of the microspheres to exert resonant optical forces on microspheres. Alternatively, standing optical waves are excited in the optical element. Optical forces are resonantly enhanced when light frequencies match WGM frequencies in the microspheres. Those microspheres for which resonance is obtained are more affected by the evanescent field than microspheres for which resonance does not occur. Greater forces are applied to resonating microspheres, which are separated from a heterogeneous mixture according to size.

摘要翻译： 微球通过共振光压效应进行分选。 当光被限制在诸如表面波导，锥形超细纤维或棱镜的光学元件的内部之内时，产生消逝的光场。 在球体附近产生的微球受到微球中ev逝场与耳语模式（WGM）的耦合所产生的力。 或者，聚焦的激光束被引导靠近微球的边缘以在微球上施加共振光学力。 或者，在光学元件中激发驻波。 当光频与微球中的WGM频率相匹配时，光学力量共振地增强。 获得共振的那些微球比不发生共振的微球更多地受到ev逝场的影响。 较大的力应用于共振微球体，其根据尺寸与异质混合物分离。

公开(公告)号：US20150355158A1

公开(公告)日：2015-12-10

申请号：US14725216

申请日：2015-05-29

申请人： Geocosm, LLC

发明人： Robert H. Lander ,  Linda M. Bonnell

IPC分类号： G01N33/24

CPC分类号： G01N33/24 ,  G01N15/00 ,  G01N19/00 ,  G01N25/00 ,  G01N29/00 ,  G01N33/383 ,  G01N33/385

摘要： Systems and methods are disclosed to analyze sediment and sedimentary rock properties. Example systems and methods transform data representing physical particles and burial histories into a three-dimensional representation of solids and pores in sediments and sedimentary rocks by analyzing effects of deposition, grain rearrangement, compaction, and chemical reactions. Resulting output may include three-dimensional representations which may be the basis of physical objects or media for laboratory tests. In an example, output may provide a basis for evaluating present-day properties for areas where sample material is unavailable, reconstructing properties for times in the geologic past, and forecasting the effects of engineering and industrial activities on properties.

摘要翻译： 公开了分析沉积物和沉积岩性质的系统和方法。 示例系统和方法通过分析沉积，颗粒重排，压实和化学反应的影响，将表示物理粒子和埋藏历史的数据转换为沉积物和沉积岩中固体和孔隙的三维表示。 得到的输出可以包括三维表示，其可以是用于实验室测试的物理对象或介质的基础。 在一个例子中，输出可以为评估样品材料不可用的区域，重建地质过去时间的特性，以及预测工程和工业活动对物业的影响提供依据。

公开(公告)号：US20150177229A1

公开(公告)日：2015-06-25

申请号：US14583003

申请日：2014-12-24

申请人： Long Hsu ,  Crystalvue Medical Corporation

发明人： Long HSU ,  William WANG ,  Sheng-Hsiang LI ,  Chung-Hao LU ,  Cheng-Hsien LIU ,  Yuh-Shyong YANG ,  Hwan-You CHANG ,  Sung-Yang WEI ,  Chung-Cheng CHOU

IPC分类号： G01N33/50 ,  G01N21/51

CPC分类号： G01N33/5091 ,  G01N15/00 ,  G01N2015/0003 ,  G01N2800/367

摘要： A cell mobility characteristics sensing apparatus including a laser light source, a light sensor, an analyzing chip, and a display is disclosed. The laser light source emits laser beams to a cell sample. The light sensor senses scattered laser beams formed by the cell sample scattering the laser beams at a plurality of time points to obtain a plurality of laser scattering patterns corresponding to the plurality of time points respectively. The analyzing chip obtains a laser scattering pattern fluctuations information of the plurality of laser scattering patterns varied with the plurality of time points to estimate the mobility characteristics of the cells in the cell sample. The display shows the mobility characteristics of the cells in the cell sample estimated by the analyzing chip.

摘要翻译： 公开了一种包括激光源，光传感器，分析芯片和显示器的电池移动特性感测装置。 激光光源向单元样品发射激光束。 光传感器感测由多个时间点散射激光束的单元样品形成的散射激光束，分别获得与多个时间点对应的多个激光散射图案。 分析芯片获得随着多个时间点变化的多个激光散射图案的激光散射图案波动信息，以估计单元样本中的单元的移动特性。 显示器显示由分析芯片估计的细胞样品中的细胞的迁移率特性。

公开(公告)号：US20150022212A1

公开(公告)日：2015-01-22

申请号：US14126673

申请日：2012-06-13

申请人： Corbett Jason ,  Fraser McNeil-Watson ,  Jack Robert

发明人： Corbett Jason ,  Fraser McNeil-Watson ,  Jack Robert

IPC分类号： G01R29/24 ,  G01N21/47

CPC分类号： G01R29/24 ,  G01N15/00 ,  G01N21/51 ,  G01N27/447 ,  G01N2021/513

摘要： The invention relates to methods and apparatus for determining properties of a surface. Embodiments disclosed include an apparatus for measuring a surface charge of a sample, comprising: a sample holder having an opposed pair of electrodes and configured to hold a sample in position in a measurement volume between the electrodes such that a planar surface of the sample is aligned orthogonal to the electrode surfaces; a measurement chamber for containing a measurement liquid and having an open end configured to receive the sample holder to position the electrodes in a preset orientation; a laser light source positioned and configured to direct a laser beam through the measurement chamber between the electrodes and parallel to the planar surface of the sample when the sample holder is received in the measurement chamber; and a detector positioned and configured to detect scattered light from the measurement volume, wherein the apparatus is configured to allow for detection of the scattered light by the detector over a range of distances from the surface of the sample.

摘要翻译： 本发明涉及用于确定表面特性的方法和装置。 所公开的实施例包括用于测量样品的表面电荷的装置，包括：样品保持器，其具有相对的一对电极并且被配置为将样品保持在电极之间的测量体积中的适当位置，使得样品的平坦表面对准 与电极表面正交; 测量室，用于容纳测量液体，并且具有构造成接收样品架以将电极定位在预定方位的开口端; 激光光源，被定位和配置为当样品保持器被容纳在测量室中时，将激光束引导通过电极之间的测量室并平行于样品的平面; 以及检测器，其被定位和配置为检测来自测量体积的散射光，其中所述装置被配置为允许在距所述样品表面的距离范围内由所述检测器检测散射光。

公开(公告)号：US20140318230A1

公开(公告)日：2014-10-30

申请号：US13871160

申请日：2013-04-26

申请人： PALL CORPORATION

发明人： Jason S. PELLEGRINO ,  Lixiang XIAO ,  Richard MORRIS ,  James J. HATHCOCK

IPC分类号： G01N15/00 ,  G01M99/00

CPC分类号： G01N15/00 ,  B01D65/10 ,  B01D2315/10 ,  B01F7/1675 ,  G01M99/00

摘要： Baffles useful for stirrer cell modules, stirrer cell modules including the baffles, and methods of using the baffles and modules, are disclosed.

摘要翻译： 公开了可用于搅拌器电池组件的挡板，包括挡板的搅拌器模块，以及使用挡板和模块的方法。

公开(公告)号：US08762117B2

公开(公告)日：2014-06-24

申请号：US13320251

申请日：2010-05-26

申请人： Kenneth Bodin ,  Claude Lacoursière ,  Martin Servin

发明人： Kenneth Bodin ,  Claude Lacoursière ,  Martin Servin

IPC分类号： G06G7/50 ,  G06G7/57 ,  G01N1/20 ,  G01N15/00 ,  G06F17/11

CPC分类号： G06G7/50 ,  G01N1/20 ,  G01N15/00 ,  G06F17/11 ,  G06F17/5018 ,  G06F2217/16 ,  G06G7/57 ,  G09B23/12

摘要： The invention relates to a method for simulating dynamic fluids comprising a plurality of pseudo particles. The method comprising the steps of: defining a fluid mass density of the pseudo particle masses; defining a mass density constraint such that the mass density on each pseudo particle is constrained to a reference mass density of a real fluid, whereby an instant propagation of density fluctuations through the entire fluid system is enabled; performing constraint stabilization on said mass density constraint using a time stepping function, wherein said time stepping function is arranged to conserve global physical symmetries and is stable for violations of said mass density constraint; solving a linear system of equations for said mass density constraint in order to calculate density constraint forces; calculating new time discrete pseudo particle velocities from previous pseudo particle velocities with addition of velocity increments calculated from said density constraint forces; and calculating new time discrete pseudo particle positions from the previous pseudo particle positions with additions of the position increments calculated from said new pseudo particle velocities. The invention also relates to an apparatus for simulating dynamic fluids and a computer program product for the same.

摘要翻译： 本发明涉及一种用于模拟包含多个假颗粒的动态流体的方法。 该方法包括以下步骤：定义假颗粒块的流体质量密度; 限定质量密度约束，使得每个伪粒子上的质量密度被限制为实际流体的参考质量密度，由此能够实现通过整个流体系统的密度波动的即时传播; 使用时间步长函数对所述质量密度约束执行约束稳定，其中所述时间步长函数被布置为保存全局物理对称性，并且对于违反所述质量密度约束是稳定的; 求解用于所述质量密度约束的线性方程组，以便计算密度约束力; 从先前的伪粒子速度计算新的时间离散伪粒子速度，并加上从所述密度约束力计算出的速度增量; 以及从先前的伪粒子位置计算新的时间离散伪粒子位置，同时加上从所述新的伪粒子速度计算的位置增量。 本发明还涉及用于模拟动态流体的装置和用于其的计算机程序产品。

公开(公告)号：US08584537B2

公开(公告)日：2013-11-19

申请号：US13137891

申请日：2011-09-20

申请人： George Gangl

发明人： George Gangl

IPC分类号： G01N1/22

CPC分类号： G01N15/00

摘要： An extraction tube for exhaust gas emission measurement systems of internal combustion engines includes at least two tubes which extend in parallel over a portion of the length of the extraction tube, and wherein each tube includes an exhaust gas extraction point to which a sampling line can be connected.

摘要翻译： 一种用于内燃机排气排放测量系统的抽吸管，包括至少两根在抽取管长度上一部分平行延伸的管，其中每个管都包括排气抽取点，抽样管线 连接的。