公开(公告)号：US09354179B2

公开(公告)日：2016-05-31

申请号：US13911115

申请日：2013-06-06

Applicant: Bio-Rad Laboratories Inc.

Inventor： Yochanan Uri ,  Boaz Ran ,  Ariel G. Notcovich ,  Shay Nimri

IPC: G01N21/01 ,  G01N30/60 ,  G01N30/88 ,  G01N21/65 ,  G01N21/552 ,  G01N21/25 ,  G01N21/03

CPC classification number: G01N21/553 ,  G01N21/253 ,  G01N21/658 ,  G01N33/54373 ,  G01N2021/0328 ,  G01N2201/0407 ,  G01N2201/0484 ,  G01N2201/062

Abstract: A tip for use in an optical detection system to analyze an analyte in a fluid sample drawn into the tip, using light reflected from a detection surface inside the tip that the analyte binds to, comprising a first detection surface and a second detection surface located in a same flow path with no controllable valve separating them, wherein the first and second detection surfaces have different surface chemistries.

Abstract translation: 一种用于光学检测系统的尖端，用于使用从分析物结合到所述尖端内部的检测表面反射的光来分析吸入所述尖端的流体样品中的分析物，所述检测表面包括第一检测表面和位于 相同的流动路径，没有可分离它们的可控阀，其中第一和第二检测表面具有不同的表面化学性质。

公开(公告)号：US20150204797A1

公开(公告)日：2015-07-23

申请号：US14416369

申请日：2013-07-18

Applicant: MSC & SGCC

Inventor： Olivier Colle ,  Florence Drouet ,  Marc Leconte

IPC: G01N21/90 ,  G01N21/958 ,  G01N21/88

CPC classification number: G01N21/90 ,  G01N21/8851 ,  G01N21/958 ,  G01N2021/8832 ,  G01N2201/0484 ,  G01N2201/062

Abstract: An in-line method for optically inspecting transparent or translucent containers (3) comprises illuminating each container with a light source that presents light intensity variation in a periodic pattern along at least a first variation direction. A number N greater than or equal to three of images of the container traveling in front of the light source and occupying N different respective positions along the travel path is taken. Between taking successive images, a relative shift between the container and the periodic pattern is created. A geometrical transformation is determined and applied in order to put the pixels belonging to the container in the N successive images of the same container into coincidence. A phase image for each container is constructed using the N registered images of the container. The phase image is analyzed in order to deduce therefrom at least the presence of defects or the quality of the container.

Abstract translation: 用于光学检查透明或半透明容器（3）的在线方法包括用沿着至少第一变化方向呈现周期性图案的光强度变化的光源照亮每个容器。 采取大于或等于在光源前面行进并且沿着行进路径占据N个不同位置的容器的图像的三个数量N。 在拍摄连续图像之间，创建容器和周期性图案之间的相对位移。 确定并应用几何变换以将属于容器的像素放入同一容器的N个连续图像中。 使用容器的N个记录图像来构建每个容器的相位图像。 分析相位图像以便至少从其中推导出缺陷的存在或容器的质量。

公开(公告)号：US07736588B2

公开(公告)日：2010-06-15

申请号：US10492899

申请日：2002-10-10

Applicant: Pieter Cornelis Langeveld ,  Karl Heinrich Van Hemert ,  Johannes Hendrik Pieter Machiel Kerkhof ,  Jacobus Stark

Inventor： Pieter Cornelis Langeveld ,  Karl Heinrich Van Hemert ,  Johannes Hendrik Pieter Machiel Kerkhof ,  Jacobus Stark

IPC: G01N33/02 ,  C12Q1/18 ,  G01J3/46

CPC classification number: G01J3/52 ,  G01J3/46 ,  G01J3/462 ,  G01J2003/466 ,  G01N31/221 ,  G01N33/04 ,  G01N33/49 ,  G01N33/493 ,  G01N2201/0484 ,  G01N2201/102

Abstract: Detection arrangement and method for detecting presence of a residue in a sample include determining color values of the sample, associated with the L*a*b color model. A value of a composite parameter Z is calculated as follows: A=wL+waa+wbb where wL, wa and wb are weighting factors having a value depending on the residue and the sample. A determination is made whether or not the sample comprises more or less than a predetermined amount of the residue in dependence on the value of the composition parameter Z. In a preferred embodiment, the arrangement is used to detect antibiotic residues, e.g. penicillin-G, in food products, elg. Milk, or body fluids, e.g. blood, urine.

Abstract translation: 用于检测样品中残留物的存在的检测装置和方法包括确定与L * a * b颜色模型相关联的样品的颜色值。 复合参数Z的值计算如下：A = wL + waa + wbb其中wL，wa和wb是具有取决于残余物和样品的值的加权因子。 根据组成参数Z的值，确定样品是否包含多于或少于预定量的残基。在优选的实施方案中，该装置用于检测抗生素残基，例如， 青霉素G，在食品中， 牛奶或体液，例如 血，尿。

公开(公告)号：US20040094626A1

公开(公告)日：2004-05-20

申请号：US10301471

申请日：2002-11-20

Inventor： Debra A. Sillman ,  Xiangyang Zhou ,  Chetan D. Jadhaw ,  Herbert F. Cattell ,  Jayati Ghosh

IPC: G06K007/10 ,  G06F017/00 ,  G06F019/00

CPC classification number: G01N21/6452 ,  G01N33/52 ,  G01N33/582 ,  G01N33/68 ,  G01N2201/0484

Abstract: Methods for programming an array scanner to scan a plurality of biopolymer arrays are provided. In the subject methods, individual scanning parameters for at least two different arrays of the plurality of arrays to be scanned are selected and input into the array scanner prior to scanning the plurality arrays. The programmed scanner then scans the plurality of arrays according to the pre-selected scanning parametersAlso provided are scanners programmed according to the subject methods, as well as computer programming that provides for programming of scanners according to the subject methods. The subject methods and compositions find use in a variety of different applications, including both genomics and proteomics applications.

Abstract translation: 提供了对阵列扫描器进行编程以扫描多个生物聚合物阵列的方法。 在主题方法中，在扫描多个阵列之前，选择要扫描的多个阵列的至少两个不同阵列的各个扫描参数并将其输入阵列扫描器。 编程的扫描仪然后根据预先选择的扫描参数扫描多个阵列。还提供根据主题方法编程的扫描仪，以及根据主题方法提供对扫描仪的编程的计算机编程。 主题方法和组合物可用于各种不同的应用，包括基因组学和蛋白质组学应用。

公开(公告)号：US4482251A

公开(公告)日：1984-11-13

申请号：US312676

申请日：1981-10-19

Applicant: Richard Saylor

Inventor： Richard Saylor

IPC: G01N21/25 ,  G01J3/50

CPC classification number: G01N21/253 ,  G01N2201/0438 ,  G01N2201/0484

Abstract: A clinical analyzer that is microprocessor controlled is disclosed. A shuttle carries a plurality of cuvettes containing liquids to be spectrophotometrically analyzed by a single beam spectrophotometer. The shuttle moves the cuvettes past the spectrophotometer in a plurality of cycles to complete a given test. At the beginning of a test, spectrophotometer lamp energization is controlled to achieve a predetermined spectrophotometer output for a reference filter. The remaining filters are then positioned one-by-one, and amplifier gain is adjusted to achieve optimum spectrophotometer output for each filter. The gain associated with each filter is stored by the microprocessor, and thereafter during the test, when each filter is used, the stored gain associated with that microprocessor is utilized in the amplifier circuitry. Additionally, at the beginning of each cycle of shuttle movement, an air calibration reading is taken, to be used by the microprocessor in determining absorbance. This air-only reading, in combination with a reference reading taken with a water-filled cuvette at any convenient time, serves to provide for accurate calibration of the system, overcoming problems of drift.

Abstract translation: 公开了一种微处理器控制的临床分析仪。 穿梭器携带多个含有液体的比色皿，以通过单光束分光光度计进行分光光度法分析。 梭子以多个周期移动比色皿通过分光光度计，以完成给定的测试。 在测试开始时，分光光度计灯通电被控制以实现用于参考滤波器的预定分光光度计输出。 然后将剩余的滤波器逐一放置，并调节放大器增益以实现每个滤波器的最佳分光光度计输出。 与每个滤波器相关联的增益由微处理器存储，然后在测试期间，当使用每个滤波器时，在该放大器电路中利用与该微处理器相关联的存储的增益。 另外，在穿梭运动的每个循环开始时，进行空气校准读数，由微处理器用于确定吸光度。 这种仅空读数，结合在任何方便的时间用含水比色杯读取的参考读数，用于提供系统的精确校准，克服漂移问题。