公开(公告)号：US6081786A

公开(公告)日：2000-06-27

申请号：US283702

申请日：1999-04-01

申请人： David W. Barry ,  Carolyn S. Underwood ,  Bruce J. McCreedy ,  David D. Hadden ,  Jason L. Lucas

发明人： David W. Barry ,  Carolyn S. Underwood ,  Bruce J. McCreedy ,  David D. Hadden ,  Jason L. Lucas

IPC分类号： G06F19/00 ,  G06Q50/22 ,  G06Q50/24 ,  G06F17/60

CPC分类号： G06F19/345 ,  G06F19/3443 ,  G06F19/3456 ,  G06Q50/22 ,  G06Q50/24 ,  G06F19/322 ,  G06F19/325 ,  G06F19/3487 ,  G06F19/363 ,  Y10S706/924

摘要： Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen for a known disease such as HIV infection are disclosed. The method comprises (a) providing patient information to a computing device (the computer device comprising: a first knowledge base comprising a plurality of different therapeutic treatment regimens for the disease; a second knowledge base comprising a plurality of expert rules for selecting a therapeutic treatment regimen for the disease; and a third knowledge base comprising advisory information useful for the treatment of a patient with different constituents of the different therapeutic treatment regimens; and (b) generating in the computing device a listing (preferably a ranked listing) of therapeutic treatment regimens for the patient; and (c) generating in the computing device advisory information for one or more treatment regimens in the listing based on the patient information and the expert rules.

摘要翻译： 公开了用于指导对已知疾病如HIV感染的治疗性治疗方案的选择的系统，方法和计算机程序产品。 该方法包括（a）向计算设备提供患者信息（该计算机设备包括：第一知识库，包括用于该疾病的多种不同的治疗方案;第二知识库，包括用于选择治疗性治疗的多个专家规则 以及第三知识库，其包括可用于治疗患有不同治疗方案的不同成分的患者的咨询信息;以及（b）在计算设备中产生治疗性治疗的列表（优选排列的列表） 并且（c）基于患者信息和专家规则，在计算设备中产生针对列表中的一种或多种治疗方案的咨询信息。

公开(公告)号：US6058352A

公开(公告)日：2000-05-02

申请号：US900319

申请日：1997-07-25

申请人： Taiwei Lu ,  Robert A. Lieberman

发明人： Taiwei Lu ,  Robert A. Lieberman

IPC分类号： G01J3/28 ,  A61B5/00 ,  A61B5/103 ,  A61B10/00 ,  G01B15/02 ,  G01J3/02 ,  G01N21/27 ,  G01N21/31 ,  G01N21/35 ,  G06F17/00 ,  G06F19/00

CPC分类号： A61B5/0059 ,  A61B5/411 ,  A61B5/445 ,  A61B5/7264 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0272 ,  G01J3/28 ,  G01N21/31 ,  G06F19/345 ,  A61B5/7232 ,  A61B5/7267 ,  G01N2021/3155 ,  G01N21/359 ,  G01N2201/1296 ,  Y10S706/924

摘要： Systems and methods using a neural network based portable absorption spectrometer system for real-time automatic evaluation of tissue injury are described. An apparatus includes an electromagnetic signal generator; an optical fiber connected to the electromagnetic signal generator; a fiber optic probe connected to the optical fiber; a broad band spectrometer connected to the fiber optic probe; and a hybrid neural network connected to the broad band spectrometer. The hybrid neural network includes a principle component analyzer of broad band spectral data obtained from said broad band spectrometer.

摘要翻译： 描述了使用基于神经网络的便携式吸收光谱仪系统的实时自动评估组织损伤的系统和方法。 一种装置包括电磁信号发生器; 连接到电磁信号发生器的光纤; 连接到光纤的光纤探针; 连接到光纤探头的宽带光谱仪; 以及连接到宽带光谱仪的混合神经网络。 混合神经网络包括从所述宽带光谱仪获得的宽带光谱数据的主成分分析仪。

公开(公告)号：US5889882A

公开(公告)日：1999-03-30

申请号：US620095

申请日：1996-03-21

申请人： Robert Allen Senn ,  Lori Lynn Barski

发明人： Robert Allen Senn ,  Lori Lynn Barski

IPC分类号： G06T5/00 ,  G06K9/34

CPC分类号： G06T7/0012 ,  G06T7/0083 ,  G06T2207/10072 ,  G06T2207/30004 ,  Y10S706/924

摘要： A method of determining the skin-line in a digital medical image comprising the steps of:providing a digital medical image including a matrix of lines and columns of pixels;determining the minimum gray level of the background pixels using a background detection routine;selecting all or at least a representative sample of said lines and/or columns of said image, and for each selected line or column;smoothing the line to minimize the effect of noise on the delineation of pixel gray level transitions;identifying significant transitions from segments of monotonically decreasing gray level values that span a minimum gray level range and start near or above said minimum background gray level;computing a set of features for each identified significant transition; andbased on the set of features computed for each of the identified significant transitions, classifying the transition as either a skin-line transition or as a non-skin-line transition.

摘要翻译： 一种确定数字医学图像中的皮肤线的方法，包括以下步骤：提供包括线和列的像素矩阵的数字医学图像; 使用背景检测程序确定背景像素的最小灰度级; 选择所述图像的所述行和/或列的所有或至少代表性样本，以及对于每个所选择的行或列; 平滑线以最小化噪声对像素灰度级转换的描绘的影响; 识别跨越最小灰度级范围并开始接近或高于所述最小背景灰度级的单调降低的灰度级值的段的显着转变; 计算每个识别的重大转变的一组特征; 并且基于为每个所识别的重要转换计算的特征集合，将转换分类为皮肤线转换或非皮肤线转换。

公开(公告)号：US5816247A

公开(公告)日：1998-10-06

申请号：US663385

申请日：1996-06-13

申请人： Douglas E. Maynard

发明人： Douglas E. Maynard

IPC分类号： A61B5/048 ,  A61B5/04

CPC分类号： A61B5/7267 ,  A61B5/048 ,  A61B5/742 ,  Y10S706/924

摘要： An apparatus and method for EEG monitoring provides multi-dimensional classification of EEG samples, using a neural network having multiple outputs trained upon a training set of samples to define an n-dimensional space in which to classify the samples and provide to the user a display of that space.

摘要翻译： 用于脑电监测的装置和方法提供EEG样本的多维分类，使用具有训练样本的训练集合的多个输出的神经网络来定义n维空间，其中对样本进行分类并向用户提供显示 的空间。

公开(公告)号：US5730720A

公开(公告)日：1998-03-24

申请号：US516580

申请日：1995-08-18

申请人： Jeffrey P. Sites ,  Philip R. Glassel ,  Michael D. Miller ,  Clark B. Norgaard ,  Thomas A. Roman ,  Dale J. Ziebarth

发明人： Jeffrey P. Sites ,  Philip R. Glassel ,  Michael D. Miller ,  Clark B. Norgaard ,  Thomas A. Roman ,  Dale J. Ziebarth

IPC分类号： A61M1/36 ,  A61M5/142 ,  A61M37/00

CPC分类号： A61M1/369 ,  A61M2205/12 ,  A61M2205/3606 ,  A61M2205/366 ,  A61M2205/505 ,  A61M2230/50 ,  A61M5/14232 ,  Y10S706/924

摘要： Method and apparatus to automatically monitor and control a perfusion hyperthermia treatment using a system including one or more programmed computers, and mechanical and sensor subsystems. The system includes a fluid path between a patient and an external fluid-treatment subsystem, wherein control of the external fluid-treatment subsystem includes feedback from sensors coupled to the patient. The resulting integrated system provides automated monitoring and control of the patient, the external fluid-treatment subsystem, and the treatment. In one embodiment, the fluid passing between the patient and the external fluid-treatment subsystem is blood. In one embodiment, an apparatus and method are provided for using a computerized system for a perfusion hyper/hypothermia treatment of a patient which obtains a body fluid having a temperature. A plurality of temperature signals representative of temperatures at each of a plurality of patient locations on or within the patient are coupled to the computer system. Measured temperatures are compared to a set of stored parameters in the computer system to generate a comparison value which controls a change in the temperature of the body fluid. The body fluid is then perfused into the patient to either warm, cool, or maintain the current temperature of the patient. In one such embodiment, the body fluid is blood withdrawn from the patient. In another such embodiment, the body fluid is saline.

公开(公告)号：US5715182A

公开(公告)日：1998-02-03

申请号：US286257

申请日：1994-08-08

申请人： Hideki Asai ,  Hideyuki Horiuchi ,  Ryohei Yabe ,  Norio Oowada

发明人： Hideki Asai ,  Hideyuki Horiuchi ,  Ryohei Yabe ,  Norio Oowada

IPC分类号： G01N15/14 ,  G06F19/00

CPC分类号： G01N15/14 ,  G01N2201/1296 ,  Y10S706/924

摘要： A particle image in a sample is formed at an imaging position by an objective lens of a microscope, projected on the image picking up plane of a TV camera via a projection lens and is subjected to photo-electric conversion. Image signals from the TV camera are supplied to an image memory via an A/D converter as well as to an image processing control unit. Image signals outputted from the image memory are supplied to a characteristic picking out unit and there a plurality of characteristics of the particle concerned are picked out. The picked-out characteristics are supplied to the classification unit and there classification of the sediment components is perfumed via a neural network with a learning capability. Accordingly, the classification unit performs provisionally an automatic classification of the objective sediment components by making use of the inputted characteristic parameters. The device allows accurate and fast automatic component particle analysis even for patient specimens containing a variety of components in high concentration.

摘要翻译： 通过显微镜的物镜在成像位置形成样品中的粒子图像，通过投影透镜投影在电视摄像机的图像拾取面上，并进行光电转换。 来自TV摄像机的图像信号经由A / D转换器以及图像处理控制单元提供给图像存储器。 从图像存储器输出的图像信号被提供给特征选择单元，并且拾取有关粒子的多个特征。 所选择的特征被提供给分类单元，并且通过具有学习能力的神经网络对沉积物成分进行分类。 因此，分类单元通过使用输入的特征参数临时执行目标沉积物成分的自动分类。 该装置允许准确和快速的自动组分颗粒分析，即使对于含有高浓度各种组分的患者标本也是如此。

公开(公告)号：US5692220A

公开(公告)日：1997-11-25

申请号：US116131

申请日：1993-09-02

申请人： Lawrence W. Diamond ,  Doyen T. Nguyen

发明人： Lawrence W. Diamond ,  Doyen T. Nguyen

IPC分类号： G01N15/14 ,  G01N33/483 ,  G01N35/00 ,  G06F19/00 ,  A61B5/00

CPC分类号： G01N35/00603 ,  G01N35/0092 ,  G06F19/366 ,  G01N15/14 ,  Y10S706/924

摘要： A system and method of diagnosis provides that data from a hematopathology analyzer, e.g., hematology analyzer and/or other blood testing instrument or test, is input and compared with patterns corresponding to specific patient conditions. The matched patterns are arranged in a hierarchy in accordance with predetermined rules. Initially the patterns matched are displayed, optionally with recommendations for additional testing. If additional testing is done, a comparison of the original test data and new data is done, the patterns matched and at least one highest ranked pattern is identified, optionally with a differential diagnosis.

摘要翻译： 诊断系统和方法提供来自血液病理学分析仪（例如，血液学分析仪和/或其他血液检测仪器或测试）的数据被输入并与与特定患者条件相对应的模式进行比较。 匹配的图案按照预定的规则排列成层次结构。 最初，匹配的模式显示，可选地附加测试的建议。 如果进行了额外的测试，则可以对原始测试数据和新数据进行比较，识别匹配的模式和至少一个最高排名模式，可选择进行鉴别诊断。

公开(公告)号：US5672154A

公开(公告)日：1997-09-30

申请号：US387943

申请日：1995-02-27

申请人： Rudolf Vallentin Sillen ,  Goran Wessberg

发明人： Rudolf Vallentin Sillen ,  Goran Wessberg

IPC分类号： A61J3/00 ,  A61J7/00 ,  A61J7/04 ,  G06F19/00 ,  G06Q50/00 ,  A61M31/00

CPC分类号： G06F19/345 ,  A61J7/0418 ,  A61J7/0454 ,  A61J7/0481 ,  G06F19/322 ,  G06F19/3443 ,  G06F19/3456 ,  A61J2200/30 ,  Y10S128/924 ,  Y10S706/924

摘要： A method and a device for giving patients individualized, situation-dependent medication advice are disclosed. Preferably, the invention is implemented in portable computers. The method is founded on knowledge-based computer technology and comprises a reminder function (1), a recording and storage function (2, 3), as well as a function for inductive data analysis (4) and rule generation. When the knowledge-based system (6) finds that a medicine should be taken, the computer emits a signal providing information on the type of medicine and the dose. The patients records the intake of medicine as well as his current state of health. This information is stored in a database together with the point of time. Inductive data analysis is used to spot the relationship between various events and symptoms as well as establish medication rules. These rules are refined upon as new information is recorded in the database, and are automatically adapted to changes in the patient's state of health.

摘要翻译： PCT No.PCT / SE93 / 00708 Sec。 371日期：1995年2月27日 102（e）1995年2月27日PCT PCT 1993年8月27日PCT公布。 公开号WO94 / 06088 日期1994年3月17日公开了一种给患者个体化，情况依赖性药物咨询的方法和装置。 优选地，本发明在便携式计算机中实现。 该方法基于知识型计算机技术，包括提醒功能（1），记录和存储功能（2,3）以及归纳数据分析（4）和规则生成功能。 当基于知识的系统（6）发现应该服用药物时，计算机发出信号，提供关于药物类型和剂量的信息。 患者记录药物摄入量以及目前的健康状况。 该信息与时间点一起存储在数据库中。 诱导性数据分析用于发现各种事件和症状之间的关系以及建立药物治疗规则。 随着新信息被记录在数据库中，这些规则被改进，并且被自动地适应于患者的健康状况的改变。

公开(公告)号：US5668998A

公开(公告)日：1997-09-16

申请号：US429397

申请日：1995-04-26

申请人： Donald Mason ,  Betsy Ann Zimmerman

发明人： Donald Mason ,  Betsy Ann Zimmerman

IPC分类号： G06F9/44 ,  G06F7/06

CPC分类号： G06F8/24 ,  Y10S706/924

摘要： A application program interface is provided to a toolkit framework of service objects which enable rapid creation of application computer programs which implement the services and protocol of the Digital Imaging and Communication in Medicine (DICOM) standard. A framework of service objects is provided which enables a programmer to easily develop application methods which provide DICOM services or other custom services. An object-oriented application interface is provided. The service objects provide a familiar connection between the familiar DICOM standard service objects and a group of associated methods within the framework. The associated methods work together to provide a DICOM service. Service Class User and Service Class Provider objects manage service object communications and are derived from baseclasses in the framework.

摘要翻译： 应用程序接口被提供给服务对象的工具箱框架，其能够快速创建实现数字成像和通信医学（DICOM）标准的服务和协议的应用计算机程序。 提供了一种服务对象的框架，使得程序员能够轻松开发提供DICOM服务或其他定制服务的应用程序。 提供面向对象的应用程序界面。 服务对象在熟悉的DICOM标准服务对象和框架内的一组关联方法之间提供了一种熟悉的连接。 相关联的方法一起工作以提供DICOM服务。 服务类用户和服务类提供者对象管理服务对象通信，并从框架中的基类派生。

公开(公告)号：US5486999A

公开(公告)日：1996-01-23

申请号：US232512

申请日：1994-04-20

申请人： Andrew H. Mebane

发明人： Andrew H. Mebane

IPC分类号： G06F19/00 ,  G06F159/00

CPC分类号： G06F19/345 ,  G06F19/327 ,  G06F19/3431 ,  G06F19/3487 ,  G06Q50/22 ,  Y10S128/925 ,  Y10S706/924

摘要： An apparatus and method for categorizing health care utilization provides an efficient aid in identifying patients who are seeking inappropriate care. The invention involves a computer system having a neural network responsive to several input variables to categorize the utilization characteristics of the patient. The input variables define selected characteristics of a patient. In one embodiment, a screening process identifies patients who are at high risk to an immediate threat to their health and eliminates those least likely to be seeking inappropriate care.

摘要翻译： 用于分类医疗保健利用的装置和方法提供了有效的帮助来识别寻求不适当护理的患者。 本发明涉及一种具有响应于若干输入变量的神经网络的计算机系统，以对患者的利用特征进行分类。 输入变量定义患者的所选特征。 在一个实施方案中，筛选过程识别处于对其健康立即威胁的高风险的患者，并消除那些最不可能寻求不适当护理的患者。