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51 条记录 (耗时 0.015 秒)

    Process for the preparation of 2-(hydroxyalkyl)acrylic compounds
    21.
    发明授权
    Process for the preparation of 2-(hydroxyalkyl)acrylic compounds 失效
    制备2-（羟烷基）丙烯酸化合物的方法

    公开(公告)号：US4820858A

    公开(公告)日：1989-04-11

    申请号：US169137

    申请日：1988-03-18

    申请人： Neil S. Isaacs ,  Jonathan Hill

    发明人： Neil S. Isaacs ,  Jonathan Hill

    IPC分类号： C07B41/00 ,  C07B43/00 ,  C07C45/72 ,  C07C47/263 ,  C07C47/267 ,  C07C47/27 ,  C07C49/24 ,  C07C49/242 ,  C07C49/248 ,  C07C67/343 ,  C07C69/734 ,  C07C121/30 ,  C07C121/34 ,  C07C121/48 ,  C07C121/70

    CPC分类号： C07C255/00 ,  C07C253/30 ,  C07C45/72 ,  C07C47/263 ,  C07C47/267 ,  C07C47/27 ,  C07C49/24 ,  C07C49/242 ,  C07C49/248 ,  C07C67/343

    摘要： The invention relates to a process for the preparation of 2-(hydroxyalkyl)acrylic compounds having the formula ##STR1## wherein X represents a --CN group, a --COOR.sub.3 group, a --COR.sub.4 group or a --CONR.sub.4 R.sub.5 group wherein R.sub.3 is an alkyl group containing 1-4 C atoms and R.sub.4 and R.sub.5 independently represent an H atom or R.sub.3, andwherein R.sub.1 and R.sub.2 independently represent an H atom or an alkyl group with 1-4 C atoms or an (hetero) aryl group, or R.sub.1 and R.sub.2 together represent a cyclic compound with 5-12 C atomsby contacting an acrylic compound H.sub.2 C.dbd.CH--X with a carbonyl compound of the formula ##STR2## wherein X, R.sub.1 and R.sub.2 denote the same as in the above, this being effected in the liquid phase in the presence of a tertiary amine, characterized in that the reaction is carried out at a pressure in excess of 500 bar in excess of 500 bar, advantageously 1,500-18,000 bar.

    摘要翻译： 本发明涉及制备具有下式的2-（羟基烷基）丙烯酸化合物的方法，其中X代表-CN基团，-COOR3基团，-COR4基团或-CONR4R5基团，其中R3是烷基 含有1-4个C原子的基团，R4和R5独立地表示H原子或R3，并且其中R1和R2独立地表示H原子或具有1-4C原子的烷基或（杂）芳基，或R1和 R 2一起表示具有5-12个碳原子的环状化合物，其通过使丙烯酸化合物H 2 C = CH-X与下式的羰基化合物接触，其中X，R 1和R 2表示与上述相同， 在叔胺存在下的液相，其特征在于反应在超过500巴，有利地1500-18,000巴的超过500巴的压力下进行。

    Process for preparing .alpha.-hydroxyaldehyde
    22.
    发明授权
    Process for preparing .alpha.-hydroxyaldehyde 失效
    制备α-羟基醛的方法

    公开(公告)号：US4383122A

    公开(公告)日：1983-05-10

    申请号：US257587

    申请日：1981-04-27

    申请人： Teruaki Mukaiyama ,  Yoji Sakito ,  Masatoshi Asami

    发明人： Teruaki Mukaiyama ,  Yoji Sakito ,  Masatoshi Asami

    IPC分类号： C07C45/27 ,  C07C45/56 ,  C07C47/263 ,  C07C47/27 ,  C07C47/277 ,  C07D487/04

    CPC分类号： C07D487/04 ,  C07C45/27 ,  C07C45/562 ,  C07C47/263 ,  C07C47/27 ,  C07C47/277

    摘要： An optically active or racemic .alpha.-hydroxyaldehyde represented by the general formula (2), ##STR1## wherein R.sub.1 represents a C.sub.6 -C.sub.14 aryl group, C.sub.1 -C.sub.10 alkyl group, C.sub.3 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, or a group containing a functional group in the organic portion of said groups and R.sub.2 represents a C.sub.1 -C.sub.10 alkyl group, C.sub.2 -C.sub.10 alkenyl group, C.sub.2 -C.sub.10 alkynyl group, C.sub.7 -C.sub.14 aralkyl group, C.sub.6 -C.sub.14 aryl group, or a group containing a functional group in the organic portion of these groups, which is an important intermediate for preparation of pharmaceuticals and agricultural chemicals, and prepared by allowing an optically active or racemic compound represented by the general formula (1), ##STR2## (wherein A represents a C.sub.6 -C.sub.14 aryl group or a C.sub.1 -C.sub.4 alkyl or alkoxy group- or halogen-substituted C.sub.6 -C.sub.14 aryl group and R.sub.1 is as defined above) to react with a Grignard reagent, and thereafter hydrolyzing the reaction product.