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28 条记录 (耗时 0.029 秒)

    Fungicidal alpha-substituted acrylates
    24.
    发明授权
    Fungicidal alpha-substituted acrylates 失效
    杀真菌α-取代丙烯酸酯

    公开(公告)号：US5124353A

    公开(公告)日：1992-06-23

    申请号：US416609

    申请日：1989-10-03

    申请人： John M. Clough ,  Christopher R. A. Godfrey

    发明人： John M. Clough ,  Christopher R. A. Godfrey

    IPC分类号： C07C253/00 ,  A01N37/34 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N37/44 ,  A01N37/46 ,  A01N37/48 ,  A01N39/00 ,  A01N39/02 ,  A01N43/40 ,  C07C67/00 ,  C07C69/618 ,  C07C69/734 ,  C07C229/30 ,  C07C229/44 ,  C07C233/15 ,  C07C233/25 ,  C07C233/43 ,  C07C233/54 ,  C07C235/42 ,  C07C237/30 ,  C07C255/54 ,  C07C255/57 ,  C07C313/00 ,  C07C323/54 ,  C07C323/62 ,  C07C323/63 ,  C07C325/00 ,  C07D207/323 ,  C07D213/30 ,  C07D213/64 ,  C07D307/38 ,  C07D307/54 ,  C07D333/14 ,  C07D333/24 ,  C07D333/54

    CPC分类号： C07C321/00 ,  A01N37/36 ,  A01N37/44 ,  A01N39/00 ,  A01N39/02 ,  A01N43/40 ,  C07C323/00

    摘要： Compounds of formula (I): ##STR1## and stereoisomers thereof, wherein V is an oxygen or a sulphur atom; X and Y, which may be the same or different, are hydrogen or halogen atoms, or optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkynyl, haloalkyl, alkoxy, haloalkoxy, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted acyloxy, optionally substituted amino, acylamino, nitro, nitrile, --CO.sub.2 R.sup.3, --CONR.sup.4 R.sup.5, or --COR.sup.6 groups; or the groups X and Y, when they are in adjacent positions on the phenyl ring, may join to form a fused ring, either aromatic or aliphatic, optionally containing one or more heteroatoms; and Z is optionally substituted methylene, optionally substituted amino, oxygen or sulphur and when Z is a substituted methylene group, the substituent may join the 2-position of the phenyl ring to form a non-aromatic fused ring; R.sup.1 and R.sup.2 are alkyl groups containing from one to four carbon atoms, optionally substituted with one or more halogen atoms; and R.sup.3, R.sup.4, R.sup.5, and R.sup.6, which may be the same or different, are hydrogen atoms or optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, optionally substituted aryl, optionally substituted aralkyl, or cycloalkylalkyl groups: and metal complexes thereof.

    摘要翻译： 式（I）化合物：其中V是氧或硫原子; X和Y可以相同或不同，是氢或卤素原子，或任选取代的烷基，任选取代的烯基，任选取代的芳基，任选取代的杂芳基，任选取代的炔基，卤代烷基，烷氧基，卤代烷氧基，任选取代的芳氧基， 取代的芳基烷氧基，任选取代的酰氧基，任选取代的氨基，酰氨基，硝基，腈，-CO 2 R 3，-CONR 4 R 5或-COR 6基团; 或基团X和Y当它们在苯环上的相邻位置时，可以连接形成任选含有一个或多个杂原子的芳族或脂族稠合的稠环; Z是任选取代的亚甲基，任选取代的氨基，氧或硫，当Z是取代的亚甲基时，取代基可以连接苯环的2-位，形成非芳香稠环; R1和R2是含有1-4个碳原子的烷基，任选地被一个或多个卤素原子取代; 和可以相同或不同的R 3，R 4，R 5和R 6是氢原子或任选取代的烷基，环烷基，烯基，炔基，任选取代的芳基，任选取代的芳烷基或环烷基烷基：及其金属络合物。

    Fungicidal and/or bactericidal compositions containing nitrothiophenes, and use thereof
    26.
    发明授权
    Fungicidal and/or bactericidal compositions containing nitrothiophenes, and use thereof 失效
    含有硝基噻吩的杀真菌剂和/或杀菌组合物及其用途

    公开(公告)号：US4649154A

    公开(公告)日：1987-03-10

    申请号：US543895

    申请日：1983-10-20

    申请人： Hendrik Dolman ,  Johannes Kuipers

    发明人： Hendrik Dolman ,  Johannes Kuipers

    IPC分类号： C07D333/14 ,  A01N43/10 ,  A01N43/40 ,  A01P1/00 ,  A01P3/00 ,  C07D213/71 ,  C07D333/36 ,  C07D333/42 ,  C07D409/12 ,  A01N43/02

    CPC分类号： C07D333/42 ,  A01N43/10 ,  A01N43/40 ,  C07D213/71

    摘要： The invention relates to new nitrothiophenes of the general formula ##STR1## wherein R is an alkyl group having 1 to 12 carbon atoms, which alkyl group may be substituted with a phenyl group substituted, if desired, with nitro, halogen, alkyl with 1 to 4 carbon atoms or alkoxy with 1 to 4 carbon atoms, with an alkoxycarbonyl group having 2 to 5 carbon atoms, or with a thiocyanato group,or R is a phenyl group, a pyridyl group or an N-oxypyridyl group, which groups may be substituted with nitro, halogen, alkyl with 1 to 4 carbon atoms, or alkoxy with 1 to 4 carbon atoms;R.sub.1 is a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or a phenyl group substituted or not substituted with nitro, halogen, alkyl with 1 to 4 carbon atoms, or alkoxy with 1 to 4 carbon atoms;R.sub.2 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a cyano group, an alkanoyl group having 1 to 5 carbon atoms, an .alpha.,.alpha.-dialkoxyalkyl- or .alpha.,.alpha.-alkylenedioxyalkyl group having 3 to 10 carbon atoms, a carboxy group, an alkoxycarbonyl group having 2 to 5 carbon atoms, an .alpha.-hydroxyalkyl group having 1 to 4 carbon atoms, an .alpha.-haloalkyl group having 1 to 4 carbon atoms, an .alpha.-alkoxyalkyl group having 2 to 6 carbon atoms, an alkoxycarboximidoyl group having 2 to 5 carbon atoms, a sulpho group, an amino-, alkylamino- or dialkylaminosulphonyl group, the alkyl group(s) of which has (have) 1 to 4 carbon atoms, or an alkoxysulphonyl group having 1 to 4 carbon atoms, andn is 0 to 2.The compositions are particularly suitable to prevent infections by phytophagous microorganisms in agriculture and horticulture. For this purpose, the seed is treated prior to sowing or the soil destined for sowing or planting is treated with the composition in a dosage from 100 to 1,500 mg of active substance per kg of seed and from 2 to 100 kg of active substance per hectare, respectively.

    Amine derivatives
    28.
    发明授权
    Amine derivatives 失效
    胺衍生物

    公开(公告)号：US4366164A

    公开(公告)日：1982-12-28

    申请号：US213407

    申请日：1980-12-05

    申请人： John W. Clitherow ,  Barry Price ,  John Bradshaw ,  Michael Martin-Smith

    发明人： John W. Clitherow ,  Barry Price ,  John Bradshaw ,  Michael Martin-Smith

    IPC分类号： A61K31/155 ,  A61K31/335 ,  A61K31/38 ,  A61P1/00 ,  C07C67/00 ,  C07C209/00 ,  C07C211/27 ,  C07C213/00 ,  C07C217/48 ,  C07C239/00 ,  C07C275/12 ,  C07C279/04 ,  C07C279/28 ,  C07C301/00 ,  C07C311/64 ,  C07C325/00 ,  C07C335/08 ,  C07D233/64 ,  C07D295/096 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D333/14 ,  C07D333/38

    CPC分类号： C07D295/096 ,  C07C279/28 ,  C07D307/38 ,  C07D307/42 ,  C07D307/52 ,  C07D333/14 ,  Y10S514/886 ,  Y10S514/926 ,  Y10S514/927

    摘要： The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached from a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.6 ;Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2 and 5 positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1 and 3 or 1 and 4 positions;x represents --CH.sub.2 --, --O-- or --S--;n represents zero or 1;m represents 2, 3 or 4 andAlk represents a straight chain alkylene group of 1 to 3 carbon atoms;andR.sub.2 represents lower alkyl or the group--(CH.sub.2).sub.y E(CH.sub.2).sub.x Gin whichy represents 2, 3 or 4 or can additionally represent zero or 1 when E is a --CH.sub.2 -- group;x represents zero, 1 or 2;E represents --CH.sub.2 --, --O-- or --S--; andG represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring; or G represents the group ##STR3## where Q' represents any of the rings defined for Q; Alk' represents any of the groups defined for Alk;and R.sub.4 ' and R.sub.5 ' which may be the same or different represent any of the groups defined for R.sub.4 or R.sub.5.The compounds of formula (I) have pharmacological activity as selective histamine H.sub.2 -antagonists.

    摘要翻译： 本发明提供了通式（I）的化合物及其生理上可接受的盐，水合物和生物前体，其中Y和Z可以相同或不同，各自表示氧，硫，= CHNO 2或= NR 3，其中R 3 是氢，硝基，氰基，低级烷基，芳基，烷基磺酰基或芳基磺酰基; p的值为2到12; R 1表示其中可以相同或不同的R 4和R 5各自表示氢，低级烷基，环烷基，低级烯基，芳烷基或被氧原子间隔的低级烷基或基团> N-R6，其中R 6表示 氢或低级烷基，或R 4和R 5与它们所连接的氮原子一起可以含有另外的氧原子或基团> NR 6的5至7元饱和杂环; Q表示呋喃或噻吩环，其中与分子的其余部分结合通过2和5位的键，或苯环，其中结合到分子的其余部分通过1和3或1的键和 4个职位; x表示-CH 2 - ， - O-或-S-; n表示0或1; m表示2,3或4，Alk表示1〜3个碳原子的直链亚烷基。 并且R 2表示低级烷基或基团 - （CH 2）y E（CH 2）x G，其中y表示2,3或4，或当E是-CH 2 - 基团时可另外表示0或1; x表示零，1或2; E表示-CH 2 - ， - O-或-S-; G表示单环5或6元碳环或杂环芳环; 或G表示组，其中Q'表示为Q定义的任何环; Alk'代表为Alk定义的任何组; 和可以相同或不同的R 4'和R 5'表示对于R 4或R 5定义的任何基团。 式（I）化合物具有作为选择性组胺H2拮抗剂的药理学活性。