公开(公告)号：US20050178462A1

公开(公告)日：2005-08-18

申请号：US10833371

申请日：2004-04-28

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/00 ,  A61J1/14 ,  A61J1/20 ,  A61J7/00 ,  A61J7/02 ,  B65D47/24 ,  B65B1/04

CPC classification number: B65B55/08 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/18 ,  A61J1/2037 ,  A61J1/2041 ,  A61J1/2055 ,  A61J1/2096 ,  A61M2207/00 ,  B65B3/003 ,  B65D47/248

Abstract: A vial has a body defining a chamber for receiving a substance therein; and a valve assembly coupled in fluid communication with the chamber and defining (i) an open position permitting at least one of (a) passage of the substance through the valve assembly and into the chamber for storing the substance in the chamber, and (b) passage of the substance out of the chamber for dispensing the substance therefrom; and (ii) a closed position forming a fluid-tight seal between the chamber and exterior of the container. A filling member engages a flexible valve member of the valve assembly to move the valve member between the closed and open positions to fill and seal the vial, respectively. A syringe is connectable to the vial. The valve assembly opens upon connecting the syringe to the vial to allow the substance within the vial to be withdrawn from the vial and into the syringe by actuating a plunger of the syringe, and the valve assembly closes upon disconnecting the vial and syringe to hermetically seal and store the substance remaining in the syringe for later use.

Abstract translation: 小瓶具有限定用于在其中接收物质的室的主体; 以及阀组件，其与所述腔室流体连通地联接并且限定（i）允许所述物质通过所述阀组件并进入所述腔室中以将所述物质存储在所述腔室中的至少一个的打开位置，以及（b ）物质从室中通过以从其中分配物质; 和（ii）在容器和容器的外部之间形成流体密封的封闭位置。 填充构件接合阀组件的柔性阀构件以在闭合位置和打开位置之间移动阀构件以分别填充和密封小瓶。 注射器可连接到小瓶。 在将注射器连接到小瓶上时，阀组件打开，以通过致动注射器的柱塞来使小瓶中的物质从小瓶中取出并进入注射器，并且在将小瓶和注射器断开以气密密封时阀组件关闭 并将剩余的物质储存在注射器中以备后用。

公开(公告)号：US20050165368A1

公开(公告)日：2005-07-28

申请号：US10990164

申请日：2004-11-15

Applicant: Daniel Py ,  Julian Chan ,  Jeffrey Atwood

Inventor： Daniel Py ,  Julian Chan ,  Jeffrey Atwood

IPC: A61F20060101 ,  A61F9/00 ,  A61M35/00

CPC classification number: B05B11/007 ,  A61F9/0008 ,  A61M11/007 ,  A61M15/08 ,  A61M35/003 ,  A61M2210/0612 ,  B05B11/00412 ,  B05B11/00416 ,  B05B11/0056 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3056 ,  B05B11/307 ,  B05B11/3074 ,  B05B11/3077

Abstract: An ophthalmic delivery device includes a body defining a fluid reservoir and a pump in fluid communication with the reservoir. The delivery device also includes a nozzle that includes a dosage chamber for holding a dosage of fluid, a valve seat, and a valve cover. The valve cover extends about the valve seat and forms an interface therebetween and the valve seat includes an outlet aperture. The interface is in fluid communication with the outlet aperture and the dosage chamber, and at least part of the valve cover is movable between (i) a closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The valve seat and the valve cover are dimensioned to dispense the dosage of fluid through the interface at a velocity of equal to or less than 6 meters per second.

Abstract translation: 眼科输送装置包括限定流体储存器的主体和与储存器流体连通的泵。 输送装置还包括喷嘴，该喷嘴包括用于保持一定量的流体的剂量室，阀座和阀盖。 阀盖围绕阀座延伸并且在它们之间形成界面，并且阀座包括出口孔。 所述界面与所述出口孔和所述剂量室流体连通，并且所述阀盖的至少一部分可在（i）与所述阀盖接合所述阀座的关闭位置之间移动以关闭所述界面并形成流体密封 密封在其间，和（ii）打开位置，其中阀盖的至少一部分响应于流体以大于阀打开压力的压力流过出口孔而与阀座间隔开，以允许加压流体在其间通过 。 阀座和阀盖的尺寸设计为以等于或小于6米/秒的速度通过界面分配流体的剂量。

公开(公告)号：USD504713S1

公开(公告)日：2005-05-03

申请号：US29174936

申请日：2003-01-27

Applicant: Daniel Py ,  Norbert M. Assion

Designer： Daniel Py ,  Norbert M. Assion

公开(公告)号：USD501498S1

公开(公告)日：2005-02-01

申请号：US29170504

申请日：2002-11-06

Applicant: Daniel Py

Designer： Daniel Py

公开(公告)号：US06805170B2

公开(公告)日：2004-10-19

申请号：US10694364

申请日：2003-10-27

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B304

CPC classification number: A61L2/081 ,  A61J1/1468 ,  A61J1/18 ,  A61L2202/121 ,  A61M2207/00 ,  B65B3/003 ,  B65D39/007 ,  B65D51/002

Abstract: A resealable cap for a medicament vial has a base portion formed of vulcanized rubber or like material known for providing a stable environment for the medicament contained within the vial, and a resealable portion overlying the base portion. The resealable portion is made of low-density polyethylene or like material, and can be punctured by a needle or like injection member for dispensing medicament into the vial. Prior to filling, the cap is assembled to the vial and the cap/vial assembly is sterilized. Then, a needle is inserted through the cap and medicament is introduced through the needle and into the vial. Upon withdrawal of the needle, the penetrated region of the cap is fused by laser or direct heat sealing to hermetically seal the needle hole in the cap.

Abstract translation: 用于药物小瓶的可重新密封的帽具有由硫化橡胶或类似材料形成的基部，其已知用于为容纳在小瓶内的药物提供稳定的环境，以及覆盖在基部上的可再密封部分。 可再密封部分由低密度聚乙烯或类似材料制成，并且可以用针或类似的注射构件刺穿以将药物分配到小瓶中。 在填充之前，将帽组装到小瓶中，并且帽/瓶组件被灭菌。 然后，将针插入帽中，并将药物通过针引入到小瓶中。 在取出针时，通过激光或直接热密封将盖的穿透区域熔合以密封盖中的针孔。

公开(公告)号：US06761286B2

公开(公告)日：2004-07-13

申请号：US10001745

申请日：2001-10-23

Applicant: Daniel Py ,  Joseph M. Ting

Inventor： Daniel Py ,  Joseph M. Ting

IPC: B65D3556

CPC classification number: B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

Abstract: A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

公开(公告)号：US06685109B2

公开(公告)日：2004-02-03

申请号：US09962949

申请日：2001-09-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B05B134

CPC classification number: B05B11/0067 ,  B05B1/3436 ,  B05B11/00412 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3094

Abstract: An aerosol tip mechanism for an aerosol-type dispenser for dispensing liquid content has a flexible outer shell, a rigid cap portion composed of lower and upper portions, and a rigid nozzle portion having a rigid shaft received within the outlet portion of the flexible outer shell. The rigid shaft interfaces the outlet portion of the outer shell, forming a first normally-closed one-way valve. The lower and upper portions of the rigid cap portion form boots adapted to receive an outlet portion of the flexible outer shell, the boots thereby constraining a lateral motion of the outlet portion of the outer shell, and symmetrically centering the outlet portion around the rigid shaft of the nozzle. The rigid nozzle portion includes a plurality of liquid channels for delivering liquid from a reservoir to a swirling chamber defined within the rigid cap portion, which liquid channels are configured to minimize energy losses of the liquid and promote a more homogeneous fluid particle size in the dispensed aerosol. The aerosol tip mechanism provides for long-term sterility of the stored fluid, which in turn allows for preservation of the sterility of non-chemically preserved formulations, which may be in the form of suspension or liquid gels.

公开(公告)号：US5944702A

公开(公告)日：1999-08-31

申请号：US927873

申请日：1997-09-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M11/00 ,  A61F9/00 ,  A61J1/05 ,  A61M35/00 ,  B05B11/00

CPC classification number: B05B11/307 ,  A61F9/0008 ,  A61M35/003 ,  B05B11/0072 ,  B05B11/3001 ,  B05B11/3074 ,  B05B11/3095

Abstract: An apparatus is used to apply medicament to an eye and stores the medicament in a medicament chamber. A nozzle is coupled in fluid communication with the medicament chamber and is formed by an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion. A seam is formed by the interface of the inner nozzle portion and the outer nozzle portion and is normally in a closed position to prevent the passage of medicament through the nozzle. The seam opens in response to the flow of medicament of sufficient pressure into the seam to permit the passage of medicament through the nozzle for release into the eye.

Abstract translation: 使用一种装置将药物施用于眼睛并将药物储存在药物室中。 喷嘴与药物室流体连通地连接并由外部喷嘴部分和容纳在外部喷嘴部分内部的内部喷嘴部分形成。 接缝由内部喷嘴部分和外部喷嘴部分的界面形成，并且通常处于关闭位置以防止药物通过喷嘴。 响应于足够压力的药物流进入接缝以使药物通过喷嘴以释放到眼睛中，接缝开口。

公开(公告)号：US5855322A

公开(公告)日：1999-01-05

申请号：US927221

申请日：1997-09-10

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D83/14 ,  A61M11/00 ,  B05B1/34 ,  B05B11/00 ,  B05B17/04

CPC classification number: B05B11/007 ,  B05B1/341 ,  B05B1/3436 ,  B05B11/0072 ,  B05B11/0075

Abstract: A nozzle mechanism for generating an aerosol-type liquid discharge is provided, which nozzle mechanism ensures one-way movement of liquid during discharge and also has a substantially zero "dead volume" at the tip of the nozzle. The nozzle mechanism includes a flexible nozzle portion with an outlet and a fluid channel, a rigid shaft received within the flexible nozzle portion, and a rigid housing surrounding the flexible nozzle portion and exposing the outlet. The rigid shaft interfaces the outlet to form a first normally-closed, one-way valve, as well as to define a swirling chamber for collecting the liquid which has been channeled from the liquid reservoir, prior to being discharged via the outlet. The outlet has a tubular wall with thickness that decreases along the elongated axis of symmetry for the outlet toward the tip of the outlet. The fluid channel is circumferentially positioned within the flexible nozzle portion to create swirling action of the liquid delivered to the swirling chamber. Once the pressure on the swirling liquid reaches a threshold pressure sufficient to radially deform the portion of the outlet forming the first normally-closed valve, the liquid in the swirling chamber is discharged through the outlet. The nozzle mechanism is coupled to a flexible body portion which has a substantially tubular shape and a wall thickness which decreases from the bottom of the body portion toward the flexible nozzle portion. The rigid shaft received within the flexible nozzle portions extends down into the flexible body portion so that a second portion of the rigid shaft interfaces the flexible body portion to form a second normally-closed, one-way valve in the fluid communication path between the liquid reservoir and the swirling chamber.

Abstract translation: 提供了一种用于产生气溶胶型液体排出口的喷嘴机构，该喷嘴机构确保了排出期间液体的单向移动，并且在喷嘴的尖端处也具有基本为零的“死体积”。 喷嘴机构包括具有出口和流体通道的柔性喷嘴部分，容纳在柔性喷嘴部分内的刚性轴以及围绕柔性喷嘴部分并暴露出口的刚性壳体。 刚性轴将出口接合以形成第一常闭单向阀，并且在通过出口排出之前，限定用于收集已经从液体储存器引导的液体的旋转室。 出口具有管状壁，其厚度沿着用于出口朝向出口的尖端的细长对称轴线减小。 流体通道周向地定位在柔性喷嘴部分内，以产生输送到旋转室的液体的旋动作用。 一旦旋转液体上的压力达到足以使形成第一常闭阀的出口的部分径向变形的阈值压力，则旋转室中的液体通过出口排出。 喷嘴机构联接到柔性主体部分，其具有基本上管状的形状和从主体部分的底部向柔性喷嘴部分减小的壁厚。 容纳在柔性喷嘴部分内的刚性轴向下延伸到柔性主体部分中，使得刚性轴的第二部分接合柔性主体部分，以在液体之间的流体连通路径中形成第二常闭单向阀 水库和旋转室。

公开(公告)号：USD368774S

公开(公告)日：1996-04-09

申请号：US29948

申请日：1994-10-19

Applicant: Daniel Py

Designer： Daniel Py