公开(公告)号：USD515436S1

公开(公告)日：2006-02-21

申请号：US29226010

申请日：2005-03-23

Applicant: Daniel Py ,  Norbert M. Assion ,  Julian V. Chan ,  Giovanni Rodriguez

Designer： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan ,  Giovanni Rodriguez

公开(公告)号：US20050223677A1

公开(公告)日：2005-10-13

申请号：US11074513

申请日：2005-03-07

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B3/00 ,  B65B3/02 ,  B65B7/28 ,  B65B31/02 ,  B65B61/00

CPC classification number: B65B3/003 ,  B65B3/022 ,  B65B31/027

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：US20050194059A1

公开(公告)日：2005-09-08

申请号：US11070440

申请日：2005-03-02

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04 ,  B67C3/00

CPC classification number: B65B7/161 ,  B65B3/003 ,  B65B7/00 ,  B65B37/06 ,  B65B43/54 ,  B65B51/22 ,  B65B55/04 ,  B65B55/08 ,  B65B57/00 ,  B65B65/02

Abstract: An apparatus is provided for needle filling and thermally resealing containers having stoppers that are needle penetrable for filling the containers with a substance, and are thermally resealable for thermally sealing a needle hole in the stopper upon withdrawal of a needle therefrom. A container support of the apparatus supports at least one container having a resealable stopper in a substantially fixed position during needle filling and thermally resealing a needle hole in the stopper upon withdrawal of a needle therefrom. A robotic arm of the apparatus is drivingly mounted adjacent to the container support and movable relative thereto. A manifold is drivingly mounted on the robotic arm and includes (1) a needle for penetrating the resealable stopper and introducing a substance through the needle and into the container; (2) a laser optic assembly for heating a needle penetrated region of the stopper and, in turn, sealing a needle hole in the stopper; and (3) a temperature sensor for sensing the temperate of a needle penetrated region of the stopper to determine whether a needle hole therein is sealed. The manifold is movable laterally relative to the container on the container support to position the manifold relative to a needle penetrable region of the stopper of the container.

Abstract translation: 提供了一种用于针头填充和热重新密封容器的装置，其具有用于针对物品填充容器的可穿刺的塞子，并且在从其中取出针时，可热再密封用于热封塞塞中的针孔。 装置的容器支撑件支撑至少一个具有可重新封闭的塞子的容器，该容器在针填充期间处于基本上固定的位置，并且在从其中取出针时将塞子中的针孔热封闭。 装置的机器臂相对于容器支架驱动地安装并相对于其移动。 歧管被驱动地安装在机器臂上，并且包括（1）用于穿透可再密封止动件的针并将物质通过针引入容器中; （2）激光光学组件，用于加热塞子的针穿透区域，并进而密封塞子中的针孔; 以及（3）温度传感器，用于检测塞子的针穿透区域的温度，以确定其中的针孔是否被密封。 歧管相对于容器支架上的容器横向移动，以使歧管相对于容器的塞子的针可穿透区域定位。

公开(公告)号：US20050178462A1

公开(公告)日：2005-08-18

申请号：US10833371

申请日：2004-04-28

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/00 ,  A61J1/14 ,  A61J1/20 ,  A61J7/00 ,  A61J7/02 ,  B65D47/24 ,  B65B1/04

CPC classification number: B65B55/08 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/18 ,  A61J1/2037 ,  A61J1/2041 ,  A61J1/2055 ,  A61J1/2096 ,  A61M2207/00 ,  B65B3/003 ,  B65D47/248

Abstract: A vial has a body defining a chamber for receiving a substance therein; and a valve assembly coupled in fluid communication with the chamber and defining (i) an open position permitting at least one of (a) passage of the substance through the valve assembly and into the chamber for storing the substance in the chamber, and (b) passage of the substance out of the chamber for dispensing the substance therefrom; and (ii) a closed position forming a fluid-tight seal between the chamber and exterior of the container. A filling member engages a flexible valve member of the valve assembly to move the valve member between the closed and open positions to fill and seal the vial, respectively. A syringe is connectable to the vial. The valve assembly opens upon connecting the syringe to the vial to allow the substance within the vial to be withdrawn from the vial and into the syringe by actuating a plunger of the syringe, and the valve assembly closes upon disconnecting the vial and syringe to hermetically seal and store the substance remaining in the syringe for later use.

Abstract translation: 小瓶具有限定用于在其中接收物质的室的主体; 以及阀组件，其与所述腔室流体连通地联接并且限定（i）允许所述物质通过所述阀组件并进入所述腔室中以将所述物质存储在所述腔室中的至少一个的打开位置，以及（b ）物质从室中通过以从其中分配物质; 和（ii）在容器和容器的外部之间形成流体密封的封闭位置。 填充构件接合阀组件的柔性阀构件以在闭合位置和打开位置之间移动阀构件以分别填充和密封小瓶。 注射器可连接到小瓶。 在将注射器连接到小瓶上时，阀组件打开，以通过致动注射器的柱塞来使小瓶中的物质从小瓶中取出并进入注射器，并且在将小瓶和注射器断开以气密密封时阀组件关闭 并将剩余的物质储存在注射器中以备后用。

公开(公告)号：USD504713S1

公开(公告)日：2005-05-03

申请号：US29174936

申请日：2003-01-27

Applicant: Daniel Py ,  Norbert M. Assion

Designer： Daniel Py ,  Norbert M. Assion

公开(公告)号：USD501498S1

公开(公告)日：2005-02-01

申请号：US29170504

申请日：2002-11-06

Applicant: Daniel Py

Designer： Daniel Py

公开(公告)号：US06805170B2

公开(公告)日：2004-10-19

申请号：US10694364

申请日：2003-10-27

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B304

CPC classification number: A61L2/081 ,  A61J1/1468 ,  A61J1/18 ,  A61L2202/121 ,  A61M2207/00 ,  B65B3/003 ,  B65D39/007 ,  B65D51/002

Abstract: A resealable cap for a medicament vial has a base portion formed of vulcanized rubber or like material known for providing a stable environment for the medicament contained within the vial, and a resealable portion overlying the base portion. The resealable portion is made of low-density polyethylene or like material, and can be punctured by a needle or like injection member for dispensing medicament into the vial. Prior to filling, the cap is assembled to the vial and the cap/vial assembly is sterilized. Then, a needle is inserted through the cap and medicament is introduced through the needle and into the vial. Upon withdrawal of the needle, the penetrated region of the cap is fused by laser or direct heat sealing to hermetically seal the needle hole in the cap.

Abstract translation: 用于药物小瓶的可重新密封的帽具有由硫化橡胶或类似材料形成的基部，其已知用于为容纳在小瓶内的药物提供稳定的环境，以及覆盖在基部上的可再密封部分。 可再密封部分由低密度聚乙烯或类似材料制成，并且可以用针或类似的注射构件刺穿以将药物分配到小瓶中。 在填充之前，将帽组装到小瓶中，并且帽/瓶组件被灭菌。 然后，将针插入帽中，并将药物通过针引入到小瓶中。 在取出针时，通过激光或直接热密封将盖的穿透区域熔合以密封盖中的针孔。

公开(公告)号：US06761286B2

公开(公告)日：2004-07-13

申请号：US10001745

申请日：2001-10-23

Applicant: Daniel Py ,  Joseph M. Ting

Inventor： Daniel Py ,  Joseph M. Ting

IPC: B65D3556

CPC classification number: B65D83/0055 ,  A61F9/0008 ,  B05B11/00412 ,  B05B11/0072 ,  B05B11/0097 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3092 ,  B05B11/3094 ,  B65D81/245

Abstract: A dispenser for dispensing a fluid includes a rigid vial that has a main fluid chamber containing a fluid, and a pump assembly that is in fluid communication with the main fluid chamber and is configured to dispense a predetermined quantity of fluid from the main fluid chamber. A flexible bladder is provided which is located within the main fluid chamber and is configured to expand to fill the ullage created within the main fluid chamber during dispensing of fluid by the pump assembly. The resilient bladder tends to force itself outwardly toward the rigid vial and, in turn, increases the pressure within the main fluid chamber in comparison to the interior of the bladder to thereby prevent the ingress of air or vapors through the bladder or otherwise into the main fluid chamber.

公开(公告)号：US06685109B2

公开(公告)日：2004-02-03

申请号：US09962949

申请日：2001-09-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B05B134

CPC classification number: B05B11/0067 ,  B05B1/3436 ,  B05B11/00412 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3094

Abstract: An aerosol tip mechanism for an aerosol-type dispenser for dispensing liquid content has a flexible outer shell, a rigid cap portion composed of lower and upper portions, and a rigid nozzle portion having a rigid shaft received within the outlet portion of the flexible outer shell. The rigid shaft interfaces the outlet portion of the outer shell, forming a first normally-closed one-way valve. The lower and upper portions of the rigid cap portion form boots adapted to receive an outlet portion of the flexible outer shell, the boots thereby constraining a lateral motion of the outlet portion of the outer shell, and symmetrically centering the outlet portion around the rigid shaft of the nozzle. The rigid nozzle portion includes a plurality of liquid channels for delivering liquid from a reservoir to a swirling chamber defined within the rigid cap portion, which liquid channels are configured to minimize energy losses of the liquid and promote a more homogeneous fluid particle size in the dispensed aerosol. The aerosol tip mechanism provides for long-term sterility of the stored fluid, which in turn allows for preservation of the sterility of non-chemically preserved formulations, which may be in the form of suspension or liquid gels.

公开(公告)号：US5944702A

公开(公告)日：1999-08-31

申请号：US927873

申请日：1997-09-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61M11/00 ,  A61F9/00 ,  A61J1/05 ,  A61M35/00 ,  B05B11/00

CPC classification number: B05B11/307 ,  A61F9/0008 ,  A61M35/003 ,  B05B11/0072 ,  B05B11/3001 ,  B05B11/3074 ,  B05B11/3095

Abstract: An apparatus is used to apply medicament to an eye and stores the medicament in a medicament chamber. A nozzle is coupled in fluid communication with the medicament chamber and is formed by an outer nozzle portion and an inner nozzle portion received within the outer nozzle portion. A seam is formed by the interface of the inner nozzle portion and the outer nozzle portion and is normally in a closed position to prevent the passage of medicament through the nozzle. The seam opens in response to the flow of medicament of sufficient pressure into the seam to permit the passage of medicament through the nozzle for release into the eye.

Abstract translation: 使用一种装置将药物施用于眼睛并将药物储存在药物室中。 喷嘴与药物室流体连通地连接并由外部喷嘴部分和容纳在外部喷嘴部分内部的内部喷嘴部分形成。 接缝由内部喷嘴部分和外部喷嘴部分的界面形成，并且通常处于关闭位置以防止药物通过喷嘴。 响应于足够压力的药物流进入接缝以使药物通过喷嘴以释放到眼睛中，接缝开口。