公开(公告)号：US07032631B2

公开(公告)日：2006-04-25

申请号：US10766172

申请日：2004-01-28

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20

CPC classification number: A61J1/18 ,  A61J1/1406 ,  A61J1/1468 ,  A61L2/08 ,  A61M2207/00 ,  B29C65/16 ,  B29C65/1616 ,  B29C65/1654 ,  B29C65/1677 ,  B29C65/18 ,  B29C66/001 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/12461 ,  B29C66/1312 ,  B29C66/342 ,  B29C66/534 ,  B29C66/5344 ,  B29C66/612 ,  B29C66/71 ,  B29C66/73755 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/8322 ,  B29C67/004 ,  B29L2031/7158 ,  B29L2031/753 ,  B65B3/003 ,  B65B7/161 ,  B65D51/002 ,  B29C65/00 ,  B29K2025/08

Abstract: A resealable cap (110, 210) for a medicament vial (114, 214) has a base portion (112, 212) formed of vulcanized rubber or like material known for providing a stable environment for the medicament contained within the vial, and a resealable portion (126, 226) overlying the base portion. The resealable portion (126, 226) is made of low-density polyethylene or like material, and can be punctured by a needle or like injection member (140, 282) for dispensing medicament into the vial (114, 214). Prior to filling, the cap (110, 210) is assembled to the vial (114, 214) and the cap/vial assembly is sterilized. Then, a needle (140, 282) is inserted through the cap (110, 210) and medicament is introduced through the needle and into the vial. Upon withdrawal of the needle (140, 282), the penetrated region of the cap (248) is fused by laser (276) or direct heat sealing (264) to hermetically seal the needle hole (294) in the cap.

Abstract translation: 用于药物小瓶（114,214）的可重新密封的帽（110,210）具有由硫化橡胶或类似材料形成的基部（112,212），其已知用于为容纳在小瓶内的药物提供稳定的环境，并且可重新密封 覆盖基部的部分（126,226）。 可再密封部分（126,226）由低密度聚乙烯或类似材料制成，并且可以被针或类似的注射构件（140,282）刺穿，用于将药物分配到小瓶（114,214）中。 在填充之前，将帽（110,210）组装到小瓶（114,214）上，并且帽/瓶组件被灭菌。 然后，将针（140,282）插入穿过盖（110,210），药物通过针引入并进入小瓶。 在针（140,282）取出时，帽（248）的穿透区域通过激光（276）或直接热密封（264）熔合，以密封帽中的针孔（294）。

公开(公告)号：US20060065677A1

公开(公告)日：2006-03-30

申请号：US11237599

申请日：2005-09-27

Applicant: Daniel Py ,  Julian Chan ,  David Fellows ,  Eric Hartman ,  Bing He

Inventor： Daniel Py ,  Julian Chan ,  David Fellows ,  Eric Hartman ,  Bing He

IPC: B67D5/40

CPC classification number: B65D83/0094 ,  A45D34/04 ,  A45D2200/055 ,  A45D2200/056 ,  A61M35/003 ,  B05B11/00416 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3033 ,  B05B11/3094 ,  B65B1/04 ,  B65D83/0033 ,  G01F11/025 ,  G01F11/08

Abstract: A dispenser for dispensing a substance, such as a pharmaceutical, ophthalmic, dermatological, cosmeceutical, cosmetic or other product, has a body defining a variable-volume storage chamber for storing the product. A dispensing portion of the dispenser is connected with the body and defines a bore coupled in fluid communication with the storage chamber for receiving substance therefrom, and an outlet aperture coupled in fluid communication with the bore. A one-way valve of the dispenser includes an axially-extending valve seat and an axially-extending flexible valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat and the seam is connectable in fluid communication with the outlet aperture to allow the passage of substance through the seam and out of the dispenser. The dispenser further comprises an actuator and piston assembly including a piston receivable within the bore, a manually-engageable actuator connected to the piston for moving the piston between first and second positions relative to the bore to dispense substance within the bore through the outlet aperture, and an integral, dome-shaped spring coupled to at least one of the piston and the actuator for biasing the piston in a direction from one of the first and second positions toward the other.

Abstract translation: 用于分配物质（例如药物，眼科，皮肤病学，药妆，化妆品或其他产品）的分配器具有限定用于存储产品的可变容积储存室的主体。 分配器的分配部分与主体连接并且限定了与储存室流体连通以接收物质的孔以及与孔流体连通的出口孔。 分配器的单向阀包括轴向延伸的阀座和位于阀座上的轴向延伸的柔性阀盖，并且在其间限定一个常闭的轴向延伸的接缝，形成在阀盖之间的流体密封 和阀座。 柔性阀盖可相对于阀座移动，并且接缝可与出口孔流体连通以允许物质通过接缝并从分配器中通过。 分配器还包括致动器和活塞组件，其包括可接收在孔内的活塞，连接到活塞的可手动接合的致动器，用于相对于孔移动活塞在第一和第二位置之间，以通过出口孔分配孔内的物质， 以及联接到所述活塞和所述致动器中的至少一个的整体的圆顶形弹簧，用于沿从所述第一位置和所述第二位置之一向另一个方向偏压所述活塞。

公开(公告)号：USD516604S1

公开(公告)日：2006-03-07

申请号：US29219237

申请日：2004-12-13

Applicant: Daniel Py

Designer： Daniel Py

公开(公告)号：USD516251S1

公开(公告)日：2006-02-28

申请号：US29190956

申请日：2003-09-29

Applicant: Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

Designer： Daniel Py ,  Julian V. Chan ,  Stephanie Ferreira ,  Gladys Valencia

公开(公告)号：US20050263543A1

公开(公告)日：2005-12-01

申请号：US11195520

申请日：2005-08-01

Applicant: Daniel Py ,  Norbert Assion ,  Julian Chan

Inventor： Daniel Py ,  Norbert Assion ,  Julian Chan

IPC: A61M5/142 ,  A45D40/26 ,  A61M5/315 ,  A61M5/50 ,  A61M11/00 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D35/44 ,  B65D47/20 ,  G01F11/02 ,  B67D5/42 ,  G01F11/00

CPC classification number: B65D47/2031 ,  A45D40/26 ,  A61M5/31586 ,  A61M5/31595 ,  A61M5/50 ,  A61M5/502 ,  B65D35/06 ,  B65D35/08 ,  B65D35/38 ,  B65D35/44 ,  G01F11/027

Abstract: A syringe is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials which may react upon exposure to air, such as glue. The syringes include a body and a plunger. Means are provided in the syringe body and the plunger to effect controlled movement of the plunger into the syringe to permit delivery of a pre-determined amount of the substance contained in the syringe. A one-way valve is provided at the dispensing tip of the syringe to hermetically seal the portion of the syringe containing the substance to be dispensed.

Abstract translation: 提供注射器用于向人或动物（例如药物，药物，化妆品和食品）递送受控量的计量量的任何不同物质，或者输送在暴露于空气中可能反应的材料，例如胶 。 注射器包括身体和柱塞。 装置设置在注射器主体和柱塞中以实现柱塞到注射器中的受控运动，以允许输送预定量的包含在注射器中的物质。 在注射器的分配尖端处设置单向阀以气密地密封包含待分配物质的注射器的部分。

公开(公告)号：US20050223677A1

公开(公告)日：2005-10-13

申请号：US11074513

申请日：2005-03-07

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B3/00 ,  B65B3/02 ,  B65B7/28 ,  B65B31/02 ,  B65B61/00

CPC classification number: B65B3/003 ,  B65B3/022 ,  B65B31/027

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：US20050194059A1

公开(公告)日：2005-09-08

申请号：US11070440

申请日：2005-03-02

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04 ,  B67C3/00

CPC classification number: B65B7/161 ,  B65B3/003 ,  B65B7/00 ,  B65B37/06 ,  B65B43/54 ,  B65B51/22 ,  B65B55/04 ,  B65B55/08 ,  B65B57/00 ,  B65B65/02

Abstract: An apparatus is provided for needle filling and thermally resealing containers having stoppers that are needle penetrable for filling the containers with a substance, and are thermally resealable for thermally sealing a needle hole in the stopper upon withdrawal of a needle therefrom. A container support of the apparatus supports at least one container having a resealable stopper in a substantially fixed position during needle filling and thermally resealing a needle hole in the stopper upon withdrawal of a needle therefrom. A robotic arm of the apparatus is drivingly mounted adjacent to the container support and movable relative thereto. A manifold is drivingly mounted on the robotic arm and includes (1) a needle for penetrating the resealable stopper and introducing a substance through the needle and into the container; (2) a laser optic assembly for heating a needle penetrated region of the stopper and, in turn, sealing a needle hole in the stopper; and (3) a temperature sensor for sensing the temperate of a needle penetrated region of the stopper to determine whether a needle hole therein is sealed. The manifold is movable laterally relative to the container on the container support to position the manifold relative to a needle penetrable region of the stopper of the container.

Abstract translation: 提供了一种用于针头填充和热重新密封容器的装置，其具有用于针对物品填充容器的可穿刺的塞子，并且在从其中取出针时，可热再密封用于热封塞塞中的针孔。 装置的容器支撑件支撑至少一个具有可重新封闭的塞子的容器，该容器在针填充期间处于基本上固定的位置，并且在从其中取出针时将塞子中的针孔热封闭。 装置的机器臂相对于容器支架驱动地安装并相对于其移动。 歧管被驱动地安装在机器臂上，并且包括（1）用于穿透可再密封止动件的针并将物质通过针引入容器中; （2）激光光学组件，用于加热塞子的针穿透区域，并进而密封塞子中的针孔; 以及（3）温度传感器，用于检测塞子的针穿透区域的温度，以确定其中的针孔是否被密封。 歧管相对于容器支架上的容器横向移动，以使歧管相对于容器的塞子的针可穿透区域定位。

公开(公告)号：US20050178462A1

公开(公告)日：2005-08-18

申请号：US10833371

申请日：2004-04-28

Applicant: Daniel Py

Inventor： Daniel Py

IPC: A61J1/00 ,  A61J1/14 ,  A61J1/20 ,  A61J7/00 ,  A61J7/02 ,  B65D47/24 ,  B65B1/04

CPC classification number: B65B55/08 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/1481 ,  A61J1/1487 ,  A61J1/18 ,  A61J1/2037 ,  A61J1/2041 ,  A61J1/2055 ,  A61J1/2096 ,  A61M2207/00 ,  B65B3/003 ,  B65D47/248

Abstract: A vial has a body defining a chamber for receiving a substance therein; and a valve assembly coupled in fluid communication with the chamber and defining (i) an open position permitting at least one of (a) passage of the substance through the valve assembly and into the chamber for storing the substance in the chamber, and (b) passage of the substance out of the chamber for dispensing the substance therefrom; and (ii) a closed position forming a fluid-tight seal between the chamber and exterior of the container. A filling member engages a flexible valve member of the valve assembly to move the valve member between the closed and open positions to fill and seal the vial, respectively. A syringe is connectable to the vial. The valve assembly opens upon connecting the syringe to the vial to allow the substance within the vial to be withdrawn from the vial and into the syringe by actuating a plunger of the syringe, and the valve assembly closes upon disconnecting the vial and syringe to hermetically seal and store the substance remaining in the syringe for later use.

Abstract translation: 小瓶具有限定用于在其中接收物质的室的主体; 以及阀组件，其与所述腔室流体连通地联接并且限定（i）允许所述物质通过所述阀组件并进入所述腔室中以将所述物质存储在所述腔室中的至少一个的打开位置，以及（b ）物质从室中通过以从其中分配物质; 和（ii）在容器和容器的外部之间形成流体密封的封闭位置。 填充构件接合阀组件的柔性阀构件以在闭合位置和打开位置之间移动阀构件以分别填充和密封小瓶。 注射器可连接到小瓶。 在将注射器连接到小瓶上时，阀组件打开，以通过致动注射器的柱塞来使小瓶中的物质从小瓶中取出并进入注射器，并且在将小瓶和注射器断开以气密密封时阀组件关闭 并将剩余的物质储存在注射器中以备后用。

公开(公告)号：US20050165368A1

公开(公告)日：2005-07-28

申请号：US10990164

申请日：2004-11-15

Applicant: Daniel Py ,  Julian Chan ,  Jeffrey Atwood

Inventor： Daniel Py ,  Julian Chan ,  Jeffrey Atwood

IPC: A61F20060101 ,  A61F9/00 ,  A61M35/00

CPC classification number: B05B11/007 ,  A61F9/0008 ,  A61M11/007 ,  A61M15/08 ,  A61M35/003 ,  A61M2210/0612 ,  B05B11/00412 ,  B05B11/00416 ,  B05B11/0056 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3056 ,  B05B11/307 ,  B05B11/3074 ,  B05B11/3077

Abstract: An ophthalmic delivery device includes a body defining a fluid reservoir and a pump in fluid communication with the reservoir. The delivery device also includes a nozzle that includes a dosage chamber for holding a dosage of fluid, a valve seat, and a valve cover. The valve cover extends about the valve seat and forms an interface therebetween and the valve seat includes an outlet aperture. The interface is in fluid communication with the outlet aperture and the dosage chamber, and at least part of the valve cover is movable between (i) a closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The valve seat and the valve cover are dimensioned to dispense the dosage of fluid through the interface at a velocity of equal to or less than 6 meters per second.

Abstract translation: 眼科输送装置包括限定流体储存器的主体和与储存器流体连通的泵。 输送装置还包括喷嘴，该喷嘴包括用于保持一定量的流体的剂量室，阀座和阀盖。 阀盖围绕阀座延伸并且在它们之间形成界面，并且阀座包括出口孔。 所述界面与所述出口孔和所述剂量室流体连通，并且所述阀盖的至少一部分可在（i）与所述阀盖接合所述阀座的关闭位置之间移动以关闭所述界面并形成流体密封 密封在其间，和（ii）打开位置，其中阀盖的至少一部分响应于流体以大于阀打开压力的压力流过出口孔而与阀座间隔开，以允许加压流体在其间通过 。 阀座和阀盖的尺寸设计为以等于或小于6米/秒的速度通过界面分配流体的剂量。

公开(公告)号：USD501498S1

公开(公告)日：2005-02-01

申请号：US29170504

申请日：2002-11-06

Applicant: Daniel Py

Designer： Daniel Py