公开(公告)号：US20190261903A1

公开(公告)日：2019-08-29

申请号：US16405931

申请日：2019-05-07

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  G01N33/49 ,  A61B5/145 ,  G01D18/00 ,  G01N27/327 ,  G01N27/02 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1473

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

公开(公告)号：US20190252079A1

公开(公告)日：2019-08-15

申请号：US16269533

申请日：2019-02-06

Applicant: DexCom, Inc.

Inventor： Alexandra Elena Constantin ,  Scott M. Belliveau ,  Naresh C. Bhavaraju ,  Jennifer Blackwell ,  Eric Cohen ,  Basab Dattaray ,  Anna Leigh Davis ,  Rian Draeger ,  Arturo Garcia ,  John Michael Gray ,  Hari Hampapuram ,  Nathaniel David Heintzmann ,  Lauren Hruby Jepson ,  Matthew Lawrence Johnson ,  Apurv Ullas Kamath ,  Katherine Yerre Koehler ,  Phil Mayou ,  Patrick Wile McBride ,  Michael Robert Mensinger ,  Sumitaka Mikami ,  Andrew Attila Pal ,  Nicholas Polytaridis ,  Philip Thomas Pupa ,  Eli Reihman ,  Peter C. Simpson ,  Tomas C. Walker ,  Daniel Justin Wiedeback

IPC: G16H70/20 ,  A61B5/145 ,  A61B5/00 ,  G06N20/00

CPC classification number: G16H70/20 ,  A61B5/0022 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/486 ,  A61B5/4866 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/746 ,  G06N5/045 ,  G06N20/00 ,  G16H50/20

Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration data sensed by a glucose concentration sensor. A host state change associated with the host glucose concentration data may be determined. A guidance message based at least in part on the host state change may also be determined. The guidance message may be delivered through a user interface.

公开(公告)号：US20190246914A1

公开(公告)日：2019-08-15

申请号：US16269528

申请日：2019-02-06

Applicant: DexCom, Inc.

Inventor： Alexandra Elena Constantin ,  Scott M. Belliveau ,  Naresh C. Bhavaraju ,  Jennifer Blackwell ,  Eric Cohen ,  Basab Dattaray ,  Anna Leigh Davis ,  Rian Draeger ,  Arturo Garcia ,  John Michael Gray ,  Hari Hampapuram ,  Nathaniel David Heintzmann ,  Lauren Hruby Jepson ,  Matthew Lawrence Johnson ,  Apurv Ullas Kamath ,  Katherine Yerre Koehler ,  Phil Mayou ,  Patrick Wile McBride ,  Michael Robert Mensinger ,  Sumitaka Mikami ,  Andrew Attila Pal ,  Nicholas Polytaridis ,  Philip Thomas Pupa ,  Eli Reihman ,  Peter C. Simpson ,  Tomas C. Walker ,  Daniel Justin Wiedeback ,  Subrai Girish Pai ,  Matthew T. Vogel

IPC: A61B5/0205 ,  A61B5/145 ,  A61B5/00 ,  A61B5/01

CPC classification number: G16H70/20 ,  A61B5/0022 ,  A61B5/1118 ,  A61B5/14532 ,  A61B5/4839 ,  A61B5/486 ,  A61B5/4866 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/746 ,  G06N5/045 ,  G06N20/00 ,  G16H50/20

Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.

公开(公告)号：US20190167163A1

公开(公告)日：2019-06-06

申请号：US16250992

申请日：2019-01-17

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Paul V. Neale ,  Sebastian Böhm ,  Matthew Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US20190053743A1

公开(公告)日：2019-02-21

申请号：US16168061

申请日：2018-10-23

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Mark Brister ,  Matthew Wightlin ,  Jack Pryor

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  C12Q1/00

Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.

公开(公告)号：US20190021596A1

公开(公告)日：2019-01-24

申请号：US16137411

申请日：2018-09-20

Applicant: DexCom, Inc.

Inventor： Mark Brister ,  Paul V. Neale ,  Peter C. Simpson ,  James H. Brauker ,  James Patrick Thrower ,  Mark Shults ,  Rathbun K. Rhodes ,  Paul V. Goode, JR. ,  Arnold L. Holmquist

IPC: A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/07

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

公开(公告)号：US20180360358A1

公开(公告)日：2018-12-20

申请号：US16011570

申请日：2018-06-18

Applicant: DexCom, Inc.

Inventor： Joseph J. Baker ,  Philip Thomas Pupa ,  Timothy Joseph Goldsmith ,  Jonathan Bodnar ,  Jason Halac ,  John Michael Gray ,  Neal Davis Johnston ,  Justen Deering England ,  Peter C. Simpson ,  Paul V. Neale ,  Jennifer Blackwell ,  Maria Noel Brown Wells ,  Kenneth Pirondini ,  Andrew Michael Reinhardt ,  Mark Douglas Kempkey ,  Young Woo Lee ,  Warren Terry ,  Patrick John Castagna ,  David A. Keller ,  Randall Scott Koplin ,  Andrew Joncich

IPC: A61B5/145 ,  A61B5/00

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

公开(公告)号：US20180303394A1

公开(公告)日：2018-10-25

申请号：US16017668

申请日：2018-06-25

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Peter C. Simpson ,  Robert J. Boock ,  Monica Rixman Swinney ,  Mark C. Brister

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  C12Q1/00 ,  G01N33/543

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/411 ,  A61B5/418 ,  A61B5/6848 ,  A61B2562/08 ,  C12Q1/006 ,  G01N33/54366 ,  G01N33/66 ,  Y02A50/55 ,  Y02A50/58

Abstract: The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

公开(公告)号：US20180289294A1

公开(公告)日：2018-10-11

申请号：US16008995

申请日：2018-06-14

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US20180279928A1

公开(公告)日：2018-10-04

申请号：US15994905

申请日：2018-05-31

Applicant: DexCom, Inc.

Inventor： Sebastian Böhm ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/1495 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  G01D18/00 ,  G01N27/02 ,  G01N27/327 ,  G01N33/49 ,  A61B5/1473

CPC classification number: A61B5/1495 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7257 ,  A61B5/7267 ,  A61B2560/0276 ,  G01D18/00 ,  G01N27/026 ,  G01N27/3274 ,  G01N33/49 ,  H05K999/00 ,  H05K999/99

Abstract: Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.