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公开(公告)号:US20230321660A1
公开(公告)日:2023-10-12
申请号:US18335608
申请日:2023-06-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Christoph Faigle , Thomas Heinemeyer , Florian Schweinberger , Roland Thiele
IPC: B01L3/00
CPC classification number: B01L3/5082 , B01L2300/023 , B01L2300/0663 , B01L2300/0832 , B01L2300/024
Abstract: A reaction vessel for a diagnostic analyzer comprising a plurality of processing stations. The reaction vessel comprises at least one sensor configured to measure at least one physical parameter associated with at least one of the processing stations of the diagnostic analyzer when disposed at the at least one of the processing stations, a memory configured to at least temporarily store at least one measurement value indicating the physical parameter provided by the sensor, a processing unit configured to control the sensor and to output measurement data including the measurement value from the memory, an interface configured to provide communication of the processing unit with an external electronic device, a power source configured to supply electric power to the sensor, the processing unit and the memory. The reaction vessel defines an internal volume. The sensor, the processing unit, the memory and the interface are arranged within the internal volume.
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公开(公告)号:US20230314452A1
公开(公告)日:2023-10-05
申请号:US18021085
申请日:2021-08-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Peter Kastner , Vinzent Rolny , Ursula-Henrike Wienhues-Thelen , Andre Ziegler , David Conen , Stefan Osswald , Michael Kuehne
IPC: G01N33/68
CPC classification number: G01N33/6896 , G16H50/30
Abstract: The present invention relates to a method for assessing whether a subject has experienced one or more silent infarcts in a subject, said method comprising a) determining the amount of IGFBP7 in a sample from the subject, b) comparing the amount determined in step a) to a reference, and c) assessing whether a subject has experienced one or more silent infarcts. The present invention further relates to a method for predicting silent infarcts and/or cognitive decline, and methods for assessing and monitoring of the extent of silent small and large noncortical and cortical infarcts in a subject. Further encompassed by the present invention are the corresponding uses.
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363.
公开(公告)号:US11747244B2
公开(公告)日:2023-09-05
申请号:US16385712
申请日:2019-04-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Michael Glauser , Dietmar Kappelhoff , Youssef Khayali
CPC classification number: G01N1/34 , B01L3/502 , G01N1/405 , G01N1/4055 , G01N1/4077 , B01L2200/0631 , B01L2200/10 , B01L2200/141 , B01L2200/143 , B01L2300/069 , B01L2300/0681 , G01N2001/4088 , G01N2035/00019 , G01N2035/00465 , G01N2035/00475
Abstract: A laboratory system and a method for separating interfering substances contained in test samples is presented. The laboratory system comprises separation vessels comprising solid surfaces and capturing molecules which are immobilized on the solid surfaces. The capturing molecules of the separation vessels are configured to bind interfering substances of laboratory tests of different analytical methods.
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公开(公告)号:US11730821B2
公开(公告)日:2023-08-22
申请号:US17933906
申请日:2022-09-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Hartmut Duefel , Uwe Kobold , Andreas Leinenbach
CPC classification number: A61K47/68 , G01N33/6848 , G01N2030/8868 , G01N2458/00
Abstract: The present disclosure is directed at an antibody conjugate having an antibody and a tag, wherein one or more element(s) present in the antibody exhibit an isotope ratio which differs from the naturally occurring isotope ratio of the one or more element(s), wherein the amount of the isotope which is less-common in nature, is increased to at least 4% of the atoms of the respective element in the antibody, as well as uses thereof.
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公开(公告)号:US11709145B2
公开(公告)日:2023-07-25
申请号:US17643463
申请日:2021-12-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Sascha Lutz , Gregor Ocvirk , Christoph Boehm , Wolfgang Burkhardt , Miriam Ruf , Heinz Kontschieder
IPC: G01N27/06 , G01N33/487
CPC classification number: G01N27/06 , G01N33/48707
Abstract: The present disclosure refers to a sensor assembly for an IVD analyzer, the sensor comprising two opposite substrates with at least one fluidic conduit for receiving a sample. The electrodes of different types of electrochemical sensors are arranged on the two opposite substrates facing the at least one fluidic conduit for coming in contact with the sample and determining sample parameters, wherein the counter electrodes and the reference electrodes are formed on one substrate and the working electrodes are formed on the opposite substrate. This achieves optimal sensor-working conditions in terms of a homogeneous and symmetrical electric field density and enables a sensor assembly with simpler geometry and smaller size.
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366.
公开(公告)号:US20230230239A1
公开(公告)日:2023-07-20
申请号:US18145513
申请日:2022-12-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Christopher Grieser , Steffen Koch , Michael Schaletzki , Oliver Stockmann
IPC: G06T7/00 , G06F3/04815 , H04N13/239 , G01N35/00 , G01N35/02
CPC classification number: G06T7/0012 , G06F3/04815 , H04N13/239 , G01N35/00584 , G01N35/02 , G06T2210/41 , G06T2200/24 , G06T2207/30024 , G06T2207/20081
Abstract: The present disclosure refers to a computer-implemented training system for user-interactive training of a plurality of in-vitro diagnostic (IVD) methods performable in an IVD laboratory system, comprising: one or more data processors; a memory device connected to the one or more data processors; a user interface provided with an output device having a display device and an input device configured to receive user input; and one or more software applications running on the one or more data processors and having a plurality of application modules. The plurality of application modules is further configured to control, in response to receiving user input, output of a plurality of views of the IVD laboratory system through the display device according to view output control data indicative of view parameters assigned to a view output mode from a plurality of view output modes; receive a training mode selection user input indicative of a user selection for an IVD method to be trained from the plurality of methods having an assigned view output mode of the plurality of view output modes.
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公开(公告)号:US20230227338A1
公开(公告)日:2023-07-20
申请号:US18099412
申请日:2023-01-20
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Kay Hagedorn , Dieter Heindl , Dirk Kessler , Hubert Paul , Martin Rempt , Hans Zahn
CPC classification number: C02F1/66 , C02F1/52 , C02F2101/30
Abstract: The present invention relates to a method for treating a liquid sample comprising at least one diagnostic assay reagent after use. The present invention further relates to a tablet, a purified liquid sample, a diagnostic assay reagent, a waste water treatment system, a kit and uses thereof for treating the said liquid sample.
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368.
公开(公告)号:US11705225B2
公开(公告)日:2023-07-18
申请号:US17534918
申请日:2021-11-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Ralf Bauer , Werner Schönenberger , Roger Iten
CPC classification number: G16H10/40 , Y10T436/11
Abstract: A system and method for managing information relating to requests for a number of tests to be made of at least one sample within a laboratory environment are disclosed. The system may include a sample reception unit, a pre-analytical unit to scan, sort and/or aliquot the sample on request according to respective test requirements included within a respective sample order, an analytical unit to run at least one test on a sorted and/or aliquoted sample, and at least one decision unit. The decision unit acts as a connecting component for interconnecting the sample reception unit, the pre-analytical unit and the analytical unit as both an intermediary and coordinator such that tests can be performed via a recursive workflow until the sample is completely measured. The decision unit is further configured to collate the test results appropriately with the sample and to give a respective report towards a host component.
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公开(公告)号:US20230221727A1
公开(公告)日:2023-07-13
申请号:US18124805
申请日:2023-03-22
Applicant: Roche Diagnostics Operations, Inc.
Inventor: David Beck
IPC: G05D1/02 , G05B19/418
CPC classification number: G05D1/0214 , G05D1/0259 , G05B19/41895 , G05B19/41815
Abstract: There is described a method of operating a distribution system. The distribution system comprises a number of carriers wherein the carriers are adapted to carry one or more goods. A transport plane of the distribution system supports the carriers. A control device controls the drive means. During an initialization of the distribution system the control device pre-defines a pattern of safe points on the transport plane, wherein on the safe points a carrier can be placed. After the initialization of the distribution system the control device calculates partial routes for the carriers so that the end position of each partial route is either one of the safe points or has a free path to one of the safe points to be reachable in the next partial route.
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370.
公开(公告)号:US20230221335A1
公开(公告)日:2023-07-13
申请号:US17916251
申请日:2021-03-30
Applicant: Roche Diagnostics Operations, Inc.
Inventor: Sibylle Berner-Gatz , Martin Hund , Katharina Buck
CPC classification number: G01N33/689 , G16H50/20 , G16H50/30
Abstract: The present invention relates to a method of assessing a female’s risk of having polycystic ovary syndrome (PCOS), a kit for use in assessing a female’s risk of having PCOS, the use of a marker combination in the assessment of a female’s risk of having PCOS, a computer system for use in a method according to the present invention as well as a computer program and a computer-readable storage medium comprising instructions, which when executed by a computer, cause the computer to carry out the method of the present invention.
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