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    PEPTIDE-LOADED CARRIER SYSTEMS AND USES THEREOF
    31.
    发明申请
    PEPTIDE-LOADED CARRIER SYSTEMS AND USES THEREOF 有权

    公开(公告)号：US20220267478A1

    公开(公告)日：2022-08-25

    申请号：US17631698

    申请日：2020-07-29

    Applicant: Academia Sinica

    Inventor： Che-ming Jack Hu ,  Chien-wei Lin ,  Jung-chen Lin ,  Chen-hsueh Pai

    IPC: C07K17/08 ,  A61K47/62 ,  A61K47/69 ,  C07K17/04 ,  A61P31/16 ,  A61P35/00

    Abstract: A carrier system that includes a nanocarrier and a peptide non-covalently associated with the nanocarrier. The peptide contains an adaptor peptide sequence fused to the N-terminus of a target peptide, the adaptor peptide sequence being designed to facilitate the association to the nanocarrier. Also disclosed is a method for improving the immunogenicity of a peptide antigen by fusing it to an adaptor peptide sequence to form an immunizing peptide and contacting the immunizing peptide with a compatible nanocarrier. Further, a method is provided for treating a condition by immunization with a target peptide that has been fused to an adaptor peptide sequence and thereby associated with a nanocarrier. The method induces an immune response against the target peptide for treating cancer, viral infection, bacterial infection, parasitic infection, autoimmunity, or undesired immune responses to a biologies treatment.

    CHIMERIC HEMAGGLUTININ PROTEIN AND A VACCINE COMPOSITION COMPRISING THE SAME
    32.
    发明申请
    CHIMERIC HEMAGGLUTININ PROTEIN AND A VACCINE COMPOSITION COMPRISING THE SAME 有权

    公开(公告)号：US20220267382A1

    公开(公告)日：2022-08-25

    申请号：US17627212

    申请日：2020-09-18

    Applicant: ACADEMIA SINICA

    Inventor： Yu-Chan CHAO ,  Chih-Hsuan TSAI ,  Chia-Jung CHANG ,  Sung-Chan WEI ,  Lin-Li LIAO ,  Huei-Ru LO

    IPC: C07K14/005 ,  A61P31/16

    Abstract: Provided is a chimeric hemagglutinin (HA) protein including an HA1 subunit and an HA2 subunit, in which the HA1 subunit is composed of a first domain derived from a parental HA1 subunit of a first subtype influenza virus and a second domain derived from a parental HA1 subunit of a second subtype influenza virus. The chimeric HA protein has improved thermal stability and can be used in a vaccine composition for preventing influenza virus infection. Also provided is a method of inducing an immune response against an influenza virus in a subject in need thereof that includes administering the chimeric HA protein to the subject, thereby conferring protection against the influenza virus infection on the subject.

    ANTI-COCCIDIAL PHYTOGENIC FORMULATIONS
    34.
    发明申请
    ANTI-COCCIDIAL PHYTOGENIC FORMULATIONS 有权

    公开(公告)号：US20220257684A1

    公开(公告)日：2022-08-18

    申请号：US17628191

    申请日：2020-07-18

    Applicant: Academia Sinica

    Inventor： Wen-Chin YANG

    IPC: A61K36/282 ,  A61K36/28 ,  A61K31/216 ,  A61P33/02 ,  A61K9/00 ,  A23K10/30 ,  A23K50/75

    Abstract: The present invention relates to anti-coccidial phytogenic formulations. Specifically, anti-coccidial compositions and use thereof are disclosed. An anti-coccidial composition comprises (a) an effective amount of Artemisia indica extract; and (b) an effective amount of Bidens pilosa extract. The composition may further comprise a pharmaceutically acceptable vehicle, excipient, or carrier, and/or an animal feed. The anti-coccidial compositions may be used in the manufacture of a medicament for killing coccidian oocysts, inhibiting oocyst sporulation, reducing sporozoite invasion, and lessening bloody stools, or for alleviating or treating coccidiosis, in a subject in need thereof. In another aspect, the invention relates to use of an anti-coccidial formulation comprising an effective amount of Artemisia indica extract, and a pharmaceutical acceptable vehicle in the manufacture of a medicament for killing coccidian oocysts and inhibiting coccidian oocyst sporulation, and sporozoite invasion.

    CELL CULTURE SYSTEMS, METHODS AND USES THEREOF
    37.
    发明申请
    CELL CULTURE SYSTEMS, METHODS AND USES THEREOF 有权

    公开(公告)号：US20220204943A1

    公开(公告)日：2022-06-30

    申请号：US17566166

    申请日：2021-12-30

    Applicant: Academia Sinica

    Inventor： Ying-Chih CHANG

    IPC: C12N5/09 ,  G01N33/50

    Abstract: The present disclosure provides a surface coating comprising a hydrophilic polymer and polyelectrolyte multilayers. Also provided is a cell culture system comprising a cell culture article having a surface coated with the surface coating. Uses and methods of preparing the surface coatings and systems are provided as well.

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