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公开(公告)号：US4677980A
公开(公告)日：1987-07-07
申请号：US782586
申请日：1985-10-01
CPC分类号： A61M5/31511 , A61M5/007 , A61M5/14546 , A61M5/14566 , A61M5/31515 , Y10S128/01
摘要： An angiographic injector has an injector portion which includes a rotating turret for housing two angiographic syringes in readiness for injection. The injector further employs a driving mechanism for connecting with and controlling the movement of a syringe plunger once one of the syringes is in place for injection. Through the use of guide means on each syringe and corresponding alignment means on a pressure jacket, the syringe is alignably and securely mounted within the pressure jacket on the rotating turret. Each syringe plunger is releasably connected to the driving mechanism for an injection operation, and released from the driving mechanism when the injection operation has been completed, such that the driving mechanism can be withdrawn from the syringe relative to the plunger without drawing body fluid of a patient into the syringe. Various types of plunger release mechanisms for this purpose are disclosed.
摘要翻译： 血管造影注射器具有注射器部分，其包括用于容纳注射用的两个血管造影注射器的旋转转台。 一旦注射器在注射器就位之后，注射器还采用驱动机构来连接和控制注射器柱塞的移动。 通过使用每个注射器上的引导装置和压力套上的相应对准装置，注射器可对准地且牢固地安装在旋转转台上的压力套内。 每个注射器柱塞可释放地连接到用于注射操作的驱动机构，并且当注射操作已经完成时从驱动机构释放，使得驱动机构可以相对于柱塞从注射器中抽出而不抽出体液 病人进入注射器。 公开了用于此目的的各种类型的柱塞释放机构。
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32.发明授权Interface devices and methods for collection of information related to procedures 有权用于收集与程序有关的信息的接口设备和方法公开(公告)号：US08521716B2
公开(公告)日：2013-08-27
申请号：US13180175
申请日：2011-07-11
IPC分类号： G06F17/30
CPC分类号： G06F19/325 , G06F19/00 , G06F19/321 , G06F19/324 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/60 , Y10S707/915 , Y10S707/99933 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： An interface device is used to collect information relating to procedures. The interface device is enabled to communicate with a first device, a second device and an information system. The interface device may be configured to receive before, during and/or after performance of each procedure, a set of personal identification information from the first device, the second device and/or the information system, and automatically, during and/or after performance of each procedure, a first set of procedure information from the first device and a second set of procedure information from the second device. The set of patient identification information is matched automatically with the first and second sets of procedure information related thereto for each procedure performed. A database automatically stores, as a record therein, the set of patient identification information and the first and the second sets of procedure information related thereto for each of the procedures performed.
摘要翻译： 接口设备用于收集与过程有关的信息。 接口设备能够与第一设备，第二设备和信息系统通信。 接口设备可以被配置为在执行每个过程之前，期间和/或之后接收来自第一设备，第二设备和/或信息系统的一组个人识别信息，并且在执行期间和/或之后自动地 每个过程的来自第一设备的第一组过程信息和来自第二设备的第二组过程信息。 所述一组患者识别信息与针对所执行的每个过程的与其相关的第一和第二组程序信息自动匹配。 数据库作为其中的记录自动存储与执行的每个过程相关的一组患者识别信息以及与其相关的第一和第二组过程信息。
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公开(公告)号：US08454561B2
公开(公告)日：2013-06-04
申请号：US12748682
申请日：2010-03-29
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley, III , David M. Reilly
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , Frederick W. Trombley, III , David M. Reilly
IPC分类号： A61M37/00
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： An assembly for connection to a system for injecting a patient is disclosed. The assembly includes an enclosure, a compartment incorporated into the enclosure, a connector, and an output. The compartment is adapted to accept a pharmaceutical container. At least one sealing member is adapted to reversibly seal the compartment. The connector is adapted to establish a fluid connection with a pharmaceutical container in the compartment. The outlet is in fluid connection with the first connector and adapted to connect to the injector.
摘要翻译： 公开了一种用于连接到用于注射患者的系统的组件。 该组件包括外壳，并入外壳中的隔室，连接器和输出端。 隔室适于接受药物容器。 至少一个密封构件适于可逆地密封隔室。 连接器适于与隔室中的药物容器建立流体连接。 出口与第一连接器流体连接并且适于连接到喷射器。
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公开(公告)号：US20130126559A1
公开(公告)日：2013-05-23
申请号：US13695189
申请日：2011-05-02
申请人： Kevin P. Cowan , Mark Trocki , Barry L. Tucker , Edward J. Rhinehart , Raymond C. Hoffman , David H. Berry , Arthur E. Uber, III
发明人： Kevin P. Cowan , Mark Trocki , Barry L. Tucker , Edward J. Rhinehart , Raymond C. Hoffman , David H. Berry , Arthur E. Uber, III
CPC分类号： B65D83/0005 , A61M5/204 , A61M5/315 , A61M5/31505 , A61M5/31513 , A61M5/31525 , A61M5/31573 , A61M5/3158 , A61M5/31591 , A61M5/31595 , A61M2005/3101 , A61M2005/3121 , A61M2005/3128 , A61M2005/31598
摘要： A displacement syringe having a housing with a distal tip and a proximal end; a moveable outer plunger within the housing having an elongated passageway; at least one moveable inner plunger within the passageway of the outer plunger; at least one first seal between the outer plunger and the housing; and at least one second seal between the inner plunger and the outer plunger is disclosed herein. The syringe may have a lock at the proximal end of the housing and/or a valve at the distal tip of the housing. The syringe may also have a plurality of inner plungers of various diameters. A transfer system and delivery system are also disclosed herein. Methods to accurately and efficiently deliver small volumes using the displacement syringe are also disclosed.
摘要翻译： 一种置换式注射器，其具有具有远侧末端和近端的壳体; 壳体内的可移动外柱塞具有细长通道; 在所述外柱塞的通道内的至少一个可动内柱塞; 所述外柱塞和所述壳体之间的至少一个第一密封; 并且本文公开了内柱塞和外柱塞之间的至少一个第二密封。 注射器可以在壳体的近端处具有锁定和/或在壳体的远侧末端处的阀。 注射器还可以具有多个各种直径的内部柱塞。 本文还公开了传送系统和传送系统。 还公开了使用位移注射器精确和有效地递送小体积的方法。
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公开(公告)号：US08382704B2
公开(公告)日：2013-02-26
申请号：US11960968
申请日：2007-12-20
申请人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
发明人： Arthur E. Uber, III , David M. Griffiths , David M. Reilly , Alan D. Hirschman , Kevin P. Cowan , Mark Trocki
IPC分类号： A61M37/00
CPC分类号： A61M5/1407 , A61M5/14216 , A61M5/14236 , A61M5/1723 , A61M2202/09 , B01F7/00258 , B01F7/00566 , B01F7/00908 , B01F7/086 , B01F9/103 , B01F11/0071 , B01F11/0074 , B01F11/0082 , B01F11/025 , B01F13/002 , B01F13/0023 , B01F13/0818 , G06F19/00
摘要： A system for delivering a cell-slurry to a patient may include a fluid, cells that are non-dissolvable or immiscible in the fluid, thereby forming the cell-slurry, a syringe adapted to contain the cell-slurry and a supernate of the cell-slurry, the syringe defining a first end having an outlet through which the cell-slurry is delivered to the patient, a fluidizing system associated with the syringe and adapted to effect dilation of the cell-slurry with a portion of the supernate, to form a dilated cell-slurry, the dilated cell-slurry being transferred from the fluidizing system to the syringe, while maintaining at least a portion of the supernate, the cell-slurry and supernate being transferred from the fluidizing system to the syringe, a pressurizing mechanism adapted to create a pressure to cause the dilated cell-slurry contained within the syringe to flow for delivery to the patient and a control unit in communication with and adapted to control the fluidizing system, the pressurizing mechanism and movement of the dilated cell-slurry.
摘要翻译： 用于将细胞浆料递送到患者的系统可以包括流体，在流体中不可溶或不混溶的细胞，从而形成细胞浆液，适于容纳细胞浆液和细胞上清液的注射器 - 注射器限定具有出口的第一端，细胞浆料通过该出口传送到患者，与注射器相关联的适于用一部分上清液进行细胞浆液的扩张的流化系统，形成 扩张的细胞浆液，将扩张的细胞浆液从流化系统转移到注射器，同时保持至少一部分上清液，细胞浆液和上清液从流化系统转移到注射器，加压机构 适于产生压力以使得包含在注射器内的扩张的细胞浆液流动以传递给患者，以及与控制流化系统连通并适于控制流化系统的控制单元 扩散细胞浆的机制和运动。
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公开(公告)号：US20120209111A1
公开(公告)日：2012-08-16
申请号：US13453335
申请日：2012-04-23
IPC分类号： A61M5/315
CPC分类号： A61M5/31 , A61M5/002 , A61M5/007 , A61M5/1452 , A61M5/14546 , A61M5/148 , A61M5/16827 , A61M5/2425 , A61M5/31511 , A61M5/31515 , A61M2005/14553 , A61M2005/3123 , A61M2005/31516 , A61M2207/10 , B29C45/1418 , B29C45/14336 , B29K2023/12 , B29L2031/7544
摘要： A bladder syringe for a fluid delivery system includes a cylindrical body, a cap-bladder assembly, a plunger element disposed in the cylindrical body, and a mounting assembly to secure the cap-bladder assembly to the cylindrical body. The cylindrical body has a distal end and a proximal end and defines a throughbore. The cap-bladder assembly is adapted for connection to the distal end of the cylindrical body, and includes a cap body and a bladder. The cap body defines an interior cavity and a distal discharge conduit and is adapted to engage the distal end of the cylindrical body. A disc-shaped bladder is disposed within the interior cavity and typically includes a central membrane portion. The plunger element is disposed in the throughbore of the cylindrical body and is vented to enable evacuation of the space between the plunger element and the cap-bladder assembly in the cylindrical body.
摘要翻译： 用于流体输送系统的膀胱注射器包括圆柱体，囊 - 囊组件，设置在圆柱体中的柱塞元件和用于将囊 - 囊组件固定到圆柱体上的安装组件。 圆柱体具有远端和近端并限定通孔。 盖囊组件适于连接到圆柱体的远端，并且包括帽体和囊。 盖体限定内腔和远端排出导管，并适于接合圆柱体的远端。 盘状囊体设置在内腔内，通常包括中央膜部分。 柱塞元件设置在圆柱形主体的通孔中并且被排气以便能够排出柱塞元件和圆柱体中的囊 - 囊组件之间的空间。
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37.发明授权公开(公告)号：US08198599B2
公开(公告)日：2012-06-12
申请号：US12664653
申请日：2009-12-14
IPC分类号： G01J1/42
摘要： A detector system measures radioactive material. A fluid path receives at least one aliquot of radiopharmaceutical. The fluid path locates the aliquot within a positioner formed with a concave configuration. A detector is located at an axial distance from the concave surface and determines the level of radioactivity of the aliquot. Alternatively, the fluid path may be less concave and a variable attenuator may be placed between the fluid path and detector. The variable attenuator may have a concavity that is based on the concavity of the fluid path so that the detector's ability to read the radioactivity is optimized. A method for forming an aliquot of radiopharmaceutical in a concave fluid passage. Positioning a detector located a distance from the concave surface to optimize reading spectral energy of the aliquot and activity is determining activity regardless of the position of the aliquot in the passage.
摘要翻译： 检测器系统测量放射性物质。 流体路径接收至少一个等分的放射性药物。 流体路径将等分试样定位在形成有凹形构型的定位器内。 检测器位于距凹面的轴向距离处，并确定等分试样的放射性水平。 或者，流体路径可以较少凹入，并且可变衰减器可以放置在流体路径和检测器之间。 可变衰减器可以具有基于流体路径的凹部的凹度，使得检测器读取放射性的能力被优化。 还描述了在凹形流体通道中形成放射性药物的等分试样的方法。 定位一个与凹面相距一定距离的检测器，通过确定活动而不考虑通道中等分试样的位置，优化读取等分试样的光谱能量和活性。
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38.发明授权公开(公告)号：US08197437B2
公开(公告)日：2012-06-12
申请号：US11691748
申请日：2007-03-27
IPC分类号： A61M31/00
CPC分类号： A61M5/007 , A61B5/0044 , A61B5/02028 , A61B5/0205 , A61B5/026 , A61B5/029 , A61B5/0295 , A61B5/055 , A61B5/7257 , A61B6/032 , A61B6/481 , A61B6/504 , A61B6/507 , A61B6/583 , A61B8/13 , A61B8/481 , A61K49/0002 , G01R33/5601 , G06F19/00 , G06F19/321 , G06F19/3468 , G16H50/50
摘要： An injection system includes an injector for injecting a fluid into a patient and a controller in operative communication with the injector for control thereof. The controller controls a diagnostic injection of the fluid based upon at least one mathematical model individualized to the patient. The model(s) are determined by collecting data corresponding to a time response curve resulting from at least one test injection of the fluid into the patient. The time response curve represents a response of a region of interest of the patient over time due to the fluid passing therethrough. An imaging system having such an injection system is also disclosed, as is a system for effecting a medical procedure. A method of delivering such a fluid to a patient using such an injection system is also disclosed, as is a method of modeling propagation of such a fluid in a patient.
摘要翻译： 注射系统包括用于将流体注射到患者体内的注射器和与注射器可操作地连通以控制的控制器。 控制器基于对患者个体化的至少一个数学模型来控制流体的诊断注射。 模型通过收集对应于由流体进入至少一次试验注射到患者体内而产生的时间响应曲线的数据来确定。 时间响应曲线表示由于流体通过其而使患者随时间变化的感兴趣区域的响应。 还公开了具有这种注射系统的成像系统，以及用于实现医疗程序的系统。 还公开了使用这种注射系统将这种流体递送到患者的方法，以及模拟患者体内这种流体的传播的方法。
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公开(公告)号：US08182444B2
公开(公告)日：2012-05-22
申请号：US12092448
申请日：2006-11-06
申请人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , David M. Reilly , Kevin P. Cowan , Barry L. Tucker , David Mishler
发明人： Arthur E. Uber, III , Alan D. Hirschman , David M. Griffiths , David M. Reilly , Kevin P. Cowan , Barry L. Tucker , David Mishler
IPC分类号： A61M5/168
CPC分类号： A61M5/142 , A61M5/1452 , A61M5/1723 , A61M5/3291 , A61M25/007 , A61M25/04 , A61M31/005 , A61M2025/0089 , A61M2025/009 , A61M2025/0092
摘要： A system for delivering a fluid comprising cells to tissue of a patient includes a container holding an injection fluid and a powered drive. A sensor system provides a measurement indicative of at least shear forces on the cells to a control system. Based at least in part on this measurement, the control system is adapted to transmit a control signal to the powered drive for pressurizing the contents of the container to deposit cells within the tissue of a patient via a fluid path and a patient interface. As an example, the cells can be pregenitor or stem cells.
摘要翻译： 用于将包含细胞的流体输送到患者的组织的系统包括容纳注射流体和动力驱动器的容器。 传感器系统提供至少指示细胞上的至少剪切力到控制系统的测量。 至少部分地基于该测量，控制系统适于将控制信号传输到动力驱动器，用于对容器的内容物进行加压，以经由流体路径和患者接口将细胞沉积在患者组织内。 例如，细胞可以是祖细胞或干细胞。
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公开(公告)号：US08160679B2
公开(公告)日：2012-04-17
申请号：US12477456
申请日：2009-06-03
申请人： Arthur E. Uber , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski , Alan Hirschman
发明人： Arthur E. Uber , Edward J. Rhinehart , Rosemary Almon-Martin , David M. Griffiths , Francis J. Sciulli , Walter Grumski , Vera Pagano , Karen Zelenski , Alan Hirschman
IPC分类号： A61B6/00
CPC分类号： A61B8/481 , A61B6/481 , A61B6/504 , A61B8/06 , A61M5/007 , A61M5/14546 , A61M5/1723 , A61M2205/581 , A61M2205/80 , G06F19/00 , G06F19/321 , G06F19/3468
摘要： A method of coordinating an imaging procedure and an injection procedure, the method comprising the steps of providing an injector system having first and second pressurizing units for pressurizing a contrast medium and a diluent for injection into a patient; providing an imaging system for producing an image of an internal region of the patient from a signal resulting from energy applied to the patient; and providing a data interface interconnecting the injector and imaging systems for enabling exchange of digital information therebetween such that the digital information transmitted between the systems is usable to enable closed loop control of at least one of the injection and the imaging procedures during which the contrast medium and the diluent injected into the patient is adjustable so as to achieve a desired level of enhancement within the internal region of the patient of which the images are acquired during the imaging procedure.
摘要翻译： 一种协调成像过程和注射程序的方法，所述方法包括以下步骤：提供具有用于加压造影剂的第一和第二加压单元和用于向患者注射的稀释剂的注射器系统; 提供成像系统，用于从施加到患者的能量产生的信号产生患者的内部区域的图像; 并且提供互连注射器和成像系统的数据接口，以使得能够在其间进行数字信息的交换，使得在系统之间传输的数字信息可用于对注射和成像过程中的至少一个进行闭环控制， 并且注射到患者体内的稀释剂是可调节的，以便在成像过程期间获取图像的患者的内部区域内实现期望的增强水平。
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