公开(公告)号：US20130126559A1

公开(公告)日：2013-05-23

申请号：US13695189

申请日：2011-05-02

申请人： Kevin P. Cowan ,  Mark Trocki ,  Barry L. Tucker ,  Edward J. Rhinehart ,  Raymond C. Hoffman ,  David H. Berry ,  Arthur E. Uber, III

发明人： Kevin P. Cowan ,  Mark Trocki ,  Barry L. Tucker ,  Edward J. Rhinehart ,  Raymond C. Hoffman ,  David H. Berry ,  Arthur E. Uber, III

IPC分类号： B65D88/54 ,  G01F11/00

CPC分类号： B65D83/0005 ,  A61M5/204 ,  A61M5/315 ,  A61M5/31505 ,  A61M5/31513 ,  A61M5/31525 ,  A61M5/31573 ,  A61M5/3158 ,  A61M5/31591 ,  A61M5/31595 ,  A61M2005/3101 ,  A61M2005/3121 ,  A61M2005/3128 ,  A61M2005/31598

摘要： A displacement syringe having a housing with a distal tip and a proximal end; a moveable outer plunger within the housing having an elongated passageway; at least one moveable inner plunger within the passageway of the outer plunger; at least one first seal between the outer plunger and the housing; and at least one second seal between the inner plunger and the outer plunger is disclosed herein. The syringe may have a lock at the proximal end of the housing and/or a valve at the distal tip of the housing. The syringe may also have a plurality of inner plungers of various diameters. A transfer system and delivery system are also disclosed herein. Methods to accurately and efficiently deliver small volumes using the displacement syringe are also disclosed.

摘要翻译： 一种置换式注射器，其具有具有远侧末端和近端的壳体; 壳体内的可移动外柱塞具有细长通道; 在所述外柱塞的通道内的至少一个可动内柱塞; 所述外柱塞和所述壳体之间的至少一个第一密封; 并且本文公开了内柱塞和外柱塞之间的至少一个第二密封。 注射器可以在壳体的近端处具有锁定和/或在壳体的远侧末端处的阀。 注射器还可以具有多个各种直径的内部柱塞。 本文还公开了传送系统和传送系统。 还公开了使用位移注射器精确和有效地递送小体积的方法。

公开(公告)号：US20080294096A1

公开(公告)日：2008-11-27

申请号：US12092448

申请日：2006-11-06

申请人： Arthur E. Uber, III ,  Alan D. Hirschman ,  Evan Facher ,  Eugene A. Gelblum ,  David M. Griffiths ,  Edward J. Rhinehart ,  David M. Reilly ,  Kevin P. Cowan ,  Page Cedarholm ,  Barry L. Tucker ,  Mark Trocki ,  David Mishler ,  Henry E. Bartony, JR. ,  Robert Parks

发明人： Arthur E. Uber, III ,  Alan D. Hirschman ,  Evan Facher ,  Eugene A. Gelblum ,  David M. Griffiths ,  Edward J. Rhinehart ,  David M. Reilly ,  Kevin P. Cowan ,  Page Cedarholm ,  Barry L. Tucker ,  Mark Trocki ,  David Mishler ,  Henry E. Bartony, JR. ,  Robert Parks

IPC分类号： A61M5/168

CPC分类号： A61M5/142 ,  A61M5/1452 ,  A61M5/1723 ,  A61M5/3291 ,  A61M25/007 ,  A61M25/04 ,  A61M31/005 ,  A61M2025/0089 ,  A61M2025/009 ,  A61M2025/0092

摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be pregenitor cells or stem cells.

摘要翻译： 一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。 通信系统适于向控制系统提供信息。 控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。 细胞可以例如是前体细胞或干细胞。

公开(公告)号：US08551074B2

公开(公告)日：2013-10-08

申请号：US12206123

申请日：2008-09-08

申请人： Raymond C. Hoffman ,  Edward J. Rhinehart ,  Kevin P. Cowan ,  Barry L. Tucker

发明人： Raymond C. Hoffman ,  Edward J. Rhinehart ,  Kevin P. Cowan ,  Barry L. Tucker

IPC分类号： A61M25/18

CPC分类号： A61M39/10 ,  A61M39/1011 ,  A61M2206/11

摘要： Systems for connecting a conduit to an injection needle may include a sealing element positioned on a distal end of the conduit, a first cooperating connector positioned around the length of conduit proximal to the sealing element and a second cooperating connector. The first cooperating connector includes a first cooperating connection mechanism and the second cooperating connector includes a second cooperating connection mechanism having a passage therein. The first cooperating connection mechanism and the second cooperating connection mechanism are adapted to form a connection between the first cooperating connector and the second cooperating connector. The connection causes the compression of the sealing element. The injection needle has a lumen with a diameter flared outward to a larger diameter at a proximal end. The second cooperating connector has a mounting hole connected to the passage and a sleeve around the injection needle so that the sleeve and the injection needle are received within the mounting hole.

摘要翻译： 用于将导管连接到注射针的系统可以包括定位在导管的远端上的密封元件，位于靠近密封元件的导管长度周围的第一配合连接器和第二配合连接器。 第一配合连接器包括第一配合连接机构，第二配合连接器包括在其中具有通道的第二配合连接机构。 第一配合连接机构和第二配合连接机构适于在第一配合连接器和第二配合连接器之间形成连接。 连接导致密封元件的压缩。 注射针头具有直径向外扩张到更近的直径的内腔。 第二配合连接器具有连接到通道的安装孔和围绕注射针的套筒，使得套筒和注射针被容纳在安装孔内。

公开(公告)号：US20100063481A1

公开(公告)日：2010-03-11

申请号：US12206123

申请日：2008-09-08

申请人： Raymond C. Hoffman ,  Edward J. Rhinehart ,  Kevin P. Cowan ,  Barry L. Tucker

发明人： Raymond C. Hoffman ,  Edward J. Rhinehart ,  Kevin P. Cowan ,  Barry L. Tucker

IPC分类号： A61M39/10

CPC分类号： A61M39/10 ,  A61M39/1011 ,  A61M2206/11

摘要： A system for connecting a conduit to a fluid path element, includes a length of conduit, a compressible sealing element positioned on a distal end of the length of conduit to be attached to the fluid path element, a first cooperating connector positioned around the length of conduit proximal to the sealing element and a second cooperating connector. The first cooperating connector includes a first cooperating connection mechanism and the second cooperating connector includes a second cooperating connection mechanism. The first cooperating connection mechanism and the second cooperating connection mechanism are adapted to form a connection between the first cooperating connector and the second cooperating connector. The connection causes the compression of the sealing element. The second cooperating connector further includes a passage therein in fluid connection with a connection for the fluid path element. Another system for connecting to a fluid path section includes a connector including a connection mechanism to connect the connector to the fluid path section and a passage therethrough. The passage is in fluid connection with a first fluid path element downstream of the connector. The first fluid path element includes a lumen therethrough. The diameter of the lumen is flared outward to a larger diameter at a proximal end of the fluid path element. The proximal end of the first fluid path element can abut a surface of the connector in which the distal end of the fluid path is formed. The inner diameter of the proximal end is greater than the diameter of the passage of the second cooperating connector. The outer diameter of the proximal end of the first fluid path element can also be flared outward

摘要翻译： 一种用于将导管连接到流体路径元件的系统，包括一段导管，一个可压缩的密封元件，该可密封的密封元件定位在待连接到流体路径元件的管道长度的远端上;第一协作连接器， 靠近密封元件的导管和第二协作连接器。 第一配合连接器包括第一配合连接机构，第二配合连接器包括第二配合连接机构。 第一配合连接机构和第二配合连接机构适于在第一配合连接器和第二配合连接器之间形成连接。 连接导致密封元件的压缩。 第二配合连接器还包括与流体路径元件的连接件流体连接的通道。 用于连接到流体路径部分的另一系统包括连接器，该连接器包括将连接器连接到流体路径部分的连接机构和通过其的通道。 通道与连接器下游的第一流体路径元件流体连接。 第一流体路径元件包括其中的内腔。 在流体路径元件的近端处，管腔的直径向外扩张到更大的直径。 第一流体路径元件的近端可邻接形成流体路径的远端的连接器的表面。 近端的内径大于第二配合连接器的通道的直径。 第一流体路径元件的近端的外径也可以向外张开

公开(公告)号：US20110178359A1

公开(公告)日：2011-07-21

申请号：US12595165

申请日：2007-12-28

申请人： Alan D. Hirschman ,  Arthur E. Uber, III ,  Kevin P. Cowan ,  David M. Reilly ,  Edward J. Rhinehart ,  John Kalafut ,  Bronwyn Uber ,  Frederick W. Trombley, III ,  Steven J. Remis ,  Paul D. Levin ,  Scott Griffith ,  Douglas Descalzi ,  Richard Dewit ,  David M. Griffiths

发明人： Alan D. Hirschman ,  Arthur E. Uber, III ,  Kevin P. Cowan ,  David M. Reilly ,  Edward J. Rhinehart ,  John Kalafut ,  Bronwyn Uber ,  Frederick W. Trombley, III ,  Steven J. Remis ,  Paul D. Levin ,  Scott Griffith ,  Douglas Descalzi ,  Richard Dewit ,  David M. Griffiths

IPC分类号： A61M36/06

CPC分类号： A61N5/1001 ,  A61B5/0205 ,  A61B5/055 ,  A61B5/7289 ,  A61B6/032 ,  A61B6/037 ,  A61B6/0478 ,  A61B6/107 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4423 ,  A61B6/507 ,  A61B6/508 ,  A61B6/5288 ,  A61B6/548 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1456 ,  A61M5/16827 ,  A61M5/16881 ,  A61M5/1723 ,  A61M5/1785 ,  A61M2205/3576 ,  A61N5/1071 ,  A61N2005/1021 ,  A61N2005/1094 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G21F5/015 ,  G21G4/08

摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.

摘要翻译： 公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与 患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。 在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。 进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

公开(公告)号：US08721596B2

公开(公告)日：2014-05-13

申请号：US10668643

申请日：2003-09-23

申请人： Mark Trocki ,  Mark W. Hitchins ,  Kevin P. Cowan ,  Edward J. Rhinehart

发明人： Mark Trocki ,  Mark W. Hitchins ,  Kevin P. Cowan ,  Edward J. Rhinehart

IPC分类号： A61M37/00

CPC分类号： A61M5/14546 ,  A61M5/14566 ,  A61M2205/60 ,  A61M2205/6063 ,  A61M2205/6072

摘要： A syringe for use with an injector includes a body having a rear end and a front end, a plunger movably disposed within the body, an attachment member associated with the body and adapted to releasably engage a syringe retaining mechanism of the injector regardless of the orientation of the syringe with respect to the injector, and an encoding device operable to provide syringe information to the injector.

摘要翻译： 用于注射器的注射器包括具有后端和前端的主体，可移动地设置在主体内的柱塞，与主体相关联并适于可释放地接合注射器的注射器保持机构而不管取向如何 相对于注射器的注射器，以及可操作以向注射器提供注射器信息的编码装置。

公开(公告)号：US06652489B2

公开(公告)日：2003-11-25

申请号：US09777020

申请日：2001-02-05

申请人： Mark Trocki ,  Mark W. Hitchins ,  Kevin P. Cowan ,  James A. Dedig ,  Francis J. Sciulli ,  Steven C. Rygg ,  Larry J. Fuchs ,  Edward J. Rhinehart ,  Robert D. Parks

发明人： Mark Trocki ,  Mark W. Hitchins ,  Kevin P. Cowan ,  James A. Dedig ,  Francis J. Sciulli ,  Steven C. Rygg ,  Larry J. Fuchs ,  Edward J. Rhinehart ,  Robert D. Parks

IPC分类号： A61M3700

CPC分类号： A61M5/14546 ,  A61M5/14566 ,  A61M2205/60 ,  A61M2205/6063 ,  A61M2205/6072

摘要： Embodiments of an injector, syringe, syringe interface, and piston/plunger assembly for an injector (of contrast medium, for example) are described. Preferably, the syringe is adapted to engage a syringe interface mechanism such that the syringe may be connected to an injector without regard to any particular orientation of the syringe to the injector or to the piston/plunger assembly.

摘要翻译： 描述了用于注射器（例如造影剂）的注射器，注射器，注射器接口和活塞/柱塞组件的实施例。 优选地，注射器适于接合注射器接口机构，使得注射器可以连接到注射器，而不考虑注射器对于注射器或活塞/柱塞组件的任何特定取向。

公开(公告)号：US20090326370A1

公开(公告)日：2009-12-31

申请号：US12534987

申请日：2009-08-04

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC分类号： A61B6/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

摘要翻译： 用于产生患者的对比度增强的医学图像的系统包括对比度或增强介质的源，与对比度或增强介质源流体连接的加压单元，可操作以将能量施加到所述对比度或增强介质的区域的能量源 患者，成像单元，其基于由施加到患者的区域的能量产生的信号以及控制单元提供患者的内部视图的视觉显示。 在一个实施例中，该信号受到患者中的对比度或增强介质的状况的影响。 为了控制程序，控制单元基于该信号来调整患者的对比度或增强介质的状况。 通信接口优选地实现喷射器子系统和成像子系统之间的信息。

公开(公告)号：US06397098B1

公开(公告)日：2002-05-28

申请号：US09300326

申请日：1999-04-27

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC分类号： A61B600

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： A system for producing a contrast-enhanced medical image of a patient includes a source of a contrast or enhancement medium, a pressurizing unit in fluid connection with the source of contrast or enhancement medium, an energy source operable to apply energy to a region of the patient, an imaging unit providing a visual display of an internal view of the patient based upon a signal resulting from the energy applied to the region of the patient, and a control unit. In an embodiment, the signal is affected by a condition of the contrast or enhancement medium in the patient. To control the procedures, the control unit adjusts the condition of the contrast or enhancement medium in the patient based upon the signal. A communication interface preferably enables information between an injector subsystem and an imaging subsystem.

公开(公告)号：US08055328B2

公开(公告)日：2011-11-08

申请号：US12534987

申请日：2009-08-04

申请人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

发明人： Arthur E. Uber, III ,  Edward J. Rhinehart ,  Rosemary Almon-Martin ,  David M. Griffiths ,  Alan D. Hirschman ,  Francis J. Sciulli ,  Walter Grumski ,  Vera Pagano ,  Karen Zelenski

IPC分类号： A61B6/00

CPC分类号： A61B8/481 ,  A61B6/481 ,  A61B6/504 ,  A61B8/06 ,  A61M5/007 ,  A61M5/14546 ,  A61M5/1723 ,  A61M2205/581 ,  A61M2205/80 ,  G06F19/00 ,  G06F19/321 ,  G06F19/3468

摘要： An interface unit enables communication with an injector system that is used for pressurizing a fluid medium for injection into a patient during an injection procedure. The interface unit includes a processor and a storage unit. The processor controls operation of the interface unit and enables exchange of digital information between the interface unit and the injector system. The storage unit, under control of the processor, records the digital information gathered from the injector system during communication therewith. The digital information includes at least injection profile, history and dose data pertaining to the injection procedure. The processor enables at least the injection profile, history and dose data of the digital information recorded within the storage unit of the interface unit to be communicable to at least one of an imaging system linked thereto and an external device linked thereto.

摘要翻译： 接口单元使得能够与注射器系统进行通信，所述注射器系统在注射过程期间用于对用于注射到患者中的流体介质进行加压。 接口单元包括处理器和存储单元。 处理器控制接口单元的操作，并能够在接口单元和喷射器系统之间交换数字信息。 在处理器的控制下，存储单元在与其通信期间记录从喷射器系统收集的数字信息。 数字信息至少包括与注射程序相关的注射分布，历史和剂量数据。 处理器至少使记录在接口单元的存储单元内的数字信息的喷射轮廓，历史和剂量数据能够连接到与其相连的成像系统和与其相连的外部装置中的至少一个。