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公开(公告)号：US06913919B2
公开(公告)日：2005-07-05
申请号：US09991181
申请日：2001-11-16
Applicant: David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , William I. Wood
Inventor： David Botstein , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Margaret Ann Roy , William I. Wood
CPC classification number: C07K14/705
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050112725A1
公开(公告)日：2005-05-26
申请号：US10978255
申请日：2004-10-29
Applicant: Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Ivar Kljavin , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
Inventor： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Ivar Kljavin , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood , Zemin Zhang
IPC: G01N33/50 , A01K67/027 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/54 , C07K16/18 , C07K16/24 , C07K16/40 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/567 , G01N33/574
CPC classification number: G01N33/567 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K14/47 , C12N15/8509 , G01N33/57484 , G01N2800/52
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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33.发明申请公开(公告)号：US20050048613A1
公开(公告)日：2005-03-03
申请号：US10899671
申请日：2004-07-27
Applicant: David Botstein , Audrey Goddard , David Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Margaret Roy , William Wood
Inventor： David Botstein , Audrey Goddard , David Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Margaret Roy , William Wood
CPC classification number: C07K14/47 , C07K14/705
Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US06551822B1
公开(公告)日：2003-04-22
申请号：US09202088
申请日：1998-12-08
Applicant: Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , David Botstein , Audrey Goddard , Margaret Roy , Napoleone Ferrara , Daniel Tumas , Ralph Schwall
Inventor： Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , David Botstein , Audrey Goddard , Margaret Roy , Napoleone Ferrara , Daniel Tumas , Ralph Schwall
IPC: C07K14475
CPC classification number: C07K14/515 , A61K38/00 , C07K2319/00 , G01N2800/32 , Y10S977/773 , Y10S977/788 , Y10S977/915
Abstract: The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5, NL8, and NL4, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
Abstract translation: 本发明涉及编码新型TIE配体NL1，NL5，NL8和NL4的分离的核酸分子，由这些核酸分子编码的蛋白质以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：US5728567A
公开(公告)日：1998-03-17
申请号：US662891
申请日：1996-08-01
Applicant: Stephen Anderson , William F. Bennett , David Botstein , Deborah L. Higgins , Nicholas F. Paoni , Mark J. Zoller
Inventor： Stephen Anderson , William F. Bennett , David Botstein , Deborah L. Higgins , Nicholas F. Paoni , Mark J. Zoller
IPC: A61K38/00 , A61K38/48 , C07H21/04 , C12N1/21 , C12N5/10 , C12N9/64 , C12N9/72 , C12N15/55 , C12N15/58 , C12N15/63 , C12N15/70 , C12N15/86
CPC classification number: C12N9/6456 , A61K38/00
Abstract: Tissue plasminogen activator (t-PA) zymogens and variants are prepared, including a fibrinolytically active variant of t-PA that has an amino acid alteration at a site within the protease domain of t-PA as compared with the corresponding wild-type t-PA, which alteration renders the variant zymogenic in the presence of plasmin-degraded fibrinogen, and/or fibrin (or plasma clot) specific, as compared to the corresponding wild-type t-PA. DNA sequences can be prepared that encode the zymogens and variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The zymogens and variants may be used in a pharmaceutical preparation to treat a vascular disease or condition or to prevent fibrin deposition or adhesion formation or reformation in mammals.
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Patent Agency Ranking
36.发明授权公开(公告)号：US09212359B2
公开(公告)日：2015-12-15
申请号：US14128700
申请日：2012-06-15
Applicant: Sanford Jay Silverman , Robert Scott McIsaac , Marcus Noyes , David Botstein
Inventor： Sanford Jay Silverman , Robert Scott McIsaac , Marcus Noyes , David Botstein
CPC classification number: C12N15/1079 , C12N15/63 , C12N15/81
Abstract: A system allows for rapid and specific induction of individual genes in eukaryotic cells using a chimeric transcriptional activator that is responsive to hormone inducer. Upon addition of the hormone, cytoplasmic transcriptional activator localizes to the nucleus and subsequently binds to promoters containing sequences that bind to its DNA-binding domain. Genetic modifications allow for rapid and specific degradation of a targeted protein upon addition of hormone by means of a regulated degron method that utilizes a protease variant. This system is useful for discovering new compounds by high throughput screening when introducing compound libraries to these protein-depleted cells.
Abstract translation: 一种系统允许使用对激素诱导剂有反应的嵌合转录激活物来快速和特异性地诱导真核细胞中的单个基因。 加入激素后，细胞质转录激活剂定位于细胞核，随后与含有结合其DNA结合域的序列的启动子结合。 遗传修饰允许通过利用蛋白酶变体的经调节的degron方法加入激素时靶向蛋白质的快速和特异性降解。 当将这些蛋白质耗尽的细胞引入化合物文库时，该系统可用于通过高通量筛选发现新的化合物。
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37.发明授权Classification of patients having diffuse large b-cell lymphoma based upon gene expression 失效基于基因表达的弥漫性大B细胞淋巴瘤患者的分类公开(公告)号：US07622253B2
公开(公告)日：2009-11-24
申请号：US11542552
申请日：2006-10-03
Applicant: Ronald Levy , Mark A. Wechser , Izidore S. Lossos , Robert J. Tibshirani , Ash A. Alizadeh , David Botstein
Inventor： Ronald Levy , Mark A. Wechser , Izidore S. Lossos , Robert J. Tibshirani , Ash A. Alizadeh , David Botstein
IPC: G01N33/50 , C12Q1/68 , G01N33/574
CPC classification number: G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/16
Abstract: Methods and kits for classifying patients having diffuse large B-cell lymphoma (DLBCL) based upon expression of a plurality of genes are disclosed. Real-time quantitative RT-PCR can be used to measure expression values. Correlating expression values of the plurality of genes in a tumor sample from the patient to reference expression values obtained from DLBCL patients can stratify patients in the classification groups. The methods and kits can be used to predict overall patient survival.
Abstract translation: 公开了基于多个基因的表达来分类具有弥漫性大B细胞淋巴瘤（DLBCL）的患者的方法和试剂盒。 实时定量RT-PCR可用于测量表达值。 将来自患者的肿瘤样品中的多个基因的表达值与从DLBCL患者获得的参照表达值相关联可以对分类组中的患者进行分层。 方法和试剂盒可用于预测总体患者生存。
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公开(公告)号：US20090197301A1
公开(公告)日：2009-08-06
申请号：US11796725
申请日：2007-04-27
Applicant: Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Chistopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
Inventor： Kevin P. Baker , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul J. Godowski , J. Chistopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Victoria Smith , Timothy A. Stewart , Daniel Tumas , Colin K. Watanabe , P. Mickey Williams , William I. Wood
CPC classification number: C07K14/47
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07557192B2
公开(公告)日：2009-07-07
申请号：US09904786
申请日：2001-07-12
Applicant: Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
Inventor： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Giang Gao , Hanspeter Gerber , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Jennie P. Mather , James Pan , Nicholas F. Paoni , Margaret Ann Roy , Timothy A. Stewart , Daniel Tumas , P. Mickey Williams , William I. Wood
IPC: C07K16/00
CPC classification number: C07K14/47 , G01N33/68 , G01N2333/485
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20090170158A1
公开(公告)日：2009-07-02
申请号：US12079178
申请日：2008-03-25
Applicant: Kevin P. Baker , David Botstein , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Mary A. Napier , Margaret Ann Roy , Daniel Tumas , William I. Wood
Inventor： Kevin P. Baker , David Botstein , Dan L. Eaton , Napoleone Ferrara , Ellen Filvaroff , Mary E. Gerritsen , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Ivar J. Kljavin , Mary A. Napier , Margaret Ann Roy , Daniel Tumas , William I. Wood
CPC classification number: C07K14/475 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02 , C12N2799/026 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/5085 , G01N33/57484 , G01N33/68
Abstract: The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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