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    Magnetically driven micro-pumping method using external rotating stirrer
    34.
    发明申请
    Magnetically driven micro-pumping method using external rotating stirrer 审中-公开
    使用外部旋转搅拌器的磁驱微泵法

    公开(公告)号：US20100254830A1

    公开(公告)日：2010-10-07

    申请号：US11545189

    申请日：2006-10-10

    Applicant: David J. Beebe ,  Ivar Meyvantsson ,  Dongshin Kim

    Inventor： David J. Beebe ,  Ivar Meyvantsson ,  Dongshin Kim

    IPC: F04B17/00

    CPC classification number: F04B19/006

    Abstract: A device and method for conducting peristaltic pumping of a fluid in a body is provided. The body includes a channel having an input and an output and being partially defined by a flexible layer. A plurality of contacts are spaced along the layer and the channel is filled with the fluid. The plurality of spaced contacts is magnetically coupled to a magnetic field in sequence so as to translate peristaltic motion to the layer thereby pumping the fluid through the channel.

    Abstract translation: 提供了一种用于在体内进行流体的蠕动泵送的装置和方法。 身体包括具有输入和输出并且由柔性层局部限定的通道。 多个触点沿着该层间隔开，并且通道充满流体。 多个间隔开的触点依次磁耦合到磁场，以便将蠕动运动转移到该层，从而将流体泵送通过通道。

    DRUG DELIVERY PLATFORM INCORPORATING HYDROGEL PUMPING MECHANISM WITH GUIDED FLUID FLOW
    35.
    发明申请
    DRUG DELIVERY PLATFORM INCORPORATING HYDROGEL PUMPING MECHANISM WITH GUIDED FLUID FLOW 有权
    具有引导流体流量的泵送泵机构的药物输送平台

    公开(公告)号：US20100030156A1

    公开(公告)日：2010-02-04

    申请号：US12184632

    申请日：2008-08-01

    Applicant: David J. Beebe ,  Benjamin J. Moga ,  Tony Escarcega ,  Kent Chase

    Inventor： David J. Beebe ,  Benjamin J. Moga ,  Tony Escarcega ,  Kent Chase

    IPC: A61M5/14

    CPC classification number: A61M5/14248 ,  A61M5/148 ,  A61M2005/14252

    Abstract: A drug delivery platform is provided for delivering a controlled infusion of a drug to an individual. The drug delivery platform includes a reservoir for receiving the drug therein and a hydrogel engageable with the reservoir. The hydrogel is movable between a first configuration and a second configuration wherein the hydrogel exerts a pressure on the reservoir to urge the drug therefrom in response to a predetermined stimulus. A flow guide distributes the predetermined stimulus over the hydrogel in response to activation by an individual.

    Abstract translation: 提供药物递送平台用于将受控的药物输注输送给个体。 药物递送平台包括用于在其中接收药物的储存器和可与贮存器接合的水凝胶。 所述水凝胶可在第一构型和第二构型之间移动，其中所述水凝胶响应于预定的刺激而在所述储器上施加压力以促使所述药物。 流动引导件响应于个人的激活而将预定的刺激分配在水凝胶上。

    METHOD FOR ROBUST CONTROL OVER A SOLUABLE FACTOR MICROENVIRONMENT WITHIN A THREE-DIMENSIONAL GEL MATRIX
    36.
    发明申请
    METHOD FOR ROBUST CONTROL OVER A SOLUABLE FACTOR MICROENVIRONMENT WITHIN A THREE-DIMENSIONAL GEL MATRIX 审中-公开
    用于三维凝胶矩阵中的可溶因子微环境的稳健控制的方法

    公开(公告)号：US20100025243A1

    公开(公告)日：2010-02-04

    申请号：US12184408

    申请日：2008-08-01

    Applicant: David J. Beebe ,  Vinay V. Abhyankar ,  Michael W. Toepke

    Inventor： David J. Beebe ,  Vinay V. Abhyankar ,  Michael W. Toepke

    IPC: B01D57/02

    CPC classification number: B01L3/5027

    Abstract: A method is provided of generating a gradient within gel matrix received in a channel of a microfluidic device. A source reservoir in communication with the input of the channel is filled with a first fluid. A sink reservoir in communication with the output of the channel is filled with a second fluid. A soluble factor is deposited in the source reservoir such that the soluble factor diffuses into the channel and forms the gradient. The soluble factor in source reservoir is replenished to maintain the gradient in a generally pseudo-steady state and the second fluid in the sink reservoir is replaced.

    Abstract translation: 提供了一种在微流体装置的通道中接收的凝胶基质内产生梯度的方法。 与通道的输入连通的源储存器被第一流体填充。 与通道的输出连通的水槽储存器被第二流体填充。 可溶性因子沉积在源储存器中，使得可溶性因子扩散到通道中并形成梯度。 补充源储层中的可溶性因子以将梯度保持在通常为假稳态，并且更换储槽中的第二流体。

    METHOD OF PATTERNING PARTICLES ON AN ARBITRARY SUBSTRATE AND CONDUCTING A MICROFLUIDIC INVASION ASSAY
    37.
    发明申请
    METHOD OF PATTERNING PARTICLES ON AN ARBITRARY SUBSTRATE AND CONDUCTING A MICROFLUIDIC INVASION ASSAY 审中-公开
    在仲裁基板上绘制颗粒并进行微流感入侵检测的方法

    公开(公告)号：US20090098659A1

    公开(公告)日：2009-04-16

    申请号：US11870754

    申请日：2007-10-11

    Applicant: Vinay V. Abhyankar ,  David J. Beebe

    Inventor： Vinay V. Abhyankar ,  David J. Beebe

    IPC: G01N1/10 ,  B05D7/22

    CPC classification number: B01L3/5027 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00518 ,  B01J2219/00533 ,  B01J2219/00648 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01L3/502761 ,  Y10T436/2575

    Abstract: A method is provided for sequentially patterning different particle populations on spatially defined regions in microfluidic device. The microfluidic device has a channel and a plurality of access ports therein. Each access port has an input and an output communicating with the channel. The method includes the step of depositing a drop of a first suspension on the input of a first access port. The first suspension includes a plurality of particles. A drop of a second suspension is deposited on the input of a second access port. The second suspension includes a plurality of particles. The particles in the first and second suspensions settle onto and are patterned along corresponding spaced portions of the channel.

    Abstract translation: 提供了一种用于在微流体装置中的空间限定区域上顺序地图案化不同颗粒群的方法。 微流体装置在其中具有通道和多个进入端口。 每个访问端口具有与该通道通信的输入和输出。 该方法包括在第一访问端口的输入端上存放一滴第一悬架的步骤。 第一悬浮液包括多个颗粒。 第二个悬架的一滴沉积在第二个进入口的输入端。 第二悬浮液包括多个颗粒。 第一和第二悬浮液中的颗粒沉降并且沿通道的相应间隔部分图案化。

    METHOD FOR CONTROLLING COMMUNICATION BETWEEN MULTIPLE ACCESS PORTS IN A MICROFLUIDIC DEVICE
    38.
    发明申请
    METHOD FOR CONTROLLING COMMUNICATION BETWEEN MULTIPLE ACCESS PORTS IN A MICROFLUIDIC DEVICE 有权
    用于控制微流控器件中的多个访问端口之间的通信的方法

    公开(公告)号：US20090051716A1

    公开(公告)日：2009-02-26

    申请号：US11843291

    申请日：2007-08-22

    Applicant: David J. Beebe ,  Ivar Meyvantsson ,  Jay W. Warwick ,  Michael Toepke

    Inventor： David J. Beebe ,  Ivar Meyvantsson ,  Jay W. Warwick ,  Michael Toepke

    IPC: B41J29/38

    CPC classification number: B41J2/175 ,  Y10T436/2575

    Abstract: A method is provided of controlling communication between multiple ports in a microfluidic device. The method includes the step of providing a channel network in a microfluidic device. The channel network including a first channel having a first input port and an output port. The first channel is filled with a fluid and a first output droplet is deposited on the output port. The first output droplet has a radius of curvature. The first output droplet flows toward the first input port in response to placement of a first input droplet having a radius of curvature greater than the radius of curvature of the first output droplet on the first input port. The first input droplet flows toward the output port in response to the first input droplet having a radius of curvature less than the radius of curvature of first output droplet.

    Abstract translation: 提供了一种控制微流体装置中的多个端口之间的通信的方法。 该方法包括在微流体装置中提供通道网络的步骤。 该信道网络包括具有第一输入端口和输出端口的第一信道。 第一通道填充有流体，并且第一输出液滴沉积在输出端口上。 第一输出液滴具有曲率半径。 响应于具有大于第一输入液滴的曲率半径的曲率半径的第一输入液滴的位置，第一输出液滴流向第一输入端口。 响应于第一输入液滴具有小于第一输出液滴的曲率半径的曲率半径，第一输入液滴流向输出端口。

    METHOD OF CELL CHROMATOGRAPHY
    39.
    发明申请
    METHOD OF CELL CHROMATOGRAPHY 审中-公开
    细胞色谱法

    公开(公告)号：US20080220463A1

    公开(公告)日：2008-09-11

    申请号：US11683256

    申请日：2007-03-07

    Applicant: David J. Beebe ,  Ivar Meyvantsson

    Inventor： David J. Beebe ,  Ivar Meyvantsson

    IPC: C12Q1/02

    CPC classification number: G01N33/538

    Abstract: A method is provided of conducting cell chromatography with a group of cells. Each cell has a fluorescence intensity. The method includes the step of depositing the group of cells into a first chamber for a first predetermined time period such that a first portion of cells of the group of cells attaches to a first surface. The cells unattached to the first surface are removed from the first chamber and deposited into a second chamber for a second predetermined time period. A second portion of cells of the unattached cells attach to a second surface. The cells unattached to the second surface are removed from the second chamber. Thereafter, the fluorescence intensities of the cells attached to the first and second surfaces are compared to a standard.

    Abstract translation: 提供了用一组细胞进行细胞色谱的方法。 每个细胞都有荧光强度。 该方法包括以下步骤：将第一组细胞沉积到第一室中达到第一预定时间段，使得该组细胞的第一部分细胞附着于第一表面。 未连接到第一表面的电池从第一腔室中移除并且沉积到第二腔室中达到第二预定时间段。 未附着的细胞的第二部分细胞附着到第二表面。 未连接到第二表面的电池从第二腔室中移出。 此后，将附着在第一表面和第二表面上的细胞的荧光强度与标准进行比较。

    Variable-focus lens assembly
    40.
    发明申请
    Variable-focus lens assembly 有权
    变焦镜头组件

    公开(公告)号：US20070279758A1

    公开(公告)日：2007-12-06

    申请号：US11442927

    申请日：2006-05-30

    Applicant: Hongrui Jiang ,  Abhishek K. Agarwal ,  Liang Dong ,  David J. Beebe

    Inventor： Hongrui Jiang ,  Abhishek K. Agarwal ,  Liang Dong ,  David J. Beebe

    IPC: G02B3/12

    CPC classification number: G02B3/14 ,  G02B3/0006

    Abstract: A variable-focus lens assembly is provided. The lens assembly includes a microfluidic device that defines a chamber for receiving a fluid therein. A slip having an aperture therethrough is disposed in the chamber. A first fluid is disposed on the first side of the slip and a second fluid is disposed on the second side of the slip. A lens is formed from the interface of the first and second fluids. The outer periphery is pinned to the slip about the aperture. A turning structure fabricated from a hydrogel material engages the slip and tunes the focal length of the lens in response to a predetermined stimulus.

    Abstract translation: 提供了可变焦距透镜组件。 透镜组件包括限定用于在其中接收流体的室的微流体装置。 具有通孔的滑动件设置在腔室中。 第一流体设置在滑动件的第一侧上，并且第二流体设置在滑动件的第二侧上。 透镜由第一和第二流体的界面形成。 外周围被钉住在孔周围的滑块上。 由水凝胶材料制成的转动结构与滑动接合并响应于预定的刺激调谐透镜的焦距。

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