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公开(公告)号：US20100010080A1
公开(公告)日：2010-01-14
申请号：US12373657
申请日：2007-07-13
IPC: A61K31/35
CPC classification number: A61K31/7048
Abstract: The invention relates to the use of a macrolide antibiotic, tylvalosin, as an anti-viral agent. Tylvalosin is particularly useful for the treatment of PRRSV.
Abstract translation: 本发明涉及大环内酯类抗生素（tylvalosin）作为抗病毒剂的用途。 泰洛伐他汀对于PRRSV的治疗特别有用。
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公开(公告)号：US07557106B2
公开(公告)日：2009-07-07
申请号：US11500981
申请日：2006-08-09
Applicant: Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
Inventor： Jean-Damien Charrier , Francesca Mazzei , David Kay , Andrew Miller
IPC: C07D403/14 , A61K31/4155
CPC classification number: C07D403/14 , C07D239/34 , C07D401/14 , C07D403/12 , C07D453/02
Abstract: The present invention provides a facile process for the preparation of tri- and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
Abstract translation: 本发明提供了制备三取代和四取代嘧啶的简便方法。 该方法可用于制备蛋白激酶抑制剂，特别是Aurora激酶。 这些抑制剂可用于治疗或减轻Aurora介导的疾病或病症的严重性。
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公开(公告)号：US20080189605A1
公开(公告)日：2008-08-07
申请号：US12023903
申请日：2008-01-31
Applicant: David Kay , Erland Unruh , Gaurav Tandon
Inventor： David Kay , Erland Unruh , Gaurav Tandon
IPC: G06F17/21
CPC classification number: G06F17/273 , G06F3/0237 , G06F17/276
Abstract: An adaptation of standard edit distance spell-check algorithms leverages probability-based regional auto-correction algorithms and data structures for ambiguous keypads and other predictive text input systems to provide enhanced typing correction and spell-check features. Strategies for optimization and for ordering results of different types are also provided.
Abstract translation: 标准编辑距离拼写检查算法的适应性利用基于概率的区域自动校正算法和数据结构，用于模糊键盘和其他预测文本输入系统，以提供增强的打字校正和拼写检查功能。 还提供了优化和排序不同类型结果的策略。
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公开(公告)号：US20070270444A1
公开(公告)日：2007-11-22
申请号：US11369220
申请日：2006-03-06
Applicant: David Bebbington , Hayley Binch , Ronald Knegtel , Julian Golec , Sanjay Patel , Jean-Damien Charrier , David Kay , Robert Davies , Pan Li , Marion Wannamaker , Cornelia Forster , Albert Pierce
Inventor： David Bebbington , Hayley Binch , Ronald Knegtel , Julian Golec , Sanjay Patel , Jean-Damien Charrier , David Kay , Robert Davies , Pan Li , Marion Wannamaker , Cornelia Forster , Albert Pierce
IPC: A61K31/519 , A61K31/505 , A61P35/00 , A61P7/12 , A61P9/00 , C07D401/00 , C07D471/00
CPC classification number: C07D401/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D491/10 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04
Abstract: This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T-R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
Abstract translation: 本发明描述了式IV的新型吡唑化合物：其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; R“X”和“R”独立地选自TR 3，或者与它们的插入原子一起形成稠合的，不饱和的或部分不饱和的， 具有1-3个选自氧，硫或氮的环杂原子的5-8元环; 和R 2，R 2，R 3和R 3如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。
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公开(公告)号：US20070250469A1
公开(公告)日：2007-10-25
申请号：US11379354
申请日：2006-04-19
Applicant: Erland Unruh , David Kay
Inventor： Erland Unruh , David Kay
IPC: G06F17/30
CPC classification number: G06F17/30631 , Y10S707/99933 , Y10S707/99936 , Y10S707/99942
Abstract: A computer readable storage medium tangibly embodying machine-readable digital data arranged to facilitate expedited searching. The data includes a plurality of words residing in a table having rows and columns, each word residing in a different row and each letter of the word occupying a different column in that row. Each continuous run of same letters in a column forms an interval. The words are positioned relative to each other to maximize lengths of the intervals, and/or optimize efficiency of compression of the columns by run length encoding.
Abstract translation: 一种计算机可读存储介质，其有形地体现为便于快速搜索的机读数字数据。 数据包括位于具有行和列的表中的多个单词，每个单词驻留在不同行中，并且该单词的每个字母占据该行中的不同列。 列中相同字母的每个连续运行形成一个间隔。 这些单词相对于彼此定位以最大化间隔的长度，和/或通过行程长度编码来优化列的压缩效率。
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Patent Agency Ranking
公开(公告)号：US20070179133A1
公开(公告)日：2007-08-02
申请号：US11504528
申请日：2006-08-15
Applicant: David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
Inventor： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC: A61K31/541 , A61K31/5377 , A61K31/53 , C07D417/02 , C07D413/02 , C07D403/02
CPC classification number: C07D403/12
Abstract: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
Abstract translation: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20060173461A1
公开(公告)日：2006-08-03
申请号：US11340026
申请日：2006-01-26
Applicant: David Kay , Lee Strnad , Dustin Ducharrme
Inventor： David Kay , Lee Strnad , Dustin Ducharrme
IPC: A61B17/58
CPC classification number: A61B17/8625 , A61B17/861 , A61B17/8635
Abstract: The present invention relates to a cannulated orthopedic screw having a torque driving head with a spherical wall for multiaxial use, a rounded fluted insertion tip and a threaded portion including a cancellous thread contiguous with a non-threaded portion. The threaded portion has a major diameter defined by a spiraling cancellous type thread and a minor diameter. The screw includes a multilobe torque driving recess.
Abstract translation: 本发明涉及一种具有扭矩驱动头的插管式矫形螺钉，该扭矩驱动头具有用于多轴使用的球形壁，圆形槽纹插入尖端和包括与无螺纹部分相邻的松质线的螺纹部分。 螺纹部分具有由螺旋形松质线型和小直径限定的大直径。 螺杆包括多叶扭矩驱动凹部。
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公开(公告)号：US20060051517A1
公开(公告)日：2006-03-09
申请号：US10849302
申请日：2004-09-03
Applicant: Daniel Haas , David Kay , Ravi Sharma
Inventor： Daniel Haas , David Kay , Ravi Sharma
IPC: B01J19/08
CPC classification number: H01L23/345 , H01L24/95 , H01L25/50 , H01L2224/83234 , H01L2224/95085 , H01L2224/95136 , H01L2924/01005 , H01L2924/01006 , H01L2924/0101 , H01L2924/01013 , H01L2924/01015 , H01L2924/01018 , H01L2924/01019 , H01L2924/01021 , H01L2924/01027 , H01L2924/01029 , H01L2924/01033 , H01L2924/01049 , H01L2924/01052 , H01L2924/01057 , H01L2924/0106 , H01L2924/01074 , H01L2924/01082 , H01L2924/10329 , H01L2924/12041 , H01L2924/12044 , H01L2924/14 , H01L2924/15155 , H01L2924/15165 , H01L2924/19041 , H01L2924/19042 , H01L2924/19043 , H01L2924/3025 , H01L2924/15153
Abstract: A support and a method for fluidic assembly are provided. The support has a surface having binding sites adapted to receive micro-components of a type that are applied to the surface using a fluid; and energy absorbing heat producers at selected binding site. Each energy absorbing heat producer is adapted to receive energy and to transduce a portion of the received energy to heat the fluid proximate to the selected binding sites; so that when the micro-components are applied using a fluid that increases viscosity when heated, the heat generated by the energy absorbing heat producers increases the viscosity of the fluid proximate to the selected binding sites to prevent the micro-components from attaching to the selected binding sites.
Abstract translation: 提供了一种用于流体组装的支撑件和方法。 支撑体具有表面，其具有适于接收使用流体施加到表面的类型的微组件的结合位点; 和能量吸收热选择结合位点的热生产者。 每个能量吸收制热器适于接收能量并转换一部分接收的能量以加热接近所选择的结合位点的流体; 使得当使用在加热时增加粘度的流体施加微组件时，由能量吸收热生产者产生的热增加了靠近所选结合位点的流体的粘度，以防止微组件附着到所选择的结合位点 结合位点。
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公开(公告)号：US20050266172A1
公开(公告)日：2005-12-01
申请号：US10855719
申请日：2004-05-27
Applicant: David Kay , Mitchell Burberry , Andrea Rivers , Michael Boroson , Lee Tutt , Giana Phelan , Daniel Haas , Kelvin Nguyen , Bradley Phillips
Inventor： David Kay , Mitchell Burberry , Andrea Rivers , Michael Boroson , Lee Tutt , Giana Phelan , Daniel Haas , Kelvin Nguyen , Bradley Phillips
CPC classification number: H01L51/0013 , C23C14/048 , H01L51/0052 , H01L51/0059 , H01L51/0062 , H01L51/0081 , H01L51/0084 , H01L51/0085 , H01L51/0089 , H01L51/56
Abstract: A method of transferring organic material from a donor element to a substrate includes providing a radiation source; and selecting the power of the radiation applied to the donor element by the radiation source to cause the transfer of organic material to the substrate wherein the time that one or more positions of the donor element receives radiation is greater than 1 millisecond.
Abstract translation: 将有机材料从供体元件转移到衬底的方法包括提供辐射源; 以及通过辐射源选择施加到施主元件的辐射的功率，以使有机材料转移到衬底，其中施主元件的一个或多个位置接收辐射的时间大于1毫秒。
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公开(公告)号：US20050209255A1
公开(公告)日：2005-09-22
申请号：US11046664
申请日：2005-01-26
Applicant: Juan-Miguel Jimenez , Sanjay Patel , David Kay , Ronald Knegtel , Oliver Philps
Inventor： Juan-Miguel Jimenez , Sanjay Patel , David Kay , Ronald Knegtel , Oliver Philps
IPC: A61K31/519 , C07D403/12 , C07D471/04 , C07D487/04 , C07D487/12 , C07D487/14
CPC classification number: C07D403/12 , C07D471/04 , C07D487/04 , C07D487/12
Abstract: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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