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    SYSTEM FOR IMAGING CAPTURED CELLS
    33.
    发明申请
    SYSTEM FOR IMAGING CAPTURED CELLS 有权
    用于成像捕获细胞的系统

    公开(公告)号：US20160341666A1

    公开(公告)日：2016-11-24

    申请号：US15199245

    申请日：2016-06-30

    Applicant: DeNovo Sciences, Inc.

    Inventor： Kalyan Handique ,  Kyle Gleason ,  Christopher Siemer ,  Priyadarshini Gogoi ,  Saedeh Sepehri Javdani ,  Gene Parunak ,  Aaron Kehrer ,  Jon Meines

    IPC: G01N21/64

    CPC classification number: G01N33/4833 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/6486 ,  G01N2021/6439

    Abstract: A system for imaging captured cells comprising: an illumination module configured to illuminate a target object; a platform configured to position the target object in relation to the illumination module; a filter module configured to filter light transmitted to the target object and/or to filter light received from the target object, an optical sensor configured to receive light from the target object and to generate image data; and a focusing and optics module configured to manipulate light transmitted to the optical sensor. The system can further comprise one or more of: a control system configured to control at least one of the illumination module, the platform, the focusing and optics module, the filter module, and the optical sensor; a tag identifying system configured to identify and communicate tag information from system elements; a thermal control module configured to adjust temperature parameters of the system; and an image stabilization module.

    Abstract translation: 一种用于拍摄细胞成像的系统，包括：照明模块，被配置为照射目标物体; 被配置为相对于所述照明模块定位所述目标物体的平台; 滤波模块，被配置为过滤传输到目标物体的光和/或滤光从目标物体接收的光;光学传感器，被配置为从目标物体接收光并产生图像数据; 以及被配置为操纵传输到光学传感器的光的聚焦和光学模块。 该系统还可以包括以下中的一个或多个：被配置为控制照明模块，平台，聚焦和光学模块，滤光器模块和光学传感器中的至少一个的控制系统; 标签识别系统，被配置为从系统元件识别和传达标签信息; 配置为调节系统的温度参数的热控制模块; 和图像稳定模块。

    SYSTEM AND METHOD FOR CAPTURING AND ANALYZING CELLS
    34.
    发明申请
    SYSTEM AND METHOD FOR CAPTURING AND ANALYZING CELLS 有权
    用于捕获和分析细胞的系统和方法

    公开(公告)号：US20160199838A1

    公开(公告)日：2016-07-14

    申请号：US15074054

    申请日：2016-03-18

    Applicant: DeNovo Sciences, Inc.

    Inventor： Kalyan Handique ,  Kyle Gleason ,  Austin Payne ,  Priyadarshini Gogoi ,  Christopher Siemer ,  Yi Zhou ,  Saedeh Javdani Sepehri

    IPC: B01L3/00

    CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L3/527 ,  B01L3/5635 ,  B01L7/00 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0684 ,  B01L2300/06 ,  B01L2300/0816 ,  B01L2300/0832 ,  B01L2300/0864 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2400/0487 ,  B01L2400/0683 ,  G01N35/0098

    Abstract: A system for isolating cells in at least one of single-cell format and single-cluster format, comprising a reservoir, including a reservoir inlet and a reservoir outlet, configured to receive a biological sample and to receive at least one fluid, a manifold configured to receive and deliver the biological sample and the at least one fluid from the reservoir into a biological sample substrate, the manifold comprising a broad surface comprising a central region configured to receive the biological sample substrate, a set of openings configured to enable fluid flow transmission across the biological sample substrate, a manifold inlet configured to transmit flow from the reservoir the first subset of openings, a manifold outlet configured at a downstream end of the broad surface and coupled to the second subset of openings, the manifold outlet configured to transmit waste fluid from the manifold.

    Abstract translation: 一种用于以单细胞格式和单簇格式的至少一种隔离细胞的系统，包括储存器，包括储存器入口和储存器出口，构造成用于接收生物样品并接收至少一种流体，歧管配置 将生物样品和至少一种流体从储存器接收并输送到生物样品基底中，所述歧管包括宽表面，所述宽表面包括构造成接收所述生物样品基底的中心区域，一组开口，其被配置为使得流体流动传递 跨越生物样品基底的歧管入口，被配置成从储存器传送第一开口子集的歧管入口，配置在宽表面的下游端并联接到第二开口子集的歧管出口，歧管出口配置成传输废物 流体从歧管。

    SYSTEM AND METHOD FOR CAPTURING AND ANALYZING CELLS
    35.
    发明申请
    SYSTEM AND METHOD FOR CAPTURING AND ANALYZING CELLS 有权
    用于捕获和分析细胞的系统和方法

    公开(公告)号：US20140349867A1

    公开(公告)日：2014-11-27

    申请号：US14163153

    申请日：2014-01-24

    Applicant: DeNovo Sciences, Inc.

    Inventor： Kalyan Handique ,  Priyadarshini Gogoi ,  Yi Zhou ,  Saedeh Sepehri Javdani

    IPC: G01N33/487 ,  C12Q1/68

    CPC classification number: C12Q1/6841 ,  C12Q1/6844 ,  C12Q1/686 ,  G01N27/44782 ,  G01N33/48721 ,  G01N33/574 ,  G01N33/57492 ,  G01N2333/70585 ,  G01N2333/70596

    Abstract: A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.

    Abstract translation: 一种用于捕获和分析一组细胞的系统和方法，包括：包括一组平行孔的阵列，每个孔包括包括腔室入口和腔室出口的腔室，并且构造成容纳单细胞，以及孔通道 流体连接到室出口; 入口通道，其流体地连接到所述一组平行孔的每个室入口; 出口通道，其流体连接到所述一组平行孔的每个孔通道; 一组流体耦合到出口通道的电泳通道，被配置为接收用于电泳分离的筛分基质; 以及包括第一电极和第二电极的一组电极，其中所述电极组被配置为提供有助于电泳组的电泳分析的电场。

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