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    Field effect transistor for detecting ionic material and method of detecting ionic material using the same
    31.
    发明授权
    Field effect transistor for detecting ionic material and method of detecting ionic material using the same 有权
    用于检测离子材料的场效应晶体管及使用其的离子材料检测方法

    公开(公告)号：US08035175B2

    公开(公告)日：2011-10-11

    申请号：US11613258

    申请日：2006-12-20

    申请人： Jeo-young Shim ,  Kyu-sang Lee ,  Kyu-tae Yoo ,  Won-seok Chung

    发明人： Jeo-young Shim ,  Kyu-sang Lee ,  Kyu-tae Yoo ,  Won-seok Chung

    IPC分类号： H01L27/14

    CPC分类号： G01N27/4145

    摘要： A field effect transistor for detecting ionic material and a method of detecting ionic material using the field effect transistor. The field effect transistor for detecting ionic material includes a substrate formed of a semiconductor material, a source region and a drain region spaced apart from each other in the substrate and doped with an opposite conductivity type to that of the substrate, a channel region interposed between the source region and the drain region, an insulating layer disposed on the channel region and formed of an electrically insulating material, a first reference electrode disposed at an edge of the upper portion of the insulating layer and a second reference electrode disposed to be spaced apart from the insulating layer.

    摘要翻译： 用于检测离子材料的场效应晶体管和使用场效应晶体管检测离子材料的方法。 用于检测离子材料的场效应晶体管包括由衬底形成的衬底，源极区和漏极区，在衬底中彼此间隔开并且掺杂有与衬底相反的导电类型，沟道区介于 源极区域和漏极区域，设置在沟道区域上并由电绝缘材料形成的绝缘层，设置在绝缘层的上部的边缘处的第一参考电极和设置成间隔开的第二参考电极 从绝缘层。

    Method of manufacturing DNA chip
    34.
    发明授权
    Method of manufacturing DNA chip 失效
    制造DNA芯片的方法

    公开(公告)号：US07700290B2

    公开(公告)日：2010-04-20

    申请号：US11479306

    申请日：2006-06-30

    申请人： Jeo-young Shim ,  Soo-suk Lee ,  Chin-sung Park ,  Kyu-youn Hwang

    发明人： Jeo-young Shim ,  Soo-suk Lee ,  Chin-sung Park ,  Kyu-youn Hwang

    IPC分类号： C12Q1/68 ,  C12M1/00 ,  C12M3/00

    CPC分类号： B01L3/50857 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0819 ,  B82Y10/00 ,  G01N27/4145 ,  H01L21/823828 ,  H01L51/0093 ,  H01L51/0545 ,  Y10T436/2575

    摘要： A method of manufacturing a DNA (deoxyribonucleic acid) chip is provided. The DNA chip has a plurality of transistors formed on a substrate and an organic layer and a DNA probe sequentially stacked on a gate of the transistor. The method includes forming an inter-layer insulation layer on the substrate to cover the transistors, planarizing the inter-layer insulation layer, forming at least two contact holes exposing gate electrodes of the transistors in the inter-layer insulation layer, selectively forming organic layers on the exposed gate electrodes, attaching a first DFR (dry film resist) layer to the upper surface of the inter-layer insulation layer to cover the contact holes, removing a portion of the first DFR layer covering a first contact hole among the contact holes, attaching a first DNA probe to the organic layers in the first contact hole, and removing a remaining portion of the first DFR layer.

    摘要翻译： 提供了DNA（脱氧核糖核酸）芯片的制造方法。 DNA芯片具有形成在基板上的多个晶体管，并且顺序层叠在晶体管的栅极上的有机层和DNA探针。 该方法包括在衬底上形成层间绝缘层以覆盖晶体管，平坦化层间绝缘层，形成暴露在层间绝缘层中的晶体管的栅电极的至少两个接触孔，选择性地形成有机层 在暴露的栅电极上，将第一DFR（干膜抗蚀剂）层附着到层间绝缘层的上表面以覆盖接触孔，去除覆盖接触孔中的第一接触孔的第一DFR层的一部分 将第一DNA探针连接到第一接触孔中的有机层，以及去除第一DFR层的剩余部分。

    Method of Detecting Bio-Molecues Using the Same Field Effect Transistor on the Gate Sensing Surface
    36.
    发明申请
    Method of Detecting Bio-Molecues Using the Same Field Effect Transistor on the Gate Sensing Surface 有权
    在栅极感应表面上使用相同的场效应晶体管检测生物分子的方法

    公开(公告)号：US20070231211A1

    公开(公告)日：2007-10-04

    申请号：US11695886

    申请日：2007-04-03

    申请人： Kyu-tae Yoo ,  Kyu-sang Lee ,  Jeo-young Shim ,  Won-seok Chung ,  Yeon-ja Cho

    发明人： Kyu-tae Yoo ,  Kyu-sang Lee ,  Jeo-young Shim ,  Won-seok Chung ,  Yeon-ja Cho

    IPC分类号： G01N30/96

    CPC分类号： G01N33/54373 ,  G01N27/4145

    摘要： Provided is a method of detecting the presence of a target bio-molecule or a concentration of the bio-molecule using a field effect transistor. The method includes: contacting a first sample having a first target bio-molecule with a reference electrode of a field effect transistor; measuring a first electric signal change of the field effect transistor; contacting a second sample with a sensing surface of the same field effect transistor; measuring a second electric signal change of the field effect transistor; and comparing the first electric signal with the second electric signal.

    摘要翻译： 提供了使用场效应晶体管检测目标生物分子的存在或生物分子的浓度的方法。 该方法包括：将具有第一目标生物分子的第一样品与场效应晶体管的参比电极接触; 测量场效应晶体管的第一电信号变化; 使第二样品与相同场效应晶体管的感测表面接触; 测量场效应晶体管的第二电信号变化; 以及将所述第一电信号与所述第二电信号进行比较。

    Microfluidic device and method of manufacturing the same
    37.
    发明申请
    Microfluidic device and method of manufacturing the same 失效
    微流体装置及其制造方法

    公开(公告)号：US20060257627A1

    公开(公告)日：2006-11-16

    申请号：US11414711

    申请日：2006-04-28

    申请人： Jeo-young Shim ,  Soo-suk Lee ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kyu-tae Yoo

    发明人： Jeo-young Shim ,  Soo-suk Lee ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kyu-tae Yoo

    IPC分类号： B05D3/00 ,  B29C71/04 ,  B32B3/00

    CPC分类号： B81C1/00119 ,  B01L3/5027 ,  Y10T428/24479

    摘要： Provided is a method of manufacturing a microfludic device in which coating film patterns made of a coupling agent are formed in microchannels. The method includes: forming the coating film patterns made of the coupling agent on a Si substrate; selectively oxidizing coupling agent-free regions of the Si substrate having thereon the coating film patterns made of the coupling agent using an oxidizing agent with an oxidation potential from 1 to 2 V; and adhering a PDMS (polydimethylsiloxane) microchannel structure to the selectively oxidized Si substrate to form the microchannels.

    摘要翻译： 本发明提供一种微流控装置的制造方法，其中，在微通道中形成由偶联剂形成的涂膜图案。 该方法包括：在Si衬底上形成由偶联剂制成的涂膜图案; 使用氧化电位为1〜2V的氧化剂选择性地氧化其上具有由偶联剂形成的涂膜图案的Si基板的无偶联剂区域; 并将PDMS（聚二甲基硅氧烷）微通道结构粘附到选择性氧化的Si衬底上以形成微通道。

    Method of electrically detecting biomolecule
    38.
    发明申请
    Method of electrically detecting biomolecule 失效
    电气检测生物分子的方法

    公开(公告)号：US20060246478A1

    公开(公告)日：2006-11-02

    申请号：US11345790

    申请日：2006-02-02

    申请人： Kyu-tae Yoo ,  Sung-ouk Jung ,  Jun-hong Min ,  Ji-na Namgoong ,  Soo-hyung Choi ,  Jeo-young Shim

    发明人： Kyu-tae Yoo ,  Sung-ouk Jung ,  Jun-hong Min ,  Ji-na Namgoong ,  Soo-hyung Choi ,  Jeo-young Shim

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/54306

    摘要： Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET.

    摘要翻译： 提供了一种使用bioFET感测生物分子的方法，该方法包括：在bioFET的栅极上形成包含Au的层; 形成固定在与栅极分离预定距离的基板上的探针，以及具有与探针不完全结合的硫醇基（-SH）的生物分子; 使探针与包含靶分子的样品反应; 以及测量在bioFET的源极和漏极之间的沟道区域中流动的电流。