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    Sensing switch and detecting method using the same
    5.
    发明授权
    Sensing switch and detecting method using the same 失效
    感应开关及使用其的检测方法

    公开(公告)号：US07510865B2

    公开(公告)日：2009-03-31

    申请号：US11347185

    申请日：2006-02-03

    申请人： Kyu-tae Yoo ,  Joon-ho Kim ,  Jun-hong Min ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kui-hyun Kim ,  Jeo-young Shim ,  Kak Namkoong

    发明人： Kyu-tae Yoo ,  Joon-ho Kim ,  Jun-hong Min ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kui-hyun Kim ,  Jeo-young Shim ,  Kak Namkoong

    IPC分类号： C12M1/34

    CPC分类号： G01N33/54373

    摘要： Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance; a receptor binding region on an upper surface of an end portion of the sensing plate; an electric or magnetic field generation device that induces deflection of the sensing plate when a receptor bound to the receptor binding region is selectively bound to an electrically or magnetically active ligand; and a pair of switching electrodes that are separated by a predetermined distance and is connected when the sensing plate contacts the substrate due to the deflection of the sensing plate. A target material need not be labelled, a signal processing of a fluorescent or electrical detection signal using an analysis apparatus is not required, and a signal can be directly decoded by confirming whether a current flows through the switch.

    摘要翻译： 提供了一种感测开关和使用该感测开关的感测方法。 感测开关包括：基板; 底物上的支撑物; 感测板，其与所述支撑体的一侧连接并且与所述基板平行预定距离; 在感测板的端部的上表面上的受体结合区域; 当与受体结合区结合的受体选择性地结合到电或磁性活性配体时，引起感测板偏转的电场或磁场产生装置; 以及一对分离预定距离的开关电极，并且当感测板由于感测板的偏转而与基板接触时被连接。 目标材料不需要标注，不需要使用分析装置的荧光或电检测信号的信号处理，并且可以通过确认电流是否流过开关直接解码信号。

    FET-type biosensor with surface modification
    7.
    发明授权
    FET-type biosensor with surface modification 有权
    具有表面改性的FET型生物传感器

    公开(公告)号：US08735077B2

    公开(公告)日：2014-05-27

    申请号：US11336110

    申请日：2006-01-20

    申请人： Jeo-young Shim ,  Su-hyeon Kim ,  Kyu-tae Yoo ,  Sung-ouk Jung ,  Joon-shik Park

    发明人： Jeo-young Shim ,  Su-hyeon Kim ,  Kyu-tae Yoo ,  Sung-ouk Jung ,  Joon-shik Park

    IPC分类号： G01N33/53

    CPC分类号： B82Y30/00 ,  B82Y15/00 ,  G01N27/4145

    摘要： Provided is a field effect transistor (FET) type biosensor including a source electrode, a gate, and a drain electrode. A ligand that can bind to a side of a nucleic acid is added to the surface of the gate. In a conventional FET type biosensor, it is difficult to detect a signal within the debye length because a target nucleic acid is directly fixed to the surface of a gate of the conventional FET. However, in the present invention, this problem can be overcome and the debye length can be increased by treating the surface of a gate of an FET sensor with a ligand that can bind to a side of a nucleic acid. The ligand can be adsorbed onto the surface of the gate. In this case, the nucleic acid is adsorbed parallel to the surface of the gate, not perpendicular to the surface of the gate, thus generating an effective depletion region. In addition, hybridization efficiency can be increased because a hybridized sample can be injected into an FET sensor at high ionic strength.

    摘要翻译： 提供了包括源电极，栅极和漏电极的场效应晶体管（FET）型生物传感器。 可以结合核酸一侧的配体加入到门的表面。 在传统的FET型生物传感器中，由于目标核酸直接固定在常规FET的栅极表面，难以检测德拜长度内的信号。 然而，在本发明中，可以克服这个问题，并且可以通过用可以结合核酸一侧的配体处理FET传感器的栅极的表面来增加德拜长度。 配体可以吸附在栅极的表面上。 在这种情况下，核酸被平行于栅极的表面吸附，而不垂直于栅极的表面，从而产生有效的耗尽区域。 此外，杂交效率可以提高，因为杂化样品可以以高离子强度注入FET传感器。

    Microfluidic device and method of manufacturing the same
    9.
    发明申请
    Microfluidic device and method of manufacturing the same 失效
    微流体装置及其制造方法

    公开(公告)号：US20060257627A1

    公开(公告)日：2006-11-16

    申请号：US11414711

    申请日：2006-04-28

    申请人： Jeo-young Shim ,  Soo-suk Lee ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kyu-tae Yoo

    发明人： Jeo-young Shim ,  Soo-suk Lee ,  Sung-ouk Jung ,  Ji-na Namgoong ,  Kyu-tae Yoo

    IPC分类号： B05D3/00 ,  B29C71/04 ,  B32B3/00

    CPC分类号： B81C1/00119 ,  B01L3/5027 ,  Y10T428/24479

    摘要： Provided is a method of manufacturing a microfludic device in which coating film patterns made of a coupling agent are formed in microchannels. The method includes: forming the coating film patterns made of the coupling agent on a Si substrate; selectively oxidizing coupling agent-free regions of the Si substrate having thereon the coating film patterns made of the coupling agent using an oxidizing agent with an oxidation potential from 1 to 2 V; and adhering a PDMS (polydimethylsiloxane) microchannel structure to the selectively oxidized Si substrate to form the microchannels.

    摘要翻译： 本发明提供一种微流控装置的制造方法，其中，在微通道中形成由偶联剂形成的涂膜图案。 该方法包括：在Si衬底上形成由偶联剂制成的涂膜图案; 使用氧化电位为1〜2V的氧化剂选择性地氧化其上具有由偶联剂形成的涂膜图案的Si基板的无偶联剂区域; 并将PDMS（聚二甲基硅氧烷）微通道结构粘附到选择性氧化的Si衬底上以形成微通道。

    Method of electrically detecting biomolecule
    10.
    发明申请
    Method of electrically detecting biomolecule 失效
    电气检测生物分子的方法

    公开(公告)号：US20060246478A1

    公开(公告)日：2006-11-02

    申请号：US11345790

    申请日：2006-02-02

    申请人： Kyu-tae Yoo ,  Sung-ouk Jung ,  Jun-hong Min ,  Ji-na Namgoong ,  Soo-hyung Choi ,  Jeo-young Shim

    发明人： Kyu-tae Yoo ,  Sung-ouk Jung ,  Jun-hong Min ,  Ji-na Namgoong ,  Soo-hyung Choi ,  Jeo-young Shim

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/54306

    摘要： Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET.

    摘要翻译： 提供了一种使用bioFET感测生物分子的方法，该方法包括：在bioFET的栅极上形成包含Au的层; 形成固定在与栅极分离预定距离的基板上的探针，以及具有与探针不完全结合的硫醇基（-SH）的生物分子; 使探针与包含靶分子的样品反应; 以及测量在bioFET的源极和漏极之间的沟道区域中流动的电流。