Abstract:
Novel 9-amino-14-membered macrolides and pharmaceutically-acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier, a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention and processes for the preparation of such compounds.
Abstract:
A new self-routing multicast network that can realize arbitrary multicast (or one-to-many) communication without any blocking. Based on the binary radix sorting, all functional components of the network are recursively constructed reverse banyan networks using a self-routing procedure that provides for pipeline distribution of switch settings. The design allows a potential to greatly reduce the network cost by reusing part of the network. The new multicast network has O(n log2 n) cost (logic gates), O(log2 n) gate delay, and O(log2 n) set-up time, where the unit of time is a gate delay. Further, with feedback part of the network can be reused and the network cost is reduced to O(n log n).
Abstract:
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
Abstract:
Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
Abstract:
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of neuromuscular disorders, conditions having muscle wasting, claudication, frailty, metabolic syndrome, muscle atrophy associated with disuse, and muscle fatigue, and other indications.
Abstract:
Certain 3,5-dibenzoyl-4-phenyl-piperidine compounds and salts thereof are provided herein. The compounds and salts may be useful in causing mitotic arrest and cell death. Also provided herein are certain pharmaceutical compositions comprising 3,5-dibenzoyl-4-phenyl-piperidine compounds or salts thereof and certain methods of use thereof.
Abstract:
Disclosed is a method for all-to-all personalized exchange for a class of multistage interconnecting networks (MINs). The method is based on a Latin square matrix corresponding to a set of admissible permutations of a multistage interconnecting network. Disclosed are first and second methods for constructing a Latin square matrix used in the personalized exchange technique. Also disclosed is a generic method for decomposing all-to-all personalized exchange patterns into admissible permutations to form the Latin square matrix for self-routing networks which are a subclass of the MINs.
Abstract:
Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate and boranophosphate linkages are disclosed.