公开(公告)号：US20090087438A1

公开(公告)日：2009-04-02

申请号：US12184330

申请日：2008-08-01

申请人： LIMIN LI

发明人： LIMIN LI

IPC分类号： A61K39/395 ,  C12N5/08 ,  A61P31/12

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/1045 ,  C07K16/1081 ,  C07K16/18 ,  C07K16/32 ,  C07K2317/34 ,  C07K2317/76 ,  Y02A50/386

摘要： The present invention provides methods of using antibodies that bind a TSG101 protein to inhibit or reduce viral production. The invention also provides methods of using the TSG101 antibodies for the treatment of viral infections, including HIV infection. The invention further provides methods of detecting viral infected cells using TSG101 antibodies.

摘要翻译： 本发明提供使用结合TSG101蛋白来抑制或减少病毒产生的抗体的方法。 本发明还提供了使用TSG101抗体治疗病毒感染（包括HIV感染）的方法。 本发明还提供了使用TSG101抗体检测病毒感染细胞的方法。

公开(公告)号：US5922617A

公开(公告)日：1999-07-13

申请号：US968659

申请日：1997-11-12

申请人： Mark S. Wang ,  Limin Li

发明人： Mark S. Wang ,  Limin Li

IPC分类号： G01N31/00 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N21/03 ,  G01N21/25 ,  G01N21/27 ,  G01N21/64 ,  G01N21/76 ,  G01N27/26 ,  G01N33/15 ,  G01N33/487 ,  G01N33/50 ,  G01N35/00 ,  G01N35/10 ,  G01N37/00 ,  G01N33/533

CPC分类号： G01N35/00069 ,  B01J19/0046 ,  B01L3/0241 ,  G01N21/253 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C40B70/00 ,  G01N35/1065 ,  Y10S436/805 ,  Y10S436/809

摘要： Methods and apparatus are employed for determining interactions between different components, of the same or different type of composition. The apparatus provides for arrays of samples in tracks, where light emitting labels are excited and emitted light detected. Headers are provided for defining sites, so that particular interactions can be rapidly detected. Particularly, disks having circular tracks with headers defining sites on the tracks, so that positive signals can be interpreted in relation to the information provided by the header. Various modifications can be made, such as preprepared segments which may then be attached to the disk for assaying.

摘要翻译： 方法和装置用于确定相同或不同类型组合物的不同组分之间的相互作用。 该装置提供轨道中的样本阵列，其中发光标记被激发并发射出光。 提供标题用于定义站点，以便可以快速检测到特定的交互。 特别地，具有圆形轨道的磁盘具有限定磁道上的位置的报头，使得可以相对于由报头提供的信息解释正信号。 可以进行各种修改，例如预制备段，然后可以连接到盘进行测定。

公开(公告)号：US5807995A

公开(公告)日：1998-09-15

申请号：US977818

申请日：1997-11-25

申请人： Stanley N. Cohen ,  Limin Li

发明人： Stanley N. Cohen ,  Limin Li

IPC分类号： C12N15/09 ,  C07K14/47 ,  C07K14/82 ,  C07K16/32 ,  C12N5/10 ,  C12N15/00 ,  C12N15/12 ,  C12N15/85 ,  C12N15/90 ,  C12P21/02 ,  C12Q1/04 ,  C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/57415 ,  C07K14/4702 ,  C12N15/00 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136

摘要： TSG101 is a tumor susceptibility gene whose homozygous functional knock out in fibroblasts leads to transformation and the ability of these cells to form metastatic tumors in nude mice. The cellular transformation that results from inactivation of TSG101 is reversible by restoration of TSG101 function. Decreased expression of TSG101 is associated with the occurrence of certain human cancers, including breast carcinomas. The TSG101 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like. The DNA is further used as a diagnostic for a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene.