公开(公告)号：US20250041254A1

公开(公告)日：2025-02-06

申请号：US18717426

申请日：2022-12-15

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Hui LI ,  Bo PENG ,  Xuanxian PENG ,  Sufang KUANG

IPC: A61K31/19 ,  A61K31/7048 ,  A61P31/04

Abstract: The present invention belongs to the technical field of biological medicine, and specifically relates to use of sodium formate in preparation of an anti-infective drug. The present invention has found through research that sodium formate can significantly increase the sensitivity of a bacterium to an antibiotic, so that the antibiotic that is originally ineffective or inefficient against a pathogenic bacterium becomes effective or efficient, thereby killing the bacterium and achieving an anti-infective effect. Sodium formate and an antibiotic are further prepared into an anti-infective composition, so that on the one hand, a significant anti-infective effect can be achieved under the condition of a low-concentration antibiotic, and on the other hand, the decreased use amount of the antibiotic can also significantly reduce the likelihood of a bacterium developing drug resistance; and sodium formate has been widely used in food and medicine with high safety.

公开(公告)号：US12144554B2

公开(公告)日：2024-11-19

申请号：US16991280

申请日：2020-08-12

Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD. ,  THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY

Inventor： Yanhui Zhang ,  Longfei Cong ,  Xiaoyan Xie ,  Ming Xu ,  Guangliang Huang ,  Xiaoer Zhang

IPC: A61B5/00 ,  A61B34/10 ,  A61B90/00

Abstract: A display method and system for ultrasound-guided intervention. The method comprises: obtaining, via a probe, a data, wherein the data comprises at least a real-time ultrasound data and a real-time spatial orientation information of the probe; obtaining, by a processor, an ablation needle plan, wherein, the ablation needle plan comprises at least a probe marker for planning, a needle insertion path and a predicted ablation area corresponding to the needle insertion path, and the probe marker for planning is generated in a form that is able to indicate one side or multiple sides of the probe such that an orientation of the probe marker for planning represents a planned orientation of the probe; generating, by the processor, a guiding image for ultrasound-guided intervention according to the obtained data and the ablation needle plan; and displaying, by a display device, the guiding image.

公开(公告)号：US20240354599A1

公开(公告)日：2024-10-24

申请号：US18304594

申请日：2023-04-21

Applicant: KAOHSIUNG MEDICAL UNIVERSITY ,  National Sun Yat-Sen University

Inventor： Hao-Wei Chen ,  Chung-Yao Kao ,  Jung-Ting Lee ,  Yu-Chen Chen

IPC: G06N5/022 ,  A61B5/20 ,  G16H50/30

CPC classification number: G06N5/022 ,  A61B5/201 ,  G16H50/30

Abstract: A method for determining a probability of a kidney stone in a subject being a uric-acid (UA) stone includes steps of: establishing, by using a machine learning algorithm, a prediction model based on a plurality of training data sets that are related to a plurality of patients, each of the plurality of training data sets at least including an estimated glomerular filtration rate (eGFR) and a value of urine pH; and feeding an input variable set into the prediction model so as to obtain the probability of the kidney stone in the subject being a UA stone. The input variable set is related to the subject and including an eGFR and a value of urine pH of the subject.

公开(公告)号：US20240352097A1

公开(公告)日：2024-10-24

申请号：US18637905

申请日：2024-04-17

Applicant: National Sun Yat-sen University

Inventor： Day-Yu CHAO ,  Yen-Hsu Chen ,  Wen-Hung Wang

IPC: C07K16/10 ,  A61K39/00 ,  A61P31/14

CPC classification number: C07K16/1081 ,  A61P31/14 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present disclosure provides a neutralizing antibody for flaviviruses, a production method, a method of treating or preventing a flaviviruses infection in a subject, and the use thereof.

公开(公告)号：US12120627B2

公开(公告)日：2024-10-15

申请号：US18530247

申请日：2023-12-06

Applicant: Sun Yat-sen University

Inventor： Yitong Liu ,  Hao Lin ,  Xingcheng Liu ,  Qiang Tu ,  Yi Xie

IPC: H04W64/00 ,  H04W84/18

CPC classification number: H04W64/00 ,  H04W84/18

Abstract: In a data processing method for node localization in wireless sensor networks, a plurality of potential coordinate calculation values for a to-be-located node are calculated based on RSSI data received by the to-be-located node from a plurality of anchor nodes. A centroid C1 of these coordinate calculation values is calculated. Then coordinate calculation values with distances to the centroid C1 less than a threshold are screened out, and a centroid C2 of the screened-out coordinate calculation values is calculated. A coordinate position of the centroid C2 is used as the position of the to-be-located node. In other words, a plurality of potential positions for the to-be-located node are calculated using multiple groups of RSSI data and these potential positions are then screened through calculation. Instead of directly processing the received RSSI data, the present disclosure processes the coordinate calculation values obtained based on the received RSSI data.

公开(公告)号：US20240317754A1

公开(公告)日：2024-09-26

申请号：US18270009

申请日：2021-09-15

Applicant: SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  SUN YAT-SEN UNIVERSITY

Inventor： Xumu ZHANG ,  Deyin GUO ,  Guanguan LI ,  Liu CAO ,  Yingjun LI ,  Tiefeng XU ,  Yanxi JI ,  Qifan ZHOU ,  Yujian YANG ,  Tiaozhen ZHU

IPC: C07D487/04 ,  A61K31/706 ,  A61P31/14

CPC classification number: C07D487/04 ,  A61K31/706 ,  A61P31/14

Abstract: Provided are methods for treating coronavirus infections by administering modified nucleosides, ester and amino acid ester prodrugs of nucleoside, their pharmaceutically acceptable salts, and drug combination thereof, of Formula (I). The compounds, combination, and methods provided are particularly useful for preventing, mitigating, or treating coronavirus infections or cytopathic effects resulting from the replication or reproduction of coronaviruses and their variants, including SARS-CoV-2.

公开(公告)号：US12098463B2

公开(公告)日：2024-09-24

申请号：US17583714

申请日：2022-01-25

Applicant: NATIONAL SUN YAT-SEN UNIVERSITY

Inventor： Chun-Hu Chen ,  Ren-Huai Jhang ,  Chang-Ying Yang

IPC: C23C18/12

CPC classification number: C23C18/1216 ,  C23C18/1295

Abstract: A method for manufacturing an amorphous multielement metal oxide hydroxide film includes: A liquid mixture is formed by dissolving an oxidizing agent selected from a group consisting of potassium permanganate, potassium chromate, potassium dichromate and potassium ferrate, and a reducing agent in a solvent. The oxidizing agent forms an oxometallate anion having a first metal atom with a first valence number. The reducing agent forms a metal cation having a second metal atom with a third valence number. An amorphous multielement metal oxide hydroxide film is deposited on a substrate by soaking the substrate in the liquid mixture. The amorphous multielement metal oxide hydroxide film includes a multielement metal oxide hydroxide having the first metal atom with a second valence smaller than the first valence number and the second metal atom with a fourth valence number larger than the third valence number.

公开(公告)号：US12092872B2

公开(公告)日：2024-09-17

申请号：US17933487

申请日：2022-09-20

Applicant: NATIONAL SUN YAT-SEN UNIVERSITY

Inventor： Yung-Jr Hung ,  Tzu-Hsiang Yen

IPC: G02B6/293

CPC classification number: G02B6/29355 ,  G02B6/2938

Abstract: A waveguide division multiplexer and demultiplexer includes a first-stage Mach-Zehnder interferometer (MZI) and two second-stage MZIs. The first-stage MZI includes two input ends and two output ends, in which one of the inputs is configured to receive an input optical beam with a first center wavelength and a second center wavelength, and the output ends are configured to respectively transmit first-stage output optical beams respectively with the first center wavelength and the second center wavelength. One input terminals of the second-stage MZI are configured to respectively receive the first-stage output optical beams, and one output terminals of the second-stage MZI are configured to transmit second-stage output optical beams with the first and second center wavelengths, respectively. Each second-stage MZI is configured in cross-state condition.

公开(公告)号：US20240276240A1

公开(公告)日：2024-08-15

申请号：US18143704

申请日：2023-05-05

Applicant: NATIONAL SUN YAT-SEN UNIVERSITY

Inventor： Chao-Kai WEN ,  Feng-Ji CHEN ,  Tzu-Hao HUANG ,  De-Ming CHIAN ,  Chuan-Yuan WANG

IPC: H04W24/02 ,  H04L43/065

CPC classification number: H04W24/02 ,  H04L43/065

Abstract: A method for signal optimization between a user equipment and a reconfigurable intelligence surface includes a phase optimization step having: generating at least one modified phase combination in the state that a performance index of a current phase combination is smaller than a preset performance threshold value; evaluating whether a corresponding performance index of the modified phase combination is not smaller than the preset performance threshold value or evaluating whether the performance index of the modified phase combination is larger than the corresponding performance index of the current phase combination, to determine an optimized phase combination, enabling a corresponding performance index to be not smaller than the preset performance threshold value or not smaller than the performance index of any modified phase combination in the phase optimization step; and replacing the current phase combination by the optimized phase combination to form an updated current phase combination.

公开(公告)号：US12047695B2

公开(公告)日：2024-07-23

申请号：US17914095

申请日：2020-05-15

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Kai Wang ,  Yihong Qi

IPC: H04N25/57 ,  H01L27/146

CPC classification number: H04N25/57 ,  H01L27/1463 ,  H01L27/1464 ,  H01L27/14643

Abstract: Provided is a photoelectric sensor, a random accessible active pixel circuit, an image sensor and a camera. A photoelectric sensor comprises a doped region, a substrate, a doped source region, a doped drain region, and two isolation regions; wherein the doped region is arranged on a bottom surface of the substrate so as to form a photodiode; a cathode of the photodiode is formed in the doped region and is connected to a positive voltage to make the photodiode work in a reverse bias region; wherein the doped source region and the doped drain region are spaced apart on top of the substrate so as to form a field effect transistor; a source is formed on a top surface of the doped source region, and a drain is formed on the top surface of the doped drain region; wherein the two isolation regions are arranged on opposite sides of the substrate, and extend from the doped source region and the doped drain region to the doped region; wherein a gate dielectric layer and a gate between the doped source region and the doped drain region are configured sequentially upwards from the top surface of the substrate; the gate is connected to a voltage to make the field effect transistor select wide dynamic range mode or high gain mode.