利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

105 条记录 (耗时 0.03 秒)

    Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase rnpep-like (rnpep-like)
    31.
    发明申请
    Diagnostics and therapeutics for diseases associated with arginyl aminopeptidase rnpep-like (rnpep-like) 审中-公开
    与精氨酰氨肽酶类似（rnpep-like）相关疾病的诊断和治疗

    公开(公告)号：US20070042423A1

    公开(公告)日：2007-02-22

    申请号：US10573583

    申请日：2004-09-16

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Stefanie Polej

    IPC分类号： G01N33/53 ,  G01N33/574

    CPC分类号： G01N33/573 ,  G01N2333/948

    摘要： The invention provides a human RNPEP-like which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of RNPEP-like as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，神经疾病和泌尿系疾病相关的人类RNPEP。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制RNPEP样活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with homo sapiens formyl peptide receptor-like 2
    32.
    发明申请
    Diagnostics and therapeutics for diseases associated with homo sapiens formyl peptide receptor-like 2 审中-公开
    与智人甲酰肽受体样相关的疾病的诊断和治疗2

    公开(公告)号：US20060057577A1

    公开(公告)日：2006-03-16

    申请号：US10508765

    申请日：2003-03-10

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Greets

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Greets

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/566 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/00

    摘要： The invention provides a human FPRL2 which is associated with the cardiovascular diseases, cns disorders, hematological diseases, genito-urinary diseases, cancer and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cns disorders, hematological diseases, genito-urinary diseases, cancer and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of FPRL2 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，疾病，血液疾病，生殖泌尿疾病，癌症和呼吸系统疾病有关的人FPRL2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，疾病，血液病，生殖泌尿疾病，癌症和呼吸系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制FPRL2的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and Therapeutics for Diseases Associated with G-Protein Coupled Receptor AdipoR2 (AdipoR2)
    37.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with G-Protein Coupled Receptor AdipoR2 (AdipoR2) 审中-公开
    与G蛋白偶联受体AdipoR2（AdipoR2）相关的疾病诊断与治疗

    公开(公告)号：US20110136107A1

    公开(公告)日：2011-06-09

    申请号：US12787632

    申请日：2010-05-26

    申请人： STEFAN GOLZ ,  ULF BRÜGGEMEIER ,  ANDREAS GEERTS

    发明人： STEFAN GOLZ ,  ULF BRÜGGEMEIER ,  ANDREAS GEERTS

    IPC分类号： C12Q1/68

    CPC分类号： A61K39/39558 ,  G01N33/6893 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/32

    摘要： The invention provides human AdipoR2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR2 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，呼吸系统疾病，炎症，神经系统疾病，泌尿系疾病相关的人AdipoR2。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，呼吸系统疾病，炎症，神经疾病，泌尿系疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制AdipoR2的活性的化合物以及包含这些化合物的药物组合物。

    IDENTIFICATION OF NEW SPLICE-VARIANTS OF G-PROTEIN COUPLED RECEPTOR EP3 AND USES THEREOF
    38.
    发明申请
    IDENTIFICATION OF NEW SPLICE-VARIANTS OF G-PROTEIN COUPLED RECEPTOR EP3 AND USES THEREOF 审中-公开
    鉴定G蛋白偶联受体EP3的新型差异及其用途

    公开(公告)号：US20110130347A1

    公开(公告)日：2011-06-02

    申请号：US12602767

    申请日：2008-05-20

    申请人： Stefan Golz ,  Andreas Geerts

    发明人： Stefan Golz ,  Andreas Geerts

    IPC分类号： A61K38/17 ,  C12Q1/68 ,  C12N5/10 ,  C12N15/63 ,  G01N33/68 ,  C07K14/47 ,  C07H21/04 ,  G01N33/53

    CPC分类号： C07K14/723

    摘要： The present invention is directed to a polynucleotide sequence of the novel G-Protein Coupled Receptors EP3-11 OR EP3-12. The present invention provides polynucleotide sequences comprising the nucleic acid sequence SEQ ID NO: 20 or SEQ ID NO: 21 or nucleic acid sequences that hybridize to SEQ ID NO: 20 or SEQ ID NO: 21 or its complimentary strand having at least 40% sequence identity. The invention also provides the human EP3-11 or EP3-12 as targets for the identification of compounds useful for the treatment and prevention of cardiovascular diseases, inflammation, reproduction disorders and cancer as a result of relative quantification of the mRNA distribution in different human tissues by expression profiling. The invention also provides assays for the identification of compounds modulating EP3-11 or EP3-12.

    摘要翻译： 本发明涉及新型G-蛋白偶联受体EP3-11或EP3-12的多核苷酸序列。 本发明提供包含核酸序列SEQ ID NO：20或SEQ ID NO：21的多核苷酸序列或与SEQ ID NO：20或SEQ ID NO：21杂交的核酸序列或其具有至少40％序列的互补链 身份 本发明还提供人类EP3-11或EP3-12作为用于鉴定可用于治疗和预防心血管疾病，炎症，繁殖障碍和癌症的化合物的靶标，作为不同人体组织中mRNA分布的相对定量的结果 通过表达谱分析。 本发明还提供了鉴定调节EP3-11或EP3-12的化合物的测定。

    ACYLGLYCEROL ACETYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF
    39.
    发明申请
    ACYLGLYCEROL ACETYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF 失效
    ACYLGLYCEROL乙酰胆碱酯酶蛋白MGAT-X1及其用途

    公开(公告)号：US20110086013A1

    公开(公告)日：2011-04-14

    申请号：US12854524

    申请日：2010-08-31

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingärtner ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingärtner ,  Andreas Geerts

    IPC分类号： A61K38/45 ,  C12N9/10 ,  C12N9/96

    CPC分类号： C07K16/40 ,  C12N9/1029

    摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。 本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。 本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定 与MGAT-X1的表达相关。 本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。