Abstract:
Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted or substituted amidine group is replaced with an unsubstituted or substituted aminomethyl group, are useful as serine protease inhibitors.
Abstract:
Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment or prevention of lipid disorders, metabolic disorders and cell-proliferative diseases. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in cholesterol metabolism. The subject compounds are particularly useful in the treatment of obesity, diabetes, hypercholesterolemia, atherosclerosis and hypolipoproteinemia.
Abstract:
Permanent magnets are mounted on a rotor of an electrical motor by an apparatus that keeps an adhesive bonding layer between the magnet and rotor in compression over wide variations in temperature and speed of rotation. The mechanical stresses on the magnets are controlled using compliant layers and spacers. The apparatus allows the removal and replacement of individual magnets.
Abstract:
A portable device for dispensing a fragrance comprising a housing (1) containing a fragrance element (3) and at least one aperture (5) in a side of the housing (1) in the vicinity of one end (6) of the housing to release fragrance from the housing (1). A lid is attached to the housing (1) to selectively open and close the aperture (5). The one end (6) of the device is shaped to abut the lower end of a users nose such that in use the fragrance can be inhaled through the aperture (5) to the nasal passage of the user.
Abstract:
A first data stream (26) requested by a first client (1) is received at a router (16). A second data stream (24) requested by a second client (2) is also received at the router (16). The router (16) determines that the first data stream (26) and the second data stream (24) are identical. The router (16) multicasts the first data stream (26) and the second data stream (24) into a single multicast data stream (28). The single multicast data stream (28) is transmitted to the first client (1) and to the second client (2).
Abstract:
An accident and emergency trolley supports and transports a patient, and includes a surface overlying an upper frame which is supported on a base frame in order to be raised and lowered relative to the base frame. The upper frame is mounted at its periphery on opposed radius arms connected to respective first and second actuators, which are operated by foot-operated pedals. The pedals are disposed on one or either side of the trolley such that operation of any single pedal enables the trolley to be raised at either end or both ends simultaneously. The opposed radius arms provide an uninterrupted window under the trolley allowing for X-ray/imaging.
Abstract:
An Internet Protocol telephone system and method uses a telephone (26) to place and receive voice over Internet Protocol (VoIP)-based telephone calls and public switched telephone network (PSTN)-based telephone calls. An off-hook condition with the telephone (26) is detected and a sequence of signals generated by the telephone (26) is received. At least a first signal generated by the telephone (26) is buffered while the system attempts to detect a predetermined signal that signifies a VoIP-based call. Upon detection of the predetermined signal, the system intercepts subsequent signals in the sequence, absent the at least first signal that was buffered, and places the VoIP-based call via an internet (12). Otherwise, the system places the PSTN-based call via a PSTN (16).
Abstract:
A cable telephony system (100) including a plurality of subscriber units (104) connected to a head-end (102) by a cable distribution network (106) in which upstream and downstream data transmissions are sent between subscribers (104) and head-end (102). Both shared and unshared connections are supported within cable telephony system (100). Transmission between a subscriber (104) and head-end (102) may involve both a shared and unshared connection in which unshared connections are employed to provide a higher quality of service when the shared connection is unable to do so.