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    DIVALENT-METAL COATED NANOPARTICLES FOR DELIVERY OF COMPOSITIONS INTO THE CENTRAL NERVOUS SYSTEM BY NASAL INSUFFLATION
    32.
    发明申请
    DIVALENT-METAL COATED NANOPARTICLES FOR DELIVERY OF COMPOSITIONS INTO THE CENTRAL NERVOUS SYSTEM BY NASAL INSUFFLATION 有权
    用于通过NASAL INSUFFLATION将组合物输送到中央神经系统的金属包覆纳米颗粒

    公开(公告)号：US20140248364A1

    公开(公告)日：2014-09-04

    申请号：US14343534

    申请日：2012-09-14

    Applicant: Juan Sanchez-Ramos ,  Vasyl Sava ,  Shijie Song ,  Shyam S. Mohapatra ,  Subhra Mohapatra

    Inventor： Juan Sanchez-Ramos ,  Vasyl Sava ,  Shijie Song ,  Shyam S. Mohapatra ,  Subhra Mohapatra

    IPC: A61K9/00 ,  A61K9/51 ,  A61K47/48 ,  A61K31/7088

    CPC classification number: C12N15/113 ,  A61K9/0043 ,  A61K9/1075 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/50 ,  A61K9/501 ,  A61K9/5115 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/541 ,  A61K47/547 ,  A61K47/6939 ,  A61K48/00 ,  A61K49/1881 ,  C12N15/88 ,  C12N15/895 ,  C12N2310/14 ,  C12N2320/32

    Abstract: The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent cation-coated or cation-containing nanoparticles to all regions of brain. It has been found that such divalent cation-containing nanoparticles, including those nanoparticles comprising manganese have affinity for the metal transport receptor proteins. Although this receptor has particular affinity for manganese, it is contemplated that other divalent ions, including magnesium, calcium, and the like may also be bound to such receptors leading to transport of the nanoparticles into the intracellular cytoplasm. Nanoparticles have been developed, therefore, as vehicles for parenteral delivery of genes, proteins and drugs. The present disclosure encompasses embodiments of nanoparticle-based compositions and methods for the use thereof for the delivery of genes, oligonucleotides, including but not limited to small interfering RNA, and other small molecule drugs, into the brain by nasal insufflation.

    Abstract translation: 本公开的组合物和方法特别针对在嗅觉神经末端表达的二价金属转运蛋白，以将二价阳离子包被或含阳离子的纳米颗粒转运到脑的所有区域。 已经发现，这种含二价阳离子的纳米颗粒，包括那些包含锰的纳米颗粒对金属转运受体蛋白质具有亲和力。 虽然这种受体对锰具有特殊的亲和力，但是预期其它二价离子（包括镁，钙等）也可以结合到这种受体上，导致纳米颗粒转运到细胞质细胞质中。 因此，已经开发了纳米颗粒，作为胃肠外递送基因，蛋白质和药物的载体。 本公开涵盖了基于纳米颗粒的组合物的实施方案及其用于通过鼻吹气将基因，寡核苷酸（包括但不限于小干扰RNA和其它小分子药物）递送至脑中的方法。

    XIAP-targeted prostate cancer therapy
    33.
    发明授权
    XIAP-targeted prostate cancer therapy 有权
    XIAP靶向前列腺癌治疗

    公开(公告)号：US08716299B2

    公开(公告)日：2014-05-06

    申请号：US11306241

    申请日：2005-12-20

    Applicant: Subhra Mohapatra ,  W. Jack Pledger

    Inventor： Subhra Mohapatra ,  W. Jack Pledger

    IPC: A61K31/52 ,  A01N43/90

    CPC classification number: G01N33/57434 ,  A61K31/366 ,  A61K31/52 ,  A61K31/522 ,  A61K31/5377 ,  A61K38/1709 ,  A61K45/06 ,  A61K2300/00

    Abstract: A treatment for prostate cancer using cyclin-dependent kinase inhibitors is provided. The effects of cyclin-dependent kinase inhibitors on the survival of prostate cancer cells was examined. Roscovitine, R-roscovitine, and CGP74514A were shown to induce the apoptosis of LNCaP and LNCaP-Rf cells, both of which express wild-type p53. The cyclin-dependent kinase inhibitors of the present invention induce the mitochondria-mediated apoptosis of prostate cancer cells by a dual mechanism: p53 accumulation and XIAP depletion.

    Abstract translation: 提供使用细胞周期蛋白依赖性激酶抑制剂治疗前列腺癌。 检查细胞周期蛋白依赖性激酶抑制剂对前列腺癌细胞存活的影响。 显示Roscovitine，R-roscovitine和CGP74514A诱导LNCaP和LNCaP-Rf细胞的凋亡，两者均表达野生型p53。 本发明的细胞周期蛋白依赖性激酶抑制剂通过双重机制诱导线粒体介导的前列腺癌细胞凋亡：p53积累和XIAP消耗。

    MOLECULARLY IMPRINTED POLYMERS HAVING AFFINITY FOR NATRIURETIC PEPTIDES
    34.
    发明申请
    MOLECULARLY IMPRINTED POLYMERS HAVING AFFINITY FOR NATRIURETIC PEPTIDES 有权
    具有自由基亲和力的分子印迹聚合物

    公开(公告)号：US20130330384A1

    公开(公告)日：2013-12-12

    申请号：US14000326

    申请日：2012-02-24

    Applicant: Subhra Mohapatra ,  Chunyan Wang

    Inventor： Subhra Mohapatra ,  Chunyan Wang

    IPC: C08F220/06

    CPC classification number: C08F220/06 ,  A61K38/00 ,  B82Y5/00 ,  C07K14/58 ,  G01N33/74 ,  G01N2333/58 ,  G01N2600/00 ,  Y10T428/24802

    Abstract: The present invention concerns molecularly imprinted polymers (MIPs) having an affinity for natriuretic peptides, such as atrial natriuretic peptide (ANP). In some embodiments, the MIP is a nanoparticle (a molecularly imprinted polymeric nanoparticle (MIPNP)). Other aspects of the invention include methods of preparing an MIP having affinity for a natriuretic peptide, methods for binding a natriuretic peptide in vitro or in vivo using an MIP of the invention, methods for interfering with the binding of a natriuretic peptide with its receptor in vivo, methods for reducing inflammation, cell growth, cell differentiation, or a cell proliferation disorder, methods for detecting natriuretic peptides, and devices and kits for sequestering and/or detecting natriuretic peptides.

    Abstract translation: 本发明涉及对钠尿肽具有亲和力的分子印迹聚合物（MIP），例如心房钠尿肽（ANP）。 在一些实施方案中，MIP是纳米颗粒（分子印迹聚合物纳米颗粒（MIPNP））。 本发明的其它方面包括制备对利尿钠肽具有亲和性的MIP的方法，使用本发明的MIP在体外或体内结合利尿钠肽的方法，用于干扰利尿钠肽与其受体的结合的方法 体内，减少炎症，细胞生长，细胞分化或细胞增殖障碍的方法，检测利尿钠肽的方法，以及用于隔离和/或检测利尿钠肽的装置和试剂盒。

    MICELLE COMPOSITIONS AND METHODS FOR THEIR USE
    35.
    发明申请
    MICELLE COMPOSITIONS AND METHODS FOR THEIR USE 审中-公开
    MICELLE组合物及其使用方法

    公开(公告)号：US20130243867A1

    公开(公告)日：2013-09-19

    申请号：US13773749

    申请日：2013-02-22

    Applicant: Subhra Mohapatra ,  Shyam S. Mohapatra ,  Mark Christian Howell ,  Suraj Kishore Dixit ,  Chunyan Wang

    Inventor： Subhra Mohapatra ,  Shyam S. Mohapatra ,  Mark Christian Howell ,  Suraj Kishore Dixit ,  Chunyan Wang

    IPC: A61K9/16 ,  A61K31/7088

    CPC classification number: A61K9/167 ,  A61K9/1075 ,  A61K31/7088 ,  A61K47/6909 ,  A61K49/1809 ,  A61K49/1821

    Abstract: Provided herein is a micelle composition comprising a polyethylene glycol (PEG), a DC-cholesterol, and a dioleoylphosphatidyl-ethanolamine (DOPE) and either or both a pharmaceutical compound core and a polynucleotide coating. Also provided herein is a method of administering one or more compounds to a cell comprising administering to the cell a micelle composition comprising 1) PEG-PE, a DC-cholesterol, and DOPE, and 2) the one or more compounds, wherein the compounds are selected from the group consisting of a polynucleotide and a pharmaceutical composition. Further provided are methods for detecting the micelle composition.

    Abstract translation: 本文提供了包含聚乙二醇（PEG），DC-胆固醇和二油酰磷脂酰乙醇胺（DOPE）以及药物化合物核心和多核苷酸涂层中的任一种或两者的胶束组合物。 本文还提供了向细胞施用一种或多种化合物的方法，包括向细胞施用包含1）PEG-PE，DC-胆固醇和DOPE的胶束组合物，和2）一种或多种化合物，其中化合物 选自多核苷酸和药物组合物。 还提供了用于检测胶束组合物的方法。

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