公开(公告)号：US11607537B2

公开(公告)日：2023-03-21

申请号：US16210771

申请日：2018-12-05

Applicant: Virginia Tech Intellectual Properties, Inc. ,  VoltMed, Inc.

Inventor： Eduardo Latouche ,  Samuel Lesko ,  Lucy Epshteyn ,  Christopher B. Arena ,  John H. Rossmeisl, Jr. ,  Melvin Lorenzo ,  Rafael Davalos

IPC: A61B18/08 ,  A61N1/05 ,  A61N1/32 ,  A61N1/37 ,  A61N1/36 ,  A61B18/14 ,  A61B18/00 ,  A61N1/08

Abstract: This disclosure describes the methods, devices, and systems of treating diseased tissue with integrated nanosecond pulse irreversible electroporation. Methods and systems as disclosed provide MRI compatible shielded electrodes and electrode leads to prevent emanating radiofrequency noise and improve image quality, disconnecting the electrode from the cable linkage to the pulse generator reduce electromagnetic interference and image artifacts, placing electrodes strategically within a guide cannula to minimize distortion from heterogeneities or maximize ablation within the tissue, utilizing conductive fluids, innate or external, such as cerebral spinal fluid or grounding pads to provide a pathway for current return, and for timing of the electrical waveforms with inherent brain electrical activity.

公开(公告)号：US20230050649A1

公开(公告)日：2023-02-16

申请号：US17305773

申请日：2021-07-14

Applicant: University of Virginia Patent Foundation ,  Virginia Tech Intellectual Properties, Inc.

Inventor： Steven Brandon Thorpe ,  Webster L. Santos ,  Kevin R. Lynch

IPC: C07D413/14 ,  C07D413/04

Abstract: Sphingosine kinases are enzymes that catalyze the biosynthesis of sphingosine-1-phosphate. The invention provides prodrugs of compounds that are effective for inhibition of sphingosine kinase type 1, sphingosine kinase type 2, or both, according to formula (I) as described herein. Formula I compounds are useful in the treatment of a range of diseases wherein increasing the level of sphingosine-1-phosphate in blood is medically indicated. The invention also provides pharmaceutical compositions of Formula I compounds.

公开(公告)号：US20230026670A1

公开(公告)日：2023-01-26

申请号：US17378941

申请日：2021-07-19

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Jian Liu ,  Dong Dong ,  Rolando Burgos

IPC: H02M7/483 ,  H02M1/00 ,  H02J3/36

Abstract: Aspects are described for hybrid modular multilevel converters that include half-bridge submodules. In some embodiments, a hybrid modular multilevel converter can include a direct current (DC) bus and an alternating current (AC) node. A first arm of the hybrid modular multilevel converter includes a first submodule chain link and a first arm inductor and a second arm includes a second submodule chain link and a second arm inductor. A capacitor connects between a first side of the first arm and a first side of the second arm.

公开(公告)号：US20220388617A1

公开(公告)日：2022-12-08

申请号：US17531007

申请日：2021-11-19

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Taylor Njaka ,  Pinhas Ben-Tzvi ,  Stefano Brizzolara

IPC: B63H1/26 ,  B63H21/21 ,  B63B39/00

Abstract: Various examples of a high-speed omnidirectional fully-actuated underwater propulsion mechanism are described. In one example, a propulsion system includes two decoupled counter-rotating rotors centered on a main axis, with each rotor comprising a plurality of pivotable blades projecting radially from the main axis, a servo-swashplate actuation mechanism comprising a plurality of servos and a linkage assembly connected from the servos to the pivotable blades, a blade-axis re-enforcing flap adapter comprising a plurality of stationary flaps, with the blade-axis re-enforcing flap adapter being positioned in a region between the two decoupled counter-rotating rotors centered on the main axis, and a controller. The controller can be configured to calculate control parameters, compensate a first control parameter among the control parameters to reduce cross-coupling of an unwanted force generated by drag forces on the two decoupled counter-rotating rotors, and generate a control signal for each of the servos based on the control parameters.

公开(公告)号：US11519877B2

公开(公告)日：2022-12-06

申请号：US16058478

申请日：2018-08-08

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Hadi Shafiee ,  Michael Benjamin Sano ,  John L. Caldwell

IPC: B03C5/00 ,  B03C5/02 ,  G01N27/447 ,  B01D57/02

Abstract: Devices and methods for performing dielectrophoresis are described. The devices contain sample channel which is separated by physical barriers from electrode channels which receive electrodes. The devices and methods may be used for the separation and analysis of particles in solution, including the separation and isolation of cells of a specific type. As the electrodes do not make contact with the sample, electrode fouling is avoided and sample integrity is better maintained.

公开(公告)号：US20220385193A1

公开(公告)日：2022-12-01

申请号：US17765611

申请日：2020-09-30

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Jih-Sheng Lai ,  Chih-Shen Yeh

IPC: H02M3/335 ,  H02M3/00 ,  H02M1/08 ,  H02M1/00 ,  H02M7/5387

Abstract: Aspects of hybrid modulation control for DC-to-AC converters are described. In one embodiment, a hybrid modulation pattern is generated. The hybrid modulation pattern separates switch gating control into multiple control regions for a half cycle of the waveform. A first control region modulates according to a first modulation technique and a second control region modulates according to a second modulation technique. The switches of a resonant converter are controlled according to the hybrid modulation pattern to generate the waveform.

公开(公告)号：US20220371181A1

公开(公告)日：2022-11-24

申请号：US17813772

申请日：2022-07-20

Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.

Inventor： Pinhas Ben-Tzvi ,  Vinaykarthik Kamidi

IPC: B25J9/10 ,  B25J9/16 ,  B62D57/032 ,  B25J19/00 ,  B25J17/00

Abstract: The present invention concerns a novel leg mechanism for quadrupedal locomotion. This design engages a linkage to couple assembly that only requires a single degree of actuation. The topological arrangement of the system produces a foot trajectory that is well-suited for dynamic gaits including trot-running, bounding, and galloping.

公开(公告)号：US11453873B2

公开(公告)日：2022-09-27

申请号：US16535451

申请日：2019-08-08

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Rafael V. Davalos ,  Paulo A. Garcia ,  John H. Rossmeisl ,  John L. Robertson ,  Robert E. Neal, II

IPC: A61B34/10 ,  C12N13/00 ,  A61B18/12 ,  A61B18/00 ,  A61N1/04 ,  G16H50/50

Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

公开(公告)号：US20220299500A1

公开(公告)日：2022-09-22

申请号：US17597995

申请日：2020-09-30

Applicant: Virginia Tech Intellectual Properties Inc.

Inventor： Aloka B. BANDARA ,  David A. BROWN

IPC: G01N33/50 ,  C12N9/02 ,  C12N15/11 ,  C12N9/22

Abstract: Disclosed herein is a recombinant human cell line that does not express functional endogenous NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 (NDUFS2). This knockout cell line can be used to advance the basic understanding of the NDUFS2 protein subunit in overall complex I assembly and function. Furthermore, this cell line can be used to test therapeutic agents to fix or bypass the dysfunctional complex I.

公开(公告)号：US20220299444A1

公开(公告)日：2022-09-22

申请号：US17677797

申请日：2022-02-22

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Aditya GARG ,  Wei ZHOU

IPC: G01N21/65 ,  G01J3/44

Abstract: Methods are provided for making a membrane or textile having a mechanically robust surface-enhanced Raman spectroscopy (SERS) substrate by in a first step adhesively bonding a micropatch array to a substrate, the micropatch array having a plurality of micron-scale pillars, each of the micron-scale pillars in the plurality of micron-scale pillars containing a plurality of plasmonic nanoparticles dispersed within a polymer matrix; and in a subsequent step etching a portion of the polymer matrix to expose at least a portion of the plasmonic nanoparticles at or near a surface of the micron-scale pillars. Membranes and textiles containing the mechanically robust surface-enhanced Raman spectroscopy (SERS) substrates are also provided.