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公开(公告)号：US11174624B2
公开(公告)日：2021-11-16
申请号：US16066991
申请日：2017-07-03
Applicant: XIAMEN UNIVERSITY
Inventor： Liang Hou , Shaojie Wang , Xiangjian Bu
Abstract: A method and the device of the working bucket number identification technology during the shoveling-and-loading process of the loader uses multi-sensor fusion technology for the three kinds of pressure sensors during the shoveling-and-loading process of the loader to realize the automatic identification of the bucket number during the shoveling-and-loading process. It can effectively improve and ensure the accuracy of the test data, while effectively preventing drivers from overworking. The method and device is also beneficial to the recognition of the loader working stage, and provides a good foundation for accurately identifying the working stage and realizing the dynamic prediction and control of the working process.
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公开(公告)号：US20210317172A1
公开(公告)日：2021-10-14
申请号：US17230243
申请日：2021-04-14
Applicant: Xiamen University
Inventor： Kejian WANG , Ying YANG , Fangyi CHEN , Yanchao CHEN , Huiyun CHEN , Hui PENG
IPC: C07K14/435 , A23K20/147 , A61K45/06 , A61P31/10
Abstract: The present disclosure discloses an antimicrobial peptide Scyreprocin of Scylla paramamosain and a method thereof, wherein an amino acid sequence of the antimicrobial peptide Scyreprocin comprises a sequence shown in SEQ ID NO 01, and the antimicrobial peptide is expressed and purified by using genetic engineering technology. The recombinant antimicrobial peptide Scyreprocin has advantages of wide antimicrobial spectrum, good antimicrobial effect, and rapid germicidal rate, shows great application significance, and has good application in preparation of antimicrobial agents. The recombinant antimicrobial peptide Scyreprocin has no cytotoxicity to mouse hepatocytes AML12, human liver cells L02, and can be safely used for medical treatment or can be used as a feed composition.
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公开(公告)号：US11111522B2
公开(公告)日：2021-09-07
申请号：US16327256
申请日：2018-04-27
Applicant: XIAMEN UNIVERSITY
Inventor： Qingge Li , Dongmei Chen , Qiuying Huang , Ye Xu , Yiqun Liao
IPC: C12Q1/68 , C12Q1/6818 , C12N15/11
Abstract: The present application relates to multiplex detection of nucleic acid molecules. In particular, the present application provides a method for detecting target nucleic acid sequences, said method can simultaneously detect the presence of multiple target nucleic acid sequences in a sample. In addition, the present application further provides a probe set, and a kit comprising one or more said probe sets, said probe set and said kit can be used to carry out the method of the invention.
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公开(公告)号：US20210269339A1
公开(公告)日：2021-09-02
申请号：US16769914
申请日：2019-04-30
Applicant: XIAMEN UNIVERSITY OF TECHNOLOGY
Inventor： Bin YAN
Abstract: The present invention provides a method for treating dye wastewater. The method includes: firstly, homogenizing the dye wastewater to balance the quality of the dye wastewater from different processes; then subjecting the homogenized dye wastewater to anaerobic treatment to remove most of chemical oxygen demand (COD) and total suspended solids (SS) in the wastewater; and finally subjecting the dye wastewater after the anaerobic treatment to circulating anaerobic-oxic treatment in a membrane bioreactor (MBR). In the present invention, the MBR is filled with a quinone-based hollow fiber membrane. The quinone acts as an electron mediator to accelerate an enzymatic reaction for dye decolorization during the anaerobic process, thereby achieving the purpose of efficient decolorization. The oxic treatment process further removes the COD and SS in the wastewater, so that the effluent meets a first-level discharge standard. The results of the examples show that by treating the dye wastewater by the method provided by the present invention, the COD in the effluent is less than 100 mg/L, the chromaticity is less than 20 times, and the SS is 0.
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公开(公告)号：US20210263029A1
公开(公告)日：2021-08-26
申请号：US17254227
申请日：2019-05-29
Applicant: XIAMEN INNODX BIOTECH CO. LTD , XIAMEN UNIVERSITY
Inventor： Zimin Chen , Junhui Xiong , Weiling Xu , Zuxing Weng , Long Wang , Xiaohong Zheng , Xudong Sun , Shengxiang Ge
IPC: G01N33/543 , G01N33/68 , G01N33/577 , G01N33/535 , G01N33/533 , G01N21/76
Abstract: The invention provides a kit for full-range detection of C-reactive protein based on chemiluminescence immunoassay and a method for full-range detection of C-reactive protein. The kit comprises an R1 reagent, an M reagent, an R2 reagent, a pre-excitation solution and an excitation solution. The R1 reagent, that is a sample treatment solution, is a 0.5M citric acid solution (pH 3.0-3.5, which is adjusted by disodium hydrogen phosphate dodecahydrate). The present invention also provides a kit for full-range detection of C-reactive protein, which comprises a flat-bottomed plate-type chemiluminescence plate coated with a first antibody, a sample treatment solution, a second antibody labeled with horseradish peroxidase (HRP) or alkaline phosphatase (AP), a color developing solution. The invention also provides a method for full-range detection of C-reactive protein using the kit. Both the first antibody and the second antibody are monoclonal antibodies that can specifically react with C-reactive protein.
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Patent Agency Ranking
公开(公告)号：US11046832B2
公开(公告)日：2021-06-29
申请号：US16567295
申请日：2019-09-11
Applicant: Xiamen University
Inventor： Lizong Dai , Chao Liu , Guorong Chen , Jiamei Huang , Zhongyu Li , Conghui Yuan , Yiting Xu , Birong Zeng , Wei′ang Luo
Abstract: The present disclosure discloses a method of manufacturing silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen, which relates to organic/inorganic hybrid nanoparticles, dispersing SiO2 in an organic solvent, then adding THPS, stirring, and finally adding p-phenylenediamine, reacting, centrifuging, washing, and drying to obtain silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen. The silicon dioxide nanoparticles modified by the polymer containing phosphorus and nitrogen have effects in flame retardancy, strengthening effect of polymer matrixes, and are expected to be widely used in the halogen-free synergistic flame retardancy of polymer materials.
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公开(公告)号：US20210154249A1
公开(公告)日：2021-05-27
申请号：US17047783
申请日：2019-04-15
Applicant: Xiamen University , Yang Sheng Tang Company, Ltd.
Inventor： Tong CHENG , Wei WANG , Xiangzhong YE , Wenkun FU , Dequan PAN , Jun ZHANG , Ningshao XIA
Abstract: Provided are Coxsackie virus CVB1 or a modified form thereof, or a genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or a nucleic acid molecule of a complement sequence of the genomic sequence or cDNA sequence, the use of same for treating tumors in subjects including humans, and the use of same in the preparation of a pharmaceutical composition for treating tumors in subjects including humans. Also provided is a method for treating tumors, comprising administering CVB1 or the modified form thereof, or the genomic sequence or cDNA sequence comprising CVB1 or the modified form thereof, or the nucleic acid molecule of the complement sequence of the genomic sequence or cDNA sequence to a subject in need thereof.
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公开(公告)号：US20210132030A1
公开(公告)日：2021-05-06
申请号：US17049973
申请日：2020-03-17
Applicant: XIAMEN UNIVERSITY
Inventor： Yishou WANG , Yancheng YOU , Diheng WU , Tingwei LIN , Xinlin QING , Hu SUN
Abstract: A coaxial capacitive sensor includes a sensor lubricating oil inlet and a sensor lubricating oil outlet. The sensor lubricating oil inlet and the sensor lubricating oil outlet separately communicate with the interior of the coaxial capacitive sensor. The interior of the coaxial capacitive sensor is provided with a center bearing, electrode support insulating substrates, and electrode plates. The plurality of electrode support insulating substrates and the center bearing divide the interior of the coaxial capacitive sensor into a plurality of detection sub-spaces, and the electrode plates are attached onto the electrode support insulating substrates, respectively. The coaxial capacitive sensor provided by the present invention can be arranged in a lubricating oil pipeline to avoid the influences of environmental factors on the testing results, and can on-line detect the characteristics of the lubricating oil abrasive particles efficiently.
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39.发明申请公开(公告)号：US20210024901A1
公开(公告)日：2021-01-28
申请号：US16825652
申请日：2020-03-20
Applicant: XIAMEN UNIVERSITY
Inventor： Keju JING , Yujiao SHEN , Wei XIONG , Xueping LING , Yinghua LU
Abstract: The present invention provides a method for changing an coenzyme activity and a preference of glucose dehydrogenase and the use thereof, and relates to the technical field of genetic engineering. In the method of the present invention, by performing a site-directed mutation of the fourth amino acid in a conserved sequence GXXXGXG of the glucose dehydrogenase, a mutant protein with the changed coenzyme activity and preference can be simply and directly obtained without a large amount of screening, such that the enzyme can be widely applied to catalyze a coenzyme regeneration reaction. In the embodiments of the present invention, four glucose dehydrogenase mutants T17G, T17K, T17RGDH DN46 and K17G are finally obtained by site-directed mutation of the 4th amino acid (which binds with a nicotinamide coenzyme ribose 2′-phosphate) in the conserved sequence GXXXGXG widely existed in glucose dehydrogenases from different sources, and upon verification, the enzyme activity, preference and the like of them all have been varied.
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公开(公告)号：US20210023198A1
公开(公告)日：2021-01-28
申请号：US16756973
申请日：2018-10-10
Applicant: Xiamen University
Inventor： Yixin Chen , Chenguang Shen , Junyu Chen , Mengya Zhang , Limin Zhang , Ningshao Xia
IPC: A61K39/145
Abstract: The disclosure relates to a mutant of hemagglutinin protein of H3N2 subtype influenza virus and use thereof. In addition, the disclosure also relates to a pharmaceutical composition (e.g., a vaccine) comprising the mutant, a method for preparing the mutant, and a method of using the mutant for prevention and/or treatment of an infection of influenza virus and/or a disease (e.g., an influenza) caused by the infection.
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