摘要:
A multiple point simulation technique for generating a model realization of a subterranean formation having different facies is described which uses a non-stationary training image which reflects facies spatial trends across the formation. The realization is formed by sequentially populating each cell; a facies pattern of neighboring cells is identified for each cell in the model grid, and then corresponding facies patterns identified in the training image. The probability of a target cell in the model grid having a given facies is calculated based on the proportion of occurrences of the corresponding facies pattern where the central cell has that facies. The contribution of each corresponding facies pattern occurrence in the training image to this proportion or probability is weighted according to the distance between its central cell and the training image cell corresponding in location to the target cell in the model grid.
摘要:
This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
摘要:
A method for establishing a connection is provided. The method includes the following steps. A mobility management entity generates a create bearer context request message and sends the message to a selected serving gateway. The create bearer context request message at least includes address information of at least one packet data network gateway and corresponding indication information of the protocol type of connection establishment. The serving gateway receives and analyzes the create bearer context request message, and determines the protocol type of the connection according to the indication information of the protocol type of connection establishment. The serving gateway processes the create bearer context request message with the determined protocol type of connection. A mobility management entity, a serving gateway, and a network system which are able to reduce time delay when connection is established are further provided.
摘要:
There is provided an interference mitigation or frequency channel collision mitigation scheme usable for a short range communication network where a network element of a cellular network is used as a coordinator or controller for the collision mitigation. Communication information regarding a communication in the short range communication network and concerning a frequency selection for a communication are processed so as to determine collision mitigation data for reducing interference in the communication in the short range communication network. The collision mitigation data regarding the communication in the short range communication network are sent to a communication network element such as a UE acting as a master node of the short range communication network.
摘要:
The invention provides a synthetic polypeptide of Formula I′: or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要:
A method is used in deduplicating sets of data blocks. A collection of data is selected from a set of storage extents. The collection of data is selected based on evaluation of digest information for first and second data blocks of the collection of data. A deduplicating technique is applied to the collection of data.
摘要:
The present invention relates to a method of treating a disease or disorder characterised by increased stress hormone levels and/or decreased androgen hormone levels in a subject, comprising administering to the subject a therapeutically effective amount of a compound represented by formula (I): wherein n is 1 or 3; R is hydrogen or —C(O)N(Ra)(Rb) wherein Ra and Rb are independently —(C1-C4) alkyl, or —(C1-C4) alkyl-(C5-C7) aryl, wherein each of Ra and Rb is optionally substituted by —(C1-C4) alkoxy; R1, R2, and R3, are independently hydrogen, halogen, cyano or —(C6-C10) aryl, wherein said —(C6-C10) aryl is optionally substituted by halogen, with the proviso that no more than one of R1, R2, and R3 is hydrogen; and R4 and R5 are hydrogen; or a pharmaceutically acceptable salt thereof.
摘要:
Embodiments of the present invention disclose a multi-network access control method, a communication system, and relevant devices to prevent interruption of normal network communication when the multi-access function is used. The method includes the following steps: A User Equipment (UE) receives multi-access indication information sent by a network device; the UE judges, according to the multi-access indication information, whether the UE uses a multi-access function; and the UE initiates an access connectivity establishment from multi-networks if the multi-access function is used. The embodiments of the present invention further provide a communication system and relevant devices. The embodiments of the present invention may prevent interruption of normal network communication when the multi-access function is used.