公开(公告)号：US08802032B2

公开(公告)日：2014-08-12

申请号：US13982768

申请日：2012-01-30

Applicant: Yoshihiro Yamashita ,  Shinya Matsuoka ,  Taku Sakazume ,  Yukinori Sakashita

Inventor： Yoshihiro Yamashita ,  Shinya Matsuoka ,  Taku Sakazume ,  Yukinori Sakashita

IPC: G01N33/00 ,  G01N33/48 ,  G01N15/06

CPC classification number: B01L3/0227 ,  G01N35/00693 ,  G01N35/1011 ,  G01N35/1016 ,  Y10T436/2575

Abstract: This invention provides an analyzer that has a liquid dispense pipette dispensing liquids with higher accuracy and precision at higher speeds. The analyzer includes a drive mechanism having a stepping motor as a power source. The drive mechanism transmits power from a rotation output shaft of the stepping motor to a moving unit for executing a target motion via at least one power transmission unit. The amount of idling of the moving unit stemming from the stepping motor getting driven in reverse is calculated from the amount of movement of the moving unit, from the amount of pulses fed to the stepping motor, and from the amount of remaining pulses so as to perform motion control of the drive mechanism accordingly.

Abstract translation: 本发明提供一种具有液体分配移液管的分析器，其以更高的速度以更高的精度和精度分配液体。 分析器包括具有作为电源的步进电机的驱动机构。 驱动机构通过至少一个动力传递单元将来自步进马达的旋转输出轴的动力传递到用于执行目标运动的移动单元。 从步进电动机反向驱动的移动单元的空转量根据移动单元的移动量，从馈送到步进电动机的脉冲量和剩余脉冲量计算，以便 相应地执行驱动机构的运动控制。

公开(公告)号：US20130143234A1

公开(公告)日：2013-06-06

申请号：US13702175

申请日：2011-06-07

Applicant: Toru Inaba ,  Shinya Matsuoka ,  Taku Sakazume ,  Yoshihiro Yamashita ,  Masafumi Shimada ,  Osamu Kogi ,  Yushi Harada

Inventor： Toru Inaba ,  Shinya Matsuoka ,  Taku Sakazume ,  Yoshihiro Yamashita ,  Masafumi Shimada ,  Osamu Kogi ,  Yushi Harada

IPC: G01N33/53

CPC classification number: G01N33/5306 ,  B03C1/01 ,  B03C1/033 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22 ,  B03C2201/24 ,  B03C2201/26 ,  G01N33/54326 ,  G01N33/57438 ,  G01N33/57484 ,  G01N35/0098

Abstract: This invention provides a sample analyzing device and sample analyzing method designed to suppress nonuniform capture of magnetic particles (10) and detect a desired substance with higher accuracy. The sample analyzing device includes a flow channel (15) that conducts thereinto a sample which contains the magnetic particles (10), and magnetic field generating means (12) that generates magnetic fields for capturing the magnetic particles (10) in a magnetic particles capturing region of the flow channel (15); wherein the flow channel has at least one of structural characteristics that a cross-sectional area of the flow channel, at a downstream end of the magnetic particles capturing region, is larger than a cross-sectional area of the flow channel, at an upstream end of the magnetic particles capturing region, and that the magnetic fields generated by the magnetic field generating means (12) have a greater magnitude at a downstream side of the magnetic particles capturing region than at an upstream side thereof.

Abstract translation: 本发明提供了一种设计用于抑制磁性颗粒（10）的不均匀捕获并以更高精度检测所需物质的样品分析装置和样品分析方法。 样品分析装置包括：导入包含磁性粒子（10）的样品的流路（15）;以及磁场产生装置（12），其产生用于在磁性粒子捕获中捕获磁性粒子（10）的磁场 流通道（15）的区域; 其中所述流动通道具有以下结构特征中的至少一个：所述流动通道的在所述磁性粒子捕获区域的下游端处的横截面面积大于所述流动通道的横截面积，在上游端 并且由磁场产生装置（12）产生的磁场在磁性颗粒捕获区域的下游侧具有比在其上游侧更大的量值。

公开(公告)号：US20130089464A1

公开(公告)日：2013-04-11

申请号：US13618248

申请日：2012-09-14

Applicant: Yukinori SAKASHITA ,  Katsuaki TAKAHASHI ,  Susumu SAKAIRI ,  Taku SAKAZUME ,  Yoshihiro YAMASHITA

Inventor： Yukinori SAKASHITA ,  Katsuaki TAKAHASHI ,  Susumu SAKAIRI ,  Taku SAKAZUME ,  Yoshihiro YAMASHITA

IPC: G01N35/10

CPC classification number: G01N35/025 ,  G01N35/0099 ,  G01N35/04 ,  G01N35/10 ,  G01N35/1002 ,  G01N2035/00435 ,  G01N2035/00524 ,  G01N2035/00534 ,  G01N2035/0425 ,  G01N2035/0443 ,  G01N2035/0453 ,  G01N2035/0455 ,  G01N2035/0465 ,  Y10T436/11 ,  Y10T436/114165

Abstract: According to an embodiment of the disclosure, the analyzer includes a reagent driving disk that accommodates a reagent configured for analysis and that transports the reagent to a desired position, and a fixed disk that has a reagent stand-by position in which to make a reagent container containing the reagent, temporarily stand by, and a magnetic particles stirring position for stirring magnetic particles. A portion of the reagent stand-by position is constituted by a loading system. A reagent container moving unit moves reagent containers containing the reagent, between the reagent driving unit and the fixed disk, according to analytical request status. Providing in a part of the fixed disk the loading system constructed so that reagent containers containing the reagent can be mounted therein during operation enables changing of reagent containers, irrespective of an operational status of the reagent driving disk, and the system to having cold-storage functionality.

Abstract translation: 根据本公开的实施例，分析仪包括试剂驱动盘，其容纳配置用于分析的试剂并将试剂输送到期望的位置，以及固定盘，其具有试剂待机位置，以制备试剂 含有试剂的容器，临时待机，以及用于搅拌磁性颗粒的磁性颗粒搅拌位置。 试剂待机位置的一部分由加载系统构成。 试剂容器移动单元根据分析请求状态移动在试剂驱动单元和固定盘之间容纳试剂的试剂容器。 在固定盘的一部分中提供装载系统，其构造使得在操作期间可以将容纳有试剂的试剂容器安装在其中，从而能够改变试剂容器，而与试剂驱动盘的操作状态无关，并且具有冷藏 功能。

公开(公告)号：US20120292153A1

公开(公告)日：2012-11-22

申请号：US13442136

申请日：2012-04-09

Applicant: Hitoshi NOGUCHI ,  Hiroshi OKADA ,  Hiroyuki USAMI ,  Yoshihiro YAMASHITA

Inventor： Hitoshi NOGUCHI ,  Hiroshi OKADA ,  Hiroyuki USAMI ,  Yoshihiro YAMASHITA

IPC: F16D13/38 ,  F16D29/00

CPC classification number: B60K6/405 ,  B60K6/48 ,  F16H57/0412 ,  F16H57/0473 ,  F16H57/0476 ,  Y02T10/6221

Abstract: A main shaft has a shaft cylindrical portion extending from an outer periphery of a large-diameter portion. A drum has a drum cylindrical portion extending from an outer periphery of a drum plate portion. An axial forward end of the drum cylindrical portion is arranged in an inside of the shaft cylindrical portion. A frictional engagement unit of a clutch is provided in an inside of the shaft cylindrical portion. A motor generator has a rotor, which is firmly fitted to outer walls of the large-diameter portion and the shaft cylindrical portion and rotatable relative to a stator. A working-oil supply passage is formed in an inside of an input shaft.

Abstract translation: 主轴具有从大直径部的外周延伸的轴筒部。 滚筒具有从鼓板部分的外周延伸的滚筒圆柱形部分。 鼓圆筒部的轴向前端配置在轴圆筒部的内侧。 离合器的摩擦接合单元设置在轴圆筒部的内侧。 电动发电机具有转子，该转子牢固地配合到大直径部分的外壁和轴圆筒部分上并相对于定子可旋转。 工作油供给通道形成在输入轴的内侧。

公开(公告)号：US08111407B2

公开(公告)日：2012-02-07

申请号：US12712012

申请日：2010-02-24

Applicant: Hiroaki Takimasa ,  Takahiro Suga ,  Yoshihiro Yamashita

Inventor： Hiroaki Takimasa ,  Takahiro Suga ,  Yoshihiro Yamashita

IPC: G01N21/00

CPC classification number: G01B11/0608 ,  G02B27/0911 ,  G02B27/0955

Abstract: A displacement is accurately measured at high speed to a measurement object having various surface states. In a displacement sensor including a confocal optical system in which an objective lens is moved along an optical axis, light emitted from a laser diode is formed into a slit beam by a cylindrical lens, a Y-axis side orthogonal to the optical axis is narrowed such that the light is collected on a surface of a measurement object, and an X-axis orthogonal to the optical axis is elongated in order to average a component of the light reflected from the surface. A photodiode receives the light reflected from the surface of the measurement object through an opening disposed in a position of conjugation with the laser diode. The opening is formed into a slit shape that is short in the Y-axis while being long in the X-axis. The displacement of the surface is measured from a position of the objective lens when a light receiving signal becomes the maximum.

Abstract translation: 高精度地测量到具有各种表面状态的测量对象。 在包括物镜沿着光轴移动的共焦光学系统的位移传感器中，从激光二极管发出的光通过柱面透镜形成为狭缝光束，与光轴正交的Y轴侧变窄 使得光被收集在测量对象的表面上，并且与光轴正交的X轴被拉长以便平均从表面反射的光的分量。 光电二极管通过设置在与激光二极管共轭的位置的开口接收从测量对象表面反射的光。 该开口形成为在X轴上长而在Y轴上短的狭缝形状。 当光接收信号变为最大值时，从物镜的位置测量表面的位移。

公开(公告)号：US20080068040A1

公开(公告)日：2008-03-20

申请号：US11852032

申请日：2007-09-07

Applicant: Chikayoshi Morishima ,  Tokuya Osawa ,  Masaru Haraguchi ,  Yoshihiro Yamashita

Inventor： Chikayoshi Morishima ,  Tokuya Osawa ,  Masaru Haraguchi ,  Yoshihiro Yamashita

IPC: H03K19/0175

CPC classification number: H03K19/0005 ,  H03K19/018578

Abstract: There is provided a semiconductor device including an output buffer circuit which reduces an area occupied by a circuit for impedance adjustment and allows high-speed impedance adjustment. In an impedance measuring circuit, the impedance values of reference transistors having the same sizes as those of a plurality of transistors composing the output buffer circuit which are equal in size are measured. An impedance code generating circuit outputs impedance codes corresponding to the impedance values of the reference transistors to an output buffer code generating circuit based on the result of the measurement from the impedance measuring circuit. The output buffer code generating circuit generates output buffer codes for adjusting the impedance of the output buffer circuit by performing an arithmetic operation process to provide an objective impedance based on the impedance codes.

Abstract translation: 提供了一种包括输出缓冲电路的半导体器件，其减少用于阻抗调整的电路占据的面积，并允许高速阻抗调节。 在阻抗测量电路中，测量与构成输出缓冲电路的多个晶体管尺寸相同尺寸的参考晶体管的尺寸相等的阻抗值。 基于来自阻抗测量电路的测量结果，阻抗代码产生电路将对应于基准晶体管的阻抗值的阻抗代码输出到输出缓冲器代码产生电路。 输出缓冲器代码产生电路通过执行算术运算处理产生用于调节输出缓冲器电路的阻抗的输出缓冲器代码，以提供基于阻抗代码的物镜阻抗。

公开(公告)号：US20070059751A1

公开(公告)日：2007-03-15

申请号：US11518175

申请日：2006-09-11

Applicant: Yoshihiro Yamashita ,  Toshinari Sakurai

Inventor： Yoshihiro Yamashita ,  Toshinari Sakurai

IPC: C12Q1/68 ,  C12N1/08

CPC classification number: C12N1/066 ,  C12N15/1006 ,  C12N15/1017

Abstract: In a nucleic acid isolation method for a solid biological sample, since two or more kinds of instruments are used for biological sample disruption and nucleic acid isolation, the operations are complicated, thereby increasing the operating labor, prolonging the operation time, and deteriorating the property of a nucleic acid associated with the prolonged operation time. A sample stuck to the instrument for disruption during the sample disruption operation is not brought to the subsequent nucleic acid isolation operation, thereby causing a problem of reducing the nucleic acid isolation efficiency. In the present nucleic acid isolation method, a step of disrupting a biological sample and a step of isolating a nucleic acid released from the disrupted sample are conducted with one instrument. The nucleic acid isolation efficiency can be improved without losing a sample stuck to an instrument for sample disruption, and the operability can be improved by simplifying the operations.

Abstract translation: 在固体生物样品的核酸分离方法中，由于使用两种或更多种仪器进行生物样品破碎和核酸分离，操作复杂，从而增加操作劳动力，延长操作时间并降低其性能 与延长的手术时间相关的核酸。 在样品破碎操作期间粘附到仪器上以破坏的样品不会进入随后的核酸分离操作，从而导致降低核酸分离效率的问题。 在本发明的核酸分离方法中，使用一台仪器进行破坏生物样品的步骤和从被破坏的样品中分离释放的核酸的步骤。 可以提高核酸分离效率，而不会将样品粘附到用于样品破坏的仪器上，并且可以通过简化操作来提高可操作性。

公开(公告)号：US20060252142A1

公开(公告)日：2006-11-09

申请号：US11418031

申请日：2006-05-05

Applicant: Yoshihiro Yamashita ,  Toshinari Sakurai

Inventor： Yoshihiro Yamashita ,  Toshinari Sakurai

IPC: C12N1/08 ,  C07H21/04

CPC classification number: C12N15/1006

Abstract: It is an objective of the present invention to isolate RNA from a sample containing nucleic acid by safe and convenient operations. As a result of intensive studies, inventors of the present invention have found that DNA is precipitated out by adding an organic solvent to a mixed solution of a sample containing DNA and RNA and a chaotropic agent, so that RNA remains soluble. The present invention relates to a method whereby a sample containing nucleic acid, a chaotropic agent, and an organic solvent are mixed, DNA is precipitated out, and the precipitate is separated from the mixed solution, such that RNA is isolated from the residual solution. In addition, in accordance with the present invention, RNA is allowed to come into contact with a silica-containing solid phase so as to be bound to the silica-containing solid phase without the addition of a reagent or the like to the residual solution. Further, it is also possible to isolate DNA from the precipitate. In accordance with the present invention, high-purity RNA can be isolated from a sample containing DNA and RNA by safe and convenient operations. In addition, it is possible to simultaneously isolate RNA and DNA from a single sample.

Abstract translation: 本发明的目的是通过安全和方便的操作从含有核酸的样品中分离RNA。 作为深入研究的结果，本发明的发明人已经发现，通过向含有DNA和RNA的样品和离液剂的混合溶液中加入有机溶剂使DNA沉淀出来，使得RNA保持溶解。 本发明涉及一种使含有核酸，离液剂和有机溶剂的样品混合的方法，使DNA沉淀出来，从混合溶液中分离出沉淀物，从残留溶液中分离出RNA。 此外，根据本发明，允许RNA与含二氧化硅的固相接触，以便将其与含二氧化硅的固相结合，而不向残留溶液中加入试剂等。 此外，还可以从沉淀物中分离DNA。 根据本发明，可以通过安全和方便的操作从含有DNA和RNA的样品中分离高纯度RNA。 此外，可以从单个样品中同时分离RNA和DNA。

公开(公告)号：US06869262B2

公开(公告)日：2005-03-22

申请号：US10090077

申请日：2002-03-01

Applicant: Yoshihiro Yamashita ,  Yoshihiro Enomoto

Inventor： Yoshihiro Yamashita ,  Yoshihiro Enomoto

IPC: B65G49/06 ,  B65G49/07 ,  H01L21/02 ,  H01L21/677 ,  H01L21/687

CPC classification number: H01L21/68707 ,  H01L21/67742 ,  Y10S414/135

Abstract: A vacuum apparatus has a process chamber for processing a workpiece and a transfer apparatus for positioning the workpiece in the process chamber and for removing the workpiece from the process chamber. The transfer apparatus has a pair of generally parallel and spaced-apart transfer bodies and a workpiece holder connected to the transfer bodies for supporting the workpiece. A feeding mechanism feeds the transfer bodies in a longitudinal direction thereof to position the workpiece holder and the workpiece in the process chamber.

Abstract translation: 真空装置具有用于处理工件的处理室和用于将工件定位在处理室中并用于从处理室移除工件的传送装置。 传送装置具有一对大致平行和间隔的传送体和连接到传送体的工件保持件，用于支撑工件。 进给机构沿着其长度方向供给传送体，以将工件保持件和工件定位在处理室中。

公开(公告)号：US06747745B2

公开(公告)日：2004-06-08

申请号：US09980310

申请日：2001-11-30

Applicant: Nobuharu Ishikawa ,  Yoshihiro Yamashita ,  Hirotaka Nakashima ,  Masahiro Kawachi ,  Koji Shimada ,  Hitoshi Oba

Inventor： Nobuharu Ishikawa ,  Yoshihiro Yamashita ,  Hirotaka Nakashima ,  Masahiro Kawachi ,  Koji Shimada ,  Hitoshi Oba

IPC: G01B1114

CPC classification number: G01S17/48 ,  G01B11/25 ,  G01S17/89 ,  G06T7/521

Abstract: In a displacement sensor (10) comprising a sensor head (1) and a controller (2) either integrally or separately, the sensor head comprises a measurement light emitting optical system (113), an image acquiring optical system (127a, 127b) and a two dimensional imaging device (122). The controller can control the imaging condition associated with the brightness of the image in the form of a video signal both under a measurement mode and an observation mode. Under the measurement mode, with a light source (112) for measurement turned on, the imaging condition is adjusted in such a manner that a measurement light radiated light image (83) can be imaged at an appropriate brightness but a surrounding part (71) of the measurement object is substantially darker than the appropriate brightness, and a desired displacement is computed according the video signal obtained by the two dimensional imaging device (122). Under the observation mode, the imaging condition is adjusted in such a manner that the measurement position and the surrounding part of the measurement object can be imaged both at an appropriate brightness, and an image of the measurement position of the surface of the measurement object and the surrounding region (71) is displayed on the screen of an image monitor (4) according the video signal obtained by the two dimensional imaging device (122).

Abstract translation: 在包括测量发光光学系统（113），图像获取光学系统（127a，127b）和图像采集光学系统（127a，127b）的传感器头（1）和控制器（2）的位移传感器（10）中， 二维成像装置（122）。 控制器可以在测量模式和观察模式下以视频信号的形式控制与图像的亮度相关联的成像条件。 在测量模式下，利用用于测量的光源（112）开启，以能够以适当的亮度成像测量光照射光图像（83）的方式调节成像条件，但是围绕部分（71） 测量对象的亮度比适当的亮度明显更暗，并且根据由二维成像设备（122）获得的视频信号来计算期望的位移。 在观察模式下，成像条件被调节为使得测量对象的测量位置和周围部分能够以适当的亮度和测量对象的表面的测量位置的图像以及 根据由二维成像装置（122）获得的视频信号，在图像监视器（4）的屏幕上显示周围区域（71）。