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    Combined treatment with cisplatin and an epidermal growth factor receptor kinase inhibitor
    32.
    发明授权
    Combined treatment with cisplatin and an epidermal growth factor receptor kinase inhibitor 有权
    联合治疗顺铂和表皮生长因子受体激酶抑制剂

    公开(公告)号：US07951405B2

    公开(公告)日：2011-05-31

    申请号：US11145495

    申请日：2005-06-03

    Applicant: Brian Higgins ,  Kenneth Kolinsky

    Inventor： Brian Higgins ,  Kenneth Kolinsky

    IPC: A61K33/24 ,  A61K31/517

    CPC classification number: A61K31/519 ,  A61K31/4706 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K33/24 ,  A61K38/50 ,  A61K2300/00

    Abstract: The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an EGFR kinase inhibitor and cisplatin combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The invention also encompasses a pharmaceutical composition that is comprised of an EGFR kinase inhibitor and cisplatin combination in combination with a pharmaceutically acceptable carrier. A preferred example of an EGFR kinase inhibitor that can be used in practicing this invention is the compound erlotinib HCl (also known as Tarceva™).

    Abstract translation: 本发明提供了一种用于治疗患者的肿瘤或肿瘤转移的方法，其包括向所述患者同时或依次施用治疗有效量的EGFR激酶抑制剂和顺铂组合，所述另外的药物或治疗剂， 癌症药物或放射治疗。 本发明还包括药物组合物，其由EGFR激酶抑制剂和顺铂组合与药学上可接受的载体组合组成。 可用于实施本发明的EGFR激酶抑制剂的优选实例是化合物厄洛替尼HCl（也称为Tarceva TM）。

    ELECTRICAL TERMINATION CIRCUIT FOR A TRAVELING-WAVE OPTOELECTRONIC DEVICE
    33.
    发明申请
    ELECTRICAL TERMINATION CIRCUIT FOR A TRAVELING-WAVE OPTOELECTRONIC DEVICE 有权
    用于行波波导光电装置的电气终端电路

    公开(公告)号：US20110049335A1

    公开(公告)日：2011-03-03

    申请号：US12859735

    申请日：2010-08-19

    Applicant: Brian Higgins ,  Gregory J. McBrien

    Inventor： Brian Higgins ,  Gregory J. McBrien

    IPC: G01J1/46 ,  G02F1/035 ,  G02F1/03 ,  H01S3/097 ,  H01P1/22

    CPC classification number: G02F1/0516 ,  G02F1/2255 ,  H01S5/042

    Abstract: An electrical termination circuit for a traveling wave optoelectronic device is disclosed. The electrical termination circuit is constructed to reflect a portion of a radio-frequency signal back into the optoelectronic device. The reflected signal is out of phase with the applied radio-frequency signal at a frequency of a detrimental spectral feature or a bump in an electro-optical transfer characteristic of the optoelectronic device. The amplitude and the phase of the reflected signal are selected so as to suppress the detrimental spectral feature without a significant reduction in the efficiency of electro-optical or optical-electrical transformation of the optoelectronic device.

    Abstract translation: 公开了一种用于行波光电子器件的终端电路。 电终端电路被构造成将射频信号的一部分反射回光电器件。 反射信号与施加的射频信号在光电子器件的电光转移特性中的有害光谱特征或凸块的频率处异相。 选择反射信号的振幅和相位，以便抑制有害光谱特征，而不会显着降低光电子器件的电光或光电转换的效率。

    Production of high-purity niobium monoxide and capacitor production therefrom
    37.
    发明申请
    Production of high-purity niobium monoxide and capacitor production therefrom 审中-公开
    生产高纯度铌氧化物和电容器生产

    公开(公告)号：US20070081937A1

    公开(公告)日：2007-04-12

    申请号：US11548753

    申请日：2006-10-12

    Applicant: Charles Motchenbacher ,  James Robison ,  Brian Higgins ,  Thomas Fonville

    Inventor： Charles Motchenbacher ,  James Robison ,  Brian Higgins ,  Thomas Fonville

    IPC: C01G31/02

    CPC classification number: H01G9/0525 ,  C01G33/00 ,  C01P2002/72 ,  C01P2004/03 ,  C01P2004/51 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/17 ,  C01P2006/40 ,  C01P2006/80

    Abstract: The present invention relates to high-purity niobium monoxide powder (NbO) produced by a process of combining a mixture of higher niobium oxides and niobium metal powder or granules; heating and reacting the compacted mixture under controlled atmosphere to achieve temperatures greater than about 1800° C., at which temperature the NbO is liquid; solidifying the liquid NbO to form a body of material; and fragmenting the body to form NbO particles suitable for application as e.g., capacitor anodes. The NbO product is unusually pure in composition and crystallography, highly dense, and can be used for capacitors and for other electronic applications. The method of production of the NbO is robust, does not require high-purity feedstock, and can reclaim value from waste streams associated with the processing of NbO electronic components.

    Abstract translation: 本发明涉及通过组合高铌氧化物和铌金属粉末或颗粒的混合物的方法制备的高纯度一氧化铌粉末（NbO）; 在受控气氛下加热和使压实的混合物反应以达到高于约1800℃的温度，在该温度下NbO是液体; 固化液体NbO以形成材料体; 并且使体部分分裂以形成适用于例如电容器阳极的NbO颗粒。 NbO产品在组成和结晶学中非常纯净，高密度，可用于电容器和其他电子应用。 NbO的生产方法是坚固的，不需要高纯度原料，并且可以从与NbO电子部件的加工相关的废物流中回收价值。

    Method for in-furnace regulation of SO3 in catalytic systems
    38.
    发明申请
    Method for in-furnace regulation of SO3 in catalytic systems 有权
    催化体系中SO3炉内调节方法

    公开(公告)号：US20050180904A1

    公开(公告)日：2005-08-18

    申请号：US10798088

    申请日：2004-03-11

    Applicant: Brian Higgins

    Inventor： Brian Higgins

    IPC: B01D53/60

    CPC classification number: F23J15/02 ,  B01D53/8625 ,  B01D2258/0283 ,  F23C6/047 ,  F23J2215/20 ,  F23J2219/10

    Abstract: A method of controlling SO3 flue gas concentration in a combustion process utilizing a SCR using a sulfurous fuel, the method steps including: providing a combustion system with low NOx burners and SCR; partially combusting the fuel in a first stage to create a reducing environment; maintaining the reducing environment for a sufficient time period such that SO3 is reduced to SO2 to achieve a desirable level of SO3; combusting the remainder of the fuel and combustion intermediates in a second stage with oxidizing environment; reducing the remaining NOx with the SCR; thereby reducing emissions NOx.

    Abstract translation: 在利用含硫燃料的SCR的燃烧过程中控制SO 3 N 2气体浓度的方法，所述方法步骤包括：提供具有低NOx燃烧器和SCR的燃烧系统; 在第一阶段部分地燃烧燃料以产生还原环境; 将还原环境保持足够的时间以使SO 3还原成SO 2以达到理想的SO 3水平; 燃料和燃烧中间体的剩余部分在氧化环境的第二阶段燃烧; 用SCR减少剩余的NOx; 从而减少NOx排放。

    Production of high-purity niobium monoxide and capacitor production therefrom
    40.
    发明申请
    Production of high-purity niobium monoxide and capacitor production therefrom 审中-公开
    生产高纯度铌氧化物和电容器生产

    公开(公告)号：US20050002854A1

    公开(公告)日：2005-01-06

    申请号：US10834427

    申请日：2004-04-29

    Applicant: Charles Motchenbacher ,  James Robison ,  Brian Higgins ,  Thomas Fonville

    Inventor： Charles Motchenbacher ,  James Robison ,  Brian Higgins ,  Thomas Fonville

    IPC: C01G33/00 ,  H01G9/052

    CPC classification number: H01G9/0525 ,  C01G33/00 ,  C01P2002/72 ,  C01P2004/03 ,  C01P2004/51 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/17 ,  C01P2006/40 ,  C01P2006/80

    Abstract: The present invention relates to high-purity niobium monoxide powder (NbO) produced by a process of combining a mixture of higher niobium oxides and niobium metal powder or granules; heating and reacting the compacted mixture under controlled atmosphere to achieve temperature greater than about 1945° C., at which temperature the NbO is liquid; solidifying the liquid NbO to form a body of material; and fragmenting the body to form NbO particles suitable for application as capacitor anodes. The NbO product is unusually pure in composition and crystallography, and can be used for capacitors and for other electronic applications. The method of production of the NbO is robust, does not require high-purity feedstock, and can reclaim value from waste streams associated with the processing of NbO electronic components. The method of production also can be used to make high-purity NbO2 and mixtures of niobium metal/niobium monoxide and niobium monoxide/niobium dioxide. The method further is ideal for doping of the product oxides to enhance particular characteristics of the materials. The method further allows the production of single crystal or directionally-solidified ingots. In contrast to the spongy, highly porous agglomerates produced by other techniques, the present invention produces solid, non-porous ingots that can be fragmented to fine, non-porous angular particles suitable for electronic applications.

    Abstract translation: 本发明涉及通过组合高铌氧化物和铌金属粉末或颗粒的混合物的方法制备的高纯度一氧化铌粉末（NbO）; 在受控气氛下加热和反应压实的混合物以达到大于约1945℃的温度，在该温度下NbO是液体; 固化液体NbO以形成物体; 并破碎机体以形成适合用作电容器阳极的NbO颗粒。 NbO产品在组成和晶体学中非常纯净，可用于电容器和其他电子应用。 NbO的生产方法是坚固的，不需要高纯度原料，并且可以从与NbO电子部件的加工相关的废物流中回收价值。 生产方法也可用于制备高纯NbO2和铌金属/一氧化铌和一氧化铌/二氧化铌的混合物。 该方法进一步理想地用于掺杂产物氧化物以增强材料的特定特性。 该方法还允许生产单晶或定向固化的锭。 与通过其它技术生产的海绵状，高度多孔的聚集体相反，本发明产生固体，非多孔的锭，其可以碎裂成适合于电子应用的精细的非多孔角度颗粒。

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