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    Implantable stimulator that prevents DC current flow without the use of discrete output coupling capacitors
    32.
    发明授权
    Implantable stimulator that prevents DC current flow without the use of discrete output coupling capacitors 失效
    可植入式刺激器，可防止直流电流流动而不使用离散输出耦合电容

    公开(公告)号：US06035237A

    公开(公告)日：2000-03-07

    申请号：US447455

    申请日：1995-05-23

    申请人： Joseph H. Schulman ,  Alfred E. Mann ,  John C. Gord ,  Ronald J. Lebel

    发明人： Joseph H. Schulman ,  Alfred E. Mann ,  John C. Gord ,  Ronald J. Lebel

    IPC分类号： A61N1/08 ,  A61N1/32 ,  A61N1/36 ,  A61N1/16

    CPC分类号： A61N1/36142 ,  A61N1/36125

    摘要： An implantable living tissue stimulator avoids the use of conventional coupling capacitors in its output stage, yet still prevents an average dc current flow from flowing through living tissue in electrical contact with the stimulator. The output stage generates and applies a biphasic stimulating current pulse to selected paired output terminals. The terminals, in turn, are electrically connected to respective electrodes which are positioned so as to contact the living tissue to be stimulated. In one embodiment, special circuitry is employed within the output stage to block dc current flow through the living tissue and to balance the electrical charge that is delivered to the living tissue. In another embodiment, the electrodes themselves are made from a material that allows them to function as a capacitor. In yet an additional embodiment, the coupling capacitors are integrated into the leads that connect the output terminals of the output stage with the electrodes.

    摘要翻译： 植入式生物组织刺激器避免了在其输出阶段使用传统的耦合电容器，但仍然阻止平均直流电流流过活组织与刺激器电接触。 输出级产生并将双相刺激电流脉冲施加到选定的配对输出端子。 这些端子又电连接到相应的电极，这些电极定位成接触待刺激的生物体组织。 在一个实施例中，在输出级内采用特殊电路来阻止直流电流流过活组织并平衡输送到生物体组织的电荷。 在另一个实施例中，电极本身由允许它们用作电容器的材料制成。 在又一个实施例中，耦合电容器集成到将输出级的输出端与电极连接的引线中。

    Glucose sensor assembly
    33.
    发明授权
    Glucose sensor assembly 失效
    葡萄糖传感器组件

    公开(公告)号：US5660163A

    公开(公告)日：1997-08-26

    申请号：US444300

    申请日：1995-05-18

    申请人： Joseph H. Schulman ,  Orville Rey Rule, III ,  David I. Whitmoyer ,  Ronald J. Lebel ,  Joseph Y. Lucisano ,  Alfred E. Mann

    发明人： Joseph H. Schulman ,  Orville Rey Rule, III ,  David I. Whitmoyer ,  Ronald J. Lebel ,  Joseph Y. Lucisano ,  Alfred E. Mann

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14865 ,  A61B5/1495 ,  A61B5/6849 ,  A61B2562/08 ,  A61B5/742

    摘要： A glucose monitoring system continuously measures the glucose concentration in a patient's blood, provides an indication of the rate of change of such concentration, and determines whether the measured concentration and rate of change are within certain preset limits. If not, an audible and/or visual alarm signal is generated. The glucose monitoring system includes a glucose sensor adapted to be inserted into the venous system of the patient, where it responds to blood glucose and produces sensor signals related to the glucose concentration. The sensor signals are delivered through a suitable interconnect cable to a glucose monitor. In one embodiment, the interconnect cable includes a contactless connector that electrically isolates the glucose sensor from the monitor, and reduces the number of conductors required to interface with a plurality of sensors. The glucose monitor interprets the sensor signals by applying a previously determined calibration to quantitatively determine the blood glucose value. The blood glucose value thus determined is then processed in order to determine the rate of change, is stored (to create a history or record), and may also be displayed in large, easy-to-read numerals. Rate of change information (trend) may also be numerically or graphically displayed.

    摘要翻译： 葡萄糖监测系统连续测量患者血液中的葡萄糖浓度，提供这种浓度变化率的指示，并确定测量的浓度和变化率是否在某些预设限度内。 如果没有，则产生声音和/或视觉报警信号。 葡萄糖监测系统包括适于插入患者静脉系统中的葡萄糖传感器，其响应于血糖并产生与葡萄糖浓度相关的传感器信号。 传感器信号通过合适的互连电缆传送到葡萄糖监测器。 在一个实施例中，互连电缆包括非接触式连接器，其将葡萄糖传感器与监视器电隔离，并且减少与多个传感器接合所需的导体的数量。 葡萄糖监测器通过应用预先确定的校准来定量地确定血糖值来解释传感器信号。 然后处理如此确定的血糖值以确定变化率，存储（创建历史或记录），并且还可以以大的易于阅读的数字显示。 变化率信息（趋势）也可以数字或图形显示。

    Safety limits for closed-loop infusion pump control
    35.
    发明授权
    Safety limits for closed-loop infusion pump control 有权
    闭环输液泵控制的安全限值

    公开(公告)号：US08784370B2

    公开(公告)日：2014-07-22

    申请号：US13327603

    申请日：2011-12-15

    申请人： Ronald J. Lebel ,  Timothy Starkweather

    发明人： Ronald J. Lebel ,  Timothy Starkweather

    IPC分类号： A61M31/00

    CPC分类号： A61M5/1723 ,  A61M5/14276 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2205/52 ,  A61M2207/00 ,  A61M2230/005 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  Y10T29/49826

    摘要： A system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state. The safety limits may comprise user-initiated event signals corresponding to events that may significantly affect the biological state. The safety limits may further comprise user-initiated event ranking signals for respective events which specify a degree, quantity, or measure for the respective event. The user-initiated event and event ranking signals may be communicated to a computing element associated with the infusion pump by an associated communication device having a user interface which comprises a plurality of user-selectable operators for entering information about the events and event rankings.

    摘要翻译： 一种系统和方法，用于响应感测的生物学状态，通过输注泵系统提供输注制剂的安全限制。 安全限制可以包括对应于可能显着影响生物状态的事件的用户发起的事件信号。 安全限制可以进一步包括用于指定相应事件的度数，数量或度量的各个事件的用户发起的事件排序信号。 用户发起的事件和事件排序信号可以通过具有用户界面的相关联的通信设备传送到与输注泵相关联的计算元件，该用户界面包括用于输入关于事件和事件排名的信息的多个用户可选操作符。

    System and method for providing closed loop infusion formulation delivery
    37.
    发明授权
    System and method for providing closed loop infusion formulation delivery 有权
    用于提供闭环输注制剂递送的系统和方法

    公开(公告)号：US08152789B2

    公开(公告)日：2012-04-10

    申请号：US10850637

    申请日：2004-05-20

    申请人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

    发明人： Timothy J. Starkweather ,  Ronald J. Lebel ,  Rajiv Shah ,  Michael E. Miller

    IPC分类号： A61M31/00

    CPC分类号： A61M5/1723 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H50/30

    摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

    摘要翻译： 一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。 该算法计算具有比例，导数和基础速率分量的传送量。 可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。 交付量的安全限制可能包含在算法中。 该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。 生物状态由感测装置感测到，该感测装置向控制器提供信号。 所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

    Safety limits for closed-loop infusion pump control
    39.
    发明授权
    Safety limits for closed-loop infusion pump control 有权
    闭环输液泵控制的安全限值

    公开(公告)号：US07569030B2

    公开(公告)日：2009-08-04

    申请号：US10979980

    申请日：2004-11-03

    申请人： Ronald J. Lebel ,  Timothy Starkweather

    发明人： Ronald J. Lebel ,  Timothy Starkweather

    IPC分类号： A61M31/00

    CPC分类号： A61M5/1723 ,  A61M5/14276 ,  A61M5/172 ,  A61M2005/14208 ,  A61M2205/52 ,  A61M2207/00 ,  A61M2230/005 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  Y10T29/49826

    摘要： A system and process for providing safety limits on the delivery of an infusion formulation by an infusion pump system in response to a sensed biological state. The safety limits may comprise user-initiated event signals corresponding to events that may significantly affect the biological state. The safety limits may further comprise user-initiated event ranking signals for respective events which specify a degree, quantity, or measure for the respective event. The user-initiated event and event ranking signals may be communicated to a computing element associated with the infusion pump by an associated communication device having a user interface which comprises a plurality of user-selectable operators for entering information about the events and event rankings.

    摘要翻译： 一种系统和方法，用于响应感测的生物学状态，通过输注泵系统提供输注制剂的安全限制。 安全限制可以包括对应于可能显着影响生物状态的事件的用户发起的事件信号。 安全限制可以进一步包括用于指定相应事件的度数，数量或度量的各个事件的用户发起的事件排序信号。 用户发起的事件和事件排序信号可以通过具有用户界面的相关联的通信设备传送到与输注泵相关联的计算元件，该用户界面包括用于输入关于事件和事件排名的信息的多个用户可选操作符。