公开(公告)号：US10040834B2

公开(公告)日：2018-08-07

申请号：US14154134

申请日：2014-01-13

申请人： TUFTS UNIVERSITY

发明人： Fiorenzo Omenetto ,  David L. Kaplan ,  Brian Lawrence ,  Mark Cronin-Golomb

IPC分类号： G02B1/06 ,  G01N33/543 ,  C07K14/435 ,  B29C39/02 ,  B29D11/00 ,  G02B1/04 ,  G02B6/138 ,  D01F4/02 ,  G01N33/544 ,  B82Y20/00 ,  G02B6/12 ,  G02B1/00 ,  G02B5/18

CPC分类号： C07K14/43586 ,  B29C39/02 ,  B29D11/00663 ,  B29D11/0074 ,  B82Y20/00 ,  D01F4/02 ,  D10B2211/04 ,  D10B2401/20 ,  G01N33/5436 ,  G01N33/54373 ,  G01N33/54386 ,  G01N33/544 ,  G01N2333/43578 ,  G02B1/005 ,  G02B1/04 ,  G02B1/041 ,  G02B1/045 ,  G02B1/046 ,  G02B1/06 ,  G02B5/18 ,  G02B6/138 ,  G02B2006/12102 ,  G02B2006/12104 ,  G02B2006/12107 ,  G02B2006/1213 ,  G02B2006/12171

摘要： A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid.

公开(公告)号：US09925299B2

公开(公告)日：2018-03-27

申请号：US14437881

申请日：2013-10-28

申请人： TUFTS UNIVERSITY

发明人： David L. Kaplan ,  Tim Jia-Ching Lo ,  Stephanie McNamara

IPC分类号： A61K35/64 ,  A61L27/54 ,  A61L27/10 ,  A61L27/12 ,  A61L27/22 ,  A61L27/46 ,  A61L27/56 ,  A61L27/38

CPC分类号： A61L27/227 ,  A61L27/12 ,  A61L27/3821 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/412 ,  A61L2430/02 ,  C08L89/00

摘要： The disclosure provides ceramic materials comprising calcium phosphate material and silk and processes and methods for preparing and uses thereof.

公开(公告)号：US09603810B2

公开(公告)日：2017-03-28

申请号：US14265781

申请日：2014-04-30

申请人： Tufts University

发明人： Jason J. Amsden ,  David L. Kaplan ,  Fiorenzo G. Omenetto

IPC分类号： A61K41/00 ,  A61K47/42 ,  B82Y10/00 ,  A61K9/70 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/47 ,  G01N21/77 ,  G02B5/18 ,  G02B6/122 ,  G02B6/26 ,  G03F7/00 ,  G02B6/02

CPC分类号： A61K9/7007 ,  A61K9/70 ,  A61K41/00 ,  A61K47/42 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N21/4788 ,  G01N21/774 ,  G01N2021/7776 ,  G02B5/1809 ,  G02B5/1847 ,  G02B6/02061 ,  G02B6/1225 ,  G02B6/262 ,  G03F7/0002 ,  Y10T428/24479

摘要： The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass transition temperature of the silk film. Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices.

公开(公告)号：US09513405B2

公开(公告)日：2016-12-06

申请号：US14065369

申请日：2013-10-28

申请人： Tufts University

发明人： David L. Kaplan ,  Fiorenzo Omenetto ,  Brian Lawrence ,  Mark Cronin-Golomb

IPC分类号： G02B1/00 ,  B29D11/00 ,  B82Y20/00 ,  G02B6/122

CPC分类号： G02B1/005 ,  B29D11/00 ,  B82Y20/00 ,  G02B6/1225 ,  Y10T428/24273 ,  Y10T428/24355 ,  Y10T428/31678

摘要： A method of manufacturing a biopolymer photonic crystal includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with a nanopattern, or a nanopattern is machined on a surface of the film. In another embodiment, a plurality of biopolymer films is stacked together. A photonic crystal is also provided that is made of a biopolymer and has a nanopatterned surface. In another embodiment, the photonic crystal includes a plurality of nanopatterned films that are stacked together.

摘要翻译： 制备生物聚合物光子晶体的方法包括提供生物聚合物，处理生物聚合物以产生生物聚合物基质溶液，提供基材，将基质溶液浇铸在基材上，以及干燥生物聚合物基质溶液以形成固化的生物聚合物膜。 膜的表面形成有纳米图案，或者在膜的表面上加工纳米图案。 在另一个实施方案中，多个生物聚合物膜堆叠在一起。 还提供了由生物聚合物制成并具有纳米图案表面的光子晶体。 在另一个实施例中，光子晶体包括堆叠在一起的多个纳米图案化膜。

公开(公告)号：US20160046138A1

公开(公告)日：2016-02-18

申请号：US14776236

申请日：2014-03-14

申请人： TUFTS UNIVERSITY

发明人： Fiorenzo G. Omenetto ,  David L. Kaplan ,  Miaomiao Yang ,  Hu Tao ,  Benedetto Marelli ,  Sunghwan Kim

IPC分类号： B41M5/00

CPC分类号： B41M5/0047

摘要： The present invention provides compositions and methods for printing a predetermined pattern on silk fibroin materials using water based “inks.” Such technique may be useful for micro- and nano-engineering applications.

摘要翻译： 本发明提供使用水基“油墨”在丝素蛋白材料上印刷预定图案的组合物和方法。这种技术可用于微米和纳米工程应用。

公开(公告)号：US20150273021A1

公开(公告)日：2015-10-01

申请号：US14434022

申请日：2013-10-11

申请人： TUFTS UNIVERSITY

发明人： David L. Kaplan ,  Michael Lovett ,  Tuna Yucel ,  Xiaoqin Wang

IPC分类号： A61K38/26 ,  A61K47/42 ,  A61K9/06 ,  A61K9/00

CPC分类号： A61K38/26 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/747 ,  A61K38/2278 ,  A61K38/28 ,  A61K45/06 ,  A61K47/42

摘要： The present invention is directed to silk-based drug delivery compositions or compositions for sustained delivery of therapeutic agent(s), such as glucagon-like peptide (GLP-1) receptor agonists, as well as methods of making and using the same.

摘要翻译： 本发明涉及用于持续递送治疗剂的丝基药物递送组合物或组合物，例如胰高血糖素样肽（GLP-1）受体激动剂，以及制备和使用它们的方法。

公开(公告)号：US11009792B2

公开(公告)日：2021-05-18

申请号：US14776083

申请日：2014-03-14

申请人： TUFTS UNIVERSITY

发明人： Fiorenzo G. Omenetto ,  David L. Kaplan ,  Sunghwan Kim ,  Benedetto Marelli

IPC分类号： G03F7/039 ,  G03F7/20 ,  G03F7/16 ,  G03F7/32 ,  G03F7/038 ,  G03F7/00

摘要： The present application provides novel methods for the fabrication of nanostructures. More specifically, the invention relates to direct electron beam lithography with the use of silk fibroin as “green” resists.

公开(公告)号：US10758645B2

公开(公告)日：2020-09-01

申请号：US15536261

申请日：2015-12-17

申请人： Tufts University

发明人： Stephanie L. McNamara ,  Benjamin P. Partlow ,  David L. Kaplan

IPC分类号： A61L27/46 ,  A61L27/38 ,  A61L27/22 ,  A61L27/56 ,  C07K14/435

摘要： The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are compositions and methods of producing soft, flexible ceramic foam with silk polymeric crosslinking to serve as binders. Materials have applications in osteochondral and dental replacement and repair.

公开(公告)号：US20190085140A1

公开(公告)日：2019-03-21

申请号：US15905274

申请日：2018-02-26

申请人： Tufts University

发明人： Fiorenzo G. Omenetto ,  David L. Kaplan ,  Mark A. Brenckle

IPC分类号： C08J5/18 ,  C08L89/00 ,  B41C1/10 ,  G03F7/00 ,  B82Y40/00

摘要： Protein-protein imprinting of silk fibroin is introduced as a rapid, high-fidelity, and/or high-throughput method for the fabrication of nanoscale structures in silk films, through controlled manipulation of heat and/or pressure. High resolution imprinting on conformal surfaces is also demonstrated.

公开(公告)号：US20190001272A1

公开(公告)日：2019-01-03

申请号：US16063485

申请日：2016-12-16

申请人： TUFTS UNIVERSITY

发明人： Gary G. Leisk ,  David L. Kaplan ,  Benjamin P. Partlow ,  Tim Jia-Ching Lo

IPC分类号： B01D61/24 ,  B01D61/28 ,  B01D61/58 ,  B01D63/06 ,  B01D61/32 ,  B01D71/10 ,  C07K14/435

摘要： The present disclosure provides, among other things, systems for processing silk. Provided systems purify silk fibroin solutions without inducing conformational changes in the silk proteins. Provided systems concentrate silk fibroin solutions. The present disclosure also provides methods of purifying and concentrating silk fibroin solutions. Provided systems and methods are useful for processing silk fibroin for any application.