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49 条记录 (耗时 0.078 秒)

    Cathepsin cysteine protease inhibitors
    33.
    发明申请
    Cathepsin cysteine protease inhibitors 审中-公开
    组织蛋白酶半胱氨酸蛋白酶抑制剂

    公开(公告)号：US20090176859A1

    公开(公告)日：2009-07-09

    申请号：US10585147

    申请日：2005-01-06

    申请人： Christopher Bayly ,  Cameron Black ,  Michel Therien

    发明人： Christopher Bayly ,  Cameron Black ,  Michel Therien

    IPC分类号： A61K31/4015 ,  C07D307/32 ,  A61K31/341 ,  C07D207/24 ,  A61P3/06

    CPC分类号： C07D401/04 ,  C07D207/24 ,  C07D211/74 ,  C07D213/56 ,  C07D223/08 ,  C07D307/32 ,  C07D309/30 ,  C07D401/06 ,  C07D401/12 ,  C07D413/06

    摘要： The present invention relates to a novel class of compounds mainly, leucinamide-amino-carboxylate derivatives of formula (I) wherein Y is CR1R2, O, S, —SO2, C=0 or NR9; Z is CR1R2, O, S, —SO2, C═O or NR9 and each G is independently a CR1CR2. Said compounds are cathepsin cysteine protease inhibitors, including but not limited to, inhibitors of cathepsin K, L, S and B and to pharmaceutical compositions thereof. These compounds are useful for treating and preventing cathepsin dependent conditions in which inhibition of bone resorption is indicated, such as osteoporosis.

    摘要翻译： 本发明涉及一类新的化合物，主要是其中Y为CR 1 R 2，O，S，-SO 2，C = O或NR 9的式（I）的亮氨酰胺 - 氨基 - 羧酸酯衍生物; Z是CR 1 R 2，O，S，-SO 2，C-O或NR 9，每个G独立地是CR 1 CR 2。 所述化合物是组织蛋白酶半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂及其药物组合物。 这些化合物可用于治疗和预防指示骨吸收抑制的组织蛋白酶依赖性条件，例如骨质疏松症。

    Apparatus and Method for Measuring Deflection of a Printed Circuit Board
    39.
    发明申请
    Apparatus and Method for Measuring Deflection of a Printed Circuit Board 审中-公开
    用于测量印刷电路板的偏转的装置和方法

    公开(公告)号：US20100131236A1

    公开(公告)日：2010-05-27

    申请号：US12083148

    申请日：2006-10-05

    申请人： Francois Lafleur ,  Michel Therien

    发明人： Francois Lafleur ,  Michel Therien

    IPC分类号： G06F15/00 ,  G01B11/14 ,  G01B7/14 ,  G01M7/00

    CPC分类号： G01N3/20 ,  G01N2203/0023 ,  G01N2203/0278 ,  G01N2203/0623 ,  G01R31/2817

    摘要： Deflection measuring apparatus and methods are used to prevent overstress of printed circuit boards (PCB) prior and during testing. They can be used to verify in a HALT, HASS of ESS testing protocol, if the PCB testing fixture and vibration testing setup would be likely to cause failure of PCB components during pre- testing and testing procedures, which failure would otherwise not occur with faultless components. Furthermore, In the context of a PCB to be integrated to a system as a product such as a computer, the deflection measuring apparatus and methods are used to prevent overstress of PCBs at the system assembly stage, to ensure that operations involved, such as plugging of PCB connectors, will not cause PCB components failure, which would otherwise not occur with faultless components.

    摘要翻译： 偏转测量装置和方法用于在测试之前和测试期间防止印刷电路板（PCB）的过应力。 如果PCB测试夹具和振动测试设置在预测试和测试过程中可能会导致PCB组件的故障，那么它们可以用于HALT，HASS的ESS测试协议中进行验证，否则无故障地发生故障 组件。 此外，在要作为诸如计算机的产品集成到系统的PCB的上下文中，使用偏转测量装置和方法来防止在系统组装阶段对PCB的过应力，以确保所涉及的操作，例如堵塞 的PCB连接器，不会导致PCB组件故障，否则不会发生无故障组件。