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    Medical device for modification of left atrial appendage and related systems and methods
    32.
    发明授权
    Medical device for modification of left atrial appendage and related systems and methods 有权
    用于修改左心耳和相关系统和方法的医疗装置

    公开(公告)号：US08636764B2

    公开(公告)日：2014-01-28

    申请号：US12818046

    申请日：2010-06-17

    申请人： Scott D. Miles ,  Clark C. Davis ,  Daryl R. Edmiston ,  Richard J. Linder

    发明人： Scott D. Miles ,  Clark C. Davis ,  Daryl R. Edmiston ,  Richard J. Linder

    IPC分类号： A61B17/08 ,  A61M29/00

    CPC分类号： A61B17/12122 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/00309 ,  A61B2017/00327 ,  A61B2017/00575 ,  A61B2017/0069 ,  A61B2017/12054

    摘要： Devices, methods and systems are provided for occluding an opening within the tissue of a body, such as a left atrial appendage. In one embodiment, a system for use in occluding an opening in the tissue of a body includes a handle, a catheter coupled with the handle and a medical device disposed within a lumen of the catheter. The medical device includes an anchor system having a plurality of anchor segments coupled with an anchor hub. The medical device further includes an occluder system having a plurality of occluder segments coupled with an occluder hub. A first actuator is configured to displace the occluder hub independent of, and relative to, the anchor hub to deploy the occluder system from a refracted state to an expanded state while the anchor system remains in a retracted state.

    摘要翻译： 提供装置，方法和系统用于阻塞身体的组织内的开口，例如左心耳。 在一个实施例中，用于阻塞身体组织中的开口的系统包括手柄，与手柄耦合的导管和设置在导管内腔内的医疗装置。 该医疗装置包括具有与锚定毂联接的多个锚定段的锚定系统。 该医疗装置还包括一封闭器系统，其具有多个与阻塞器毂联接的封堵器段。 第一致动器构造成独立于锚定毂并且相对于锚定毂移位封闭器毂，以在锚定系统保持处于缩回状态的同时将封堵器系统从折射状态展开到展开状态。

    Compliant Electrode for Patent Foramen Ovale Closure Device
    34.
    发明申请
    Compliant Electrode for Patent Foramen Ovale Closure Device 失效
    专利孔封闭装置的电极

    公开(公告)号：US20080215085A1

    公开(公告)日：2008-09-04

    申请号：US11534953

    申请日：2006-09-25

    申请人： Brian K. Whisenant ,  Clark C. Davis ,  Daryl R. Edmiston

    发明人： Brian K. Whisenant ,  Clark C. Davis ,  Daryl R. Edmiston

    IPC分类号： A61B17/03

    CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/0063 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2090/3966 ,  C08L2201/12

    摘要： A medical device for use in delivering RF energy to a tissue opening is disclosed. In one embodiment, the medical device comprises a compliant electrode. The compliant electrode can include a shape memory material, such as NITINOL, to facilitate the electrode having at least one relaxed orientation. The electrode can be deployed from a delivery shaft inside the left atrium, for example, of a heart through the delivery shaft. The electrode can be configured to substantially conform to the tissue proximate the tissue opening. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.

    摘要翻译： 公开了一种用于向组织开口输送RF能量的医疗装置。 在一个实施例中，医疗装置包括顺应性电极。 柔性电极可以包括诸如NITINOL的形状记忆材料，以便于具有至少一个松弛取向的电极。 电极可以从左心房内的输送轴，例如通过输送轴的心脏部署。 电极可以构造成基本上符合组织开口附近的组织。 在将能量施加到左右电极之间的组织之后，左电极可以通过被收回到输送轴中而从左心房移除，此后从开口移除输送轴。

    Compliant electrode for patent foramen ovale closure device
    35.
    发明授权
    Compliant electrode for patent foramen ovale closure device 失效
    用于卵圆孔闭合装置的电极

    公开(公告)号：US07799023B2

    公开(公告)日：2010-09-21

    申请号：US11534953

    申请日：2006-09-25

    申请人： Brian K. Whisenant ,  Clark C. Davis ,  Daryl R. Edmiston

    发明人： Brian K. Whisenant ,  Clark C. Davis ,  Daryl R. Edmiston

    IPC分类号： A61B18/18

    CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/0063 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2090/3966 ,  C08L2201/12

    摘要： A medical device for use in delivering RF energy to a tissue opening is disclosed. In one embodiment, the medical device comprises a compliant electrode. The compliant electrode can include a shape memory material, such as NITINOL, to facilitate the electrode having at least one relaxed orientation. The electrode can be deployed from a delivery shaft inside the left atrium, for example, of a heart through the delivery shaft. The electrode can be configured to substantially conform to the tissue proximate the tissue opening. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.

    摘要翻译： 公开了一种用于向组织开口输送RF能量的医疗装置。 在一个实施例中，医疗装置包括顺应性电极。 顺应性电极可以包括诸如NITINOL的形状记忆材料，以便于具有至少一个松弛取向的电极。 电极可以从左心房内的输送轴，例如通过输送轴的心脏部署。 电极可以构造成基本上符合组织开口附近的组织。 在将能量施加到左右电极之间的组织之后，左电极可以通过被收回到输送轴中而从左心房移除，此后从开口排出输送轴。

    COMPLIANT ELECTRODE FOR PATENT FORAMEN OVALE CLOSURE DEVICE
    36.
    发明申请
    COMPLIANT ELECTRODE FOR PATENT FORAMEN OVALE CLOSURE DEVICE 审中-公开
    专用型烤箱封闭装置的合适电极

    公开(公告)号：US20110093037A1

    公开(公告)日：2011-04-21

    申请号：US12885287

    申请日：2010-09-17

    申请人： Brian K. Whisenant ,  Clark C. Davis ,  Daryl R. Edmiston

    发明人： Brian K. Whisenant ,  Clark C. Davis ,  Daryl R. Edmiston

    IPC分类号： A61N1/05

    CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/0063 ,  A61B2018/1435 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2090/3966 ,  C08L2201/12

    摘要： A medical device for use in delivering RF energy to a tissue opening is disclosed. In one embodiment, the medical device comprises a compliant electrode. The compliant electrode can include a shape memory material, such as NITINOL, to facilitate the electrode having at least one relaxed orientation. The electrode can be deployed from a delivery shaft inside the left atrium, for example, of a heart through the delivery shaft. The electrode can be configured to substantially conform to the tissue proximate the tissue opening. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.

    摘要翻译： 公开了一种用于向组织开口输送RF能量的医疗装置。 在一个实施例中，医疗装置包括顺应性电极。 柔性电极可以包括诸如NITINOL的形状记忆材料，以便于具有至少一个松弛取向的电极。 电极可以从左心房内的输送轴，例如通过输送轴的心脏部署。 电极可以构造成基本上符合组织开口附近的组织。 在将能量施加到左右电极之间的组织之后，左电极可以通过被收回到输送轴中而从左心房移除，此后从开口排出输送轴。

    MEDICAL DEVICE FOR PERCUTANEOUS PARAVALVULAR LEAK AND RELATED SYSTEMS AND METHODS
    39.
    发明申请
    MEDICAL DEVICE FOR PERCUTANEOUS PARAVALVULAR LEAK AND RELATED SYSTEMS AND METHODS 审中-公开
    用于经常性旁路淋巴结的医疗装置及相关系统和方法

    公开(公告)号：US20090112311A1

    公开(公告)日：2009-04-30

    申请号：US12253882

    申请日：2008-10-17

    申请人： Scott D. Miles ,  Clark C. Davis ,  Richard J. Linder

    发明人： Scott D. Miles ,  Clark C. Davis ,  Richard J. Linder

    IPC分类号： A61F2/24

    CPC分类号： A61F2/24 ,  A61F2/2409 ,  A61F2/2445 ,  A61F2250/0069

    摘要： The present invention provides devices, systems and methods for closing a paravalvular leak. In accordance with one embodiment, a medical device includes at least one multicellular frame member configured to be implanted at a paravalvular leak. The medical device further includes at least one tissue in-growth member associated with the frame member, the tissue in-growth member being configured to promote tissue growth and permanently maintain the frame member at the leak. The frame member may be self expanding device formed, for example, of a shape-memory alloy. The tissue in-growth member may be formed from a polymer material. In one particular embodiment, the frame member may be a substantially tubular structure and the tissue in-growth member may be disposed within an interior space defined by the tubular structure. In another embodiment, the frame ember may be a substantially flat or planar structure.

    摘要翻译： 本发明提供了用于闭合瓣膜泄漏的装置，系统和方法。 根据一个实施例，医疗装置包括至少一个多细胞框架构件，其被配置为以瓣间泄漏植入。 医疗装置还包括与框架构件相关联的至少一个组织生长构件，所述组织生长构件被构造成促进组织生长并将框架构件永久地保持在泄漏处。 框架构件可以是例如由形状记忆合金形成的自扩张装置。 组织生长部件可以由聚合物材料形成。 在一个具体实施例中，框架构件可以是基本上管状的结构，并且组织生长构件可以设置在由管状结构限定的内部空间内。 在另一个实施例中，框架余烬可以是基本平坦或平面的结构。

    Patent foramen ovale closure device and methods for determining RF dose for patent foramen ovale closure
    40.
    发明授权
    Patent foramen ovale closure device and methods for determining RF dose for patent foramen ovale closure 有权
    卵圆孔闭合装置的专利和用于确定卵圆孔闭合专利的RF剂量的方法

    公开(公告)号：US08221405B2

    公开(公告)日：2012-07-17

    申请号：US11671428

    申请日：2007-02-05

    申请人： Brian K. Whisenant ,  Clark C. Davis ,  Scott Miles ,  Richard Linder ,  Daryl Edmiston

    发明人： Brian K. Whisenant ,  Clark C. Davis ,  Scott Miles ,  Richard Linder ,  Daryl Edmiston

    IPC分类号： A61B18/18

    CPC分类号： A61B5/053

    摘要： A medical system and device for use in delivering RF energy to a tissue opening and a method for determining an RF dose is disclosed. In one embodiment, the medical device includes an electrode or anchor and one or more devices, such as an impedance electrode, RF electrode and/or thermocouple. The electrode or anchor can be deployed from a delivery shaft inside the left atrium, for example, of a heart and substantially conform to the tissue proximate the tissue opening. Tissue characteristics, such as temperature and/or impedance, can be measured, before, during and after application of RF energy to the tissue, by one or more devices to determine an RF dose. After energy is applied to the tissue between the left and right electrodes, the left electrode can be removed from the left atrium by being received back into the delivery shaft and the delivery shaft thereafter removed from the opening.

    摘要翻译： 公开了一种用于将RF能量递送到组织开口的医疗系统和装置以及用于确定RF剂量的方法。 在一个实施例中，医疗装置包括电极或锚定器以及一个或多个装置，例如阻抗电极，RF电极和/或热电偶。 电极或锚固件可以从左心房内的输送轴例如心脏展开，并且基本上符合组织开口附近的组织。 组织特征如温度和/或阻抗可以在RF能量施加到组织之前，期间和之后由一个或多个装置测量以确定RF剂量。 在将能量施加到左右电极之间的组织之后，左电极可以通过被收回到输送轴中而从左心房移除，此后从开口移除输送轴。