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公开(公告)号:US20070154910A1
公开(公告)日:2007-07-05
申请号:US11565909
申请日:2006-12-01
申请人: Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
发明人: Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
CPC分类号: C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further re lates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20050208622A1
公开(公告)日:2005-09-22
申请号:US10970493
申请日:2004-10-22
申请人: Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
发明人: Paul Moore , Steven Ruben , David LaFleur , Yanggu Shi , Craig Rosen , Henrik Olsen , Reinhard Ebner , Laurie Brewer
CPC分类号: C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US07091315B1
公开(公告)日:2006-08-15
申请号:US10103295
申请日:2002-03-22
申请人: Steven M. Ruben , Craig A. Rosen , Henrik Olsen
发明人: Steven M. Ruben , Craig A. Rosen , Henrik Olsen
CPC分类号: C07K14/47 , A61K38/00 , C07K2319/30
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20050214786A1
公开(公告)日:2005-09-29
申请号:US10921235
申请日:2004-08-19
申请人: Charles Birse , George Komatsoulis , Gil Choi , Henrik Olsen , Jian Ni , Kevin Baker , Craig Rosen , Steven Ruben , Michele Fiscella , Paul Moore , Ping Wei
发明人: Charles Birse , George Komatsoulis , Gil Choi , Henrik Olsen , Jian Ni , Kevin Baker , Craig Rosen , Steven Ruben , Michele Fiscella , Paul Moore , Ping Wei
CPC分类号: C07H21/04 , C07K14/47 , C12Q1/6883
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US20050042667A1
公开(公告)日:2005-02-24
申请号:US10935098
申请日:2004-09-08
申请人: David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
发明人: David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
IPC分类号: C12N15/09 , A61K31/711 , A61K38/00 , A61K39/395 , A61K48/00 , A61P5/00 , A61P7/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/18 , A61P35/00 , A61P35/02 , A61P37/00 , C07K14/435 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/21 , C12N5/10 , C12Q1/68 , C07H21/04 , C12N9/00
摘要: The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及36种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US20060057582A1
公开(公告)日:2006-03-16
申请号:US10644807
申请日:2003-08-21
申请人: Craig Rosen , George Komatsoulis , Charles Birse , Gil Choi , Henrik Olsen , Jian Ni , Adam Bell
发明人: Craig Rosen , George Komatsoulis , Charles Birse , Gil Choi , Henrik Olsen , Jian Ni , Adam Bell
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号:US20080020969A1
公开(公告)日:2008-01-24
申请号:US11780874
申请日:2007-07-20
申请人: David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
发明人: David LaFleur , Daniel Soppet , Henrik Olsen , Steven Ruben , Jian Ni , Craig Rosen , Laurie Brewer , Roxanne Duan , Reinhard Ebner
IPC分类号: A61K38/00 , A61K48/00 , C07H21/00 , C07K14/00 , C12N15/00 , C12N15/87 , C12N5/06 , C12P21/04 , G01N33/53
摘要: The present invention relates to 36 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译: 本发明涉及36种新型人分泌蛋白和含有编码这种蛋白质的基因的编码区的分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号:US20060099622A1
公开(公告)日:2006-05-11
申请号:US11246999
申请日:2005-10-11
申请人: Jian Ni , Paul Young , Joseph Kenny , Henrik Olsen , Paul Moore , Ying-Fei Wei , John Greene , Steven Ruben , Ding Liu , Paul Crocker
发明人: Jian Ni , Paul Young , Joseph Kenny , Henrik Olsen , Paul Moore , Ying-Fei Wei , John Greene , Steven Ruben , Ding Liu , Paul Crocker
CPC分类号: C12Q1/6883 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C07K14/70546 , C12N9/6424 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要: The present invention relates to 12 novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号:US5922572A
公开(公告)日:1999-07-13
申请号:US187186
申请日:1994-01-25
申请人: Craig A. Rosen , Henrik Olsen , Mark D. Adams , Ewen Kirkness
发明人: Craig A. Rosen , Henrik Olsen , Mark D. Adams , Ewen Kirkness
IPC分类号: C12N15/09 , A61K38/00 , A61K38/22 , A61K39/395 , A61K48/00 , A61P7/00 , A61P7/06 , A61P25/00 , A61P35/02 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/475 , C07K16/18 , C12N1/21 , C12N5/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C12N15/12
CPC分类号: C07K14/475 , A61K38/00
摘要: Disclosed is a human maturation factor polypeptide and DNA(RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases related to the underexpression of such human haemopoietic maturation factor polypeptide.
摘要翻译: 公开了编码这种造血成熟因子多肽的人成熟因子多肽和DNA(RNA)。 还提供了通过重组技术和针对这种多肽的抗体产生这种多肽的方法。 这样的多肽可以与合适的药物载体或稀释剂组合以提供针对与这种人造血成熟因子多肽的低表达相关的各种疾病的诊断,治疗和/或预防效果。
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公开(公告)号:US06790826B2
公开(公告)日:2004-09-14
申请号:US10004832
申请日:2001-12-07
申请人: Ewen F. Kirkness , Mark D. Adams , Henrik Olsen , Craig A. Rosen
发明人: Ewen F. Kirkness , Mark D. Adams , Henrik Olsen , Craig A. Rosen
IPC分类号: A61K3816
CPC分类号: C07K14/475 , A61K38/00
摘要: Disclosed are human haemopoietic maturation factor polypeptides and DNA (RNA) encoding such haemopoietic maturation factor polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and for using such polypeptides for treating leukemia, auto-immune diseases and blood related disorders. Antagonists against such polypeptides and their use as a therapeutic to prevent expansion of T-cell populations are also disclosed. Diagnostic assays are also disclosed to detect both the presence of mutations in the haemopoietic maturation factor nucleic acid sequences and altered levels of the protein.
摘要翻译: 公开了人类造血成熟因子多肽和编码这种造血成熟因子多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法,并且使用这些多肽来治疗白血病,自身免疫疾病和与血液相关的疾病。 还公开了抗这些多肽的拮抗剂及其作为治疗剂用于预防T细胞群扩增的用途。 还公开了诊断测定以检测造血成熟因子核酸序列中突变的存在和蛋白质的改变的水平。
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