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39 条记录 (耗时 0.056 秒)

    Faims apparatus and method using carrier gases that contain a trace amount of a dopant species
    31.
    发明申请
    Faims apparatus and method using carrier gases that contain a trace amount of a dopant species 有权
    Faims装置和方法，其使用含有微量掺杂物质的载气

    公开(公告)号：US20050161596A1

    公开(公告)日：2005-07-28

    申请号：US10503713

    申请日：2003-02-07

    申请人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Barbara Ells

    发明人： Roger Guevremont ,  Randy Purves ,  David Barnett ,  Barbara Ells

    IPC分类号： G01N27/64 ,  H01J49/04 ,  H01J49/28

    CPC分类号： G01N27/624 ,  H01J49/04

    摘要： Disclosed is a method and apparatus for improving at least one of a peak separation and a signal intensity relating to an ion of interest being transmitted through an analyzer region of a FAIMS apparatus. A method according to the instant invention includes a step of introducing ions including an ion of interest into an analyzer region of a FAIMS. A flow of a doped carrier gas other than air is also provided through the analyzer region. The doped carrier gas includes a carrier gas and a trace amount of a predetermined dopant gas, the predetermined dopant gas selected for improving at least one of a peak separation and a signal intensity relating to the ion of interest relative to the peak separation and the signal intensity relating to the ion of interest in the presence of the carrier gas only. The ion of interest is selectively transmitted through the analyzer region in the presence of the doped carrier gas, and detected at a detector.

    摘要翻译： 公开了一种用于改善通过FAIMS装置的分析器区域传输的与感兴趣的离子相关的峰值分离和信号强度中的至少一个的方法和装置。 根据本发明的方法包括将包含感兴趣的离子的离子引入到FAIMS的分析器区域中的步骤。 除了空气之外的掺杂载气的流动也通过分析器区域提供。 掺杂的载气包括载气和痕量的预定掺杂气体，所选择的预定掺杂剂气体相对于峰值分离和信号来改善峰值分离和与感兴趣的离子相关的信号强度中的至少一个 仅在载气存在下与感兴趣的离子有关的强度。 感兴趣的离子在掺杂的载气的存在下选择性地透过分析器区域，并在检测器处检测。

    Method for separation and enrichment of isotopes in gaseous phase
    33.
    发明授权
    Method for separation and enrichment of isotopes in gaseous phase 失效
    在气相中分离和富集同位素的方法

    公开(公告)号：US06831271B1

    公开(公告)日：2004-12-14

    申请号：US09762238

    申请日：2001-05-09

    申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

    发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

    IPC分类号： H01J4940

    CPC分类号： G01N27/624 ,  B01D59/46 ,  B01D59/48 ,  H01J49/004 ,  H01J49/044

    摘要： The present invention relates to a method for separating and enriching stable isotopes in gas phase using the principles of high field asymmetric waveform ion mobility spectrometry, substantially at atmospheric pressure (760 torr) and substantially at room temperature (298 K). Specifically, the method of the present invention may be used to separate and enrich isotopes of chlorine. Electrospray ionization may be used to generate a gaseous mixture of ions and the ion beam exiting the high field asymmetric waveform ion mobility spectrometer may be sampled into a mass spectrometer for isotope identification.

    摘要翻译： 本发明涉及一种基于大气压（760乇）和基本上在室温（298K）的高场非对称波形离子淌度光谱法的原理分离和富集气相中稳定同位素的方法。 具体地说，本发明的方法可用于分离和富集氯的同位素。 可以使用电喷雾离子化来产生离子的气体混合物，离开高场非对称波形离子迁移谱仪的离子束可以被采样到用于同位素鉴定的质谱仪中。

    FAIMS apparatus and method using carrier gas of mixed composition
    35.
    发明授权
    FAIMS apparatus and method using carrier gas of mixed composition 有权
    FAIMS装置和方法采用载气混合组成

    公开(公告)号：US06774360B2

    公开(公告)日：2004-08-10

    申请号：US10220604

    申请日：2002-09-03

    申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

    发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

    IPC分类号： H01J4940

    CPC分类号： H01J49/004 ,  G01N27/624

    摘要： A method and an apparatus is disclosed for selectively transmitting ions with a FAIMS analyzer in which a flow of carrier gas of a mixed composition is provided. Ions that are transmitted at a same combination of applied potentials when a first carrier gas is provided are in certain cases transmitted at different combinations of applied potentials when a second other carrier gas having a different composition is provided.

    摘要翻译： 公开了一种利用FAIMS分析仪选择性地传输离子的方法和装置，其中提供了混合组合物的载气流。 当提供第一载气时，以相同的施加电位组合传输的离子在某些情况下以不同的施加电位组合传输，当提供具有不同组成的第二其它载气时。

    FAIMS apparatus and method with laser-based ionization source
    36.
    发明授权
    FAIMS apparatus and method with laser-based ionization source 有权
    FAIMS仪器和方法与激光电离源

    公开(公告)号：US06653627B2

    公开(公告)日：2003-11-25

    申请号：US10220602

    申请日：2002-09-03

    申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

    发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

    IPC分类号： H01J4940

    CPC分类号： H01J49/004 ,  G01N27/624

    摘要： Generally, the present invention provides a device for heating the sample stream inlet of an ion mobility spectrometry (IMS) sensor. The heating device increases the temperature of the sample stream inlet surface to reduce the amount of time between adsorption and desorption taking place on the surface. This greatly improves the ability of the IMS sensor to follow rapidly changing analyte concentration levels. An alternate preferred embodiment of the present invention provides a flow smoothing device for decreasing the turbulence present in the fluid flow entering the IMS sensor's carrier stream inlet. This flow smoothing insert permits increasing the fluid flow rate entering the IMS sensor's carrier stream inlet to levels which maximize the IMS sensor's measurement sensitivity without causing mixing of the sample and carrier fluid stream flows.

    摘要翻译： 通常，本发明提供了用于加热离子迁移谱（IMS）传感器的样品流入口的装置。 加热装置增加了样品流入口表面的温度，以减少在表面上发生的吸附和解吸时间。 这大大提高了IMS传感器跟随快速变化的分析物浓度水平的能力。 本发明的替代优选实施例提供一种用于减少流入IMS传感器的载体流入口的流体流中存在的湍流的流动平滑装置。 这种流动平滑插入件允许将进入IMS传感器的载体流入口的流体流速增加到使得传感器的测量灵敏度最大化的水平，而不引起样品和载体流体流流的混合。

    Specimen collection fluid
    37.
    发明授权
    Specimen collection fluid 失效
    标本采集液

    公开(公告)号：US06579672B1

    公开(公告)日：2003-06-17

    申请号：US09194333

    申请日：1999-04-26

    申请人： Vivian Granger ,  David Barnett

    发明人： Vivian Granger ,  David Barnett

    IPC分类号： A01N102

    CPC分类号： G01N33/5094 ,  G01N33/50 ,  Y10T436/101666

    摘要： A sterile aqueous specimen collection fluid containing a buffer, an aliphatic aldehyde at a concentration of 0.15M to 3.4M, and one or more heavy metal salts at a concentration of 0.2×10−3M to 0.2M, and having a pH of 6.8 to 8.0. Also disclosed is a method of colleting a specimen with such a fluid for haematological analysis.

    摘要翻译： 含有缓冲液，浓度为0.15M至3.4M的脂族醛和一种或多种浓度为0.2×10-3M至0.2M的重金属盐，pH为6.8至8.0的无菌水样本收集液 。 还公开了一种使用这种用于血液学分析的流体的样本的收集方法。

    Preparation and stabilization of cells using aged transition metal solutions
    38.
    发明授权
    Preparation and stabilization of cells using aged transition metal solutions 失效
    使用老化的过渡金属溶液制备和稳定细胞

    公开(公告)号：US06197540B1

    公开(公告)日：2001-03-06

    申请号：US08578591

    申请日：1996-06-21

    申请人： Vivian Granger ,  David Barnett ,  John T. Reilly ,  Petra S. M. Mayr ,  Shawn P. Fay

    发明人： Vivian Granger ,  David Barnett ,  John T. Reilly ,  Petra S. M. Mayr ,  Shawn P. Fay

    IPC分类号： A61K944

    CPC分类号： G01N33/50 ,  G01N33/5002 ,  G01N33/5094 ,  G01N33/56972 ,  G01N33/56977 ,  G01N33/96 ,  G01N2496/05 ,  Y10T436/101666

    摘要： The invention is directed to novel stabilized blood compositions and methods of stabilizing blood compositions for use in the quality control of analytical techniques. The novel blood compositions comprise leucocytes and an effective amount of an aged transition metal solution. The novel method comprises removing leucocytes from a blood composition to yield a depleted blood composition, stabilizing the leucocytes by treatment with an effective amount of a stabilizing agent comprising an aged transition metal solution, and then, adding the resultant stabilized leucocytes to the depleted blood composition or a second blood component composition.

    摘要翻译： 本发明涉及新颖的稳定血液组合物和稳定血液组合物的方法，用于分析技术的质量控制。 新型血液组合物包含白细胞和有效量的老化过渡金属溶液。 该新方法包括从血液组合物中除去白细胞以产生耗尽的血液组合物，通过用有效量的包含老化过渡金属溶液的稳定剂进行处理来稳定白细胞，然后将所得稳定的白细胞加入贫血血液组合物 或第二血液成分组合物。