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42 条记录 (耗时 0.031 秒)

    Bone Graft
    32.
    发明申请
    Bone Graft 有权
    骨移植

    公开(公告)号：US20080145392A1

    公开(公告)日：2008-06-19

    申请号：US11622955

    申请日：2007-01-12

    申请人： David Knaack ,  Kathy Traianedes ,  Michele Diegman ,  Nanette Forsyth ,  John Winterbottom

    发明人： David Knaack ,  Kathy Traianedes ,  Michele Diegman ,  Nanette Forsyth ,  John Winterbottom

    IPC分类号： A61F2/28 ,  A61K35/32 ,  A61P19/00

    CPC分类号： A61F2/28 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30677 ,  A61L27/227 ,  A61L27/3608 ,  A61L27/3633 ,  A61L27/365 ,  A61L27/505 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/602 ,  A61L2300/802 ,  A61L2430/02 ,  B33Y80/00

    摘要： An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-.beta., BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions

    摘要翻译： 提供了与稳定剂混合的改进的脱矿质骨基质（DBM）或其它基质组合物，其作为（1）扩散阻挡层，（2）酶抑制剂，（3）竞争性底物，或（4） 掩蔽部分。 扩散屏障作为屏障，以保护DBM中发现的骨诱导因子不被植入部位的蛋白水解酶和糖酵解酶降解。 稳定剂可以是任何可生物降解的材料，例如淀粉，改性淀粉，纤维素，葡聚糖，聚合物，蛋白质和胶原蛋白。 当稳定剂在体内降解或溶解时，骨诱导因子如TGF-β，BMP和IGF被活化或暴露，并且活化因子用于将细胞从血管内空间募集到损伤部位并导致 分化成骨形成细胞。 本发明还提供了制备，测试和使用本发明改进的骨吸收性基质组合物的方法

    Bone graft
    33.
    发明授权
    Bone graft 有权
    骨移植

    公开(公告)号：US07163691B2

    公开(公告)日：2007-01-16

    申请号：US10271140

    申请日：2002-10-15

    申请人： David Knaack ,  Kathy Traianedes ,  Michele Diegman ,  Nanette Forsyth ,  John Winterbottom

    发明人： David Knaack ,  Kathy Traianedes ,  Michele Diegman ,  Nanette Forsyth ,  John Winterbottom

    IPC分类号： A61F2/28

    CPC分类号： A61F2/28 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30677 ,  A61L27/227 ,  A61L27/3608 ,  A61L27/3633 ,  A61L27/365 ,  A61L27/505 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/602 ,  A61L2300/802 ,  A61L2430/02 ,  B33Y80/00

    摘要： An improved demineralized bone matrix (DBM) or other matrix composition is provided that has been mixed with a stabilizing agent that acts as (1) a diffusion barrier, (2) a enzyme inhibitor, (3) a competitive substrate, or (4) a masking moiety. A diffusion barrier acts as a barrier so as to protect the osteoinductive factors found in DBM from being degraded by proteolytic and glycolytic enzymes at the implantation site. Stabilizing agents may be any biodegradable material such as starches, modified starches, cellulose, dextran, polymers, proteins, and collagen. As the stabilizing agents degrades or dissolves in vivo, the osteoinductive factors such as TGF-β, BMP, and IGF are activated or exposed, and the activated factors work to recruit cells from the preivascular space to the site of injury and to cause differentiation into bone-forming cells. The invention also provides methods of preparing, testing, and using the inventive improved osteodinductive matrix compositions.

    摘要翻译： 提供了与稳定剂混合的改进的脱矿质骨基质（DBM）或其它基质组合物，其作为（1）扩散阻挡层，（2）酶抑制剂，（3）竞争性底物，或（4） 掩蔽部分。 扩散屏障作为屏障，以保护DBM中发现的骨诱导因子不被植入部位的蛋白水解酶和糖酵解酶降解。 稳定剂可以是任何可生物降解的材料，例如淀粉，改性淀粉，纤维素，葡聚糖，聚合物，蛋白质和胶原蛋白。 当稳定剂在体内降解或溶解时，诸如TGF-β，BMP和IGF的骨诱导因子被活化或暴露，并且活化因子用于将细胞从血管内空间募集到损伤部位并引起分化 骨形成细胞。 本发明还提供了制备，测试和使用本发明改进的骨吸收性基质组合物的方法。

    Shaft synchronous balancing apparatus
    37.
    发明授权
    Shaft synchronous balancing apparatus 失效
    轴同步平衡装置

    公开(公告)号：US5089969A

    公开(公告)日：1992-02-18

    申请号：US482550

    申请日：1990-02-21

    申请人： Charles Bradshaw ,  Bill Tack ,  Mike Hansford ,  John Winterbottom

    发明人： Charles Bradshaw ,  Bill Tack ,  Mike Hansford ,  John Winterbottom

    IPC分类号： G01M1/22

    CPC分类号： G01M1/22

    摘要： A shaft synchronous balancing apparatus wherein a rotor to be balanced is rotated in conjunction with appropriate balance plane located transducers and a non-contacting shaft monitoring pick-up, for example of an optical variety. The latter pick-up derives a one times per revolution reference signal which is treated by a software driven process control system including dual timer-counters to evaluate the period of revolution, T, and to develop N incremental sampling pulses having a duration or time constant of T/N. Preferably, N is an even integer power of 2. Periodic updating of the duration of a time constant is developed utilizing only one software interrupt in conjunction with the two counter timers. A nulling technique for canceling offset at the signal treatment stages is provided which accommodates for the high amplification levels necessary at the front end of the system. Additionally, a gain adjust feature achieves optimum precision and reliability for the system by performing within three discrete ranges.

    摘要翻译： 一种轴同步平衡装置，其中待平衡的转子与适当的平衡平面位置的换能器和非接触轴监测拾取器（例如光学品种）一起旋转。 后一个拾取器每转一次参考信号得到一个由包括双定时器计数器的软件驱动过程控制系统处理的参考信号，以评估转速周期T，并且产生具有持续时间或时间常数的N个增量采样脉冲 的T / N。 优选地，N是2的偶数整数倍。通过结合两个计数器定时器仅利用一个软件中断来开发时间常数的持续时间的周期性更新。 提供了用于在信号处理阶段消除偏移的归零技术，其适应系统前端所需的高放大电平。 此外，增益调整功能通过在三个离散范围内执行，实现了系统的最佳精度和可靠性。