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    Devices, systems, and methods for peripheral arteriovenous fistula creation
    31.
    发明授权
    Devices, systems, and methods for peripheral arteriovenous fistula creation 有权
    用于外周动静脉瘘创建的装置，系统和方法

    公开(公告)号：US08382697B2

    公开(公告)日：2013-02-26

    申请号：US12017437

    申请日：2008-01-22

    申请人： Rodney Brenneman ,  Dean A. Schaefer ,  J. Christopher Flaherty

    发明人： Rodney Brenneman ,  Dean A. Schaefer ,  J. Christopher Flaherty

    IPC分类号： A61M5/00

    CPC分类号： A61M1/3655 ,  A61B17/083 ,  A61B17/10 ,  A61B17/11 ,  A61B17/32053 ,  A61B2017/00867 ,  A61B2017/1107 ,  A61B2017/1139 ,  A61M39/0247 ,  A61M2039/0258 ,  A61M2039/0273 ,  A61M2039/0276 ,  A61M2039/0279

    摘要： Devices, systems and methods are disclosed for the formation of an arteriovenous fistula in the limb of the patient. Embodiments include an apparatus for the creation, modification and maintenance of a fistula, including the modification of an existing dialysis fistula; and a method of supplying oxygenated blood to the venous circulation of a patient. A kit of anastomotic implants is described which supports a broad base of patient anatomies and fistula locations. The devices, systems and methods can be used to treat patients with one or more numerous ailments including chronic obstructive pulmonary disease, congestive heart failure, hypertension, hypotension, respiratory failure, pulmonary arterial hypertension, lung fibrosis and adult respiratory distress syndrome.

    摘要翻译： 公开了用于在患者肢体中形成动静脉瘘的装置，系统和方法。 实施例包括用于创建，修改和维持瘘的装置，包括修改现有的透析瘘; 以及向患者的静脉循环供给氧合血液的方法。 描述了一套吻合植入物，其支持患者解剖结构和瘘位置的广泛基础。 装置，系统和方法可用于治疗患有一种或多种许多疾病的患者，包括慢性阻塞性肺病，充血性心力衰竭，高血压，低血压，呼吸衰竭，肺动脉高压，肺纤维化和成人呼吸窘迫综合征。

    METHODS FOR STABILIZATION OF BONE STRUCTURES
    34.
    发明申请
    METHODS FOR STABILIZATION OF BONE STRUCTURES 有权
    骨结构稳定方法

    公开(公告)号：US20110144701A1

    公开(公告)日：2011-06-16

    申请号：US12966807

    申请日：2010-12-13

    申请人： Moti Altarac ,  Stanley Kyle Hayes ,  Joey Camia Reglos ,  J. Christopher Flaherty

    发明人： Moti Altarac ,  Stanley Kyle Hayes ,  Joey Camia Reglos ,  J. Christopher Flaherty

    IPC分类号： A61B17/86

    CPC分类号： A61B17/7032 ,  A61B17/7005 ,  A61B17/7037 ,  A61B17/704

    摘要： Methods, systems, devices and tools for placing bone stabilization components in a patient are provided. The systems and devices have a reduced number of discrete components that allow placement through small incisions and tubes. More particularly, the present invention is directed to screws for use in systems and methods of treating the spine, which eliminate pain and enable spinal motion, which effectively mimics that of a normally functioning spine. Methods are also provided for installation of the screw and other subject systems.

    摘要翻译： 提供了用于将骨稳定组件放置在患者体内的方法，系统，装置和工具。 系统和设备具有减少数量的分立部件，允许通过小切口和管放置。 更具体地，本发明涉及用于治疗脊柱的系统和方法的螺钉，其消除疼痛并使脊柱运动，其有效地模拟正常功能脊柱的疼痛。 还提供了用于安装螺钉和其它主题系统的方法。

    Methods and Apparatus for Acute or Chronic Delivery or Substances or Apparatus to Extravascular Treatment Sites
    37.
    发明申请
    Methods and Apparatus for Acute or Chronic Delivery or Substances or Apparatus to Extravascular Treatment Sites 有权
    用于急性或慢性输送的方法和装置，或用于血管外治疗部位的物质或装置

    公开(公告)号：US20100016836A1

    公开(公告)日：2010-01-21

    申请号：US12567915

    申请日：2009-09-28

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M25/06 ,  A61K35/12

    CPC分类号： A61M25/065 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2018/00392 ,  A61M25/0069 ,  A61M25/0084 ,  A61M25/0102 ,  A61M2025/018

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    38.
    发明授权
    Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    将物质或器械急性或慢性传播至血管外治疗部位的方法和装置

    公开(公告)号：US07606615B2

    公开(公告)日：2009-10-20

    申请号：US10458153

    申请日：2003-06-10

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M25/00

    CPC分类号： A61M25/065 ,  A61B17/00491 ,  A61B17/0057 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B18/24 ,  A61B2017/00243 ,  A61B2017/00247 ,  A61B2017/00575 ,  A61B2018/00392 ,  A61M25/0069 ,  A61M25/0084 ,  A61M25/0102 ,  A61M2025/018

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites
    40.
    发明授权
    Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
    用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法

    公开(公告)号：US07357794B2

    公开(公告)日：2008-04-15

    申请号：US10466622

    申请日：2002-01-17

    申请人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    发明人： Joshua Makower ,  Theodore C. Lamson ,  J. Christopher Flaherty ,  John A. Reggie ,  John Y. Chang ,  Joseph Catanese, III ,  David R. Tholfsen

    IPC分类号： A61M31/00

    CPC分类号： A61M25/0108 ,  A61B6/12 ,  A61M5/007 ,  A61M25/0084 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/009 ,  A61M2210/12

    摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

    摘要翻译： 用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。 将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁 。 此后，输送导管穿过穿透器的内腔到目标部位。 然后将所需的物质或装置输送到目标部位或从目标部位获得。 在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品 从目标网站。 或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得 该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。