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64 条记录 (耗时 0.033 秒)

    Carboxylic polysaccharide derivatives
    31.
    发明授权
    Carboxylic polysaccharide derivatives 失效
    羧酸多糖衍生物

    公开(公告)号：US5538730A

    公开(公告)日：1996-07-23

    申请号：US216858

    申请日：1994-03-24

    申请人： Aurelio Romeo ,  Gino Toffano ,  Lanfranco Callegaro

    发明人： Aurelio Romeo ,  Gino Toffano ,  Lanfranco Callegaro

    IPC分类号： A61K8/72 ,  A61K8/00 ,  A61K8/73 ,  A61L15/28 ,  A61L27/00 ,  A61L27/20 ,  A61Q19/00 ,  C08B37/08 ,  A61K47/38 ,  A61K9/00

    CPC分类号： A61K8/736 ,  A61L15/28 ,  A61L27/20 ,  A61Q19/00 ,  C08B37/003

    摘要： Copolymers of the formula: ##STR1## wherein the bonds between the glucoside units are .beta. (1.fwdarw.4), the degree of polymerization referred to a single glucoside unit varies from about 50 to 50,000, R is a free or esterified carboxy group and S is an amino or acylamino group. The part designated by x may vary between about 5% and 100% and that designated by y may vary between about 95% and 0%. At least a part of the R groups are esterified carboxy groups, and at least a part of the S groups are acylamino groups. Salts of these copolymers are also disclosed. The products of the invention are particularly useful in the cosmetic field.

    摘要翻译： 下式的共聚物：其中葡萄糖苷单元之间的键是β（1-> 4），所指的单糖苷单元的聚合度在约50至50,000之间变化，R是游离或酯化的羧基， S是氨基或酰氨基。 由x指定的部分可以在约5％和100％之间变化，并且由y指定的部分可以在约95％和0％之间变化。 R基团的至少一部分是酯化的羧基，并且至少一部分S基团是酰基氨基。 还公开了这些共聚物的盐。 本发明的产品在化妆品领域特别有用。

    Biological material suitable for the therapy of osteoarthrosis, ligament damage and for the treatment of joint disorders
    33.
    发明授权
    Biological material suitable for the therapy of osteoarthrosis, ligament damage and for the treatment of joint disorders 有权
    生物材料适用于治疗骨关节炎，韧带损伤和治疗关节疾病

    公开(公告)号：US08771672B2

    公开(公告)日：2014-07-08

    申请号：US13380971

    申请日：2010-06-29

    申请人： Lanfranco Callegaro ,  Anna Maria Zanellato

    发明人： Lanfranco Callegaro ,  Anna Maria Zanellato

    IPC分类号： A61K35/12 ,  A61K35/16 ,  A61P17/02 ,  A61P19/00 ,  A61P19/02

    CPC分类号： A61K35/19 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/16 ,  A61K35/28 ,  A61K47/36 ,  A61K47/38 ,  A61L27/20 ,  A61L27/3616 ,  A61L27/3834 ,  A61L27/60

    摘要： The present invention regards a biological material comprising: a) a liquid carrier comprising a viscous solution containing at least one natural and/or semisynthetic polysaccharide, and having a Dynamic viscosity measured at 20° C. and at shear rate of D=350 s−1, comprised between 100 and 250 c Poise and/or a Kinematic viscosity comprised between 99 and 248 cSt (measured at the same conditions); b) a culture of mesenchymal stem cells, and/or c) a platelet-rich hemo-derivative. This type of material in form of viscous liquid is particularly suitable for the therapy of osteoarthrosis, ligament damage, in particular tendon and cartilage damage) and may be administered intra-articularly, intradermally or directly applied in situ without altering the properties of the mesenchymal stem cells and/or platelets contained therein.

    摘要翻译： 本发明涉及一种生物材料，其包括：a）液体载体，其包含含有至少一种天然和/或半合成多糖的粘稠溶液，并且具有在20℃下测得的动态粘度和D = 350s- 1，在100和250c之间Poise和/或运动粘度在99和248cSt之间（在相同条件下测量）; b）间充质干细胞的培养，和/或c）富含血小板的血红素衍生物。 这种粘稠液体形式的材料特别适用于治疗骨关节炎，韧带损伤，特别是肌腱和软骨损伤），并且可以在原位进行关节内，皮内或直接施用，而不改变间充质干细胞的性质 细胞和/或血小板。

    BIOLOGICAL MATERIAL SUITABLE FOR THE THERAPY OF OSTEOARTHROSIS, LIGAMENT DAMAGE AND FOR THE TREATMENT OF JOINT DISORDERS
    34.
    发明申请
    BIOLOGICAL MATERIAL SUITABLE FOR THE THERAPY OF OSTEOARTHROSIS, LIGAMENT DAMAGE AND FOR THE TREATMENT OF JOINT DISORDERS 有权
    生物材料适用于骨质疏松症，大便性损伤和治疗关节病的治疗

    公开(公告)号：US20120114609A1

    公开(公告)日：2012-05-10

    申请号：US13380971

    申请日：2010-06-29

    申请人： Lanfranco Callegaro ,  Anna Maria Zanellato

    发明人： Lanfranco Callegaro ,  Anna Maria Zanellato

    IPC分类号： A61K35/48 ,  A61K35/28 ,  A61P19/08 ,  A61K35/16 ,  A61P19/02 ,  A61P19/00 ,  A61K35/12 ,  A61P17/02

    CPC分类号： A61K35/19 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/16 ,  A61K35/28 ,  A61K47/36 ,  A61K47/38 ,  A61L27/20 ,  A61L27/3616 ,  A61L27/3834 ,  A61L27/60

    摘要： The present invention regards a biological material comprising: a) a liquid carrier comprising a viscous solution containing at least one natural and/or semisynthetic polysaccharide, and having a Dynamic viscosity measured at 20° C. and at shear rate of D=350 s−1, comprised between 100 and 250 c Poise and/or a Kinematic viscosity comprised between 99 and 248cSt (measured at the same conditions); b) a culture of mesenchymal stem cells, and/or c) a platelet-rich hemo-derivative. This type of material in form of viscous liquid is particularly suitable for the therapy of osteoarthrosis, ligament damage, in particular tendon and cartilage damage) and may be administered intra-articularly, intradermally or directly applied in situ without altering the properties of the mesenchymal stem cells and/or platelets contained therein.

    摘要翻译： 本发明涉及一种生物材料，其包括：a）液体载体，其包含含有至少一种天然和/或半合成多糖的粘稠溶液，并且具有在20℃下测得的动态粘度和D = 350s- 1，在100和250c之间Poise和/或运动粘度在99和248cSt之间（在相同条件下测量）; b）间充质干细胞的培养，和/或c）富含血小板的血红素衍生物。 这种粘稠液体形式的材料特别适用于治疗骨关节炎，韧带损伤，特别是肌腱和软骨损伤），并且可以在原位进行关节内，皮内或直接施用，而不改变间充质干细胞的性质 细胞和/或血小板。

    Three-dimensional prostheses containing hyaluronic acid derivatives
    38.
    发明授权
    Three-dimensional prostheses containing hyaluronic acid derivatives 有权
    含有透明质酸衍生物的三维假体

    公开(公告)号：US06642213B1

    公开(公告)日：2003-11-04

    申请号：US09719200

    申请日：2000-12-08

    申请人： Andrea Pastorello ,  Marco Radice ,  Lanfranco Callegaro

    发明人： Andrea Pastorello ,  Marco Radice ,  Lanfranco Callegaro

    IPC分类号： A61K31715

    CPC分类号： C08B37/0072 ,  A61L15/28 ,  A61L27/20 ,  A61L27/3804 ,  C08L5/08

    摘要： A three-dimensional prosthesis is described in the shape of a body part comprising at least one three-dimensional matrix having an essentially fibrous or porous structure and containing a hyaluronic acid derivative, said prosthesis, contains at least two of said three-dimensional matrixes, the first of said three-dimensional matrixes incorporating or being adhered to the second and possible further matrixes, said three-dimensional matrix(es) optionally inicorporating and/or being adhered to a bidimensional perforated matrix and containing a hyaluronic acid derivative. This prosthesis is used for reconstruction of human or animal body part.

    摘要翻译： 三维假体被描述为身体部位的形状，其包括至少一个具有基本纤维或多孔结构并且含有透明质酸衍生物的三维基质，所述假体包含至少两个所述三维基质， 所述三维矩阵中的第一个结合或粘附到第二和可能的另外的基质上，所述三维基质任选地合并和/或被粘附到二维穿孔基质并且含有透明质酸衍生物。 该假体用于重建人体或动物体部位。

    Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery
    39.
    发明授权
    Hyaluronic acid esters, threads and biomaterials containing them, and their use in surgery 有权
    含有透明质酸酯，线和生物材料，以及它们在手术中的应用

    公开(公告)号：US06632802B2

    公开(公告)日：2003-10-14

    申请号：US09941055

    申请日：2001-08-28

    申请人： Davide Bellini ,  Lanfranco Callegaro

    发明人： Davide Bellini ,  Lanfranco Callegaro

    IPC分类号： A61K31715

    CPC分类号： A61L17/105 ,  C08B37/0072

    摘要： The application discloses esters of hyaluronic acid, wherein a first part of the carboxylic functions is esterified with an araliphatic alcohol and a second part is esterified with at least one long-chain, straight aliphatic alcohol with between 10 and 22 carbon atoms. The possible remaining non-esterified carboxylic functions, if present, are salified. The application further discloses biocompatible threads having a multifilament conformation comprising filaments formed by the aforesaid esters, and their use in the fields of medicine and surgery.

    摘要翻译： 本申请公开了透明质酸的酯，其中羧酸官能团的第一部分用芳脂族醇酯化，第二部分与至少一种具有10至22个碳原子的长链直链脂肪醇酯化。 剩余的未酯化的羧酸官能团（如果存在的话）是成盐的。 本申请进一步公开了具有复丝构象的生物相容性线，其包含由上述酯形成的长丝，以及它们在医学和外科领域中的用途。