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1.发明授权N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation 有权N-硫酸化透明质酸化合物及其衍生物及其制备方法公开(公告)号：US06833363B2
公开(公告)日：2004-12-21
申请号：US09972707
申请日：2001-10-03
申请人： David Renier , Lanfranco Callegaro
发明人： David Renier , Lanfranco Callegaro
IPC分类号： A61K31728
CPC分类号： C08B37/0072 , A61L24/08 , A61L26/0023 , A61L26/0052 , A61L27/20 , A61L27/26 , A61L29/043 , A61L29/049 , A61L31/041 , A61L31/042 , A61L33/08 , C08L5/08 , C08L1/04
摘要： The present invention is directed to novel sulphated compounds of hyaluronic acid and derivatives thereof, optionally salified, wherein the glucosamines are partially N-sulphated and partially or totally O-sulphated in position 6. The compounds of the invention have anticoagulant and antithrombotic activities and are useful in the preparation of pharmaceutical compositions and biomaterial and in the production of coatings for biomaterials compositions and biomaterials and in the production of coating for biomedical objects.
摘要翻译： 本发明涉及透明质酸及其衍生物的新型硫酸化化合物，任选地盐化，其中葡糖胺部分被N-硫酸化并在位置6部分或全部O-硫酸化。本发明的化合物具有抗凝血和抗血栓形成活性， 可用于制备药物组合物和生物材料以及用于生物材料组合物和生物材料的涂层以及生产用于生物医学物体的涂层。
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2.发明授权Biomaterials comprising N-sulphated hyaluronic acid compounds or derivatives thereof 有权包含N-硫酸化透明质酸化合物或其衍生物的生物材料公开(公告)号：US06579978B1
公开(公告)日：2003-06-17
申请号：US09402510
申请日：1999-12-06
申请人： David Renier , Lanfranco Callegaro
发明人： David Renier , Lanfranco Callegaro
IPC分类号： C08B3700
CPC分类号： C08B37/0072 , A61L24/08 , A61L26/0023 , A61L26/0052 , A61L27/20 , A61L27/26 , A61L29/043 , A61L29/049 , A61L31/041 , A61L31/042 , A61L33/08 , C08L5/08 , C08L1/04
摘要： The present invention is directed to novel sulphated compounds of hyaluronic acid and derivatives thereof, optionally salified, wherein the glucosamines are partially N-sulphated or partially N-sulphated and partially or totally O-sulphated in position 6. The compounds of the invention have anticoagulant and antithrombotic activities and are useful in the preparation of pharmaceutical compositions and biomaterials and in the production of coatings for biomedical objects.
摘要翻译： 本发明涉及透明质酸及其衍生物的新型硫酸化化合物，任选地盐化，其中葡糖胺部分被N-硫酸化或部分N-硫酸化并在位置6部分或全部O-硫酸化。本发明的化合物具有抗凝血剂 和抗血栓形成活性，并且可用于制备药物组合物和生物材料以及生产用于生物医学物体的涂层。
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3.发明授权Biomaterials, their preparation by electrospinning and their use in the biomedical and surgical field 有权生物材料，它们通过静电纺丝制备及其在生物医学和外科领域的应用公开(公告)号：US08865964B2
公开(公告)日：2014-10-21
申请号：US13056541
申请日：2009-07-24
CPC分类号： A61L27/60 , Y10T442/3065 , Y10T442/614 , Y10T442/626
摘要： There is described a new non-woven fabric produced with the electrospinning technique, and the use thereof as new biomaterial for the biomedical and surgical field.
摘要翻译： 描述了一种用静电纺丝技术生产的新型无纺织物，并将其用作生物医学和外科领域的新生物材料。
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4.发明授权公开(公告)号：US08147811B1
公开(公告)日：2012-04-03
申请号：US10019387
申请日：2000-06-29
IPC分类号： A61K8/18
CPC分类号： A61K31/728 , A61K31/715 , A61L15/28 , A61L15/44 , A61L17/005 , A61L17/10 , A61L31/042 , A61L31/16 , A61L2300/00 , A61L2300/236 , A61L2300/404 , A61L2300/414 , A61L2300/45 , A61K31/00 , A61K2300/00 , C08L5/08
摘要： Use of hyaluronic acid derivatives for the preparation of biomaterials for the prevention of the formation and the treatment of cutaneous scars, wherein the hyaluronic acid derivatives are optionally combined with pharmacologically or biologically active compounds.
摘要翻译： 透明质酸衍生物用于制备用于预防皮肤瘢痕形成和治疗的生物材料的透明质酸衍生物，其中任选地与药理学或生物活性化合物组合。
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5.发明授权Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy 有权使用含有透明质酸衍生物的立体支架的生物材料用于在关节镜中制备植入物，以及用于通过关节镜检查植入所述生物材料的器械的试剂盒公开(公告)号：US07722616B2
公开(公告)日：2010-05-25
申请号：US10250408
申请日：2001-12-27
CPC分类号： A61L27/3804 , A61L27/20 , A61L27/3852 , C08L5/08
摘要： The invention relates to use of a biological material containing cells supported on three-dimensional scaffolds containing at least one hyaluronic acid derivative for the preparation of grafts suitable for application by arthroscopy, and a kit of surgical instruments for implanting said biological material by arthroscopy.
摘要翻译： 本发明涉及包含支持在含有至少一种透明质酸衍生物的三维支架上的细胞的生物材料用于制备适于通过关节镜检查应用的移植物的用途，以及用于通过关节镜检查植入所述生物材料的外科器械套件的用途。
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6.发明授权Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins 失效用于输送成骨蛋白质的透明质酸衍生物的可注射载体制剂公开(公告)号：US07608580B2
公开(公告)日：2009-10-27
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/16
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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7.发明申请INJECTABLE CARRIER FORMULATIONS OF HYALURONIC ACID DERIVATIVES FOR DELIVERY OF OSTEOGENIC PROTEINS 失效用于递送蛋白质的羟丙酸衍生物的可手动载体配方公开(公告)号：US20070134342A1
公开(公告)日：2007-06-14
申请号：US11624463
申请日：2007-01-18
申请人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
发明人： Hyun Kim , Rebecca Li , Alessandra Pavesio , Lanfranco Callegaro , Howard Seeherman , John Wozney
IPC分类号： A61K38/18 , A61K31/728 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/0019 , A61K38/1875 , A61K47/26 , A61K47/36 , A61L27/20 , A61L27/227 , A61L27/46 , A61L2300/414 , A61L2400/06 , A61K2300/00 , C08L5/08
摘要： An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.
摘要翻译： 公开了用于递送成骨蛋白质的可注射制剂。 该制剂包含成骨蛋白的药学上可接受的混合物; 并且还公开了包含成骨蛋白，透明质酸衍生物和磷酸三钙的制剂。 还公开了从透明质酸配制多孔可注射凝胶和糊剂的方法。
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8.发明授权Process for preparing a hyaluronic acid fraction having a low polydispersion index 有权具有低多分散指数的透明质酸级分的制备方法公开(公告)号：US06232303B1
公开(公告)日：2001-05-15
申请号：US09426536
申请日：1999-10-26
申请人： Lanfranco Callegaro , Davide Renier
发明人： Lanfranco Callegaro , Davide Renier
IPC分类号： A61K3170
CPC分类号： C08B37/0072
摘要： A process for preparing a hyaluronic acid fraction having an average molecular weight comprised between 5000 and 300,000 and a polydispersion index lower than 1.7, comprising treating the starting high molecular weight hyaluronic acid, contemporaneously with sodium hypochlorite and ultrasounds.
摘要翻译： 一种制备平均分子量在5000至300,000之间并且多分散指数低于1.7的透明质酸级分的方法，包括用次氯酸钠和超声波同时处理起始高分子量透明质酸。
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9.发明授权
公开(公告)号：US5521164A
公开(公告)日：1996-05-28
申请号：US116268
申请日：1993-09-03
IPC分类号： A61K31/70 , A61K31/7028 , A61P25/00 , C07H1/08 , C07H15/04 , C07H15/10 , C07H15/12 , A61K35/30 , A61K31/715
摘要： The process of the invention relates to a process for the preparation of a ganglioside mixture, free from contaminants associated with non-conventional, life-threatening viruses, without altering the biological and pharmacological characteristics of the mixture on the central and peripheral nervous systems.
摘要翻译： 本发明的方法涉及一种制备神经节苷脂混合物的方法，所述神经节苷脂混合物没有与非传统的危及生命的病毒相关的污染物，而不改变中枢和周围神经系统上混合物的生物学和药理学特性。
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公开(公告)号：US5300493A
公开(公告)日：1994-04-05
申请号：US945495
申请日：1992-09-16
申请人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
发明人： Aurelio Romeo , Gino Toffano , Lanfranco Callegaro
IPC分类号： A61K20060101 , A61K31/045 , A61K31/715 , A61K31/73
CPC分类号： A61K31/045 , A61K31/715 , Y10S514/925 , Y10S514/926
摘要： Acidic polysaccharide esters containing carboxylic groups are useful for protecting against and curing ulcers of the gastro-enteric system. These esters include choline esters with acidic polysaccharide selected from the group consisting of hyaluronic acid, alginic acid, gellan, oxidized cellulose, oxidized chitin, carboxy-hydrocarbyl-cellulose, carboxy-hydrocarbyl-starch and carboxy-hydrocarbyl-chitin, wherein the term hydrocarbyl means the residue of a hydrocarbon selected from the group consisting of by alkyl, aralkyl and cycloalkyl.
摘要翻译： 含有羧基的酸性多糖酯可用于防止和治疗胃肠系统的溃疡。 这些酯包括选自透明质酸，海藻酸，结冷胶，氧化纤维素，氧化几丁质，羧基 - 烃基 - 纤维素，羧基 - 烃基 - 淀粉和羧基 - 烃基几丁质的酸性多糖的胆碱酯，其中术语烃基 是指选自烷基，芳烷基和环烷基的烃的残基。
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