公开(公告)号：US20240279186A1

公开(公告)日：2024-08-22

申请号：US18428316

申请日：2024-01-31

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:






or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20240254091A1

公开(公告)日：2024-08-01

申请号：US18476141

申请日：2023-09-27

Applicant: GILEAD SCIENCES, INC.

Inventor： Gregory Chin ,  Richard L. Mackman ,  Michael R. Mish ,  Jeff Zablocki

IPC: C07D239/95 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  A61P31/18 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

CPC classification number: C07D239/95 ,  A61K31/517 ,  A61K31/519 ,  A61K45/06 ,  A61P31/18 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.

公开(公告)号：US20240116946A1

公开(公告)日：2024-04-11

申请号：US18376159

申请日：2023-10-03

Applicant: Gilead Sciences, Inc.

Inventor： Stephen E. Ammann ,  Xinpei Cai ,  Eda Y. Canales ,  Weng K. Chang ,  Gregory F. Chin ,  Henok H. Kinfe ,  Scott E. Lazerwith ,  Jessica L. McKinley ,  Michael R. Mish ,  Devan Naduthambi ,  Jason K. Perry ,  Kevin X. Rodriguez ,  Scott D. Schroeder ,  Christopher J. Swank ,  Joshua J. Van Veldhuizen

IPC: C07D495/04 ,  C07D401/04 ,  C07D519/00

CPC classification number: C07D495/04 ,  C07D401/04 ,  C07D519/00

Abstract: The present disclosure relates to compounds of Formula I:




and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.

公开(公告)号：US20240116928A1

公开(公告)日：2024-04-11

申请号：US18344560

申请日：2023-06-29

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Jennifer L. Cosman Ellis ,  Richard L. Mackman ,  Michael R. Mish

IPC: C07D471/04 ,  C07D401/14

CPC classification number: C07D471/04 ,  C07D401/14

Abstract: There is provided a compound of Formula (I):






or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of wherein the various substituents are defined herein,

公开(公告)号：US11919869B2

公开(公告)日：2024-03-05

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20230183189A1

公开(公告)日：2023-06-15

申请号：US18050404

申请日：2022-10-27

Applicant: Gilead Sciences, Inc.

Inventor： Mark J. Bartlett ,  Gregory F. Chin ,  Michael O. Clarke ,  Jennifer L. Cosman ,  Deeba Ensan ,  Bindu Goyal ,  Stephen Ho ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  Kyle C. Tamshen ,  Hai Yang

IPC: C07D247/00

CPC classification number: C07D247/00

Abstract: Provided herein is A compound of Formula I:




or a pharmaceutically acceptable salt thereof, wherein the various substituents are described herein.

公开(公告)号：US20220356196A1

公开(公告)日：2022-11-10

申请号：US17176497

申请日：2021-02-16

Applicant: Gilead Sciences, Inc.

Inventor： Daniel H. Byun ,  Gregory F. Chin ,  Byoung-kwon Chun ,  Michael O. Clarke ,  Bindu Goyal ,  Hon C. Hui ,  Petr Jansa ,  Richard L. Mackman ,  Michael R. Mish ,  Dustin S. Siegel ,  David Sperandio ,  Hai Yang ,  Lijun Zhang

IPC: C07F9/6561

Abstract: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.

公开(公告)号：US20220241281A1

公开(公告)日：2022-08-04

申请号：US17496962

申请日：2021-10-08

Applicant: Gilead Sciences, Inc.

Inventor： Gregory Chin ,  Michael O`Neil Hanrahan Clarke ,  Xiaochun Han ,  Tim Hansen ,  Yunfeng Eric Hu ,  Dmitry Koltun ,  Ryan McFadden ,  Michael R. Mish ,  Eric Q. Parkhill ,  David Sperandio ,  Lianhong Xu ,  Hai Yang

IPC: A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D519/00

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

公开(公告)号：US20220218709A1

公开(公告)日：2022-07-14

申请号：US17540563

申请日：2021-12-02

Applicant: GILEAD SCIENCES, INC.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Richard L. Mackman ,  Samuel E. Metobo ,  Michael R. Mish ,  Hyung-Jung Pyun ,  Jeff Zablocki

IPC: A61K31/517 ,  C07D471/04 ,  C07D239/84 ,  C07D401/04

Abstract: The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D] pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

公开(公告)号：US11179397B2

公开(公告)日：2021-11-23

申请号：US16591092

申请日：2019-10-02

Applicant: Gilead Sciences, Inc.

Inventor： Gregory Chin ,  Michael O' Neil Hanrahan Clarke ,  Xiaochun Han ,  Tim Hansen ,  Yunfeng Eric Hu ,  Dmitry Koltun ,  Ryan McFadden ,  Michael R. Mish ,  Eric Q. Parkhill ,  David Sperandio ,  Lianhong Xu ,  Hai Yang

IPC: C07D487/04 ,  A61K31/519 ,  A61K45/06 ,  C07D471/04 ,  C07D471/10 ,  C07D519/00

Abstract: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.