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    Adjustment of Sensor Sensitivity by Controlling Copolymer Film Thickness Through a Controlled Drying Step
    31.
    发明申请
    Adjustment of Sensor Sensitivity by Controlling Copolymer Film Thickness Through a Controlled Drying Step 有权
    通过控制干燥步骤控制共聚物膜厚度来调节传感器灵敏度

    公开(公告)号：US20150148647A1

    公开(公告)日：2015-05-28

    申请号：US14092655

    申请日：2013-11-27

    Applicant: Google Inc.

    Inventor： Zenghe Liu ,  Huanfen Yao

    IPC: H01M4/04 ,  A61B5/145

    CPC classification number: A61B5/14532 ,  A61B5/1486 ,  A61B5/6821 ,  C12Q1/001 ,  C12Q1/002 ,  C12Q1/005 ,  G01N27/3271 ,  G02C7/04

    Abstract: An analyte sensor and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The method of making the analyte sensor includes depositing a precursor mixture containing monomers and an analyte sensing component onto an electrode, exposing the deposited precursor mixture to a controlled environment for a specified period of time, and photopolymerizing the deposited exposed precursor mixture into a copolymer layer in contact with a surface of the electrode. Exposing the deposited precursor mixture to a controlled environment can increase the sensitivity of the sensor by reducing the thickness of the copolymer layer and/or by causing the analyte sensitive component within the copolymer layer to have a non-uniform concentration within the layer.

    Abstract translation: 公开了分析物传感器和用于制造分析物传感器的方法。 一方面，分析物传感器包括与电极表面接触的交联的亲水共聚物和嵌入交联的亲水共聚物内的分析物感测组分。 制备分析物传感器的方法包括将含有单体和分析物感测组分的前体混合物沉积到电极上，将沉积的前体混合物暴露于受控环境达指定的时间段，并将沉积的暴露的前体混合物光聚合成共聚物层 与电极的表面接触。 将沉积的前体混合物暴露于受控环境可以通过减小共聚物层的厚度和/或通过使共聚物层内的分析物敏感组分在层内具有不均匀的浓度来增加传感器的灵敏度。

    Methods for Adhering a Substrate to a Polymer Layer
    33.
    发明申请
    Methods for Adhering a Substrate to a Polymer Layer 有权
    将基材粘合到聚合物层上的方法

    公开(公告)号：US20150005602A1

    公开(公告)日：2015-01-01

    申请号：US13930687

    申请日：2013-06-28

    Applicant: Google Inc

    Inventor： Jeffrey George Linhardt ,  Zenghe Liu

    IPC: A61B3/10

    CPC classification number: A61B3/101 ,  B29C65/522 ,  B29D11/00048 ,  B29D11/00817 ,  B32B37/185 ,  B32B2551/00 ,  G02C7/04 ,  G02C7/049 ,  G02C2202/16

    Abstract: The present disclosure provides a method including forming a polymer layer defining a side of an eye-mountable device. The method may also include providing an adhesive in a ring-shaped pattern on a ring-shaped substrate or on the first polymer layer. The method may also include providing the ring-shaped substrate on the first polymer layer in a predetermined rotational orientation. The method may also include applying a force to one or more of the ring-shaped substrate and the polymer layer to adhere the first polymer layer to the ring-shaped substrate. The method may also include curing the ring-shaped substrate and the first polymer layer.

    Abstract translation: 本公开提供了一种方法，包括形成限定眼睛安装装置的侧面的聚合物层。 该方法还可以包括在环形基底上或在第一聚合物层上提供呈环状图案的粘合剂。 该方法还可以包括以预定的旋转方向在第一聚合物层上提供环形基材。 该方法还可以包括向一个或多个环形基底和聚合物层施加力以将第一聚合物层粘附到环形基底上。 该方法还可以包括固化环形基底和第一聚合物层。

    Porous Polymeric Formulation Prepared Using Monomer
    34.
    发明申请
    Porous Polymeric Formulation Prepared Using Monomer 有权
    使用单体制备的多孔聚合物配方

    公开(公告)号：US20150001073A1

    公开(公告)日：2015-01-01

    申请号：US13930858

    申请日：2013-06-28

    Applicant: Google Inc.

    Inventor： Zenghe Liu ,  Jeffrey George Linhardt

    IPC: C12Q1/00

    CPC classification number: C12Q1/003

    Abstract: An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. In one aspect, the analyte sensor includes a crosslinked, hydrophilic copolymer in contact with a surface of an electrode, and an analyte sensing component embedded within the crosslinked, hydrophilic copolymer. The crosslinked, hydrophilic copolymer has methacrylate-derived backbone chains of first methacrylate-derived units, second methacrylate-derived units and third methacrylate-derived units. The first and second methacrylate-derived units have side chains that can be the same or different, and the third methacrylate-derived units in different backbone chains are connected by hydrophilic crosslinks.

    Abstract translation: 公开了用于连续或半连续监测生理参数的分析物传感器和用于制备分析物传感器的方法。 一方面，分析物传感器包括与电极表面接触的交联的亲水共聚物和嵌入交联的亲水共聚物内的分析物感测组分。 交联的亲水共聚物具有衍生自第一甲基丙烯酸酯单元，第二甲基丙烯酸酯衍生单元和第三甲基丙烯酸酯衍生单元的甲基丙烯酸酯衍生的主链。 第一和第二甲基丙烯酸酯衍生单元具有可以相同或不同的侧链，并且不同主链中的第三甲基丙烯酸酯衍生单元通过亲水性交联连接。

    Chemically Reactive Enzyme Immobilization
    35.
    发明申请
    Chemically Reactive Enzyme Immobilization 有权
    化学活性酶固定化

    公开(公告)号：US20150001072A1

    公开(公告)日：2015-01-01

    申请号：US13930821

    申请日：2013-06-28

    Applicant: Google Inc.

    Inventor： Zenghe Liu ,  Jeffrey George Linhardt

    IPC: G01N27/327 ,  B05D5/12

    CPC classification number: G01N27/327 ,  A61B5/1486 ,  A61B5/6821 ,  C12Q1/006 ,  G01N27/3271

    Abstract: An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked, hydrophilic copolymer sensing layer in contact with a surface of an electrode, where the sensing layer includes methacrylate-derived backbone chains having covalent bonds to an analyte sensing component. The method includes combining the precursor components of the sensing layer, depositing the combined mixture on a surface of an electrode, and curing the deposited mixture.

    Abstract translation: 公开了用于连续或半连续监测生理参数的分析物传感器和用于制备分析物传感器的方法。 分析物传感器包括与电极表面接触的交联的亲水共聚物感测层，其中感测层包括具有与分析物感测组分共价键的甲基丙烯酸酯衍生的骨架链。 该方法包括组合感测层的前体组分，将组合的混合物沉积在电极的表面上，并固化沉积的混合物。

    In-vitro contact lens testing
    36.
    发明申请
    In-vitro contact lens testing 审中-公开
    体外隐形眼镜测试

    公开(公告)号：US20140329303A1

    公开(公告)日：2014-11-06

    申请号：US14338429

    申请日：2014-07-23

    Applicant: Google Inc.

    Inventor： Zenghe Liu ,  James Etzkorn

    IPC: G01N33/52 ,  G01N33/53 ,  G01N33/543 ,  G01N21/64

    CPC classification number: G01N33/528 ,  B01J2219/00612 ,  B01J2219/00621 ,  G01N21/6486 ,  G01N21/75 ,  G01N33/5304 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/62 ,  G01N33/66 ,  G01N33/92 ,  G01N33/98 ,  G01N2333/46 ,  Y10T436/144444

    Abstract: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.

    Abstract translation: 介绍了用于测试分析物的隐形眼镜的隐形眼镜测试仪器和方法。 一方面，提供了一种装置，其包括构造成保持一个或多个隐形眼镜的壳体，以及设置在壳体内并包括试剂的测试室，所述试剂被配置为响应于存在预定的 放置在测试室中的隐形眼镜上或其内的生物标志物，其中化学反应产生与生成生物标志物的个体的状态信息相关的已知结果。

    CONTACT LENSES HAVING TWO-ELECTRODE ELECTROCHEMICAL SENSORS
    39.
    发明申请
    CONTACT LENSES HAVING TWO-ELECTRODE ELECTROCHEMICAL SENSORS 审中-公开

    公开(公告)号：US20140194713A1

    公开(公告)日：2014-07-10

    申请号：US14029281

    申请日：2013-09-17

    Applicant: GOOGLE INC.

    Inventor： Zenghe Liu

    IPC: A61B5/1486 ,  A61B5/00 ,  A61B5/145

    CPC classification number: A61B5/1486 ,  A61B5/0004 ,  A61B5/002 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1495 ,  A61B5/6821

    Abstract: Apparatus, systems and methods employing contact lenses with two-electrode electrochemical sensors are provided. In some aspects, the contact lens includes: a substrate that forms at least part of a body of the contact lens; and a circuit, disposed on or within the substrate, and including a two-electrode electrochemical sensor. The two-electrode electrochemical sensor can include: a working electrode; and a combination reference-counter electrode. The electrochemical sensor can be an amperometric sensor that senses a biological feature of a wearer of the contact lens. The working electrode can generate a signal indicative of the sensed analyte, and the combination reference-counter electrode can pass the signal generated from the working electrode. The signal can be employed to determine the analyte concentration of a solution in contact with the contact lens.

    IN-VITRO CONTACT LENS TESTING
    40.
    发明申请
    IN-VITRO CONTACT LENS TESTING 有权
    IN-VITRO接触式镜头测试

    公开(公告)号：US20140087452A1

    公开(公告)日：2014-03-27

    申请号：US13627727

    申请日：2012-09-26

    Applicant: Google Inc.

    Inventor： Zenghe Liu ,  James Etzkorn

    IPC: C12M1/34 ,  G01N33/53

    CPC classification number: G01N33/528 ,  B01J2219/00612 ,  B01J2219/00621 ,  G01N21/6486 ,  G01N21/75 ,  G01N33/5304 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/62 ,  G01N33/66 ,  G01N33/92 ,  G01N33/98 ,  G01N2333/46 ,  Y10T436/144444

    Abstract: Contact lens testing apparatuses and method for testing contact lenses for analytes are presented. In an aspect, a device is provided that includes a housing configured to hold one or more contact lenses, and a testing compartment provided within the housing and comprising a reagent, the reagent configured to facilitate a chemical reaction in response to the existence of a predetermined biomarker disposed on or within a contact lens placed in the testing compartment, wherein the chemical reaction produces a known result related to state information of an individual from which the biomarker was generated.

    Abstract translation: 介绍了用于测试分析物的隐形眼镜的隐形眼镜测试仪器和方法。 一方面，提供了一种装置，其包括构造成保持一个或多个隐形眼镜的壳体，以及设置在壳体内并包括试剂的测试室，所述试剂被配置为响应于存在预定的 放置在测试室中的隐形眼镜上或其内的生物标志物，其中化学反应产生与生成生物标志物的个体的状态信息相关的已知结果。

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